Prospective Pilot Evaluation of the Safety, Tolerability, and Efficacy of Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel plus Clascoterone 1% Cream in Adult Patients with Acne.

Background: Acne vulgaris (acne) is a common disorder with a complex, multi-faceted pathophysiology. To date, there has not been a single topical treatment that targets all aspects of acne pathophysiology (ie, increased sebum production, presence of , inflammation, and follicular hyperkeratinization). As such, topical treatments need to be utilized in combination to target all four of the major recognized pathophysiologic components in acne lesion formation.

Efficient Defluorination: Application of Calcium Sulfate Precipitation Method in Zinc Sulfate Solution.

In the process of zinc hydrometallurgy, the content of fluorine in zinc sulfate solution directly affects the stripping of the zinc plate, which easily leads to the deterioration of working conditions. It not only has a serious impact on the entire zinc hydrometallurgical system but also causes huge economic losses. Especially in the process of zinc secondary resource utilization, the concentration of fluoride ions in the electrolyte exceeds the control standard of smelting enterprises, which has become a long-term technical challenge in the smelting industry.

Molecular phylogeny and biogeography of the genus Tulipa (Amana spp.) in East Asia.

The East Asian tulips (Amana spp.), which are endemic to East Asia, include the species A. edulis, recognized as the source of the traditional Chinese medicine (TCM) known as "Guangcigu.

Laser-chemical composite manufacturing of biomimetic stepped armor functional metal surface with wear resistance and anti-icing characteristics.

Superhydrophobic surfaces have been demonstrated to exhibit excellent anti-icing effects, but they are susceptible to the loss of ice repellency as a result of external impacts. This paper proposes a novel bionic armour structure that combines an armour structure with an arrowroot bionic structure. A composite method combining laser etching and chemical modification was employed to achieve superhydrophobicity on the surface of the aluminium alloy.

Modeling dissolved organic carbon export from water supply catchments in the northeastern United States.

Natural organic matter (NOM) in rivers is an important energy source to sustain aquatic ecosystem health. However, in surface water supply systems where chlorination is often used for disinfection, NOM is also a precursor for the carcinogenic and mutagenic disinfection byproducts such as trihalomethanes and haloacetic acids. Effective management of NOM in rivers to maintain both aquatic ecosystem functions and high-quality water supply requires better understanding of the NOM transport patterns.

Exploration of biomass-derived carbon dots based on chestnut shell for the sensitive detection of phosphate and tetracycline hydrochloride.

Phosphate pollution leads to the deterioration of water quality, posing a serious threat to human health. Tetracycline hydrochloride (TC), a class of broad-spectrum bacteriostatic agents, has garnered attention due to its extensive use and potential toxicity. Therefore, developing a highly selective and sensitive fluorescent probe for the detection of phosphates and TC is of significant importance.

Multi-gate neuron-like transistors based on ensembles of aligned nanowires on flexible substrates.

The intriguing way the receptors in biological skin encode the tactile data has inspired the development of electronic skins (e-skin) with brain-inspired or neuromorphic computing. Starting with local (near sensor) data processing, there is an inherent mechanism in play that helps to scale down the data. This is particularly attractive when one considers the huge data produced by large number of sensors expected in a large area e-skin such as the whole-body skin of a robot.

Coronavirus Cryptic Landscape and Draft Genome of a Novel CoV Clade Related to MERS From Bats Circulating in Northeastern Brazil.

We identified seven distinct coronaviruses (CoVs) in bats from Brazil, classified into 229E-related (Alpha-CoV), Nobecovirus, Sarbecovirus, and Merbecovirus (Beta-CoV), including one closely related to MERS-like CoV with 82.8% genome coverage. To accomplish this, we screened 423 oral and rectal swabs from 16 different bat species using molecular assays, RNA sequencing, and evolutionary analysis.

Associations between anthropogenic heat emissions and serum lipids among adults in northeastern China.

Few epidemiological studies have investigated associations between anthropogenic heat emissions (AE) and serum lipids. We recruited 15,477 adults from 33 communities in northeastern China in 2009. We estimated AE flux by using data on energy consumption and socio-economic statistics covering building, transportation, industry, and human metabolism.

