[Assessment of visual functions within the sensory domain of intrinsic capacity in older adults].

Unlabelled: Intrinsic capacity and quality of life of older adults are determined by many factors, including the functional state of the organ of vision.

Purpose: This study assessed the visual functions of elderly residents of Northern European Russia and examined the relationship between visual impairment and sociodemographic characteristics, ophthalmic conditions, and preservation of work capacity and social functions.

Material And Methods: This cross-sectional study included a random population sample of older adults (ages 60-74) from Arkhangelsk, Russia (=604).

[Professor Boksha Vyacheslav Georgievich.].

September 14, 2024 was the 100th anniversary of the birth of a major scientist, specialist in the field of medical climatology, clinical physiology of respiration and circulation, Honored Scientist of the Ukrainian SSR, Doctor of Medical Sciences, Professor Vyacheslav Georgievich Boksha (14.09.1924-22.

[Changes in the morphological characteristics of the endodontic system and parameters of human dental hard tissues in the North-Western region of Siberia during the X-XX centuries].

The Aim Of The Study: Was a comparative analysis of the structural features of the endodontic system and the thickness of hard dental tissues over the past ten centuries.

Materials And Methods: 180 teeth of people who lived from the X to XX centuries AD were studied using cone-beam computed tomography in endodontic mode: the volume of the endodontic system and the thickness of hard dental tissues were calculated using the algorithm developed by us. The Pearson correlation coefficient and Student's t-test were calculated in Excel program, and the data was analyzed with GraphPad Prism 8 Statistics Guide statistical program.

The Relevance of Spinal Muscular Atrophy Biomarkers in the Treatment Era.

Spinal muscular atrophy (SMA) is a severe neuromuscular disorder that currently has an approved treatment for all forms of the disease. Previously, biomarkers were primarily used for diagnostic purposes, such as detecting the presence of the disease or determining a specific clinical type of SMA. Currently, with the availability of therapy, biomarkers have become more valuable due to their potential for prognostic, predictive, and pharmacodynamic applications.

Multiomics analysis of Staphylococcus aureus ST239 strains resistant to virulent Herelleviridae phages.

In the context of the antimicrobial therapy crisis, the significance of studying and implementing alternative treatment methods, particularly phage therapy, is increasingly evident. This study aimed to investigate the resistance of clinical Staphylococcus aureus ST239 strains to Herelleviridae phages through comparative genomics, transcriptomics, and proteomics. Analysis of resistant and sensitive S.

[Results of intestinal ureteral plastic surgery].

Unlabelled: THE AIM OF THE RESEARCH: is to present the features of the technique and results of intestinal reconstruction surgery of ureters.

Materials And Methods: From 2001 to 2024 ileoureteroplasty was performed in 217 patients. The average age was 51+/-3.

[Retrograde endoscopic treatment of stones in horseshoe kidney].

Introduction: Horseshoe kidney is often associated with ureteropelvic junction obstruction and nephrolithiasis. Retrograde intrarenal surgery (RIRS) is becoming one of the main treatment options for large stones in such patients.

Aim: To study the results of RIRS in patients with horseshoe kidney.

Patient-specific 3D-Printed PEEK implants for spinal tumor surgery.

Aims & Objectives: This study evaluates the feasibility and clinical outcomes of using 3D-printed polyetheretherketone (PEEK) patient-specific implants (PSI) for vertebral body replacement (VBR) in patients with spinal tumors. The research question focuses on postoperative results, implant integration, and complications over a 12-month period.

Methods: A single-center, retrospective case series analyzed five patients who underwent spinal reconstruction after tumor resection using PEEK 3D VBR between April 2022 and June 2023.

The Wound-Healing Effect of a Novel Fibroblasts-Impregnated Hydroxyethylcellulose Gel in a Rat Full-Thickness Burn Model: A Preclinical Study.

The objective of this study was to assess the efficacy of a cell-containing wound dressing based on fibroblasts in hydroxyethylcellulose (HEC) gel for the local treatment of deep partial-thickness and/or full-thickness skin burns in an animal model. The rats (male Wistar, n = 100) were subjected to a full-thickness thermal burn (16 cm). Radical necrectomy was performed one day after the burn.

[Analysis of defects in health care delivery for children based on the data of commission forensic medical examinations performed in the Republic of Uzbekistan].

Objective: To perform a retrospective analysis of the commission forensic medical examinations' data of pediatric profile with identification of defects in health care delivery and establishment of their connection with unfavorable outcome.

Material And Methods: The data of 3854 commission forensic medical examinations performed in the period from 2012 to 2021 regarding the evaluation of quality of health care delivery for children with the establishment of nature and type of defects in health care delivery, determination of disease (injury) outcome, identification of cause-effect relationship between the defect in health care delivery and negative disease (injury) outcome.

Results And Conclusions: Defects in health care delivery were equal 9% in the studied commission forensic medical examinations.

[Pathogenesis and pathological anatomy of chlamydial infections].

