Suppressing the progression of bladder cancer using cyclovirobuxine D based on network pharmacology and bioinformatics approaches.

Limited treatment options are available for bladder cancer (BCa) resulting in extremely high mortality rates. Cyclovirobuxine D (CVB-D), a naturally alkaloid, reportedly exhibits notable antitumor activity against diverse tumor types. However, its impact on CVB-D on BCa and its precise molecular targets remain unexplored.

Atomic Gap-State Engineering of MoS for Alkaline Water and Seawater Splitting.

Transition-metal dichalcogenides (TMDs), such as molybdenum disulfide (MoS), have emerged as a generation of nonprecious catalysts for the hydrogen evolution reaction (HER), largely due to their theoretical hydrogen adsorption energy close to that of platinum. However, efforts to activate the basal planes of TMDs have primarily centered around strategies such as introducing numerous atomic vacancies, creating vacancy-heteroatom complexes, or applying significant strain, especially for acidic media. These approaches, while potentially effective, present substantial challenges in practical large-scale deployment.

Polystyrene Microplastics Induce Photosynthetic Impairment in sp. at Physiological and Transcriptomic Levels.

The rising concentration of microplastics (MPs) in aquatic environments poses increasing ecological risks, yet their impacts on biological communities remain largely unrevealed. This study investigated how aminopolystyrene microplastics (PS-NH) affect physiology and gene expression using the freshwater alga sp. as the test species.

Characterization of MADS-Box Gene Family in and Functional Study of in Regulating Floral Transition and Formation.

In flowering plants, MADS-box genes play regulatory roles in flower induction, floral initiation, and floral morphogenesis. (. ) is a traditional Chinese medicinal plant.

Anisotropic Microparticles with a Controllable Structure via Soap-Free Seeded Emulsion Polymerization.

Anisotropic particles have a wide range of applications in materials science such as emulsion stabilization, oil-water separation, and catalysis due to their asymmetric structure and properties. Nevertheless, designing and synthesizing large quantities of anisotropic particles with controlled morphologies continue to present considerable challenges. In this study, we successfully synthesized anisotropic microspheres using a soap-free seed emulsion polymerization method.

Targeting Shp2 as a therapeutic strategy for neurodegenerative diseases.

The incidence of neurodegenerative diseases (NDs) has increased recently. However, most of the current governance strategies are palliative and lack effective therapeutic drugs. Therefore, elucidating the pathological mechanism of NDs is the key to the development of targeted drugs.

Nomogram for Predicting 90-day Outcomes in Patients with Acute Vertebrobasilar Artery Occlusion Undergoing Endovascular Treatment: A Multicenter Cohort Study.

Background And Purpose: In this study, we aimed to develop and validate a novel nomogram model for predicting 90-day non-favorable clinical outcomes in patients with acute vertebrobasilar artery occlusion after endovascular treatment by integrating clinical and MRI features.

Materials And Methods: This multicenter retrospective study analyzed data from 181 patients with vertebrobasilar artery occlusion eligible for endovascular treatment from two Chinese stroke centers. We developed a predictive model for non-favorable clinical outcomes (modified Rankin Scale score >3) using the data of 125 patients from Stroke Center A (2019-2023).

The return of stagnant slab recorded by intraplate volcanism.

Subducted plates often stagnate in the mantle transition zone (MTZ), and the fate of the stagnant slabs is still debatable. They may sink into the lower mantle, or remain partially trapped in the MTZ, but it is uncertain whether they can return to the upper mantle. We report geochemical evidence of late-Miocene (~6 Ma) basalts from, and upper mantle seismic evidence beneath Shuangyashan, an area above the slab tear of the stagnant Pacific plate in eastern Asia, to show how the slab returns to the upper mantle from the MTZ.

Machine Learning-Driven Prediction, Preparation, and Evaluation of Functional Nanomedicines Via Drug-Drug Self-Assembly.

Small molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small molecules for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen drug combinations for self-assembling nanomedicines, employing physiochemical parameters to predict formation via machine learning.

Preservation and early evolution of scalidophoran ventral nerve cord.

