Wuling San and Xiao Chaihu Decoction affect airway inflammatory response and airway smooth muscle cell proliferation in mice with allergic asthma via miR-486-5p/AQP5 axis.

Objective: This study aimed to investigate the effects of Wuling San and Xiao Chaihu Decoction on allergic asthma, and elucidate the potential mechanism of Wuling San and Xiao Chaihu Decoction for ameliorating allergic asthma.

Methods: BALB/c mice were intraperitoneally injected with ovalbumin (OVA) to establish animal model of allergic asthma. Transforming growth factor beta 1 (TGF-β1) was used to induce the proliferation of airway smooth muscle cells (ASMCs) in order to establish the cell model.