Effect of Intravenous Tirofiban Versus Placebo on First-Pass Successful Reperfusion in Endovascular Stroke Thrombectomy: Insights From the RESCUE BT Randomized Clinical Trial.

Background: First-pass successful reperfusion (FPSR), defined as a successful/complete reperfusion achieved after a single thrombectomy pass, is predictive of favorable outcome in patients with acute ischemic stroke with large-vessel occlusion. It is unknown whether intravenous tirofiban is effective in increasing the rate of FPSR in acute anterior large-vessel occlusion stroke.

Methods And Results: Patients who had acute large-vessel occlusion stroke presenting within 24 hours and underwent endovascular thrombectomy were analyzed from the RESCUE BT (Intravenous Tirofiban for Patients With Large Vessel Occlusion Stroke) clinical trial, of which the main analysis was neutral.

Behavioral and economic traits reflect distinct resource acquisition strategies in tendril vines and stem twining vines.

Climbing plants are important components of tropical and many temperate forest ecosystems. Current studies regard climbing plants as a single ecological plant type and ignore the ecological differences resulting from their climbing mechanisms, which may lead to a misrepresentation of the role of climbing plants in forest dynamics. Based on behavioral traits and economic traits of climbing plants, we test the hypothesis that tendril climbers and stem twiners are characterized by different resource acquisition strategies.

Circular RNAs in human diseases.

Circular RNAs (circRNAs) are a unique class of RNA molecules formed through back-splicing rather than linear splicing. As an emerging field in molecular biology, circRNAs have garnered significant attention due to their distinct structure and potential functional implications. A comprehensive understanding of circRNAs' functions and potential clinical applications remains elusive despite accumulating evidence of their involvement in disease pathogenesis.

Surviving at the highest and coldest: Nutritional and chemical components of fallback foods for Yunnan snub-nosed monkeys.

Fallback foods (FBF), categorized into staple and filler types, are suboptimal food sources chosen by animals in response to a scarcity of preferred food items during specific periods. Using lichens as FBF by Yunnan snub-nosed monkeys () represents a distinctive ecological adaptation and evolutionary development within nonhuman primates. This study delves into the annual dietary choices of the species to address issues, elucidate the nutritional value, and understand the ecological significance of lichens for this primate species, which resides at the highest altitudes and experiences the coldest weather among global primates.

Confirmation of the valid specific status of Kim & Yoon, 1996 (Hymenoptera, Vespidae) based on molecular and morphological evidence.

The taxonomic validity of , especially in relation to , has been the subject of a long-term debate. Herein, the valid specific status of the former was supported through an integrated analysis of morphological characters and DNA barcodes. The pronotal rugae and male genitalia of the two species are different, and partial mitochondrial genes (cytochrome oxidase subunit I, COI) indicate that they form significantly distinct lineages.

New species and new record of Diakonoff, 1973 from China (Lepidoptera: Tortricidae: Olethreutinae).

In China, six species of Diakonoff, 1973 were previously recorded. In the present study, four other species were recognized using morphology and DNA barcording analysis. Among these, three of which, sp.

 sp. nov. (Fabaceae, Hedysareae), a new species from the Qilianshan Mountains in Gansu, China.

(Fabaceae, Hedysareae) is described and illustrated from the Qilianshan Mountains in Gansu, China. This new species is similar to , but can be distinguished by its corolla being light purple to purple, standard 15-19 mm long, wings 14-16 mm long, keels 16-19 mm long, and the ovary and legume being glabrous. The new species can be easily distinguished from Ledeb.

An update to the taxonomy of MacLeay, 1819 (sensu lato) from China (Coleoptera, Scarabaeidae, Sericinae, Sericini).

In this paper we update the knowledge on the species of McLeay, 1819 (sensu lato) occurring in Yunnan, Sichuan, and Shaanxi provinces, China. Three new species are described: Liu, Ahrens, Li & Su, , Liu, Ahrens, Li & Su, , and Liu, Ahrens, Li & Su, The key to the species groups and species is updated. The habitus and male genitalia of the new species are illustrated, and a map showing their distribution is provided.

A new combination and a new synonym of Gesneriaceae in China.

W.T.Wang was shown to be conspecific with Y.

Advanced strategies to evade the mononuclear phagocyte system clearance of nanomaterials.

Nanomaterials are promising carriers to improve the bioavailability and therapeutic efficiency of drugs by providing preferential drug accumulation at their sites of action, but their delivery efficacy is severely limited by a series of biological barriers, especially the mononuclear phagocytic system (MPS)-the first and major barrier encountered by systemically administered nanomaterials. Herein, the current strategies for evading the MPS clearance of nanomaterials are summarized. First, engineering nanomaterials methods including surface modification, cell hitchhiking, and physiological environment modulation to reduce the MPS clearance are explored.

Revision of Chevrolat, 1836 (Coleoptera, Chrysomelidae, Galerucinae) from China, with descriptions of three new species.

In this study, 21 species of the leaf-beetle genus in China are described, including three new species, , and , and 1 new record, Jacoby, 1900. Additionally, Chen, 1964 is elevated to species. A key to the Chinese species of is provided.

Identification of PIK3CG as a hub in septic myocardial injury using network pharmacology and weighted gene co-expression network analysis.

Sepsis causes multiple organ injuries, among which the heart is one most severely damaged organ. Melatonin (MEL) alleviates septic myocardial injury, although a systematic and comprehensive approach is still lacking to understand the precise protective machinery of MEL. This study aimed to examine the underlying mechanisms of MEL on improvement of septic myocardial injury at a systematic level.

