98 results match your criteria: "Northwestern University Feinberg School of Medicine Chicago Illinois.[Affiliation]"

Introduction: Measurements of health-related quality of life (HRQoL) are important for capturing disease impact beyond physical health and relative to other diseases but have rarely been assessed in primary progressive aphasia (PPA).

Methods: HRQoL was characterized overall, by sex and subtype in PPA ( = 118) using the Health Utilities Index-2/3 (HUI2/3). Multiple linear regression assessed associations between HRQoL and language severity.

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Objective: To characterize neighborhood-level area deprivation's association with oropharyngeal carcinoma clinicodemographics, tumor staging, recurrence, and overall survival.

Study Design: Retrospective study.

Setting: Single institution academic medical center.

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Article Synopsis
  • Adverse psychosocial factors like stress and loneliness can affect gene expression related to inflammation and cognitive decline, suggesting that people facing these challenges may experience higher levels of CTRA gene expression.
  • In participants with normal cognition and mild cognitive impairment (MCI), a sense of eudaimonic well-being (EWB) was linked to lower levels of CTRA gene expression, indicating its potential protective role against stress.
  • Coping strategies varied based on cognitive status, influencing the relationship with CTRA gene expression, while loneliness did not significantly affect gene expression in this low-loneliness group.
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  • The study investigates the combination of venetoclax (VEN) and vincristine (L-VCR) for patients with relapsed or refractory acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LL).
  • In a dose escalation trial with 18 patients, the maximum tolerated dose (MTD) of the drug combination was determined to be VEN at 600 mg, with significant adverse events reported in 89% of participants.
  • The preliminary results showed a 22% complete response rate, with some patients achieving no measurable residual disease, indicating potential efficacy for this treatment approach.
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Objectives: Pediatric epistaxis is a common, often non-operative condition encountered by Otolaryngologists. The present study seeks to (1) describe our outcomes of epistaxis management, (2) estimate the associated healthcare burden, and (3) propose a clinical model to optimize care coordination with primary care and advanced practice providers.

Methods: Retrospective case series of pediatric patients treated outpatient for epistaxis by a single otolaryngologist from 2021 to 2022.

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Objective: This study aimed to evaluate the association of dynamic contrast enhancement (DCE) with clinically significant prostate cancer (csPCa, Gleason Grade Group ≥2) and compare biparametric magnetic resonance imaging (bpMRI) and multiparametric MRI (mpMRI) nomograms.

Subjects/patients And Methods: We identified a retrospective cohort of biopsy naïve patients who underwent pre-biopsy MRI separated by individual MRI series from 2018 to 2022. csPCa detection rates were calculated for patients with peripheral zone (PZ) lesions scored 3-5 on diffusion weighted imaging (DWI) with available DCE (annotated as - or +).

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Objectives: In the United States, pediatric emergency department (ED) visits for behavioral health (BH) are increasing. We sought to determine ED-level characteristics associated with having recommended BH-related policies.

Methods: We conducted a retrospective serial cross-sectional study of National Pediatric Readiness Project assessments administered to US EDs in 2013 and 2021.

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Objective: The objectives of the study were to assess emergency medicine (EM) physician perceptions of the EM job market 2 years after "The Emergency Medicine Physician Workforce: Projections for 2030" was published in and to examine how the workforce report may have influenced perceptions about job prospects.

Methods: A cross-sectional survey was conducted in 2022 of EM residents, fellows, and attendings at 21 practice sites. Main outcomes were perceptions of the likelihood of currently finding any job, currently finding a desirable job, and confidence in the future EM job market.

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Article Synopsis
  • CBF-AML is classified as a favorable risk leukemia and often treated with intensive chemotherapy (IC) that may include the drug gemtuzumab ozogamicin (GO).
  • A study of 200 patients showed that adding GO to IC did not improve overall survival (OS) or event-free survival (EFS) compared to IC alone, with 3-year EFS rates of 50% and 47%, respectively.
  • In contrast, patients receiving IC with KIT inhibitors (like dasatinib or midostaurin) had a significantly better 3-year EFS of 85%, highlighting the effectiveness of KIT inhibitors over the addition of GO.
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Article Synopsis
  • * The condition commonly affects the urinary tract and gastrointestinal tract, particularly the colon and rectum, and is seldom seen in children.
  • * Treatment involves using specific antibiotics that target macrophages and cholinergic agents to enhance the immune response, with a reported case in a pediatric leukemia patient highlighting its rarity.
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Introduction: The rapid development of artificial intelligence (AI) in healthcare has exposed the unmet need for growing a multidisciplinary workforce that can collaborate effectively in the learning health systems. Maximizing the synergy among multiple teams is critical for Collaborative AI in Healthcare.

