854 results match your criteria: "North Manchester General Hospital.[Affiliation]"

Background Scapular fractures, an uncommon injury that can be brought on by a high-energy mechanism because of its proximity to the pectoral and shoulder muscles, are frequently linked to fatal injuries. This study aimed to compare surgical versus conservative treatment of scapular fractures and the results of treated patients. Methods The traumatic scapular fracture patients in this cross-sectional study (n = 391) were treated at a major trauma centre (level 1) in the United Kingdom between 2012 and 2018.

View Article and Find Full Text PDF

Introduction: Salvage arthroplasty for failed proximal femoral fracture fixation is a complex procedure. This involves the removal of the primary failed or broken implant followed by a hip joint replacement procedure. The complications and technical difficulties associated with these surgeries are often difficult to anticipate.

View Article and Find Full Text PDF

Parastomal varices are an uncommon but significant source of hemorrhage in patients with portal hypertension, often posing diagnostic and therapeutic challenges. We report the case of a 73-year-old male with a history of alcoholic liver disease and a urostomy following cystoprostatectomy for bladder cancer. The patient presented with profuse bleeding from his urostomy site.

View Article and Find Full Text PDF

Acute urinary retention (AUR) in young adults is an uncommon presentation often signalling an underlying pathology, particularly when associated with genetic conditions like neurofibromatosis type 1 (NF1). We report the case of a 25-year-old male with a known family history of NF1, who presented with acute urinary retention and progressive pelvic pain. Physical examination was notable for axillary freckling and café-au-lait spots, consistent with NF1.

View Article and Find Full Text PDF

Background Computed tomography (CT) scans play a crucial role in emergency surgical care, serving both diagnostic and prognostic functions. They significantly contribute to timely and effective patient care. This study aims to compare abdominal CT scan reports prepared by locally employed radiologists with those from outsourced radiology reporting services for patients presenting with acute surgical conditions.

View Article and Find Full Text PDF

Introduction:  Perioperative hypothermia is defined as a patient's core body temperature of less than 36°C, which can lead to several complications. Even mild hypothermia increases the incidence of post-operative wound infection, post-operative ischaemic cardiac events and intra-operative blood loss and prolongs post-operative recovery. It is, hence, essential to maintain and provide normothermia during the perioperative phases for optimal surgical results and patient satisfaction.

View Article and Find Full Text PDF

Advanced breast cancer can present with bleeding tumors that are difficult to control using traditional techniques. The use of topical agents has been reported in the local management of bleeding malignant tumors. We report a challenging case of persistent bleeding in a 40-year-old female patient with metastatic breast cancer, presenting with significant uncontrollable bleeding from the fungating breast tumor where conventional measures failed to halt blood loss.

View Article and Find Full Text PDF

Leptomeningeal disease (LMD) is a rare yet serious complication of advanced malignancy, often seen in breast cancer and associated with a poor prognosis.  This case report highlights the rapid progression and diagnostic challenges encountered in a woman in her 40s with advanced breast cancer who presented with severe headaches, absence seizures, and diplopia. The patient's complex past history included invasive ductal carcinoma, prior brain metastasis, and recent craniotomy, which added significant challenges to diagnosis and management.

View Article and Find Full Text PDF

Introduction Supracondylar fractures are common in children. Percutaneous K-wire fixation is an accepted standard treatment for displaced supracondylar fractures in children, but the ideal wire configuration remains controversial. This study aimed to review the radiographic outcome and complications of Gartland type II and type III supracondylar fractures treated by the crossed and lateral K-wire fixation.

View Article and Find Full Text PDF

UK guidelines for the investigation and management of eosinophilia in returning travellers and migrants.

J Infect

November 2024

Hospital for Tropical Diseases, Capper Street, London, WC1E 6JB, UK; London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. Electronic address:

Eosinophilia is a common finding in returning travellers, migrants and other travelling groups. In this setting it often indicates an underlying helminth infection. Infections associated with eosinophilia are frequently either asymptomatic or associated with non-specific symptoms but some can cause severe disease.

