1 results match your criteria: "Northwestern University Feinberg Medical School. Chicago[Affiliation]"
Functions of dehydroepiandrosterone in relation to breast cancer.
Steroids
March 2022
Department of Obstetrics and Gynecology and the Robert H Lurie Comprehensive Cancer Center of Northwestern, Northwestern University Feinberg Medical School. Chicago, IL 60911, USA. Electronic address:
Article Synopsis
- DHEA sulfate (DS) is significantly more concentrated in breast fluid than in serum, and its transport into cells is facilitated by specific OATPs, which can vary by cell type and location.
- Research indicates a positive correlation between serum DS and breast cancer risk, particularly with DHEA in postmenopausal women, suggesting that DHEA and its metabolites may independently contribute to cancer risk.
- DHEA’s role in breast cancer may involve increasing IGF-I levels, inhibiting glucocorticoids, retaining pre-adipocytes with aromatase activity, and potentially stimulating pathways linked to tumor promotion, despite also having some antitumor properties.