Systemic transphobia and ongoing barriers to healthcare for transgender and nonbinary people: A historical analysis of #TransHealthFail.

Transgender (T+) people report negative healthcare experiences such as being misgendered, pathologizing gender, and gatekeeping care, as well as treatment refusal. Less is known about T+ patients' perceptions of interrelated factors associated with, and consequences of, negative experiences. The purpose of this analysis was to explore T+ patients' negative healthcare experiences through Twitter posts using the hashtag #transhealthfail.

Quad-Nanopore Array Enables High-Resolution Identification of Four Single-Stranded DNA Homopolymers.

The solid-state nanopore technique holds the potential to develop mechanically stable and miniaturized DNA sequencing devices. However, the limited temporal resolution due to the high electric field inside the nanopore and the lack of an effective speed control strategy have hindered the realization of sequencing. Here, we reported a quad-array (four nanopores milled with ∼30 nm interpore spacing as a detection unit) that induced a redistribution of the electric field inside and outside the nanopore array and offered high-resolution discrimination of four ssDNA homopolymer types.

Prevalence of Chronic Kidney Disease Among Elderly Patients in the Northeastern Region of Romania: A Descriptive, Cross-Sectional, Retrospective Analysis.

In Romania, data pertaining to the incidence and prevalence of chronic kidney disease (CKD) are scant, with an even more limited understanding of the elderly demographic. In this study, we used a descriptive cross-sectional retrospective approach, drawing data from the Geriatrics and Gerontology Clinic at Dr. C.

One anti-tumour C21 steroidal glycoside from Wight.

The roots of Wight is rich in C21 steroidal glycosides according to previous research. In this study, a systematic chemical study was performed on the roots of , leading to the isolation of one previously undescribed C21 steroidal glycoside compound () and a known compound, gagamine (). bioassay indicated that compound showed a strong inhibitory effect on AGS cells, with the IC value 7.

Topological Data Analysis Based Characteristics of Electroencephalogram Signals in Children With Sleep Apnea.

This study aims to identify differences in the functional neural connectivity of the brain of paediatric patients with obstructive sleep apnea. Using EEG signals from 3673 paediatric patients, we grouped subjects into OSA or control groups based on sleep oxygen desaturation levels and apnea-hypopnea index (AHI), and applied topological data analysis (TDA) techniques. We evaluated our approach through statistical testing of TDA-based EEG features, which indicate fundamental differences in the functional neural connectivity of subjects with sleep apnea as compared to controls.

Modeling current and future distributions of invasive Asteraceae species in Northeast China.

The ecological balance and agricultural productivity of northeastern China are seriously threatened by the long-term invasion and spread of Asteraceae plants, which have severely disrupted the region's biodiversity and ecosystem stability. Ambrosia artemisiifolia L., Ambrosia trifida L.

An acoustic squeezer for assessment of multiparameter cell mechanical properties.

Cells' ability to sense and respond to mechanical stimuli is fundamental to various biological processes and serves as a crucial biomarker of their physiological and pathological states. Traditional methods for assessing cell mechanical properties, such as atomic force microscopy and micropipette aspiration, are hindered by complex procedures and the risk of cellular damage due to direct contact. Here we introduce a novel non-contact acoustic squeezer that leverages focused interdigital transducers to induce cell deformation through a robust standing surface acoustic wave (SSAW) field.

Revisiting the Treatment Algorithm for Atlantoaxial Dislocation after 10 Years: A Multi-center Study with Mid-to-long-term Follow-up.

Study Design: A multi-center retrospective cohort study.

Objective: To overcome the limitations of former single-center strategy studies, an updated classification guiding surgical management of Atlantoaxial dislocation (AAD) is proposed in this study based on a large multi-center retrospective cohort study with mid-to-long-term follow-up.

Summary Of Background Data: AAD is the most prevalent disorder affecting the cranio-vertebral junction, often leading to myelopathy and impairment of cranial nerve function, which can result in significant morbidity or even mortality.