The Effects of Hydrological Disasters on the Population's Health in the Northeast Region of Brazil.

The Northeast region of Brazil is characterized by long periods of drought. However, the region is also frequently affected by floods. The socioeconomic characteristics of the locality make the population more vulnerable to the impacts of these disasters.

Enhancing prehospital decision-making: exploring user needs and design considerations for clinical decision support systems.

Background: In prehospital emergency care, providers face significant challenges in making informed decisions due to factors such as limited cognitive support, high-stress environments, and lack of experience with certain patient conditions. Effective Clinical Decision Support Systems (CDSS) have great potential to alleviate these challenges. However, such systems have not yet been widely adopted in real-world practice and have been found to cause workflow disruptions and usability issues.

Soil Nitrogen Supply Exerts Largest Influence on Leaf Nitrogen in Environments with the Greatest Leaf Nitrogen Demand.

Accurately representing the relationships between nitrogen supply and photosynthesis is crucial for reliably predicting carbon-nitrogen cycle coupling in Earth System Models (ESMs). Most ESMs assume positive correlations amongst soil nitrogen supply, leaf nitrogen content, and photosynthetic capacity. However, leaf photosynthetic nitrogen demand may influence the leaf nitrogen response to soil nitrogen supply; thus, responses to nitrogen supply are expected to be the largest in environments where demand is the greatest.

Differential impacts of strabismic and anisometropic amblyopia on the mesoscale functional organization of the human visual cortex.

We employed high-resolution fMRI to distinguish the impacts of anisometropia and strabismus amblyopia on the evoked ocular dominance (OD) response. Sixteen amblyopic participants (8 females) plus 8 individuals with normal vision (1 female), participated in this study for whom, we measured the difference between the response to stimulation of the two eyes, across areas V1-V4.In controls, the evoked OD response formed the expected striped pattern within V1.

Rationale and Design of the HERZCHECK trial: Detection of Early Heart Failure Using Telemedicine and CMR in Structurally Weak Regions (NCT05122793).

Background And Aims: Heart failure (HF) is an imminent global health problem. Yet established screening algorithms for asymptomatic pre-HF, allowing for early and effective preventive interventions, are largely lacking. The HERZCHECK trial, conducted in structurally underserved rural regions of North-Eastern Germany, aims to close this gap by evaluating the feasibility, diagnostic efficacy, and cost-effectiveness of a fully mobile, telemedically-supervised screening approach, combining cardiac magnetic resonance imaging (CMR) and laboratory testing as central elements.

Improvement of the Thermoelectric Properties in CNT/BiTe Composite Films Due to Evolution of the Depletion Layer and Point Defects under the Pulse Current Field.

A carbon nanotube (CNT) composite is an effective method to improve the thermoelectricity of materials. However, the depletion layer between the CNT and thermoelectric (TE) material always decreases the contribution of CNT to the conductivity of the TE material. It is important to eliminate the depletion layer for improving the TE properties.

Cellular Senescence Genes as Cutting-Edge Signatures for Abdominal Aortic Aneurysm Diagnosis: Potential for Innovative Therapeutic Interventions.

Abdominal aortic aneurysm (AAA) is the most prevalent dilated arterial aneurysm that poses a significant threat to older adults, but the molecular mechanisms linking senescence to AAA progression remain poorly understood. This study aims to identify cellular senescence-related genes (SRGs) implicated in AAA development and assess their potential as therapeutic targets. Four hundred and twenty-nine differentially expressed genes (DEGs) were identified from the GSE57691 training set, and 867 SRGs were obtained.

Thought-Feeling Accuracy in Person Perception and Metaperception: An Integrative Perspective.

People often want to know what their interaction partners are thinking. How accurate are they, what information do they use, what predicts how accurate they will be, and does accuracy matter? We organize our review of thought-feeling accuracy, defined as the accuracy of individuals' judgments about the content of another person's thoughts and feelings in live interaction, around these questions. At the same time, we argue that often people are especially interested in what others are thinking about them, such that research on the accuracy of individuals' metaperceptions regarding others' views of them is highly relevant to understanding thought-feeling accuracy more broadly construed.

