1,553 results match your criteria: "Northern Jiangsu People's Hospital[Affiliation]"

After spinal cord injury (SCI), phagocytes endocytose myelin debris to form foam cells, exacerbating the inflammatory response. It has been previously shown that macrophages become foam cells through the phagocytosis of myelin debris via receptor-dependent mechanisms after SCI. Blocking receptor-mediated endocytosis did not completely prevent foam cell formation, so we investigated receptor-independent endocytosis.

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Background: Addition of magnetic resonance imaging (MRI) in prostate cancer screening remains controversial issue. Despite the increased utilization of MRI, several studies have revealed its potential suboptimal diagnostic efficacy in young patients. This study aimed to further substantiate the limited diagnostic efficiency of MRI positivity [defined as Prostate Imaging Reporting and Data System (PI-RADS) scores ≥3] among young individuals aged ≤55 years suspected of prostate cancer, and more significantly, to evaluate two proposed approaches.

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Background: Histone lactylation is a novel epigenetic modification that is involved in a variety of critical biological regulations. However, the role of lactylation-related genes in lung adenocarcinoma has yet to be investigated.

Methods: RNA-seq data and clinical information of LUAD were downloaded from TCGA and GEO datasets.

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Gastric cancer (GC) remains a significant global health challenge due to its high morbidity and mortality rates. The development of GC is a multi-hit process and the exploration of precancerous lesions is crucial. To elucidate the molecular and cellular dynamics underlying gastric carcinogenesis, we conducted an integrative single-cell RNA sequencing analysis of 26,028 high-quality cells from gastric antral mucosa biopsies across various stages, including non-atrophic gastritis, chronic atrophic gastritis, intestinal metaplasia, and early gastric cancer.

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Metastasis is the major cause of hepatocellular carcinoma (HCC) mortality. But the effective biomarkers for HCC metastasis remain underexplored. Here we integrated GEO (Gene Expression Omnibus) and TCGA (The Cancer Genome Atlas) datasets to screen candidate genes for hepatocellular carcinoma metastasis, a consensus metastasis-derived prognostic signature (MDPS) was constructed by machine learning.

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To investigate the effect of laparoscopic splenectomy and azygoportal disconnection (LSD) on liver synthesis and development of liver cirrhosis. This is a prospective case series study.The clinical data of liver cirrhotic patients with portal hypertension who received LSD at the Department of Hepatobiliary Surgery of Northern Jiangsu People's Hospital Affiliated to Yangzhou University from September 2014 to January 2016 were included.

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Conditional Tnfaip6-Knockout in Inner Ear Hair Cells Does not Alter Auditory Function.

Neurosci Bull

December 2024

Department of Otolaryngology-Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.

Noise-induced hearing loss is a worldwide public health issue that is characterized by temporary or permanent changes in hearing sensitivity. This condition is closely linked to inflammatory responses, and interventions targeting the inflammatory gene tumor necrosis factor-alpha (TNFα) are known to mitigate cochlear noise damage. TNFα-induced proteins (TNFAIPs) are a family of translucent acidic proteins, and TNFAIP6 has a notable association with inflammatory responses.

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Objective: To explore the mediating effect of social isolation between perceived social support and type D personality in gastrointestinal cancer survivors based on the WHITE heuristic cognitive-behavioral model of emotion cognition theory.

Methods: The study utilized a convenience sampling method to recruit 183 survivors of gastrointestinal cancer who were undergoing chemoradiotherapy. SPSS 26.

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Nutritional Inequality and Co-Morbid Chronic Disease Among Breast Cancer Survivors in China.

Nutrients

November 2024

Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, China.

Background/objectives: Breast cancer survivors often face an elevated risk of developing co-morbid chronic diseases, which may be exacerbated by nutritional inequalities. This study aimed to comprehensively assess the associations between nutrition literacy, dietary quality, and the risk of co-morbidity in breast cancer survivors in China.

Methods: A cross-sectional study was conducted among cancer survivors enrolled in the Shanghai Cancer Rehabilitation Club from March to July 2023.

