MicroRNA Triggered Dimerization of DNA Tetrahedron for Enhanced Biosensing Performance of Solid-State Nanochannels Functionalized with MoS Nanosheets.

Solid-state nanochannels (SSN) have great development potential as a biosensing interface. The integration of two-dimensional nanomaterials with nanochannels endows SSN with diverse properties, including distinguishing DNA nanostructures. In this study, by modifying MoS nanosheets, the outer surface of SSN could be endowed with robust adsorption properties for single-stranded DNA.

Swimming Modes of Bacteria Escaping from a Soft Confined Space.

Navigating through soft and highly confined environments is crucial for bacteria moving within living organisms' tissues, yet this topic has been less explored. In our study, we experimentally harnessed the unique biconcave geometry of red blood cells (RBCs) to enable real-time visualization of swimming interacting with soft RBCs. Our findings show that RBCs adhering to a rigid surface can enclose spaces comparable to the size of bacteria, effectively entrapping them.

Efficacy of Tocilizumab in Refractory Graves Orbitopathy From Real-World Clinical Practice: An Observational Study.

Context: The efficacy of tocilizumab (TCZ) in treating Graves orbitopathy (GO) remains uncertain due to the small sample sizes of earlier studies, and there is a lack of research on the drug for juvenile GO.

Objective: To evaluate the effectiveness of TCZ in treating GO that is resistant to conventional therapy.

Design: This observational study at a tertiary care center included 79 Chinese GO patients, 15 of whom were pediatric patients, with 52 of these patients having moderate to severe active GO (all adult patients having steroid-resistant GO).

Harnessing biosynthesized selenium nanoparticles for recruitment of beneficial soil microbes to plant roots.

Root exudates can benefit plant growth and health by reshaping the rhizosphere microbiome. Whether nanoparticles biosynthesized by rhizosphere microbes play a similar role in plant microbiome manipulation remains enigmatic. Herein, we collect elemental selenium nanoparticles (SeNPs) from selenobacteria associated with maize roots.

Exploration the effective components of Gastrodia elata in improving cerebral ischemia reperfusion injury based on "Spectrum-effect" correlation and zebrafish verification experiment.

Background: Gastrodia elata (GE) has been widely used in clinical practice for many years with the functions of relieving stroke, suppressing liver Yang, dispelling wind and clearing collaterals. Our group's previous experimental studies have proved that GE has therapeutic effect on cerebral ischemia reperfusion injury (CIRI) (Ding et al., 2022).

Synthesis, evaluation and mechanism study of novel pyrazole enamides to alleviate lung injury.

Particulate matter with diameter ≤2.5 μm particles (PM2.5) can trigger pulmonary inflammation and lung injury.

Ecological compensation based on multiscale ecosystem carbon sequestration service flow.

Scientific assessments of the supply, demand and flow of ecosystem services and the formulation of ecological compensation policies are important for the promotion of sustainable regional development. Based on the supply-demand ratio model, breakpoint model, field strength model, geographic information system spatial analysis and statistical methods, we assessed the supply, demand and supply-demand relationships of carbon sequestration services on the Loess Plateau for 2000, 2010 and 2020. We also analyzed the interregional flow of carbon sequestration services at multiple scales and accounted for horizontal ecological compensation.

Ribosomal protein S3A (RPS3A), as a transcription regulator of colony-stimulating factor 1 (CSF1), promotes glioma progression through regulating the recruitment and autophagy-mediated M2 polarization of tumor-associated macrophages.

Dysregulated expression of ribosomal protein S3A (RPS3A) is associated with the tissue infiltration of immune-related cells in a variety of cancers. However, the role of RPS3A in immune cell infiltration in glioma remains unclear. This study aimed to explore the role of RPS3A in the glioma immune microenvironment.

Spike-spindle coupling during sleep and its mechanism explanation in childhood focal epilepsy.

Childhood focal epilepsy (CFE) is a serious neurological disorder characterized by epileptic seizures arising from a focal or multi-focal zone of the brain in clinics. During non-rapid eye movement (NREM) sleep stage, epileptiform discharges become frequent, and sleep spindles are generated through local interaction between thalamic neurons for CFE patients. Recent research has shown that epileptiform spikes significantly induce spindle oscillations within 1 s (say, spike-spindle coupling) during NREM sleep in focal epilepsy, which might damage cognitive function of epilepsy patients.

Effects of Microheterogeneous Wettability and Pore-Throat Structure on Asphaltene Precipitation in Tight Sandstone: Results from Nuclear Magnetic Resonance.

The pore throat structure and microheterogeneous wettability of tight sandstone reservoirs are complex, which leads to varying asphaltene precipitation locations, contents, and distributions in different pores during CO flooding. Clarifying the heterogeneous wettability of different pore throat structures and their effects on asphaltene precipitation and adsorption is crucial for improving CO displacement efficiency. A series of experiments were conducted in this study, including X-ray diffraction (XRD), cast thin section (CTS), field emission scanning electron microscopy (FE-SEM), high-pressure mercury intrusion (HPMI), environmental scanning electron microscopy (E-SEM), nuclear magnetic resonance (NMR), and CO flooding experiments, to investigate the pore structure complexity of tight sandstone reservoirs of the Yanchang Formation in the Ordos Basin, China.

