197 results match your criteria: "Northumbria University Newcastle[Affiliation]"

Interval versus constant-load exercise training in adults with Cystic Fibrosis.

Respir Physiol Neurobiol

June 2021

1st Respiratory Medicine Department, "Sotiria" Hospital for Diseases of the Chest, National and Kapodistrian University of Athens Medical School, Athens, Greece; Faculty of Health and Life Sciences, Department of Sport, Exercise and Rehabilitation, Northumbria University Newcastle, Newcastle Upon Tyne, UK. Electronic address:

Background: The efficacy of interval exercise (IE) compared to constant-load exercise (CLE) training remains unsettled in adults with Cystic Fibrosis (CF).

Methods: Twenty-four adults with CF were randomised to 30-min IE (100 % peak work capacity (WRpeak) for 30-s alternated with 40 % WRpeak for 30-s; n = 12) or 30-min CLE (70 % WRpeak; n = 12) training, 3 times weekly, for 12 weeks. Isometric quadriceps muscle strength was assessed using a strain gauge Myometer.

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The European Respiratory Society (ERS) accepted 4062 abstracts for presentation at the ERS International Congress in 2020. Although the conference was held virtually, making it possible to replay presentations, it remains a challenge to keep abreast of all the clinical and scientific advances. Therefore, this article provides highlights from the General Pneumology Assembly.

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Objective: To document the level of physical function in patients with coronavirus disease 2019 (COVID-19) recovering from acute respiratory failure and investigate which patient clinical characteristics could predict physical function assessed by the Short Physical Performance Battery (SPPB) test.

Design: Cross-sectional study.

Setting: Subacute unit of a Rehabilitation Institute.

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Proteome Variation with Collagen Yield in Ancient Bone.

J Proteome Res

March 2021

Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.

Isotope analyses are some of the most common analytical methods applied to ancient bone, aiding the interpretation of past diets and chronology. For this, the evaluation of "collagen yield" (as defined in radiocarbon dating and stable isotope research) is a routine step that allows for the selection of specimens that are deemed adequate for subsequent analyses, with samples containing less than ∼1% "collagen yield" normally being used for isotopic analysis but discounted for radiocarbon dating. The aims of this study were to use proteomic methods of MALDI-TOF (matrix assisted laser desorption ionization time-of-fligh mass spectrometry) and LC-ESI-MS/MS (liquid chromatography electrospray ionization tandem mass spectrometry) to investigate the endogeneity of the dominant proteinaceous biomolecules within samples that are typically considered to contain poorly preserved protein.

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Background: The Daily-PROactive and Clinical visit-PROactive Physical Activity (D-PPAC and C-PPAC) instruments in chronic obstructive pulmonary disease (COPD) combines questionnaire with activity monitor data to measure patients' experience of physical activity. Their amount, difficulty and total scores range from 0 (worst) to 100 (best) but require further psychometric evaluation.

Objective: To test reliability, validity and responsiveness, and to define minimal important difference (MID), of the D-PPAC and C-PPAC instruments, in a large population of patients with stable COPD from diverse severities, settings and countries.

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The migration of acetochlor from feed to milk.

RSC Adv

December 2020

Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University Harbin 150030 China

Acetochlor has been widely used globally for its effective weed control, but the dietary intake of associated residues by people has become a major concern nowadays. Milk is regarded as the best solvent to dissolve pesticides due to its fat-rich characteristic. In this study, we aimed to evaluate the transfer of acetochlor from feed to raw milk.

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Intelligent human-machine interfaces (HMIs) integrated wearable electronics are essential to promote the Internet of Things (IoT). Herein, a curcumin-assisted electroless deposition technology is developed for the first time to achieve stretchable strain sensing yarns (SSSYs) with high conductivity (0.2 Ω cm) and ultralight weight (1.

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High-intensity exercise impairs extradiaphragmatic respiratory muscle perfusion in patients with COPD.

J Appl Physiol (1985)

February 2021

Faculty of Movement and Rehabilitation Sciences, Department of Rehabilitation Sciences, Research Group for Rehabilitation in Internal Disorders, KU Leuven, Leuven, Belgium.

