85 results match your criteria: "Northwestern Medical School[Affiliation]"
Heart Lung Circ
April 2024
Internal Medicine, Wayne State University, Detroit, MI, USA.
Background: Literature regarding outcomes associated with surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR) among amyloidosis (AM) with aortic stenosis (AS) is limited.
Objectives: We aim to study the mortality and in-hospital clinical outcomes among AM with AS associated with SAVR or TAVR.
Methods: We performed a retrospective study of all hospitalisation encounters associated with a diagnosis of AM with AS, using the Nationwide Readmissions Database for the years 2012-2019.
FASEB Bioadv
August 2020
Clinical Pharmacology and Safety Sciences AstraZeneca R&D Mölndal Sweden.
PGC1α-Related Coactivator (PRC) is a transcriptional coactivator promoting cytokine expression in vitro in response to mitochondrial injury and oxidative stress, however, its physiological role has remained elusive. Herein we investigate aspects of the immune response function of PRC, first in an in vivo thioacetamide (TAA)-induced mouse model of drug-induced liver injury (DILI), and subsequently in vitro in human monocytes, HepG2, and dendritic (DC) cells. TAA treatment resulted in the dose-dependent induction of PRC mRNA and protein, both of which were shown to correlate with liver injury markers.
View Article and Find Full Text PDFJ Palliat Med
March 2020
Division of Palliative Care and Geriatric Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Relationships of care for those facing illness are inherent to the practice of medicine. Palliative care provides interpersonal space to patients and families that helps them face serious illness and dying. We consider therapeutic holding uniquely critical in palliative care but see it as applying in varied forms throughout medicine.
View Article and Find Full Text PDFAm J Addict
December 2018
Former Professor of Psychiatry, Northwestern Medical School, Chicago, Illinois.
Background And Objectives: Outcome intervention data from Medicare, veteran, prison, and United States' public populations can identify best practices to decrease opioid misuse. Prescription policies for treating pain in the United States and other countries are relevant to preventing overdose.
Methods: Three strategies are considered: (1) Demand Reduction counsels and educates patients and current or potential opioid users about risks and treatment options to reduce motivation to consume opioids.
Cell Rep
April 2018
Cold Spring Harbor Laboratory, Cancer Biology, Cold Spring Harbor, NY, USA. Electronic address:
A hallmark of advanced prostate cancer (PC) is the concomitant loss of PTEN and p53 function. To selectively eliminate such cells, we screened cytotoxic compounds on Pten;Trp53 fibroblasts and their Pten-WT reference. Highly selective killing of Pten-null cells can be achieved by deguelin, a natural insecticide.
View Article and Find Full Text PDFJ Biol Chem
December 2016
From the Department of Cell and Molecular Biology, Northwestern Medical School, Chicago, Illinois 60611
PGC-1-related coactivator (PRC) has a dual function in growth-regulated mitochondrial biogenesis and as a sensor of metabolic stress. PRC induction by mitochondrial inhibitors, intracellular ROS, or topoisomerase I inhibition orchestrates an inflammatory program associated with the adaptation to cellular stress. Activation of this program is accompanied by the coordinate expression of c-MYC, which is linked kinetically to that of PRC in response to multiple stress inducers.
View Article and Find Full Text PDFPM R
September 2016
McGaw Medical Center of Northwestern University, Northwestern Medical School/RIC, Chicago, IL, United States.
PM R
September 2016
McGaw Medical Center of Northwestern University, Northwestern Medical School/RIC, Chicago, IL, United States.
PM R
September 2016
McGaw Medical Center of Northwestern University, Northwestern Medical School/RIC, Chicago, IL, United States.
PM R
September 2016
McGaw Medical Center of Northwestern University, Northwestern Medical School/RIC, Chicago, IL, United States.
PM R
September 2016
McGaw Medical Center of Northwestern University, Northwestern Medical School/RIC, Chicago, IL, United States.
PM R
September 2016
McGaw Medical Center of Northwestern University, Northwestern Medical School/RIC, Chicago, Illinois, United States.
PM R
September 2016
McGaw Medical Center of Northwestern University, Northwestern Medical School/RIC, Chicago, Illinois, United States.
Free Radic Biol Med
December 2013
Free Radical and Radiation Biology Division, Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:
Polychlorinated biphenyls and their metabolites are environmental pollutants that are believed to have adverse health effects presumably by inducing oxidative stress. To determine if 1-(4-Chlorophenyl)-benzo-2,5-quinone (4-ClBQ; metabolite of 4-monochlorobiphenyl, PCB3)-induced oxidative stress is associated with changes in the expression of specific antioxidant genes, mRNA levels of 92 oxidative stress-response genes were analyzed using TaqMan Array Human Antioxidant Mechanisms (Life Technologies), and results were verified by performing quantitative RT-PCR assays. The expression of selenoprotein P (sepp1) was significantly downregulated (8- to 10-fold) in 4-ClBQ-treated HaCaT human skin keratinocytes, which correlated with a significant increase in MitoSOX oxidation.