Mitogenomic phylogeny and divergence time estimation of Artemia Leach, 1819 (Branchiopoda: Anostraca) with emphasis on parthenogenetic lineages.

The brine shrimp Artemia, a crustacean adapted to the extreme conditions of hypersaline environments, comprises nine regionally distributed sexual species scattered (island-like) over heterogeneous environments and asexual (parthenogenetic) lineages with different ploidies. Such sexual and asexual interaction within the genus raises questions regarding the origin and time of divergence of both sexual species and asexual lineages, including the persistence of the latter over time, a problem not yet clarified using single mitochondrial and nuclear markers. Based on the complete mitochondrial genome of all species and parthenogenetic lineages, this article first describes the mitogenomic characteristics (nucleotide compositions, genome mapping, codon usage, and tRNA secondary structure) of sexual species and asexual types and, secondly, it provides a comprehensive updated phylogenetic analysis.

Enhancing SLAM algorithm with Top-K optimization and semantic descriptors.

To address the computational challenges faced by edge devices using deep learning to process LiDAR point cloud data, this paper proposes a SLAM algorithm incorporating Top-K optimization to generate semantic descriptors and global semantic map for laser data efficiently. This approach aims to reduce computational complexity while enhancing processing speed. The algorithm extracts semantic information from LiDAR data, constructs two-dimensional semantic descriptors, and improves the robot's semantic understanding of its surrounding environment.

Deep reinforcement learning trajectory planning for robotic manipulator based on simulation-efficient training.

The paper proposes a new M2ACD(Multi-Actor-Critic Deep Deterministic Policy Gradient) algorithm to apply trajectory planning of the robotic manipulator in complex environments. First, the paper presents a general inverse kinematics algorithm that transforms the inverse kinematics problem into a general Newton-MP iterative method. The M2ACD algorithm based on multiple actors and critics is structured.

Tunable superconductivity coexisting with the anomalous Hall effect in a transition metal dichalcogenide.

Transition metal dichalcogenides display a high technological potential due to their wide range of electronic ground states. Here, we unveil that by tuning hydrostatic pressure P, a cascade of electronic phase transitions can be induced in the few-layer transition metal dichalcogenide 1T'-WS. As P increases, we observe the suppression of superconductivity with the concomitant emergence of an anomalous Hall effect (AHE) at GPa.

Giant Exchange Bias in Antiferromagnetic Mixed-Valence MOFs.

Regulating magnetism of a metal-organic framework (MOF) is highly desirable in magnetoelectric devices. Single-crystalline MOFs of [(CH)NH][FeFeCo(HCOO)] ( = 0, 0.2, 0.

Impact of physical disability on transplant candidacy: A multi-institutional survey of transplant professionals.

Background: While the solid organ transplant evaluation process is designed to function equitably, discriminatory practices remain, resulting in disparities in access for persons with disabilities. Physical function and frailty status are often-cited factors in establishing transplant, despite limited consensus on their assessment and impact.

Objective: The purpose of this study was to describe how transplant healthcare professionals conceptualize the relationship between physical disability and transplant candidacy.

CB Cannabinoid Receptor Agonists Induce Acute Respiratory Depression in Awake Mice.

Recreational use of synthetic cannabinoid agonists (i.e., "spice compounds") that target the cannabinoid type 1 receptor (CB) can cause acute respiratory failure in humans.

Size-dependent internalization of gold nanoparticles in individual Tetrahymena thermophila characterized by single-cell mass cytometry.

Aquatic organisms are inevitably exposed to metallic nanoparticles (NPs) in natural environments, leading to potential harm, ecological disruption, and environmental pollution concerns. Importantly, the size of NPs plays a critical role in influencing their uptake by these organisms. Utilizing mass cytometry, we investigated the internalization characteristics of different-sized gold NPs (AuNPs) in an unicellular ciliate Tetrahymena thermophila, under a low exposure concentration of 1 ng mL.

The relationship between enterprise human capital structure and international M&A performance based on cultural differences in China.