The study investigated whether high-intensity exercise impairs inspiratory and expiratory muscle perfusion in patients with chronic obstructive pulmonary disease (COPD). We compared respiratory local muscle perfusion between constant-load cycling[sustained at 80% peak work rate (WRpeak)] and voluntary normocapnic hyperpnea reproducing similar work of breathing (WoB) in 18 patients [forced expiratory volume in the first second (FEV): 58 ± 24% predicted]. Local muscle blood flow index (BFI), using indocyanine green dye, and fractional oxygen saturation (%StiO) were simultaneously assessed by near-infrared spectroscopy (NIRS) over the intercostal, scalene, rectus abdominis, and vastus lateralis muscles.

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Patterns of Physical Activity Progression in Patients With COPD.

Arch Bronconeumol (Engl Ed)

March 2021

ISGlobal, Barcelona, Spain; Pompeu Fabra University (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. Electronic address:

Introduction: Although mean physical activity in COPD patients declines by 400-500steps/day annually, it is unknown whether the natural progression is the same for all patients. We aimed to identify distinct physical activity progression patterns using a hypothesis-free approach and to assess their determinants.

Methods: We pooled data from two cohorts (usual care arm of Urban Training [NCT01897298] and PROactive initial validation [NCT01388218] studies) measuring physical activity at baseline and 12 months (Dynaport MoveMonitor).

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Background: Coronavirus disease 2019 (COVID-19) is likely to exacerbate the symptoms of poor mental health in family caregivers.

Aims: To investigate whether rates of depressive symptomatology increased in caregivers during COVID-19 and whether the unintended consequences of health protective measures, i.e.

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The production of methane-rich biogas from the anaerobic digestion (AD) of microalgae is limited by an unfavorable biomass carbon-to-nitrogen (C/N) ratio; however, this may be ameliorated using a co-digestion strategy with carbon-rich feedstocks. For reliable plant operation, and to improve the economics of the process, secure co-feedstock supply (ideally as a waste-stream) is important. To this end, this study investigated the feasibility of co-digesting microalgae () with potato processing waste (potato discarded parts, PPW; potato peel, PPW) and glycerol, while monitoring the response of the methanogenic community.

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Human activity has led to increased atmospheric concentrations of many gases, including halocarbons, and may lead to emissions of many more gases. Many of these gases are, on a per molecule basis, powerful greenhouse gases, although at present-day concentrations their climate effect is in the so-called weak limit (i.e.

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Degrowth and the Blue Belt: Rethinking marine conservation in the British Overseas Territories.

Ocean Coast Manag

October 2020

Northumbria University Newcastle, Lipman Building, Newcastle Upon Tyne, NE1 8ST, United Kingdom.

The UK Government has developed a 'Blue Belt', a network of large Marine Protected Areas involving seven British Overseas Territories. The Blue Belt is now one of the world's largest enclosures of space for conservation, enclosing four million km of ocean in some of the most remote spaces on earth. To be economically feasible, the UK's bold conservation targets are integrated with wider tourism, fishing, and economic growth-motivated governance agendas.

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A study on contactless airborne transfer of textile fibres between different garments in small compact semi-enclosed spaces.

Forensic Sci Int

October 2020

Centre for Forensic Science, Department of Applied Sciences, Faculty of Health & Life Sciences, Northumbria University Newcastle, Ellison Building, NE1 8ST, Newcastle Upon Tyne, United Kingdom.

Interpretation of fibre evidence at activity level requires extensive knowledge of all the possible transfer mechanisms that may explain the presence of fibres on a recipient surface of interest. Herein, we investigate a transfer method that has been largely understudied in previous literature: contactless transfer between garments through airborne travel. Volunteers were asked to wear UV-luminescent garments composed of different textile materials and situate themselves in a semi-enclosed space (elevator) for a pre-determined period of time with other participants, who wore non-luminescent recipient garments.

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We report on the key influence of mesoscopic super-open-eye core-shell spheroids of TiO- and LiFePO-wrapped nanocarbon carved anode/cathode electrodes with uniform interior accommodation/storage pockets for the creation of fully reversible and dynamic Li-ion power battery (LIB) models. The mesoscopic core-shell anode/cathode electrodes provide potential half- and full-cell LIB-CR2032 configuration designs, and large-scale pouch models. In these variable mesoscopic LIB models, the broad-free-access and large-open-eye like gate-in-transport surfaces featured electrodes are key factors of built-in LIBs with excellent charge/discharge capacity, energy density performances, and outstanding cycling stability.

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Thermodynamic limit and dispersive regularization in matrix models.