Metagenomic sequencing combined with flow cytometry facilitated a novel microbial risk assessment framework for bacterial pathogens in municipal wastewater without cultivation.

A workflow that combined metagenomic sequencing with flow cytometry was developed. The absolute abundance of pathogens was accurately estimated in mock communities and real samples. Metagenome-assembled genomes binned from metagenomic data set is robust in phylogenetic analysis and virulence profiling.

Insights into the phylogeny of the ciliate of class Colpodea based on multigene data.

In the class Colpodea, there are many unresolved evolutionary relationships among taxa. Here, we report 30 new sequences including SSU-rRNA, ITS1-5.8S- ITS2 rRNA, and the mitochondrial small subunit ribosomal RNA (mtSSU-rRNA) genes of five colpodeans, and conduct phylogenetic analyses based on each individual gene and a two-gene concatenated dataset.

New scientific analyses reveal mixing of copper sources in the early Iron Age metal production at Ili, western China.

The crucial role that Xinjiang played in cultural communication across the Eurasian steppe in prehistory is evidenced by the large number of copper-based objects that represent the early metallurgical technologies found across this region. Our research adds new chemical and isotopic analyses of 44 copper-based objects dated to the early Iron Age of Ili in Xinjiang, western China. As noted in a number of publications, tin bronze and arsenic copper/bronze were the dominant alloying types across Xinjiang during the second and first millennium BC, whereas some specific types of objects such as cauldrons are often made from pure copper.

Purification, antioxidant activities, encapsulation, and release profile of total flavonoids in Peony seed meal.

As potential biomass resources, biomass waste products have been considered worldwide in recent decades. Peony seed meal (PSM) is a kind of agricultural resource waste containing polyphenols, in particular flavonoids. In this study, the total flavonoids of PSM were extracted and purified by AB-8 macroporous resin (MR), the antioxidant activities of three extract fractions were evaluated, and the total flavonoids were encapsulated with alginate and chitosan by the complex coacervation method.

Reference gene selection for real-time quantitative PCR assays in different tissues of based on full-length transcriptome sequencing.

() produces various types of effective lycopodium alkaloids, especially Huperzine A (HupA), which is a promising drug for the treatment of Alzheimer's disease. Numerous studies focused on the chemistry, bioactivities, toxicology, and clinical trials of HupA; however, the public genomic and transcriptomic resources are very limited for research, especially for the selection of optimum reference genes. Based on the full-length transcriptome datasets and previous studies, 10 traditional and three new candidate reference genes were selected in different tissue of .

Modeling of fractional-order COVID-19 epidemic model with quarantine and social distancing.

Different countries of the world are facing a serious pandemic of corona virus disease (COVID-19). One of the most typical treatments for COVID-19 is social distancing, which includes lockdown; it will help to decrease the number of contacts for undiagnosed individuals. The main aim of this article is to construct and evaluate a fractional-order COVID-19 epidemic model with quarantine and social distancing.

Generalized form of fractional order COVID-19 model with Mittag-Leffler kernel.

An important advantage of fractional derivatives is that we can formulate models describing much better systems with memory effects. Fractional operators with different memory are related to the different type of relaxation process of the nonlocal dynamical systems. Therefore, we investigate the COVID-19 model with the fractional derivatives in this paper.

A new soft-matter material with old chemistry: Passerini multicomponent polymerization-induced assembly of AIE-active double-helical polymers with rapid visible-light degradability.

Mimicking the superstructures and functions of natural chiral materials is beneficial to understand specific biological activities in living organisms and broaden applications in the fields of chemistry and materials sciences. However, it is still a great challenge to construct water-soluble, double-helical polymers with multiple responsiveness. Herein, we report for the first time a straightforward, general strategy to address this issue by taking advantage of Passerini multicomponent polymerization-induced assembly (PMPIA).

An illustrated key to the species of Latreille (Hymenoptera, Gasteruptiidae) from Palaearctic China, with description of four new species.

Four new species of the genus Latreille, 1797 (Hymenoptera: Evanioidea: Gasteruptiidae: Gasteruptiinae) are described from China. Three are from Shaanxi (NW China; Tan & van Achterberg, , Tan & van Achterberg, , and Tan & van Achterberg, ) and one from S China and Ningxia ( Tan & van Achterberg, ). Eleven species are newly recorded for Shaanxi ( Kieffer, 1912, Pasteels, 1958, Pasteels, 1958, Enderlein, 1913, Zhao, van Achterberg & Xu, 2012, (Tournier, 1877), (Thomson, 1883), Enderlein, 1913, Kieffer, 1911, (Thomson, 1883) and Kieffer, 1911).

The genus Lower (Lepidoptera, Tortricidae) in China, with descriptions of two new species.

Species of the genus Lower, 1901 (Lepidoptera, Tortricidae, Olethreutinae) from China are studied. and are described, (Meyrick, 1920) is recorded for the first time from China, and (Diakonoff, 1968) is newly recorded from the Chinese mainland. Adults and genitalia are illustrated, and a distribution map of the Chinese species is given.

Modeling and simulation of fractional order COVID-19 model with quarantined-isolated people.

The dynamics of diseases and effectiveness of control policies play important role in the prevention of epidemic diseases. To this end, this paper is concerned with the design of fractional order coronavirus disease (COVID-19) model with Caputo Fabrizio fractional derivative operator of order Ω ∈ (0, 1] for the COVID-19. Verify the nonnegative special solution and convergence of the scheme with in the domain.