Modulation of adzuki (Vigna angularis) bean milk analog substrates and metabolites through singular and/or combined treatment of germination and lactic acid fermentation.

Given the growing interest in dairy-free milk analog products, new and diversified alternatives are pivotal to push the market forward. Germination and fermentation are traditional processing technologies used in plant-based milk production. However, the combination of both has not been extensively investigated.

FoxO is required for neoblast differentiation during planarian regeneration.

Stem cells are of great importance in the maintenance and regeneration of tissues, with Forkhead box O (FoxO) proteins emerging as pivotal regulators of their functions. However, the precise impact of FoxO proteins on stem cell behavior within regenerative environments remains ambiguous. Planarians, renowned for their abundance of adult stem cells (neoblasts), serve as an excellent model for investigating the dynamics of stem cells during regeneration.

Cretaceous coastal mountain building and potential impacts on climate change in East Asia.

Crustal thickness and elevation variations control mountain building and climate change at convergent margins. As an archetypal Andean-type convergent margin, eastern Asia preserves voluminous magmas ideal for quantifying these processes and their impacts on climate. Here, we use Sr/Y and Ce/Y proxies to show that the crust experienced alternating thickening and thinning during the Late Mesozoic.

Constraints to Child Language Development in Peri-Urban and Rural Areas: A Mixed-Methods Analysis From Southwestern China.

Purpose: This mixed-methods study examined how differences in parental time, knowledge, and economic constraints, as well as community socioeconomic contexts, may contribute to differences in home language environment and child language ability outcomes between peri-urban and rural households in China.

Method: We conducted an explanatory sequential mixed-methods analysis using data from 158 children aged 18-24 months among peri-urban and rural households with low socioeconomic status (SES) in southwestern China. Audio recordings were collected from each household and analyzed using the Language ENvironment Analysis system.

A Femtosecond Fiber Laser-Based Compact Label-Free Multimodality Nonlinear Optical Microscopy and Its Ex Vivo Bioimaging.

Nonlinear multimode imaging is a versatile tool to realize complex structural and compositional information of biological samples. In this study, we presented a novel integrated multimode nonlinear optical microscopy system by using an Er3 + -doped femtosecond fiber laser. The system could perform second harmonic generation (SHG), third harmonic generation (THG), and three-photon fluorescence (3PEF) imaging modes simultaneously.

A Scalable Pore-space-partitioned Metal-organic Framework Powered by Polycatenation Strategy for Efficient Acetylene Purification.

Efficient separation of acetylene (CH) from carbon dioxide (CO) and ethylene (CH) is a significant challenge in the petrochemical industry due to their similar physicochemical properties. Pore space partition (PSP) has shown promise in enhancing gas adsorption capacity and selectivity by reducing pore size and increasing the density of guest binding sites. Herein, we firstly employ the 2D→3D polycatenation strategy to construct a PSP metal-organic framework (MOF) Ni-dcpp-bpy, incorporating functional N/O sites to enhance CH purification.

Low-Temperature and Highly Efficient Reduction of O-Containing CO Mixtures via Pt-Ni/CeO Oxygen Carriers.

Poor O tolerance and high reaction temperature of the conventional oxygen carriers challenge the direct utilization of impure CO via chemical looping. Here, Pt-Ni bimetallic Ce-based oxygen carriers with excellent O tolerance are developed for highly efficient reduction of O-containing CO at low temperatures. At a temperature as low as 700 °C, high CO conversion (≈92%) is obtained over 0.

SaTDT enhanced plant tolerance to NaCl stress by modulating the levels of malic acid and citric acid in cells.

The issue of soil salinization is a global concern that significantly impairs crop productivity, quality, and distribution. Tonoplast Dicarboxylate Transporter (TDT) is a pivotal malic acid transporter localized on the vacuolar membrane, involving in maintaining intracellular pH homeostasis in plants. However, the molecular mechanisms and regulatory pathways underlying plant salt tolerance through TDT remain elusive.

Key β1-4 galactosylated glycan receptors of SARS-CoV-2 and its inhibitor from the galactosylated glycoproteins of bovine milk.

Introduction: The binding of the spike (S) protein of SARS-CoV-2 to angiotensin-converting enzyme 2 (ACE2) is a critical stage in the process of infection. While previous studies indicated that the S protein and ACE2 are extensively glycosylated, the functions of glycans in their interactions remain uncertain.

Objectives: This study aimed to investigate the glycan receptors of SARS-CoV-2 and evaluate the inhibitory effects of galactosylated glycoproteins derived from bovine milk on the attachment of SARS-CoV-2 pseudovirus.

Perceived risk induced multiscale model: Coupled within-host and between-host dynamics and behavioral dynamics.

A novel multiscale model is formulated to examine the co-evolution among behavioral dynamics, disease transmission dynamics and viral dynamics, in which perceived risk act as a bridge for realizing the bidirectional coupling of between-host dynamics and within-host dynamics. The model is validated by real data and exhibits rich dynamic behaviors including the periodic oscillations of the solutions, the discordance of transmission dynamics and viral dynamics. It is observed that new infections may increase with improving treatment efficacy, which may reveal the hidden mechanisms why it is hard to eliminate HIV/AIDS infection only with the strategy of treatment.

Genome Assembly and Winged fruit Gene Regulation of Chinese Wingnut: Insights from Genomic and Transcriptomic Analyses.

The genomic basis and biology of winged fruit are interesting issues in ecological and evolutionary biology. Chinese wingnut (Pterocarya stenoptera) is an important garden and economic tree species in China. The genomic resources of this hardwood tree could provide advanced genomic studies of Juglandaceae and their evolutionary relationships.