The review presents modern view on the global problem of chlamydial infections. Current nomenclature of chlamydiae was adduced. Epidemiology, etiology, clinical features, pathogenesis, diagnosis and treatment of chlamydiosis received full coverage.

Epidermal growth factor receptor-mutated lung carcinomas with insufficient response to epidermal growth factor receptor inhibitors.

Administration of single-agent epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is a standard treatment option for metastatic non-small cell lung carcinomas with EGFR exon 19 deletions (ex19del) and L858R substitutions. However, there is a significant interpatient heterogeneity with regard to the degree of the response and its duration. Patients with EGFR ex19del mutation, TP53 wild-type, good performance status, low tumor burden and no circulating tumor DNA (ctDNA) at baseline have the best chances to derive pronounced benefit from TKI therapy.

Comparative Effectiveness of an Autologous Dentin Matrix for Alveolar Ridge Preservation.

An urgent issue is the preservation or reconstruction of the volume of bone tissue in planning and surgical treatment in the fields of medicine, such as traumatology, orthopedics, maxillofacial surgery and dentistry. After tooth extraction, resorption of the bone tissue of the alveolar crest of the jaws occurs, which must either be further eliminated by performing additional operations or using osteoplastic material for socket preservation at the extraction stage. The aim of the study was a comparative analysis of various osteoplastic materials used to preserve the volume of bone tissue in the preimplantation period.

Efficacy and Safety of Postbiotic Contained Inactivated Lactobacillus reuteri ( Limosilactobacillus reuteri ) DSM 17648 as Adjuvant Therapy in the Eradication of Helicobacter pylori in Adults With Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Trial.

Introduction: Increasing the effectiveness of eradication therapy is an important task in gastroenterology. The aim of this study was to evaluate the efficacy and safety of postbiotic containing inactivated (nonviable) Limosilactobacillus (Lactobacillus) reuteri DSM 17648 (Pylopass) as adjuvant treatment of Helicobacter pylori eradication in patients with functional dyspepsia (FD).

Methods: This randomized, double-blind, placebo-controlled, multicenter, parallel study included H.

New characteristics of polycystic ovary syndrome phenotypes according to gas chromatography-mass spectrometry-based study of urinary steroid metabolome.

Background: The most common cause of hyperandrogenism in women is polycystic ovary syndrome (PCOS), the prevalence of which among women of reproductive age ranges from 8.0 to 21%. The clinical manifestations of PCOS are diverse, and the degree of metabolic and hormonal disorders depends on the PCOS phenotype.

[The relationship between intraocular pressure and age-related variations in ocular rigidity].

Purpose: This study aimed to identify the correlation between age-related fluctuations in the average values of rigidity of the fibrous tunic of the eye (FTE) and corresponding ranges of true intraocular pressure (IOP) in healthy eyes and eyes with open-angle glaucoma (OAG); using the identified ranges of FTE rigidity, to establish the appropriate IOP zones for healthy and glaucomatous eyes, taking into account the aging periods as classified by the World Health Organization (WHO).

Material And Methods: Ocular-Response Analyzer tonometry was used according to the Koshits-Svetlova dynamic diagnostic method to examine 674 patients with healthy eyes and 518 patients with glaucomatous eyes, aged 18 to 90 years, classified according to the WHO aging periods, and a theoretical analysis was conducted to estimate clinical values of FTE rigidity, the current level of true IOP, and the calculated individual IOP level in a patient's eye during youth.

Results: The following IOP level zones were identified for patients with healthy and glaucomatous eyes: low IOP zone (≤13 mm Hg); medium IOP zone (14-20 mm Hg); elevated IOP zone (21-26 mm Hg); high IOP zone (27-32 mm Hg); subcompensated IOP zone (33-39 mm Hg); and decompensated IOP zone (≥40 mm Hg).

Skeletal abnormalities, pediatric-onset severe osteoporosis, and multiple fragility fractures in a patient with a novel variant.

We report a case of a patient with a germline heterozygous truncating variant of gene (c.2172del, p.Tyr724Ter) causing neurodevelopmental disorder with spastic diplegia and visual defects syndrome (NEDSDV) associated with a new clinical feature - severe pediatric-onset osteoporosis and multiple fractures.

Correction: Sulatskaya et al. Structural Features of Amyloid Fibrils Formed from the Full-Length and Truncated Forms of Beta-2-Microglobulin Probed by Fluorescent Dye Thioflavin T. 2018, , 2762.

In the original publication [...

[Analysis of the work of the Immunohistochemical Quality Control Center of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of Russia in 2023].

The article demonstrates a detailed analysis of the results of the rounds of quality control of immunohistochemical studies conducted by the Central Committee of the Immunohistochemical Quality Control Center of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of Russia in 2023. Typical shortcomings and errors in the immunohistochemical examination of various tumors have been identified and ways to eliminate them are given. Particular attention is paid to defining a panel of standard breast cancer markers and eliminating the shortcomings of immunohistochemical examination of markers of accompanying diagnosis.