View Article and Find Full Text PDFJ Biol Chem
March 2013
Department of Cell and Molecular Biology, Northwestern Medical School, Chicago, Illinois 60611. Electronic address:
PGC-1-related coactivator (PRC), a growth-regulated member of the PGC-1 coactivator family, contributes to the expression of the mitochondrial respiratory apparatus. PRC also orchestrates a robust response to metabolic stress by promoting the expression of multiple genes specifying inflammation, proliferation, and metabolic reprogramming. Here, we demonstrate that this PRC-dependent stress program is activated during apoptosis and senescence, two major protective mechanisms against cellular dysfunction.
View Article and Find Full Text PDFJ Biol Chem
March 2012
Department of Microbiology-Immunology, Northwestern Medical School Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Symptomatic gonococcal infection, caused exclusively by the human-specific pathogen Neisseria gonorrhoeae (the gonococcus), is characterized by the influx of polymorphonuclear leukocytes (PMNs) to the site of infection. Although PMNs possess a potent antimicrobial arsenal comprising both oxidative and non-oxidative killing mechanisms, gonococci survive this interaction, suggesting that the gonococcus has evolved many defenses against PMN killing. We previously identified the NG1686 protein as a gonococcal virulence factor that protects against both non-oxidative PMN-mediated killing and oxidative killing by hydrogen peroxide.
View Article and Find Full Text PDFBiochim Biophys Acta
October 2012
Department of Cell and Molecular Biology, Northwestern Medical School, Chicago, IL 60611, USA.
Nucleus-encoded regulatory factors are major contributors to mitochondrial biogenesis and function. Several act within the organelle to regulate mitochondrial transcription and translation while others direct the expression of nuclear genes encoding the respiratory chain and other oxidative functions. Loss-of-function studies for many of these factors reveal a wide spectrum of phenotypes.
View Article and Find Full Text PDFJ Biol Chem
November 2011
Department of Cell and Molecular Biology, Northwestern Medical School, Chicago, Illinois 0611, USA.
PGC-1-related coactivator (PRC) is a growth-regulated transcriptional cofactor that activates many nuclear genes specifying mitochondrial respiratory function. Stable PRC silencing in U2OS cells results in a complex phenotype typical of mitochondrial dysfunction including abundant abnormal mitochondria, reduced respiratory subunit expression, diminished respiratory enzymes and ATP levels, and elevated lactate production. The PRC response to metabolic stress was investigated by subjecting cells to metabolic insults including treatment with the uncoupler carbonyl cyanide 3-chlorophenylhydrazone (CCCP), expression of a dominant negative allele of nuclear respiratory factor 1 (NRF-1), and glucose deprivation.
View Article and Find Full Text PDFAm J Obstet Gynecol
December 2011
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern Medical School, Chicago, IL, USA.
The objective of this study was to assess outcomes that are associated with the implementation of a shoulder dystocia protocol that is focused on team response. We identified women who had a shoulder dystocia during 3 time periods: 6 months before (period A), 6 months during (period B), and 6 months after (period C) the institution of a shoulder dystocia protocol. Documentation and health outcomes were compared among the time periods.
View Article and Find Full Text PDFBiochim Biophys Acta
July 2011
Department of Cell and Molecular Biology, Northwestern Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA.
The PGC-1 family of regulated coactivators, consisting of PGC-1α, PGC-1β and PRC, plays a central role in a regulatory network governing the transcriptional control of mitochondrial biogenesis and respiratory function. These coactivators target multiple transcription factors including NRF-1, NRF-2 and the orphan nuclear hormone receptor, ERRα, among others. In addition, they themselves are the targets of coactivator and co-repressor complexes that regulate gene expression through chromatin remodeling.
View Article and Find Full Text PDFAnn N Y Acad Sci
December 2008
Department of Cell and Molecular Biology, Northwestern Medical School, Chicago, IL 60611, USA.
Expression of the respiratory apparatus depends on both nuclear and mitochondrial genes. Although these genes are sequestered in distinct cellular organelles, their transcription relies on nucleus-encoded factors. Certain of these factors are directed to the mitochondria, where they sponsor the bi-directional transcription of mitochondrial DNA.
View Article and Find Full Text PDFJ Biol Chem
January 2009
Department of Cell and Molecular Biology, Northwestern Medical School, Chicago, Illinois 60611, USA.
PRC, a member of the PGC-1 coactivator family, is responsive to serum growth factors and up-regulated in proliferating cells. Here, we investigated its in vivo role by stably silencing PRC expression with two different short hairpin RNAs (shRNA1 and shRNA4) that were lentivirally introduced into U2OS cells. shRNA1 transductants exhibited nearly complete knockdown of PRC protein, whereas shRNA4 transductants expressed PRC protein at approximately 15% of the control level.
View Article and Find Full Text PDF