Potent neutralization by a RBD antibody with broad specificity for SARS-CoV-2 JN.1 and other variants.

SARS-CoV-2 continues to be a public health burden, driven in-part by its continued antigenic diversification and resulting emergence of new variants. By increasing herd immunity, current vaccines have improved infection outcomes for many. However, prophylactic and treatment interventions that are not compromised by viral evolution of the Spike protein are still needed.

Focuses and Trends of Research on Platelet-Rich Fibrin: A Bibliometric and Visual Analysis.

 A rapid expansion of study on platelet-rich fibrin (PRF) has gained more attention in the subject. In this study, bibliometrics were used to assess the outputs and trends of relevant PRF studies. An in-depth analysis of the publication patterns and progress in PRF research worldwide was conducted for the purpose of filling in this research gap.

Enhanced dielectric performances of strontium barium titanate nanorod composites via improved interfacial compatibility.

High performance film capacitor has attracted widespread attention due to their increasing applications in electronic devices. However, the insufficient dielectric properties of dielectrics in capacitors severely restrict their practical application. In this work, the dielectric performances of polyarylene ether nitrile (PEN) are effectively enhanced by the synthesizing and employing of carboxylated PEN (CPEN) modified one-dimensional (1D) strontium barium titanate nanorod (BSTNR) (CPEN@BSTNR), as well as applying of hot stretching technique.

A dual-band broadband absorber using frequency selective surface for satellite antenna.

A dual-band broadband absorber based on frequency selective surface (FSS) is proposed. This double-layer absorber consists of two layers of FSS structure; each layer has a unique construction and plays its wave-absorbing function in different frequency bands. In the low-frequency band, layer I is a transmission channel, and layer II effectively absorbs electromagnetic waves.

Green and rapid quantitative detection of selenium in selenium-enriched kefir grain based on Fourier transform infrared spectroscopy.

Rapid monitoring of total and organic selenium content in kefir grain was essential for microbial screening and selenium-enriched food development. Firstly, spectral information of selenium-enriched kefir grain was obtained using an attenuated total reflection Fourier transform infrared spectrometer. Secondly, the performance of the quantitative prediction models established by the four-variable screening method with three machine learning algorithms, respectively, was compared.

Carvacrol alleviates LPS-induced myocardial dysfunction by inhibiting the TLR4/MyD88/NF-κB and NLRP3 inflammasome in cardiomyocytes.

Background: Sepsis-induced myocardial dysfunction (SIMD) may contribute to the poor prognosis of septic patients. Carvacrol (2-methyl-5-isopropyl phenol), a phenolic monoterpene compound extracted from various aromatic plants and fragrance essential oils, has multiple beneficial effects such as antibacterial, anti-inflammatory, and antioxidant properties. These attributes make it potentially useful for treating many diseases.

Organic matter accumulation under the Middle-Upper Ordovician tectonic transition on the western margin of the North China platform.

The tectonic of the Middle and Late Ordovician in the western margin of the north China Platform is complex, and the accumulation models of organic matter of the Wulalike Formation formed during this period are still unclear. Total organic carbon (TOC) content, mineral composition, organic carbon isotope composition, as well as the major and trace elements in the shale samples were all measured in this study. The Wulalike Formation was formed during a tectonic transition from a passive continental margin to an active continental margin.

Radiocarbon chronology and settlement patterns in the Bronze Age of the Qaidam Basin, Northwestern China.

Prehistoric settlement patterns on the Tibetan Plateau, particularly in the Qaidam Basin, have drawn significant scholarly interest. Yet, limited data have hindered a comprehensive understanding the Bronze Age chronology and landscape exploitation in this region. This paper presents 24 newly obtained radiocarbon dates from eight archaeological sites within the Qaidam Basin on the Tibetan Plateau.

Advancing the understanding of autoimmune/inflammatory syndrome induced by adjuvants (ASIA): Global research trends, key themes, and emerging frontiers.

Background: This study investigates global research on autoimmune/inflammatory syndrome induced by adjuvants (ASIA) to address gaps in disciplinary trends, research directions, and emerging topics, aiming to enhance understanding of ASIA's role in immune dysregulation and multi-system diseases.

Methods: This study uses bibliometric methods, based on data from the Web of Science (WOS) database, to analyze 203 ASIA-related publications from 2011 to 2024. Analytical tools, including VOSviewer, CiteSpace, and the bibliometrix R package, were employed to identify key research directions and frontier topics.

An intelligent spectral identification approach for the simultaneous detection of endocrine-disrupting chemicals in aquatic environments.

With the rapid progression of industrialization, the application and release of endocrine disruptors (EDCs), including bisphenol A (BPA), octylphenol and nonylphenol have significantly increased, presenting substantial health hazards. Conventional analytical techniques, such as high-performance liquid chromatography and gas chromatography-mass spectrometry, are highly sophisticated but suffer from complex procedures and high costs. To overcome these limitations, this study introduces an innovative spectral methodology for the simultaneous detection of multiple aquatic multicomponent EDCs.