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Introduction: Anti-MDA5-positive dermatomyositis (anti-MDA5-DM) is a rare autoimmune disease that often leads to rapid-progressive interstitial lung disease (RP-ILD). The lack of effective prediction and treatment methods makes RP-ILD a major risk factor for death in patients with this condition. S100A6 is a member of the S100 Ca2 + - binding protein family, which plays important roles in inflammation, tumor, injury, and fibroblast reparation.

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Introduction: Percutaneous vertebroplasty (PVP) is a frequently employed technique for treating osteoporotic vertebral compression fracture (OVCF). However, there is still controversy regarding whether PVP with different courses affects clinical efficacy. Therefore, this study aims to investigate the impact of different courses of OVCF on early clinical and radiological outcomes after PVP.

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Background:  Portal vein system thrombosis (PVST) is a frequent and possibly fatal concurrent disorder following splenectomy. The optimal anticoagulant to prevent PVST following splenectomy remains unclear.

Objectives:  The purpose of this study was to compare the safety and efficacy of apixaban versus aspirin in preventing PVST after laparoscopic splenectomy (LS) for cirrhotic hypersplenism.

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Purpose: The completely degloving injury of multiple fingers is a challenging clinical problem. Based on our technical experience, a novel two-stage surgery of abdominal hypodermal pocket followed by separation and full thickness skin grafting was conducted.

Methods: From January 2017 to August 2020, 7 cases (17 fingers) of degloving injury of multiple whole fingers who were treated in a two-stage fashion; an emergency first stage surgery of abdominal hypodermal pocket embedding and a second stage surgery (4 weeks later) of full thickness skin grafting, were retrospectively studied.

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Microglia in morphine tolerance: cellular and molecular mechanisms and therapeutic potential.

Front Pharmacol

November 2024

Department of Anesthesiology, Women and Children's Hospital, Peking University People's Hospital, Qingdao University, Qingdao, Shandong, China.

Morphine has a crucial role in treating both moderate to severe pain and chronic pain. However, prolonged administration of morphine can lead to tolerance of analgesia, resulting in increased doses and poor treatment of pain. Many patients, such as those with terminal cancer, require high doses of morphine for long periods.

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To identify the influencing factors of shoulder joint function after Arthroscopic Rotator Cuff Repair (ARCR) in patients with Type 2 Diabetes Mellitus (T2DM). A sequential explanatory mixed-methods design was conducted. Participants were recruited from the Northern Jiangsu People's Hospital from January 2023 to May 2023.

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Objective: The main purpose of this study is to evaluate the changes in sleep quality among patients with cirrhotic cardiomyopathy (CCM).

Methods: The study included liver cirrhosis patients aged 18-75 from Northern Jiangsu People's Hospital Affiliated to Yangzhou University and collected their clinical examination results to assess the clinical characteristics and related risk factors of patients with CCM.

Results: The study found that the onset of CCM was not related to the etiology of inducing cirrhosis.

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Background: The management of acute ischemic stroke due to isolated posterior cerebral artery occlusion (iPCAO) remains a topic of debate. This study investigates the efficacy and safety of endovascular treatment (EVT) versus best medical treatment (BMT) in patients with iPCAO.

Methods: A systematic search was conducted across electronic databases including PubMed, Embase, and the Cochrane Library.

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Hyperoside attenuates sepsis-induced acute lung injury by Nrf2 activation and ferroptosis inhibition.

Int Immunopharmacol

January 2025

State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210023, China. Electronic address:

Sepsis-induced acute lung injury (ALI) is a life-threatening condition associated with high morbidity and mortality rates in intensive care units (ICUs). Emerging evidence from clinical studies suggests that compounds derived from traditional Chinese medicine (TCM) have shown promising therapeutic effects in treating sepsis-induced ALI. Hyperoside is a bioactive compound extracted from TCM.

