The return of stagnant slab recorded by intraplate volcanism.

Subducted plates often stagnate in the mantle transition zone (MTZ), and the fate of the stagnant slabs is still debatable. They may sink into the lower mantle, or remain partially trapped in the MTZ, but it is uncertain whether they can return to the upper mantle. We report geochemical evidence of late-Miocene (~6 Ma) basalts from, and upper mantle seismic evidence beneath Shuangyashan, an area above the slab tear of the stagnant Pacific plate in eastern Asia, to show how the slab returns to the upper mantle from the MTZ.

PsDMAP1/PsTIP60-regulated H4K16ac is required for ROS-dependent virulence adaptation of on host plants.

Host plants and various fungicides inhibit plant pathogens by inducing the release of excessive reactive oxygen species (ROS) and causing DNA damage, either directly or indirectly leading to cell death. The mechanisms by which the oomycete manages ROS stress resulting from plant immune responses and fungicides remains unclear. This study elucidates the role of histone acetylation in ROS-induced DNA damage responses (DDR) to adapt to stress.

Machine Learning-Driven Prediction, Preparation, and Evaluation of Functional Nanomedicines Via Drug-Drug Self-Assembly.

Small molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small molecules for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen drug combinations for self-assembling nanomedicines, employing physiochemical parameters to predict formation via machine learning.

Preservation and early evolution of scalidophoran ventral nerve cord.

Ecdysozoan worms (Nematoida + Scalidophora) are typified by disparate grades of neural organization reflecting a complex evolutionary history. The fossil record offers a unique opportunity to reconstruct the early character evolution of the nervous system via the exceptional preservation of extinct representatives. We focus on their nervous system as it appears in early and mid-Cambrian fossils.

Metabolomic and transcriptomic remodeling of bone marrow myeloid cells in response to maternal obesity.

Maternal obesity puts the offspring at high risk of developing obesity and cardio-metabolic diseases in adulthood. Here, we utilized a mouse model of maternal high-fat diet (HFD)-induced obesity that recapitulates metabolic perturbations seen in humans. We show increased adiposity in the offspring of HFD-fed mothers (Off-HFD) when compared to the offspring regular diet-fed mothers (Off-RD).

Variation in Hypertension Control by Race and Ethnicity, and Geography in US Veterans.

Background: Hypertension control and related cardiovascular outcomes among Americans remain suboptimal, and differ by race, ethnicity, and geography. Healthcare access is one of multiple critical factors in hypertension control. Understanding the degree to which healthcare access, versus other factors, produce these outcomes can inform policies and interventions to improve cardiovascular outcomes and reduce disparities.

Structural and load-dependent arterial stiffness across the adult life span.

Background: The arterial stiffening is attributed to the intrinsic structural stiffening and/or load-dependent stiffening by increased blood pressure (BP). The respective lifetime alterations and major determinants of the two components with normal aging are not clear.

Methods: A total of 3053 healthy adults (1922 women) aged 18-79 years were enrolled.

Novel insights into sheep domestication in Southwest Asia based on genome-wide sequencing.

The origin of domestic sheep (Ovis aries) can be traced back to the Asian mouflon (Ovis gmelini), in the Near East around 10 000 years ago. Genetic divergence within mouflon populations can occur due to factors such as geographical isolation, social structures, and environmental pressures, leading to different affinities with domestic sheep. However, few studies have reported the extent to which mouflon sheep contribute to domestic sheep in different regions.

Amelioration of Obesity-Related Disorders in High-Fat Diet-Fed C57BL/6 Mice Following Fecal Microbiota Transplantation From DL-Norvaline-Dosed Mice.

Fecal microbiota transplantation (FMT) could significantly alter the recipient's gut bacteria composition and attenuate obesity and obesity-related metabolic syndromes. DL-norvaline is a nonproteinogenic amino acid and possesses anti-obesity potential. However, the specific mechanisms by which gut microbiota might mediate beneficial effects of DL-norvaline have not been completely elucidated.

Research progress on the impact of climate change on wheat production in China.

It is crucial to elucidate the impact of climate change on wheat production in China. This article provides a review of the current climate change scenario and its effects on wheat cultivation in China, along with an examination of potential future impacts and possible response strategies. Against the backdrop of climate change, several key trends emerge: increasing temperature during the wheat growing season, raising precipitation, elevated CO concentration, and diminished radiation.

Linkage and association analysis to identify wheat pre-harvest sprouting resistance genetic regions and develop KASP markers.

Unlabelled: Pre-harvest sprouting (PHS) of wheat ( L.) is one of the complex traits that result in rainfall-dependent reductions in grain production and quality worldwide. Breeding new varieties and germplasm with PHS resistance is of great importance to reduce this problem.

What Do Patients Seek Care for at a Health Facility in the Aftermath of an Earthquake? Experiences From an Emergency Medical Team in Türkoğlu, Türkiye 2023.

On February 6, 2023, a strong earthquake (7.8 Richter scale) shook southwestern Türkiye, and also affected areas in northwest Syria, resulting in over 50 000 fatalities and more than 100 000 injured in Türkiye, in addition to the displacement of approximately 3 million people. In response to an international request for assistance from the Turkish government, the United Kingdom (UK) government deployed an Emergency Medical Team (EMT) Type 1 to provide outpatient care.