Ecdysozoan worms (Nematoida + Scalidophora) are typified by disparate grades of neural organization reflecting a complex evolutionary history. The fossil record offers a unique opportunity to reconstruct the early character evolution of the nervous system via the exceptional preservation of extinct representatives. We focus on their nervous system as it appears in early and mid-Cambrian fossils.

Structural and load-dependent arterial stiffness across the adult life span.

Background: The arterial stiffening is attributed to the intrinsic structural stiffening and/or load-dependent stiffening by increased blood pressure (BP). The respective lifetime alterations and major determinants of the two components with normal aging are not clear.

Methods: A total of 3053 healthy adults (1922 women) aged 18-79 years were enrolled.

Dynamic changes and influential factors of blowouts in a desert artificial ecosystem at the southeastern margin of Tengger Desert in China.

The wind-blown sand protection system in the Shapotou section of the Baotou-Lanzhou Railway is a representative artificial ecosystem in a desert region. Over the past 70 years, this system has transformed mobile dunes into fixed dunes through vegetation succession, relying solely on natural rainfall without additional irrigation. However, ecosystem sustainability has been endangered by the emergence of numerous blowouts.

A Discussion on the Critical Electric Rayleigh Number for AC Electrokinetic Flow of Binary Fluids in a Divergent Microchannel.

Electrokinetic (EK) flow is a type of flow driven or manipulated by electric body forces, influenced by various factors such as electric field intensity, electric field form, frequency, electric permittivity/conductivity, fluid viscosity, etc. The diversity of dimensionless parameters, such as the electric Rayleigh number, complicates the comparison of the EK flow stability. Consequently, comparing the performance and cost of micromixers or reactors based on EK flow is challenging, posing an obstacle to their industrial and engineering applications.

Mangiferin Attenuates Myocardial Ischemia Reperfusion Injury by Regulating the GAS6/Axl Signaling Pathway.

Ischemia reperfusion-induced myocardial injury is a prominent pathological feature in patients with coronary artery disease, contributing to significant mortality and morbidity rates. Mangiferin (MGF), the main active ingredient extracted from Anemarrhena asphodeloides Bge, has anti-inflammatory, anti-oxidation, anti-diabetes, and anti-tumor effects. The present study confirmed that the GAS6/Axl pathway was identified as a promising novel target for the treatment of myocardial ischemia reperfusion (IR) injury.

Hijacking the hyaluronan assisted iron endocytosis to promote the ferroptosis in anticancer photodynamic therapy.

Photodynamic therapy (PDT) eradicates tumor cells by the light-stimulated reactive oxygen species, which also induces lipid peroxidation (LPO) and subsequently ferroptosis, an iron-depended cell death. Ferroptosis has a tremendous therapeutic potential in cancer treatment, however, the ferroptosis efficiency is largely limited by the available iron in cells. Through hijacking the CD44-mediated iron endocytosis of hyaluronan (HA), here PDT with enhanced ferroptosis was realized by a HA@Ce6 nanogel self-assembled from HA, a photosensitizer Chlorin e6 (Ce6) and Fe as cross-linkers.

The efficient separation of bioactive components from Eucommia ulmoides Oliver using membrane filtration technology and its mechanisms in preventing alcoholic liver disease.

The efficient extraction and purification of active components from Eucommia ulmoides Oliver (EUO) are crucial for their utilization. The structure and properties of the prepared EUO leaf polysaccharides (ELPs) and extractum (ELE) were comprehensively characterized in this study, and the intervention mechanism of the EUO polysaccharides and extractum in alcoholic liver disease (ALD) were investigated. The yield of EUO extractum was 24.

Recent Advances and Perspectives on Coupled Water Electrolysis for Energy-Saving Hydrogen Production.

Overall water splitting (OWS) to produce hydrogen has attracted large attention in recent years due to its ecological-friendliness and sustainability. However, the efficiency of OWS has been forced by the sluggish kinetics of the four-electron oxygen evolution reaction (OER). The replacement of OER by alternative electrooxidation of small molecules with more thermodynamically favorable potentials may fundamentally break the limitation and achieve hydrogen production with low energy consumption, which may also be accompanied by the production of more value-added chemicals than oxygen or by electrochemical degradation of pollutants.