Electric Field-Induced Synergetic Enhancement of Local Hydroxyl Concentration and Photogenerated Carrier Density for Removal of CO in Electrocatalytic Formic Acid Oxidation.

Direct formic acid fuel cell (DFAFC) is an efficient power generation device, due to its high energy density, low fuel crossover and low emission. However, the anodic reaction of DFAFC, formic acid oxidation (FAOR), inevitably proceeds through an indirect pathway, adsorbing carbon monoxide intermediate (CO), resulting in a rapid decline of activity for FAOR. Therefore, effectively removing CO is the key to the development of DFAFC.

DNA Reaction Network Central Controller for Dynamic Spatiotemporal Logical Assembly and Its Application for Rational Design of Fluorometric/Electrical Biosensing.

This work introduces a fluorometric/electrical dual-biosensing logic system based on a DNA reaction network (DRN). This system was used to spatiotemporally modulate the kinetic behavior of DNA nanostructures. The system, acting as a programmable and modulative central controller introduced to implement, enabled the monitoring of the target gliotoxin.

p-n-Type LaCoO/NiFe LDH Heterostructures for Enhanced Photogenerated Carrier-Assisted Electrocatalytic Oxygen Evolution Reaction.

The oxygen evolution reaction (OER) poses a significant kinetic challenge for various critical energy conversion and storage technologies including electrocatalytic water splitting and metal-air batteries. In this study, a LaCoO/NiFe layered double hydroxide (LDH) catalyst was synthesized through the growth of n-type NiFe LDH on the surface of the p-type LaCoO semiconductor, resulting in a p-n heterostructure for a photogenerated carrier-assisted electrocatalytic OER (PCA-eOER). The alignment of their band structures facilitates the formation of an internal electric field at the heterojunction interface, which promotes the creation of oxygen vacancies and enhances electron transport.

Proguanil inhibits proliferation and migration in glioblastoma development through targeting CSF1R receptor.

Glioblastoma (GBM) is the most common and aggressive malignant tumor of the central nervous system, characterized by high morbidity and invasive potential, necessitating urgent development of novel therapeutic strategies. Studies have shown that colony stimulating factor-1 receptor (CSF1R) is abnormally expressed in a variety of solid tumors, which is closely related to the development of tumor cells. In this study, the CSF1R/cell membrane Chromatographic model was successfully constructed, and was used to screen active compounds targeting CSF1R from more than 60 compounds.

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Deoxynivalenol (DON) contamination in cereals is a widespread issue with global implications, necessitating the development of efficient detection methods. Here, a fluorescent aptasensor integrating target-responsive DNA three-way junction (TWJ) and DNA walking machine was developed to detect DON. The DON-specific aptamer (Apt) and the walker (Walker DNA) are integrated into TWJs.

Expression, optimization and biological activity analysis of recombinant type III collagen in Komagataella phaffii.

Type III collagen, a fundamental constituent of the extracellular matrix (ECM), is extensively utilized across the biomedicine, tissue engineering, and cosmetic industries because of its exceptional biocompatibility and biodegradability. Despite its widespread application, traditional methods of collagen production are often hindered by the limit yield, potential immunogenicity, and batch-to-batch variability. In the present study, we describe a synthetic biological approach for expressing full-length recombinant type III collagen (RCIII) in the Komagataella phaffii system.

Nonadjacent dependencies and sequential structure of chimpanzee action during a natural tool-use task.

Many of the complex behaviours of humans involve the production of nonadjacent dependencies between sequence elements, which in part can be generated through the hierarchical organization of sequences. To understand how these structural properties of human behaviours evolved, we can gain valuable insight from studying the sequential behaviours of nonhuman animals. Among the behaviours of nonhuman apes, tool use has been hypothesised to be a domain of behaviour which likely involves hierarchical organization, and may therefore possess nonadjacent dependencies between sequential actions.

Variants of and were related to endometrial cancer risk in the Chinese population.

Objectives: Krüppel‑like factors (KLFs) are implicated in the progression of endometrial cancer (EC). This present study explored the correlation between variants of KLF5, KLF12 and EC risk in the Chinese population.

Methods: The Agena MassARRAY technology platform was utilized to genotype six single nucleotide polymorphisms (SNPs) in KLF5 and KLF12 genes among 509 women diagnosed with EC and 506 age-matched healthy women.

α2,6-linked sialylated oligosaccharides riched in goat milk alleviate food allergy by regulating the gut flora and mucin O-glycosylation.

The nutritious goat milk has low allergenicity. Oligosaccharides represent one of the crucial functional constituents in goat milk, which are structurally similar to human milk oligosaccharides (HMOs). Currently, the anti-allergic activity of GMOs has not been reported.

Liraglutide improves cognition function in streptozotocin-induced diabetic rats by downregulating β-secretase and γ-secretase and alleviating oxidative stress in HT-22 cells.

Diabetes has been regarded as an independent risk factor for Alzheimer's disease (AD). Liraglutide could improve cognition in AD mouse models, but its precise mechanism remains unclear. In this study, we used STZ-induced diabetic rats and HT-22 cells to investigate the effects of liraglutide.

The Sericini (Coleoptera: Scarabaeidae: Sericinae) from the Nanling Mountains, China.

In this paper we update the knowledge on the species of Sericini occurring in the Nanling Mountains, China. This includes new records of 19 known species. Furthermore, six new species are described: Maladera paradaanensis Liu, Ahrens, Li & Yang, new species, M.

Two new species of tortricid moths (Lepidoptera: Olethreutinae: Olethreutini) injurious to Picea crassifolia in China.

Two new species of the genus Pseudohermenias, P. absimilis sp. nov.