Mind the gap in kidney care: Translating what we know into what we do.

Historically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease onset and progression, this is far too long. The time is now to narrow the gap between what we know and what we do.

The association between preoperative anemia and postoperative mortality among non-cardiac surgical patients in Northwest Ethiopia: a prospective cohort study.

Introduction: In a low-income country, the impact of preoperative anemia on postoperative mortality among noncardiac surgery patients is little understood. As a result, we aim to investigate the association between preoperative anemia and postoperative mortality in noncardiac surgery patients in Northwest Ethiopia.

Methods: This is a prospective follow-up study of 3506 noncardiac surgery patients who were included in the final analysis between June 1, 2019, and July 1, 2021.

Feasibility exploration of nano-thermal rod applied to deicing of tunnel pavement in cold region.

This study investigates the feasibility of using nano-thermal rod for deicing tunnel pavements in cold region. The heating performance of the nano-thermal rod was compared with that of carbon fiber heating wire under low voltage conditions. Experimental studies were conducted in a controlled environmental chamber to evaluate the effects of arrangement parameters (spacing, buried depth, input power) and environmental factors (ambient temperature and moisture) on heating rate and effectiveness.

Population genomics and connectivity of Vazella pourtalesii sponge grounds of the northwest Atlantic with conservation implications of deep sea vulnerable marine ecosystems.

Sponges are key ecosystem engineers that shape, structure and enhance the biodiversity of marine benthic communities globally. Sponge aggregations and reefs are recognized as vulnerable marine ecosystems (or VMEs) due to their susceptibility to damage from bottom-contact fishing gears. Ensuring their long-term sustainability, preservation, and ecosystem functions requires the implementation of sound scientific conservation tools.

Engineering high-activity crosslinked enzyme aggregates via SpyCatcher/SpyTag-mediated self-assembly.

Crosslinked Enzyme Aggregates (CLEAs) are favored for their operational stability and recyclability. However, the traditional CLEAs preparation may distort the enzyme's active site and reduce activity. Therefore, we developed a universally applicable crosslinked SpyCatcher scaffold system designed for the facile preparation of CLEAs.

Dynamic changes and influential factors of blowouts in a desert artificial ecosystem at the southeastern margin of Tengger Desert in China.

The wind-blown sand protection system in the Shapotou section of the Baotou-Lanzhou Railway is a representative artificial ecosystem in a desert region. Over the past 70 years, this system has transformed mobile dunes into fixed dunes through vegetation succession, relying solely on natural rainfall without additional irrigation. However, ecosystem sustainability has been endangered by the emergence of numerous blowouts.

Multifunctional layer-by-layer smart film with betalains and selenium nanoparticles for intelligent meat freshness monitoring and preservation.

Multifunctional pH-responsive films were fabricated via layer-by-layer deposition of gelatin, chitosan, and carboxymethyl cellulose (CMC), incorporating selenium nanoparticles (SeNPs) and beetroot extract (BTE), to monitor and preserve beef freshness. SeNPs were synthesized and characterized via various techniques. BTE exhibited promising functional properties, and films demonstrated a significant color transition from red to yellow across pH 2-14.

Visible light-driven multichannel concerted antibacterial films with Photodynamically enhanced self-cascading Chemodynamic actions for long-term preservation of perishable food.

This work pioneered an innovative visible light-powered, self-cascading peroxide antimicrobial packaging system (RPFe-CS), featuring a photodynamic enhancement effect achieved through the demand-oriented design of riboflavin sodium phosphate and Fe coordination complexes (RPFe) fillers with photodynamic and peroxidase activities, and the ingenious selection of slightly acidic chitosan (CS) film matrix. In this system, the photo-responsive properties of RPFe particles not only generate the •O, •OH, and O required for photodynamic sterilization, but also the produced HO serves as a necessary substrate for peroxidase to exert its bactericidal effect, endowing the packaging system with a "self-production and self-marketing" cascade process. The RPFe-CS film achieved efficient eradication to bacteria and fungi reaching up to 99.

Recent progresses and perspectives of polyethylene biodegradation by bacteria and fungi: A review.

Plastics pollution has become a serious threat to the people and environment due to the mass production, unreasonable disposal and continuous pollution. Polyethylene (PE), one of the most utilized plastics all over the world, is considered as a highly recalcitrant environmental destruction problem on account of strong hydrophobicity and high molecular weight. Therefore, it is urgently necessary to seek economical and efficient treatment and disposal methods for PE.

Photocatalytic removal of U(VI) from aqueous solution under visible light by bismuth oxyiodide/graphitic carbon nitride composite.

Applicable to convert soluble U(VI) into the less mobile U(IV) form, the photocatalytic process is widely regarded as an efficient solution to uranium pollution. In the present study, BiOI/g-CN (BICN) composites were produced through uncomplicated hydrothermal synthesis, followed by U(VI) photocatalytic reduction. Batch experiments were conducted to demonstrate the exceptional capability of BICN to address uranium contamination.