Stimulus-Responsive Organometallic Assemblies Based on Azobenzene-Functionalized Poly-NHC Ligands.

The reversible photoisomerization of azobenzene (AZB) and its derivatives has been applied across various fields. Developing discrete AZB-functionalized organometallic cages is essential for manufacturing functional materials. In this work, we designed and fabricated a series of three-dimensional, hexaazobenzene-terminated poly-NHC-based (NHC = N-heterocyclic carbene) complexes [M3(A)2](BF4)3 and [M3(B)2](BF4)3 (M = Ag, Au).

Variable Imaging Appearances and Diagnostic Certainty Challenges in Confirming Pancreatic Neuroendocrine Tumours (NET): A Case Report.

Introduction: A pancreatic neuroendocrine tumour (NET) originates from the neuroendocrine cells responsible for producing and releasing hormones. They are uncommon findings, mainly seen arising from the head of the pancreas and their appearances may vary among different imaging modalities.

Case Report: Interesting case of an asymptomatic patient with an incidental finding of a pancreatic lesion and its variable appearances across different modalities and final histology findings.

Facile Fabrication of Monodisperse Vinyl Hybrid Core-Shell Silica Microsphere with Short Range Radial Channel in bi-phase System.

The development of monodisperse hybrid silica microspheres with highly regular pore structure and uniform distribution of functional groups have significant value in the biomolecular separation field. In this work, the short range ordered pore channels are precisely constructed onto the non-porous silica microsphere surface by a bi-phase assembly method, and the cylindrical silica channel introduced a plethora of vinyl groups by "one-pot" co-condensation to form vinyl hybrid silica shell. As hydrophilic interaction chromatography (HILIC) stationary phase, the vinyl hybrid core-shell silica microsphere is simply modified with zwitterion glutathione (SiO@SiO-GSH), in which the HILIC enrichment process is significantly shortened due to its specific porous characteristics.

A Novel Pband Cys Induced Switch Off-On Strategy and Its Application in Detection Based on the Platform of N-Methylmesoporphyrin IX Fluorescence Being Amplied by G-Quadruplex.

Lead (Pb) ions give an imminent danger since they have been known to cause persistent damage to humans, plants, and animals, even at low concentrations, and cysteine (Cys) elevated levels are critical indicators for many diseases. Therefore, their detection is critical in pharmaceutical and environmental samples. This study tailored an innovative fluorescence switch off-on assay to detect Pb and Cys based on the amplification of G-quadruplex (G-4) to N-methylmesoporphyrin IX (NMM).

A novel spectroscopy-deep learning approach for aqueous multi-heavy metal detection.

Addressing heavy metal contamination in water bodies is a critical concern for environmental scientists. Traditional detection methods are often complex and costly. Recent advancements in artificial intelligence (AI), particularly machine learning (ML) and deep learning (DL), have shown significant potential in analytical chemistry.

Intercalation-Induced Interlayer and Defect Engineering in TiCT MXene for Ultralow-Reflection Electromagnetic Interference Shielding.

Interlayer and defect engineering significantly affects the electrical conductivity and electromagnetic interference (EMI) shielding of TiCT MXene. Previous studies have prioritized the size of the intercalant over its synergy with chemical affinity, limiting the elucidation of the intercalation mechanism and the precise control of the interlayer spacing (spacing). Herein, we synthesize MXene aerogels with a tunable spacing and defect density using a series of amine molecules of different sizes and chemical affinities as intercalants and cross-linkers.

UV-C Exposure Enhanced the Cd Adsorption Capability of the Radiation-Resistant Strain sp. M1-B02.

Microbial adsorption is a cost-effective and environmentally friendly remediation method for heavy metal pollution. The adsorption mechanism of cadmium (Cd) by bacteria inhabiting extreme environments is largely unexplored. This study describes the biosorption of Cd by sp.