Laparoscopic Gastric Sleeve in a Complex Elderly Patient: A Case Report.

Obesity has been regarded as an epidemic in recent years. Various treatments have been developed, with bariatric surgery showing the highest levels of safety and effectiveness. This has increased its popularity and demand not only among young adults but also among elderly patients.

A pectic polysaccharide from Murray alleviates dextran sulfate sodium-induced colitis in mice.

Inflammatory bowel disorders (IBD) can lead to severe complications like perforation, bleeding, and colon cancer, posing life-threatening risks. Murray ( Murr.), rich in polysaccharides, has been utilized in traditional diets for thousands of years.

Mechanistic study of the adsorption capabilities of heavy metals on the surface of ferrihydrite: batch sorption, modeling, and density functional theory.

Ferrihydrite (Fh), a widely distributed mineral in the environment, plays a crucial role in the geochemical cycling of elements. This study used experimental and computational approaches to investigate the adsorption behavior of seven heavy metal ions on Fh. The pH edge analysis revealed that the adsorption capacity followed the order: Pb > Cu > Zn > Cd > Ni > Co > Mn, with Pb showed the highest adsorption.

Sensitivity of future regional and global energy markets and macroeconomic activity to a hypothetical global energy market disruption.

In this paper we contribute to a long history of research studying interactions between energy systems, international energy trade, and macroeconomic activity. We develop and employ methods to quantify transmission pathways for energy markets to affect the macroeconomy and CO emissions. We track the long-term consequences of a hypothetical permanent disruption to global energy markets, cession of Russian fossil fuel exports, for energy markets, regional and global economic activity (gross domestic product [GDP]), labor and capital markets, and CO emissions against two dramatically different reference scenarios.

A comparative evaluation of rehabilitation approaches for ecological recovery in arid limestone mine sites.

Limestone mining in arid regions, particularly within fragile environments, leads to severe environmental pollution and ecological degradation. Developing a scientifically sound and effective ecological rehabilitation strategy is therefore critical. This study constructed a three-dimensional ecological rehabilitation model integrating soil amelioration and vegetation reconstruction.

Exploring aspects of mentoring for black and minoritised healthcare professionals in the UK: a nominal group technique study.

Objective: Mentoring plays a crucial role in career development, particularly for black and minoritised ethnic (BME) professionals. However, existing literature lacks clarity on the impact of mentoring and how best to deliver for career success. This study aimed to ascertain perceptions and build consensus on what is important in mentoring for BME healthcare professionals.

Effects of minocycline on patients with acute anterior circulation ischaemic stroke undergoing intravenous thrombectomy (MIST-A): the study protocol for a multicentre, prospective, randomised, open-label, blinded-endpoint trial.

Introduction: Despite the implementation of mechanical thrombectomy, acute ischaemic stroke with large vessel occlusion (AIS-LVO) remains a significant health concern, characterised by substantial morbidity and mortality. Our trial aims to evaluate the efficacy and safety of minocycline in reducing infarct volume and improving functional outcomes in patients undergoing mechanical thrombectomy for anterior circulation AIS-LVO.

Methods And Analysis: The MIST-A trial is a prospective, randomised, open-label, blinded-endpoint trial to be conducted across 12 medical centres.

How to Approach a Child About Concerns for Their Mental Health and Seeking Help: A Delphi Expert Consensus Study to Develop Guidelines on Mental Health First Aid for Supporting Children.

Background: Adults who live or work with children are an important source of support and are gateways to professional help when a child is experiencing a mental health problem. This study aimed to develop consensus-based guidelines on how adults such as parents, educators or health professionals should approach a child aged 5-12 years to discuss concerns about the child's mental health and seek help.

Methods: A Delphi consensus method with three rounds was used.

Socioeconomic status moderate the relationship between mental health literacy, social participation, and active aging among Chinese older adults: evidence from a moderated network analysis.

Objective: The aging population represents a formidable global challenge, with China experiencing an accelerated demographic shift. While previous research has established a directional link between mental health literacy, social participation, and active aging, the moderating effect of socioeconomic status (SES) on these associations remains underexplored. This study sought to address this gap by employing moderated network analysis, in contrast to the total score approaches commonly used in prior literature.

Delays in health care seeking for diarrheal disease and associated factors among caregivers of under five children in health centers of northwest Ethiopia: a mixed-method study.

Background: Approximately 70% of child deaths due to diarrhea are caused by a lack of timely healthcare. However, there was little evidence of factors associated with delays in seeking health care for patients with diarrheal diseases in the study area. Therefore, this study aimed to investigate delays in seeking healthcare for children with diarrhea and identify associated factors among caregivers in health centers of Northwest Ethiopia.

Efficacy of adalimumab in pediatric non-infectious uveitis with and without anterior segment inflammation.

Background: This study aimed to identify the clinical characteristics of cases that is related to the response rate of adalimumab (ADA) treatment.

Methods: A retrospective review of medical records was conducted for pediatric patients with non-infectious uveitis undergoing ADA treatment for a minimum of six months. The patients were stratified into two groups: those with anterior segment inflammation (ASI+) and those without anterior segment inflammation (ASI-).

Prevalence of cataract and its associated factors among adult diabetic patients attending at diabetic care clinics in Northwest Ethiopia, 2023.

Baground: Cataract is a major public health concern and the leading cause of blindness and low vision in Ethiopia. However, no studies have been conducted to assess the prevalence of cataract and associated factors among adult diabetic patients in the study area. Therefore, this study aimed to assess the prevalence of cataract and associated factors among adult diabetic patients in Northwest Ethiopia.

New Insights into the Pathogenesis of Alcoholic Liver Disease Based on Global Research.

