2 results match your criteria: "Northeast Louisiana University Monroe[Affiliation]"
Nutritional impact on the final outcome of liver injury inflicted by model hepatotoxicants: effect of glucose loading.
FASEB J
February 1995
Division of Pharmacology and Toxicology, College of Pharmacy and Health Sciences, Northeast Louisiana University Monroe, 71209-0470, USA.
Article Synopsis
- A study found that giving male rats 15% glucose in their drinking water for 7 days made them more susceptible to liver damage from various toxic substances, including acetaminophen and thioacetamide.
- Specifically, a normally non-lethal dose of thioacetamide became lethal in glucose-loaded rats, highlighting the adverse effects of glucose on liver injury progression.
- Further analysis showed that glucose loading inhibited liver cell regeneration and repair processes, leading to faster deterioration of liver health and increased mortality from thioacetamide toxicity.
Ongoing hepatocellular regeneration and resiliency toward galactosamine hepatotoxicity.
Arch Toxicol
March 1993
Division of Pharmacology and Toxicology, College of Pharmacy and Health Sciences, Northeast Louisiana University Monroe.
In previous studies, we reported that the age-dependent hepatotoxicity of galactosamine (GalN) was evident in hepatocytes maintained in primary cultures. Cellular proliferation and tissue repair are not manifested in response to injury in this in vitro system. Neonatal (5-day) rats have ongoing hepatocellular proliferation in contrast to adult (5-month) rats, and should be therefore resilient to GalN toxicity.
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