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Background: Parkinson's disease psychosis (PDP) is one of the most severe and disabling non-motor symptoms in the progression of Parkinson's disease (PD), significantly impacting the prognosis of PD patients. In recent years, there has been an increase in literature on PDP. However, bibliometrics has rarely been applied to PDP research.

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Reassessing the Risk of Venous Thromboembolism (VTE) Events in Women.

Clin Appl Thromb Hemost

December 2024

Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

This research aims to reassess women's risk of venous thromboembolism (VTE) events. We conducted an in-depth analysis of the environmental risk factors associated with VTE and their interactions with gender while also exploring the genetic underpinnings of the disease. VTE is identified as a multifactorial condition influenced by a combination of genetic, non-predisposing, and predisposing environmental factors.

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Asperosaponin VI inhibition of DNMT alleviates GPX4 suppression-mediated osteoblast ferroptosis and diabetic osteoporosis.

J Adv Res

December 2024

Department of Orthopaedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, 98 West Nantong Road, Yangzhou 225001, China; Department of Orthopaedics, Northern Jiangsu People's Hospital, 98 West Nantong Road, Yangzhou 225001, China; The Yangzhou School of Clinical Medicine of Dalian Medical University, 98 West Nantong Road, Yangzhou 225001, China; Northern Jiangsu People's Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, 98 West Nantong Road, Yangzhou 225001, China. Electronic address:

Introduction: Diabetic osteoporosis (DOP) is an insidious complication of diabetes with limited therapeutic options. DOP is pathologically associated with various types of regulated cell death, but the precise role of ferroptosis in the process remains poorly understood. Asperosaponin VI (AVI), known for its clinical efficacy in treating bone fractures and osteoporosis, may exert its osteoprotective effects through mechanisms involving ferroptosis, however this has not been established.

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The therapeutic potential of recombinant ANGPTL4 in Parkinson's disease: Evidence from in vivo and in vitro studies.

Free Radic Biol Med

December 2024

Department of Basic Medicine, Institute of Translational Medicine, Medical College, Yangzhou University, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, China. Electronic address:

Background: The established body of knowledge attests to the pivotal influence of ANGPTL4 on lipid metabolism and vascular biology. Nevertheless, its potential implication in neurodegenerative disease remains to be fully characterized.

Methods: The present investigation delves into the involvement of ANGPTL4 in the pathological progression of PD, both in vitro and in vivo.

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Background: Ischemic stroke is a leading cause of disability and mortality worldwide, with limited effective treatments. Neuroinflammation plays a crucial role in the progression of ischemic brain injury. Glycoprotein nonmetastatic melanoma protein B (GPNMB) has emerged as a potential regulator of inflammation, but its role and underlying mechanisms in ischemic stroke remain largely unknown.

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Examination of Core Clinical Symptoms of Postoperative Fatigue Syndrome Following Colonoscopy With Sedation.

J Perianesth Nurs

December 2024

Department of Anesthesiology, Northern Jiangsu People's Hospital, Yangzhou, China. Electronic address:

Article Synopsis
  • - The study aimed to identify and categorize discomfort symptoms following sedative-administered colonoscopy, with the goal of developing criteria to recognize postoperative fatigue syndrome (POFS).
  • - Researchers conducted follow-up interviews with 542 patients who had undergone the procedure to collect data on 19 different discomfort symptoms, including fatigue, lethargy, and dizziness.
  • - The key findings suggest that the main symptoms defining POFS are fatigue, lethargy, dizziness, and headache, which should be included in diagnostic criteria for this syndrome.
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Article Synopsis
  • Researchers investigated how oxidative stress response-related genes (OSRGs) impact lung adenocarcinoma (LUAD) to create a genetic signature that could predict patient prognosis and suggest treatment options.
  • They developed a risk prediction model using clinical data and various assay methods to analyze the relationship between gene expression and factors like immune cell infiltration and chemotherapy sensitivity.
  • The study concluded that the identified gene signature could serve as a reliable biomarker for predicting patient outcomes and therapy responses in LUAD, with specific findings on the effects of DKK1 on cell behavior.
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