[Assessment of visual functions within the sensory domain of intrinsic capacity in older adults].

Unlabelled: Intrinsic capacity and quality of life of older adults are determined by many factors, including the functional state of the organ of vision.

Purpose: This study assessed the visual functions of elderly residents of Northern European Russia and examined the relationship between visual impairment and sociodemographic characteristics, ophthalmic conditions, and preservation of work capacity and social functions.

Material And Methods: This cross-sectional study included a random population sample of older adults (ages 60-74) from Arkhangelsk, Russia (=604).

[The possibilities of a dosage form with the active substance acylsarcosinate and sucrose laurate, in the implementation of the issue of cerumenolysis. Literature review].

The observed increase in cases of earwax plugs in patients, as well as the variety of methods of their removal using agents with different cerumenolysis activity, emphasize the need to search for the most modern and multifunctional otolaryngological preparations with proven efficacy. Based on the results of the analysis and generalization of literature sources on the treatment and prevention of ear sulfur plugs, presented in specialized publications in the Russian scientific eLibrary and scientific databases MedLine, Web of Science, Scopus, the need to optimize treatment methods and preventive measures has been identified. In this regard, it is recommended to widely use the preparation A-Cerumen Plus as one of the most progressive means.

[Epidemiology of central auditory disorders in school-age children. Literature review].

Unlabelled: Central auditory disorders (CSD) - this is a violation of the processing of sound stimuli, including speech, above the cochlear nuclei of the brain stem, which is mainly manifested by difficulties in speech recognition, especially in noisy environments. Children with this pathology are more likely to have behavioral problems, impaired auditory, linguistic and cognitive development, and especially difficulties with learning at school.

Objective: To analyze the literature data on the epidemiology of central auditory disorders in school-age children.

Outcomes of a 12-month course of early and late rituximab BCD020 biosimilar administration in juvenile systemic lupus erythematosus: A retrospective study.

Background: Juvenile systemic lupus erythematosus (SLE) is a severe, life-threatening disease. However, the role of rituximab in managing juvenile SLE remains undefined, although early biological intervention may improve disease outcomes.

Aim: To assess the differences in the outcomes of different types of rituximab administration (early and late).

[Professor Boksha Vyacheslav Georgievich.].

September 14, 2024 was the 100th anniversary of the birth of a major scientist, specialist in the field of medical climatology, clinical physiology of respiration and circulation, Honored Scientist of the Ukrainian SSR, Doctor of Medical Sciences, Professor Vyacheslav Georgievich Boksha (14.09.1924-22.

Respiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023-2024: EPICOVIDEHA-EPIFLUEHA Report.

Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season.

[Changes in the morphological characteristics of the endodontic system and parameters of human dental hard tissues in the North-Western region of Siberia during the X-XX centuries].

The Aim Of The Study: Was a comparative analysis of the structural features of the endodontic system and the thickness of hard dental tissues over the past ten centuries.

Materials And Methods: 180 teeth of people who lived from the X to XX centuries AD were studied using cone-beam computed tomography in endodontic mode: the volume of the endodontic system and the thickness of hard dental tissues were calculated using the algorithm developed by us. The Pearson correlation coefficient and Student's t-test were calculated in Excel program, and the data was analyzed with GraphPad Prism 8 Statistics Guide statistical program.

[Craniovertebral intradural meningiomas: analysis of postoperative outcomes (a retrospective two-center study)].

Objective: To analyze the postoperative outcomes in patients with craniovertebral meningiomas with preoperative justification of surgical approach depending on tumor localization.

Material And Methods: We examined 36 patients with craniovertebral meningiomas. The Karnofsky, Frankel and cranial nerve dysfunction scales were used to assess functional status of patients.

The Relevance of Spinal Muscular Atrophy Biomarkers in the Treatment Era.

Spinal muscular atrophy (SMA) is a severe neuromuscular disorder that currently has an approved treatment for all forms of the disease. Previously, biomarkers were primarily used for diagnostic purposes, such as detecting the presence of the disease or determining a specific clinical type of SMA. Currently, with the availability of therapy, biomarkers have become more valuable due to their potential for prognostic, predictive, and pharmacodynamic applications.

Multiomics analysis of Staphylococcus aureus ST239 strains resistant to virulent Herelleviridae phages.

In the context of the antimicrobial therapy crisis, the significance of studying and implementing alternative treatment methods, particularly phage therapy, is increasingly evident. This study aimed to investigate the resistance of clinical Staphylococcus aureus ST239 strains to Herelleviridae phages through comparative genomics, transcriptomics, and proteomics. Analysis of resistant and sensitive S.

[Psychoemotional state and sexual function in women with chronic pelvic pain in genital endometriosis].

The of this review is to consider current ideas about psychophysiology of chronic pelvic pain (CPP) in external genital endometriosis (GE), as well as the impact of the psychoemotional state and sexual function in women with CPP on its development and maintenance. The review is based on the study of original Russian and English-language articles and our own extensive clinical experience. References are made to statistically reliable, randomized and placebo-controlled studies of the last 20 years, in some cases to small and open-ended studies indicating their low evidence.