Phys Rev E

May 2020

Department of Mathematics, Physics and Electrical Engineering, Northumbria University Newcastle, Newcastle upon Tyne NE1 8ST, United Kingdom.

We show that Hermitian matrix models support the occurrence of a phase transition characterized by dispersive regularization of the order parameter near the critical point. Using the identification of the partition function with a solution of the reduction of the Toda hierarchy known as the Volterra system, we argue that the singularity is resolved by the onset of a multidimensional dispersive shock of the order parameter in the space of coupling constants. This analysis explains the origin and mechanism leading to the emergence of chaotic behaviors observed in M^{6} matrix models and extends its validity to even nonlinearity of arbitrary order.

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Key Points: Exercise intolerance is common in chronic obstructive pulmonary disease (COPD) patients. In patients with COPD, we compared an interval exercise (IE) protocol (alternating 30 s at 100% peak work rate (WR ) with 30 s at 50% WR ) with moderate-intensity constant-load exercise (CLE) at 75% WR , which yielded the same work rate. Exercise endurance time and total work output were almost twice as high for IE than CLE.

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Stability studies of ZnO and AlN thin film acoustic wave devices in acid and alkali harsh environments.

RSC Adv

May 2020

State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, College of Mechanical and Vehicle Engineering, Hunan University Changsha 410082 China

Surface acoustic wave (SAW) devices based on piezoelectric thin-films such as ZnO and AlN are widely used in sensing, microfluidics and lab-on-a-chip applications. However, for many of these applications, the SAW devices will inevitably be used in acid or alkali harsh environments, which may cause their early failures. In this work, we investigated the behavior and degradation mechanisms of thin film based SAW devices in acid and alkali harsh environments.

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In a cross-over RCT, portable NIV (pNIV) reduced dynamic hyperinflation (DH) compared to pursed lip breathing (PLB) during recovery from intermittent exercise in COPD, but not consistently in all subjects. In this post-hoc analysis, DH response was defined as a reduction ≥4.5 % of predicted resting inspiratory capacity with pNIV compared to PLB.

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Low dimensional BiS materials are excellent for use in photodetectors with excellent stability and fast response time. In this work, we developed a visible light sensor with good performance based on surface acoustic wave (SAW) devices using BiS nanobelts as the sensing materials. The SAW delay-line sensor was fabricated on ST-cut quartz with a designed wavelength of 15.

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Respiratory and locomotor muscle blood flow during exercise in health and chronic obstructive pulmonary disease.

Exp Physiol

December 2020

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California San Diego, San Diego, CA, USA.

New Findings: What is the topic of this review? The work presented here focuses mostly on testing the theory of blood flow redistribution from the locomotor to the respiratory muscles during heavy exercise in healthy participants and in patients with COPD. What advances does it highlight? Studies presented and the direct experimental approach to measure muscle blood flow by indocyanine green dye detected by near infrared spectroscopy, show that exercise interferes with respiratory muscle blood flow especially in COPD, but even in healthy.

Abstract: We have developed an indicator-dilution method to measure muscle blood flow at rest and during exercise using the light absorbing tracer indocyanine green dye (ICG) injected as an intravenous bolus, with surface optodes placed over muscles of interest to record the ICG signal by near-infrared spectroscopy.

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Effects of Isometric Handgrip Training in Patients With Peripheral Artery Disease: A Randomized Controlled Trial.

J Am Heart Assoc

February 2020

Graduated Program in Rehabilitation Sciences Universidade Nove de Julho São Paulo Brazil.

Background Meta-analyses have shown that isometric handgrip training (IHT) can reduce brachial systolic and diastolic blood pressure (BP) by >6/4 mm Hg, respectively. However, whether IHT promotes these effects among patients with peripheral artery disease, who exhibit severe impairment in cardiovascular function, is currently unknown. This study aimed to evaluate the effects of IHT on the cardiovascular function of patients with peripheral artery disease.

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A label-free quartz crystal microbalance (QCM) biosensor was developed for the selective and real-time estimation of carcinoembryonic antigen (CEA) through the present study. Graphene oxide-Au nanoparticles (GO-AuNPs) was synthesised on the surface of the QCM electrode and the antibody of CEA (monoclonal anti-CEA from mouse) was covalently immobilized on this layer as the bioreceptor for CEA. Mercaptoacetic acid-EDC-NHS reaction mechanism was used for anti-CEA immobilization.

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