With the rapid development of China's economy, increasing Chinese companies have acquired international technology resources, improved production efficiency, opened up international markets through international mergers and acquisitions, and realized the expansion of enterprises in the global capitalist market. Especially in recent years, the rapid development of international mergers and acquisitions of Chinese enterprises, as well as the increasingly frequent activity in the international market, makes the performance of international mergers and acquisitions become the focus of attention of enterprises, and also increasingly become a focus of scholars. Although the human capital structure of enterprises as an internal factor of enterprises has been studied by most scholars.

Sources and fate of dissolved sulphate, carbonate, and nitrate in groundwater of the temperate climate zone: a high-resolution multi-isotope (H, C, O, S) study in north-eastern Germany.

Different natural and anthropogenic drivers impact the groundwater in the catchment area of the southern Baltic Sea, north-eastern Germany. To understand the sources and fate of dissolved sulphate, carbonate, and nitrate on a regional scale, in the present study, the hydrogeochemical and multi-stable isotope (H, C, O, S) composition of groundwater samples from up to more than 300 sites (depths from near-surface down to 291 m) was studied. To investigate the element sources and the water-rock-microbe interaction processes that took place along the groundwater flow path, a mass balance approach is combined with physico-chemical modelling.

Optimizing power allocation for URLLC-D2D in 5G networks with Rician fading channel.

The rapid evolution of wireless technologies within the 5G network brings significant challenges in managing the increased connectivity and traffic of mobile devices. This enhanced connectivity brings challenges for base stations, which must handle increased traffic and efficiently serve a growing number of mobile devices. One of the key solutions to address these challenges is integrating device-to-device (D2D) communication with ultra-reliable and low-latency communication (URLLC).

Dominance of Vaccine-Specific Genotypes in Koalas From North-Eastern Australia.

is a significant cause of morbidity and mortality in koalas and a major contributor to population decline. Due to its crucial role in vaccine development and use as a strain typing tool, multiple studies have investigated the prevalence and diversity of the outer membrane protein A (MOMP), encoded by A. This prior work has shown that A genotypes vary across geographical regions, with multiple genotypes identified across Eastern Australia.

Molecular Characterization of Aminoglycoside-modifying Enzymes (AMEs)in Aminoglycoside-Resistant : A Cross-sectional Study in Northeastern Iran.

Background & Objective: The resistance genes encoding aminoglycoside-modifying enzymes (AMEs) are now widely prevalent in different populations of . The study aimed to determine the frequency of AMEs-encoding genes in clinical isolates of .

Methods: A total of 105 isolates were obtained from the different clinical samples; and then were identified by conventional biochemical tests.

Biochemical Characterization of Disease-Associated Variants of Human Ornithine Transcarbamylase.

Human ornithine transcarbamylase deficiency (OTCD) is the most common ureagenesis disorder in the world. OTCD is an X-linked genetic deficiency in which patients experience hyperammonemia to varying degrees depending on the severity of the genetic mutation. More than two-thirds of the known mutations are caused by single nucleotide substitutions.

Quadriceps motor unit properties following ACL reconstruction are associated with corticospinal excitability and motor cortex activations.

Quadriceps weakness is a primary concern following anterior cruciate ligament reconstruction (ACLR), and neuroimaging studies have revealed higher motor inhibition and structural atrophy of the corticospinal tract. To investigate the contributions of supraspinal mechanisms underlying spinal motoneuron impairments and quadriceps weakness, this study explored the firing patterns of motor units (MUs) in the vastus medialis muscle following ACLR. Twenty individuals with primary ACLR and twenty matched controls performed a unilateral knee extension torque-control task at 50% of maximal voluntary effort.

Nephrolepris cordifolia (L.) C.Presl Frond Micromorphology, Hydrosol Phytochemical Profiling and Antibacterial Activity against Foodborne Bacteria.

Fern species from biodiversity-rich Northeastern India are relatively underexplored. Morphological, phytochemical, and antimicrobial profiling of Nephrolepris cordifolia (L.) C.