[Results of intestinal ureteral plastic surgery].

Unlabelled: THE AIM OF THE RESEARCH: is to present the features of the technique and results of intestinal reconstruction surgery of ureters.

Materials And Methods: From 2001 to 2024 ileoureteroplasty was performed in 217 patients. The average age was 51+/-3.

[Retrograde endoscopic treatment of stones in horseshoe kidney].

Introduction: Horseshoe kidney is often associated with ureteropelvic junction obstruction and nephrolithiasis. Retrograde intrarenal surgery (RIRS) is becoming one of the main treatment options for large stones in such patients.

Aim: To study the results of RIRS in patients with horseshoe kidney.

Patient-specific 3D-Printed PEEK implants for spinal tumor surgery.

Aims & Objectives: This study evaluates the feasibility and clinical outcomes of using 3D-printed polyetheretherketone (PEEK) patient-specific implants (PSI) for vertebral body replacement (VBR) in patients with spinal tumors. The research question focuses on postoperative results, implant integration, and complications over a 12-month period.

Methods: A single-center, retrospective case series analyzed five patients who underwent spinal reconstruction after tumor resection using PEEK 3D VBR between April 2022 and June 2023.

[Establishment and development of rehabilitation medicine in Russia: the role of the Russian Academy of Sciences].

An analysis of the results of studying physical therapy methods obtained for 300 years of existence of the Russian Academy of Sciences is presented. The first hundred years brought together attempts of physical therapy methods' experiential studiyng, which led to the formation of physiotherapy in the late 19 century. The synthesis of empirical knowledge allowed to form unifying theories of restorative and rehabilitation medicine in the 20 century.

The Wound-Healing Effect of a Novel Fibroblasts-Impregnated Hydroxyethylcellulose Gel in a Rat Full-Thickness Burn Model: A Preclinical Study.

The objective of this study was to assess the efficacy of a cell-containing wound dressing based on fibroblasts in hydroxyethylcellulose (HEC) gel for the local treatment of deep partial-thickness and/or full-thickness skin burns in an animal model. The rats (male Wistar, n = 100) were subjected to a full-thickness thermal burn (16 cm). Radical necrectomy was performed one day after the burn.

[On improvement of legal regulation of personnel training in the sphere of state forensic medical activity].

Legislation and industry-specific regulatory documents of Russia, some historical aspects and current problems of staffing in forensic medical organizations were analyzed to improve legal and regulatory framework for skilled personnel training in the sphere of forensic medical examination. Changes in the qualification requirements to medical and pharmaceutical workers with higher education in specialty are proposed, namely to remove restrictions on the possibility of postgraduate training in forensic medical examination specialty for those who have received higher medical education (specialist's degree program) in «medical and preventative care» specialty, considering the interdisciplinary relationship between forensic medical activity and preventive medicine, common approaches to the specialist's degree programs formation and general medical thinking development in students. This will help to achieve the target of the President and the Government of the Russian Federation on provision of health care with qualified personnel and increase of staffing of specialists in forensic medical organizations.

[Analysis of defects in health care delivery for children based on the data of commission forensic medical examinations performed in the Republic of Uzbekistan].

Objective: To perform a retrospective analysis of the commission forensic medical examinations' data of pediatric profile with identification of defects in health care delivery and establishment of their connection with unfavorable outcome.

Material And Methods: The data of 3854 commission forensic medical examinations performed in the period from 2012 to 2021 regarding the evaluation of quality of health care delivery for children with the establishment of nature and type of defects in health care delivery, determination of disease (injury) outcome, identification of cause-effect relationship between the defect in health care delivery and negative disease (injury) outcome.

Results And Conclusions: Defects in health care delivery were equal 9% in the studied commission forensic medical examinations.

[Pathogenesis and pathological anatomy of chlamydial infections].

The review presents modern view on the global problem of chlamydial infections. Current nomenclature of chlamydiae was adduced. Epidemiology, etiology, clinical features, pathogenesis, diagnosis and treatment of chlamydiosis received full coverage.

Epidermal growth factor receptor-mutated lung carcinomas with insufficient response to epidermal growth factor receptor inhibitors.

Administration of single-agent epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is a standard treatment option for metastatic non-small cell lung carcinomas with EGFR exon 19 deletions (ex19del) and L858R substitutions. However, there is a significant interpatient heterogeneity with regard to the degree of the response and its duration. Patients with EGFR ex19del mutation, TP53 wild-type, good performance status, low tumor burden and no circulating tumor DNA (ctDNA) at baseline have the best chances to derive pronounced benefit from TKI therapy.

Comparative Effectiveness of an Autologous Dentin Matrix for Alveolar Ridge Preservation.

An urgent issue is the preservation or reconstruction of the volume of bone tissue in planning and surgical treatment in the fields of medicine, such as traumatology, orthopedics, maxillofacial surgery and dentistry. After tooth extraction, resorption of the bone tissue of the alveolar crest of the jaws occurs, which must either be further eliminated by performing additional operations or using osteoplastic material for socket preservation at the extraction stage. The aim of the study was a comparative analysis of various osteoplastic materials used to preserve the volume of bone tissue in the preimplantation period.