Unraveling the genetic evolution of SARS-CoV-2 Recombinants using mutational dynamics across the different lineages.

Introduction: Recombination serves as a common strategy employed by RNA viruses for their genetic evolution. Extensive genomic surveillance during the COVID-19 pandemic has reported SARS-CoV-2 Recombinant strains indicating recombination events during the viral evolution. This study introspects the phenomenon of genome recombination by tracing the footprint of prominent lineages of SARS-CoV-2 at different time points in the context of on-going evolution and emergence of Recombinants.

ChatGPT in the Material Design: Selected Case Studies to Assess the Potential of ChatGPT.

The pursuit of designing smart and functional materials is of paramount importance across various domains, such as material science, engineering, chemical technology, electronics, biomedicine, energy, and numerous others. Consequently, researchers are actively involved in the development of innovative models and strategies for material design. Recent advancements in analytical tools, experimentation, and computer technology additionally enhance the material design possibilities.

Anti-diabetic and anti-urease inhibition potential of Roxb. seeds through a bioassay-guided approach.

Using HPLC-PDA and HRMS analysis, five compounds -coumaric acid, sinapic acid, quercetin, -ferulic and gallic acid were identified in seeds of Roxb. The GC-MS analysis identified 1-dodecanol, phenol, 3,5-bis(1,1-dimethylethyl), Oleic Acid and 1-Heptacosanol which possess anti-diabetic properpties. A bioassay-guided technique was used to determine the degree of inhibition that seeds crude methanol extract and its most active sub-fraction had against the α-glucosidase and urease enzymes.

Highly efficient visible-light induced N-doped ZnO@g-CN and S-doped ZnO@g-CN photocatalysts for environmental remediation.

Facile, cost-effective and eco-friendly synthesis of N-doped ZnO@g-CN and S-doped ZnO@g-CN photocatalysts towards efficient degradation of environmental pollutants was achieved. The as-synthesized 2 wt% N-doped ZnO@g-CN and 2 wt% S-doped ZnO@g-CN achieved 96.2% and 90.

Copper tetrathiovanadate (CuVS): a newly emerging electrode for rechargeable aqueous aluminum-ion batteries.

We report the electrochemistry of Al ion storage in copper tetrathiovanadate (CuVS) in an aqueous electrolyte for the first time. It is found that CuVS could deliver an initial discharge capacity of 111 mA h g at a current rate of 0.5 A g and 77 mA h g up to the 300 cycle at 2 A g along with an excellent rate capability.

Mushroom mediated selective bioreduction of S-(+)-carvone to -(-)-dihydrocarvone: approach towards a safer biocatalysis.

Dihydrocarvone, possessing four stereoisomers is an important flavour and chiral building block in chemical synthesis. Ascomycetes are well known for the selective bioreduction of carvone to dihydrocarvone. Often, these fungi produce mycotoxins which may contaminate the biocatalytic product.

Biogenic Synthesis of Nanoparticles from the Edible Plant for Use in Antimicrobial Fabric.

With increasing demand of the public toward antimicrobial textiles, there should be the proper fabrication of such types of clothes, and it is possible with biogenically synthesized metal nanoparticles (NPs). It is necessary to find cheap and eco-friendly resources for such synthesis. In this work, we used from Assam, India, to synthesize copper and silver (Ag) NPs.

Synthesis and Photophysical Properties of 3-Substituted-1-Indazoles: A Pd-Catalyzed Double C-N Bond Formation Strategy via 1,6-Conjugate Addition.

A Pd-catalyzed cascade process for the direct synthesis of 3-substituted-1-indazole employing -quinone methide (-QM) and arylhydrazine through Pd-catalyzed double C-N bond formation via 1,6-conjugate addition is reported. This reaction strategy affords efficient and practical access to synthetically important diverse 3-substituted-1-indazoles in good yields. The photophysical properties of the synthesized 3-substituted-1-indazoles are investigated, and some of them showed very good fluorescence properties with quantum yields up to 85%.

Begomovirus and DNA-satellites association with mosaic and leaf curl disease of and : the new hosts for chilli leaf curl virus.

Unlabelled: The numerous plants of L, and L, well-known weeds with medicinal properties in agriculture and horticulture crops exhibiting severe mosaic, enation and leaf curl symptoms, were collected from the Varanasi and Mirzapur districts of Uttar Pradesh, India. The begomovirus infection in and was validated by PCR using virus-specific primers. The whole genome of the represented isolate of (SN1),  (PM1), and beta satellite was amplified, cloned and sequenced.

Hypothetical biosynthetic pathways of pharmaceutically potential hallucinogenic metabolites in Myristicaceae, mechanistic convergence and co-evolutionary trends in plants and humans.

The family Myristicaceae harbour mind-altering phenylpropanoids like myristicin, elemicin, safrole, tryptamine derivatives such as N,N-dimethyltryptamine (DMT) and 5-methoxy N,N-dimethyltryptamine (5-MeO-DMT) and β-carbolines such as 1-methyl-6-methoxy-dihydro-β-carboline and 2-methyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline. This study aimed to systematically review and propose the hypothetical biosynthetic pathways of hallucinogenic metabolites of Myristicaceae which have the potential to be used pharmaceutically. Relevant publications were retrieved from online databases, including Google Scholar, PubMed Central, Science Direct and the distribution of the hallucinogens among the family was compiled.

Intercalation vs Adsorption Strategies of Myo-Inositol Hexakisphosphate into Zn-Fe Layered Double Hydroxide: A Tiff between Anion Exchange and Coprecipitation.

