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Incidence of Sepsis and Mortality With Prior Exposure of HMG-COA Reductase Inhibitors in a Surgical Intensive Care Population.

Shock

January 2016

*Department of Pharmacy Services, Brigham and Women's Hospital, Boston, Massachusetts †St John's University College of Pharmacy and Health Sciences, Queens, New York ‡Department of Surgery, North Shore-LIJ Health System Long Island Jewish Medical Center, New Hyde Park, New York.

The anti-inflammatory properties of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) may reduce the risk of developing sepsis in surgical intensive care patients and improve outcomes in those who do become septic. The objective of this study was to assess whether surgical intensive care unit (SICU) patients with prior exposure to HMG-CoA reductase inhibitors had a lower incidence of developing sepsis and improved outcomes. A retrospective cohort study was conducted.

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