Para-Bombay blood group: Report of a rare blood group.

Para-Bombay blood group is a rare blood group typically characterized by the absence of H antigens on red blood cell and the presence of ABH substances on secretion. It can be easily missed and often mistaken as blood group O without extended testing. Detection is important as it significantly affect transfusion management.

Red blood cell alloimmunization among transfusion-dependent thalassemia major patients in Northeastern Iran.

Background: Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. However, this practice increases the risk of alloimmunization.

Detection of genomic variants in BRCA1 and BRCA2 across gastric cancer patients using next generation sequencing.

Objectives: To explore the landscape of BRCA1/2 mutations in gastric cancer patients.

Methods: Next-generation sequencing (NGS), Sanger sequencing, reverse transcription quantitative polymerase chain reaction (RT-qPCR), Immunohistochemistry, The Cancer Genome Atlas (TCGA), gnomAD, and DAVID.

Results: With 95% of bases boasting a phred score surpassing 30 and a minimum coverage depth of 500X, our NGS approach ensures high-quality data acquisition.

Recent innovations in strategies to prepare metal-organic framework-based mixed matrix membranes.

Mixed matrix membranes (MMMs) composed of metal-organic frameworks (MOFs) and polymer matrixes have garnered significant attention due to their potential to overcome the permeability-selectivity trade-off inherent in polymeric membranes. Nevertheless, the application and industrial production of MOF-based MMMs have been hindered by issues such as poor interfacial compatibility and cumbersome fabrication processes. Recently, strategies have emerged as promising approaches for fabricating MOF-based MMMs, offering enhanced interfacial compatibility between MOF fillers and polymers, as well as a simplified construction process.

Microwave synthesis of molybdenum disulfide quantum dots and the application in bilirubin sensing.

Molybdenum disulfide quantum dots (MoS2 QDs) is a new type of graphite like nanomaterial, which exhibited well chemical stability, unique fluorescence characteristics, and excellent biocompatibility. The conventional hydrothermal synthesis of MoS2 generally requires a long-term reaction at high temperature and high pressure. Herein, we have developed a simple and fast MoS2 QDs synthesis scheme using microwave heating, and further modified the surface of MoS2 QDs using 3-aminophenylboronic acid.

STDCformer: Spatial-temporal dual-path cross-attention model for fMRI-based autism spectrum disorder identification.

Resting-state functional magnetic resonance imaging (rs-fMRI) is a non-invasive neuroimaging technique widely utilized in the research of Autism Spectrum Disorder (ASD), providing preliminary insights into the potential biological mechanisms underlying ASD. Deep learning techniques have demonstrated significant potential in the analysis of rs-fMRI. However, accurately distinguishing between healthy control group and ASD has been a longstanding challenge.

Out-of-focus signal rejection for pO measurements using two-photon phosphorescence lifetime microscopy.

Two-photon phosphorescence lifetime microscopy has been a key tool for studying cerebral oxygenation in mice. However, the accuracy of the partial pressure of oxygen (pO) measurements is affected by out-of-focus signal. In this work, we applied reconfigurable differential aberration imaging to characterize and correct for out-of-focus signal contamination in intravascular pO imaging.

Unraveling Chemical Profile, Antioxidant, Antialzheimer and Antimicrobial Potentials of Three Propolis from Northeastern Regions of Algeria: In Vitro and in Silico Evaluation.

This study investigates the pharmaceutical potential both in vitro and in silico of ethanolic propolis extract from three Algerian regions namely TAH (Tahir-Jijel), ATH (Oued Athmania-Mila) and OZ (Oued Zhor-skikda). Twenty-three compounds were identified via HPLC‒DAD, with key constituents including caffeic acid, cynarin, chrysin, naringin, and hesperetin. Moreover, Antioxidant and anti-Alzheimer activities were assessed by multiple assays.