Methods: We have developed a series of data, tools, and educational resources for cultivating the next generation of multidisciplinary workforce for Collaborative AI in Healthcare.

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Introduction: Although prostate magnetic resonance imaging (MRI) is commonly used in the diagnosis, staging and active surveillance of prostate cancer, little is known about patient perspectives on MRI.

Methods: We performed a qualitative study consisting of in-depth, semi-structured interviews of patients with low- and intermediate-risk prostate cancer managed with active surveillance. Interviews focused on experiences with and knowledge of prostate MRI and MRI-ultrasound fusion biopsy during active surveillance.

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  • Early identification of atypical disruptive behaviors in autistic toddlers is essential for timely access to screenings and interventions, and the study focuses on a new dimensional assessment tool called MAP-DB-IT to measure these behaviors on a spectrum.* -
  • In the study, 82 autistic toddlers underwent an 8-week caregiver-mediated intervention, during which mothers completed the MAP-DB-IT and ITSEA measures to track changes in disruptive behaviors at three different time points.* -
  • Results indicated that the MAP-DB-IT has strong internal consistency and shows valid correlations with ITSEA measures, confirming its effectiveness in assessing and monitoring disruptive behaviors in autistic toddlers.*
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Splenic steal syndrome (SASS) represents a challenge to interventional radiologists after orthotopic liver transplantation. In this case series, we present three cases of patients who developed SASS after their liver transplants.

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Background: Anti-obesity medications (AOMs) have historically had limited weight-loss efficacy. However, newer glucagon-like peptide-1 receptor agonist (GLP-1 RA)-based therapies seem to be more effective, including dual agonists of GLP-1R and the glucagon receptor (GCGR) or glucose-dependent insulinotropic polypeptide receptor.

Objective: To explore healthcare professionals' (HCPs) experience in obesity treatment and their understanding of agonists of GCGR, glucose-dependent insulinotropic polypeptide (GIP) RA, and GLP-1 RA.

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Objectives: Online educational platforms with open access have seen a growing adoption in the field of medical education. However, the extent of their global usage is still unclear. To fill this knowledge gap, our objective is to examine the usage patterns of two renowned open-access resources in Otolaryngology.

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Background And Aims: Imposter phenomenon (IP), or perceived fraudulence, describes an ongoing fear of exposure as a fraud or imposter, despite objective successes and accomplishments. Although there is a growing interest of IP in medicine, IP in the physical therapy profession has been minimally examined. We aimed to determine the prevalence and predictors of IP among licensed physical therapists in the United States.

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Objectives: The Salivary Gland Committee of the American Academy of Otolaryngology-Head and Neck Surgery seeks to standardize terminology and technique for ultrasonograpy used in the evaluation and treatment of salivary gland disorders.

Methods: Development of expert opinion obtained through interaction with international practitioners representing multiple specialties. This committee work includes a comprehensive literature review with presentation of case examples to propose a standardized protocol for the language used in ultrasound salivary gland assessment.

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A pediatric capacity crisis developed across the country in the Fall and Winter of 2022 due to a combination of factors, including a surge in respiratory viruses, staffing shortages, and historical closures of inpatient pediatric units. The COVID-19 pandemic and associated surge in critically ill adult patients demonstrated that health care systems and health care workers can quickly implement creative and collaborative system-wide solutions to deliver the best care possible during a capacity crisis. Similar solutions are needed to respond to future surges in pediatric volume and to maintain a high standard of care during such a surge.

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Background: Tissue-based gene expression (genomic) tests provide estimates of prostate cancer aggressiveness and are increasingly used for patients considering or engaged in active surveillance. However, little is known about patient experiences with genomic testing and its role in their decision-making.

Methods: We performed a qualitative study consisting of in-depth, semi-structured interviews of patients with low- or favourable-intermediate-risk prostate cancer managed with active surveillance.

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Objective: Given the aging population and growing burden of frailty, we conducted this scoping review to describe the available literature regarding the use and impact of frailty assessment tools in the assessment and care of emergency department (ED) patients older than 60 years.

Methods: A search was made of the available literature using the Covidence system using various search terms. Inclusion criteria comprised peer-reviewed literature focusing on frailty screening tools used for a geriatric population (60+ years of age) presenting to EDs.

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In patients with infectious symptoms and severe muscle pain, it is crucial to consider pyomyositis as a significant potential cause. A normal complete blood count should not exclude this possibility early in the course. Early advanced imaging modalities and blood cultures are crucial in narrowing the differential.

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