Background And Aims: Alcoholic liver disease (ALD) is the leading cause of death among alcohol-related diseases, yet its pathogenesis remains incompletely understood. This article employs data mining methods to conduct an indepth study of articles on ALD published in the past three decades, aiming to elucidate the pathogenesis of ALD.

Methods: Firstly, articles related to the pathogenesis of ALD were retrieved from the Web of Science (WOS) database.

Highly electroactive thiazolium [5,4-d]thiazol-2,5-dicarboxylic acid-silver electrochemiluminescent metal-organic frameworks: synthesis, properties and application in glutathione detection.

Thiazolo[5,4-d]thiazole-2,5-dicarboxylic acid (HThz), a thiazolothiazole (TTz) derivative with carboxylic acid groups, was synthesized as a ligand for the creation of five MOFs, each associated with distinct metal ions including Ag, Mn, Co, Zn, and Cu. The cathodic electrochemiluminescence (ECL) of HThz and the resulting MOFs was investigated. HThz was found to generate ECL signals, but this process was heavily reliant on potassium persulfate (KSO) as a co-reactant.

Numerical analysis of the hydraulic fracture propagation behavior encountering gravel in conglomerate reservoirs.

Hydraulic fracturing, which forms complex fracture networks, is a common technique for efficiently exploiting low-permeability conglomerate reservoirs. However, the presence of gravel makes conglomerate highly heterogeneous, endowing the deformation, failure, and internal micro-scale fracture expansion mechanisms with uniqueness. The mechanism of fracture expansion when encountering gravel in conglomerate reservoirs remains unclear, challenging the design and effective implementation of hydraulic fracturing.

Robust collection and processing for label-free single voxel proteomics.

With advanced mass spectrometry (MS)-based proteomics, genome-scale proteome coverage can be achieved from bulk tissues. However, such bulk measurement lacks spatial resolution and obscures tissue heterogeneity, precluding proteome mapping of tissue microenvironment. Here we report an integrated wet collection of single microscale tissue voxels and Surfactant-assisted One-Pot voxel processing method termed wcSOP for robust label-free single voxel proteomics.

Structural characterization of polysaccharides from Polygonatum Sibiricum and effect on alleviating hyperlipidemia in egg yolk emulsion-induced mice.

Polysaccharides are the major bioactive composition of Polygonatum sibiricum (P. sibiricum). However, the structural and functional identifications of these polysaccharides were still limited.

Two glycoside hydrolase family 1 proteins mediate glycosylated modification at the 5-position of anthocyanin in grape hyacinth.

Glycosylation modification of anthocyanins is important as a preceding step to acylation modification. Cyanidin-3-O-(p-coumaroyl)glucoside-5-O-malonylglucoside (Cy3pCG5MaG) is one of the major anthocyanin substances in blue-flowered grape hyacinth, but its 5-position glycosylation is unknown. Here, we identified two glycoside hydrolase family 1 genes, MaAGGT1 and MaAGGT5, which use acyl-glucose as a donor and are involved in the glycosylation modification of anthocyanins in grape hyacinth.

Assembly of soil multitrophic community regulates multifunctionality via multifaceted biotic factors in subtropical ecosystems.

Soil biodiversity underpins multiple ecosystem functions and services essential for human well-being. Understanding the determinants of biodiversity-ecosystem function relationships (BEFr) is critical for the conservation and management of soil ecosystems. Community assembly processes determine community diversity and structure.

A paradigm shift for evaluating natural attenuation of radioactive iodine in soils and sediments: Species-specific mechanisms and pathways.

The primary approach to assessing monitored natural attenuation (MNA) is currently based on a conceptual model utilizing the total contaminant concentrations, assuming a single aqueous species. However, many contaminants, such as metals and radionuclide - including iodine, can exist in multiple species that behave chemically differently in the environment and can exist simultaneously. For example, radioiodine often occurs concurrently as three major aqueous species: iodide (I), iodate (IO), and organo-I, which undergo distinct attenuation pathways and exhibit markedly different mobility and geochemical behavior.

State shifts in the deep Critical Zone drive landscape evolution in volcanic terrains.

Volcanic provinces are among the most active but least well understood landscapes on Earth. Here, we show that the central Cascade arc, USA, exhibits systematic spatial covariation of topography and hydrology that are linked to aging volcanic bedrock, suggesting systematic controls on landscape evolution. At the Cascade crest, a locus of Quaternary volcanism, water circulates deeply through the upper [Formula: see text]1 km of crust but transitions to shallow and dominantly horizontal flow as rocks age away from the arc front.

Senescent cell-derived extracellular vesicles inhibit cancer recurrence by coordinating immune surveillance.

Senescence is a non-proliferative, survival state that cancer cells can enter to escape therapy. In addition to soluble factors, senescence cells secrete extracellular vesicles (EVs), which are important mediators of intercellular communication. To explore the role of senescent cell-derived EVs (senEVs) in inflammatory responses to senescence, we developed an engraftment-based senescence model in wild-type mice and genetically blocked senEV release in vivo, without significantly affecting soluble mediators.

New evidence finds young people in Mainland China are now bicultural.

This study reports new evidence that young people in Mainland China are now bicultural. We followed the established method of testing biculturalism by priming participants with images from two different cultures and measuring whether those images activate different thought styles. First, we replicated findings from 25 years ago that college students in Hong Kong are bicultural (Study 1).

Generation of glucosylantimycins by heterologous expression of a promiscuous glycosyltransferase in a deepsea-derived .

Antimycins are a class of depsipeptide compounds that exhibit diverse bioactivities. However, their potential clinical applications are hampered by high cell toxicities. Glycosylation usually has profound impacts on the physicochemical properties, bioactivities and toxicities of natural products.