Myo-inositol hexakisphosphates (IHPs) or phytates are the most abundant organic phosphates having the potential to serve as a phosphorus reserve in soil. Understanding the fate of IHP interaction with soil minerals tends to be crucial for its efficient storage and utilization as a slow-release organic phosphate fertilizer. We have systematically compared the effective intercalation strategy of a phytate onto Zn-Fe layered double hydroxide (LDH) acting as storage/carrier material through coprecipitation and anion exchange.

Chemical and toxicological studies on black crust formed over historical monuments as a probable health hazard.

Studies to date have mostly investigated environmental factors responsible for deterioration of historical monuments. Black crusts formed on historical monuments are considered as factor for deterioration of structures or as an indicator of environmental status of the surrounding area. Black crust formed on historical monuments has never been investigated as a health hazard.

Mitochondria-targeted biotin-conjugated BODIPYs for cancer imaging and therapy.

Two BODIPY-biotin conjugates and are designed and synthesized for targeted PDT applications. Both have good absorption with a high molar absorption coefficient and decent singlet oxygen generation quantum yields. The photosensitizers and were found to be localized in the mitochondria with excellent photocytotoxicity of up to 18.

Experimental and Computational Insights into the Overall Water Splitting Reaction by the Fe-Co-Ni-P Electrocatalyst.

Nonprecious transition-metal phosphides (TMPs) are versatile materials with tunable electronic and structural properties that could be promising as catalysts for energy conversion applications. Despite the facts, TMPs are not explored thoroughly to understand the chemistry behind their rich catalytic properties for the water splitting reaction. Herein, spiky ball-shaped monodispersed TMP nanoparticles composed of Fe, Co, and Ni are developed and used as efficient electrocatalysts for hydrogen and oxygen evolution reaction (HER, OER), and overall water splitting in alkaline medium; and their surface chemistry was explored to understand the reaction mechanism.

-Butylhydroperoxide mediated radical cyanoalkylation/cyanoalkenylation of 2-anilino-1,4-naphthoquinones with vinylarenes/arylalkynes and azobis(alkylcarbonitrile)s.

A novel sustainable methodology based on one-pot cyanoalkylation/cyanoalkenylation of 2-anilino-1,4-naphthoquinones with vinylarenes/arylalkynes and azobis(alkylcarbonitrile)s involving a three-component radical cascade pathway has been achieved. Here, -butylhydroperoxide (TBHP) acts as an efficient oxidant, and it smoothly drives the reaction, producing the three-component products in very good to excellent yields. This cascade reaction eliminates the use of any base, additive, metal and hazardous cyanating agent.

Molecular genetic divergence analysis amongst high curcumin lines of Golden Crop (Curcuma longa L.) using SSR marker and use in trait-specific breeding.

Curcuma longa L., is recognized worldwide as a medicinally and economically important plant species due to its curcumin content which is an industrially important compound. In this study, a total of 329 accessions were collected from four states of India and planted in the experimental farm of CSIR-NEIST, Jorhat, India, in augmented design.

Molecular Property Diagnostic Suite Compound Library (MPDS-CL): a structure-based classification of the chemical space.

Molecular Property Diagnostic Suite Compound Library (MPDS-CL) is an open-source Galaxy-based cheminformatics web portal which presents a structure-based classification of the molecules. A structure-based classification of nearly 150 million unique compounds, obtained from 42 publicly available databases and curated for redundancy removal through 97 hierarchically well-defined atom composition-based portions, has been done. These are further subjected to 56-bit fingerprint-based classification algorithm which led to the formation of 56 structurally well-defined classes.

Screening of potent inhibitor from Lam. against arachidonic inflammatory enzymes: an insight from molecular docking, ADMET, molecular dynamics simulation and MM-PBSA approaches.

The three primary enzymes COX (cyclooxygenase), LOX (lipoxygenase) and CYT-P450 (cytochrome P450), which are part of the arachidonic inflammatory pathway, play crucial role in the development of asthma, rheumatoid arthritis and cardiovascular diseases. Ethnomedicinally, plant-derived chemicals have a major role in the treatment of fatal illnesses. Lam.

A membrane targeted multifunctional cationic nanoparticle conjugated fusogenic nanoemulsion (CFusoN): induced membrane depolarization and lipid solubilization to accelerate the killing of .

Bacterial infections caused by are one of the growing concerns for human health care management globally. Antibiotic-associated adverse effects and the emergence of bacterial resistant strains necessitate the development of an alternative yet effective approach. Nanoemulsion-based therapy has emerged as a potential therapeutic strategy to combat bacterial infestation.

A Gemini basic ionic liquid and functionalized cellulose nanocrystal-based mixed matrix membrane for CO/N separation.

Owing to the adverse environmental impact, carbon capture and separation have gained tremendous interest throughout the globe. Herein, a CO/N gas separative mixed matrix membrane containing amine functionalized cellulose nanocrystals and a Gemini basic ionic liquid has been developed, which exhibits the highest permeance of 21 033 GPU and moderate selectivity of 21.3.

Atomically Dispersed Manganese on Graphene Nanosheets as Biocompatible Nanozyme for Glutathione Detection in Liver Tissue Lysate Using Microfluidic Paper-based Analytical Devices.

Recently, single atom catalysts (SACs) featuring M-N (M = metal) active sites on carbon support have drawn considerable attention due to their promising enzyme-like catalytic properties. However, typical synthesis methods of SACs often involve energy-intensive carbonization processes. Herein, we report a facile one-pot, low-temperature, wet impregnation method to fully utilize M-N sites of manganese phthalocyanine (MnPc) by decorating molecular MnPc over the sheets of graphene nanoplatelets (GNP).