View Article and Find Full Text PDF
Article Synopsis
  • Perioperative hypothermia, a frequent but often overlooked issue during surgery, is influenced by factors like cold environments and anesthetic effects.
  • A study conducted at North Manchester General Hospital analyzed temperature data from 200 elective surgery patients, revealing varying hypothermia rates at different surgical phases.
  • The findings indicate a significant incidence of intraoperative hypothermia, emphasizing the need for proactive measures like patient pre-warming to prevent this complication.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to evaluate hearing outcomes at 24 months for infants with mild congenital cytomegalovirus (cCMV) infection, comparing those who received antiviral treatment to those who did not.
  • Utilizing data from the European Registry of Children with cCMV, researchers included infants diagnosed with cCMV early in life, who had normal physical exams and mild imaging findings.
  • Results showed that 34.7% of the 196 participants received antiviral treatment, but there was no significant difference in hearing loss prevalence between treated (4.6%) and untreated groups (6.3%) after two years.
View Article and Find Full Text PDF
Article Synopsis
  • Total hip replacement indications are expanding beyond osteoarthritis to include trauma and pathological fractures in active patients, leading to more complications like periprosthetic femoral fractures.
  • A case study of a 71-year-old woman highlights challenges in treating these fractures due to factors like poor bone quality, infection, and stress fractures after her hip replacement.
  • After multiple interventions including internal fixation and bone grafting, the patient eventually regained her mobility 13 months post-surgery, but complications such as implant failure and nonunion were significant hurdles in her recovery.
View Article and Find Full Text PDF
Article Synopsis
  • The study reviews the effectiveness of preoperative Computed Tomographic Angiography (CTA) in mapping Thoraco-dorsal Artery Perforator (TDAP) flaps used in breast and soft tissue reconstruction, noting that traditional methods can yield false results.
  • Five studies were analyzed, highlighting a high risk of bias, with a total of 72 patients and varying degrees of agreement between CTA findings and standard Doppler techniques.
  • The research indicates a lack of standardized scanning protocols, calls for further investigation to clearly establish the role of CTA in TDAP planning, and suggests that better imaging may aid in surgical preparation despite current challenges.
View Article and Find Full Text PDF

Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on intensive care unit patient prognosis: a causal inference approach using data from the Eurobact2 study.

Clin Microbiol Infect

December 2024

OUTCOMEREA Research Group, Drancy, France; Institut National de la Santé et de la Recherche Medicale, Infection Antimicrobial Modelisation Evolution, U1137, Team Decision Science in Infectious Diseases, Paris, France; Assistance Publique Hôpitaux de Paris, Bichat hospital, Medical and infectious diseases ICU, F75018, Paris France. Electronic address:

Article Synopsis
  • Hospital-acquired bloodstream infections (HA-BSI) in ICU patients can be life-threatening, and this study aimed to see how early adequate antibiotic treatment affects 28-day mortality rates for patients who survive at least one day after infection onset.
  • Using data from a multicenter study with 2,418 patients, researchers found that those who received adequate treatment within 24 hours had a lower 28-day mortality rate (32.8%) compared to those who were inadequately treated (40%).
  • The study concluded that inadequate antibiotic therapy within 24 hours contributes significantly to 28-day mortality, indicating that quicker treatment could greatly improve patient outcomes in cases of HA-BSI.
View Article and Find Full Text PDF
Article Synopsis
  • Semaglutide, a medication used for managing type 2 diabetes and obesity, has become popular but may be linked to acute pancreatitis, a serious condition.
  • A case study describes a 36-year-old woman who developed sudden stomach pain after starting semaglutide for weight loss without medical advice, leading to a diagnosis of acute pancreatitis.
  • After stopping semaglutide, her symptoms improved significantly, highlighting the need for greater awareness among patients and healthcare providers about the potential risks associated with this medication.
View Article and Find Full Text PDF
Article Synopsis
  • The COVID-19 pandemic led to a significant increase in virtual healthcare services, prompting a review of how effective these methods are for delivering HIV care, particularly for marginalized groups.
  • A systematic review analyzed data from 4143 records, ultimately including 26 studies that primarily used videoconferencing for consultations between healthcare workers and people living with HIV (PLHIV).
  • Results showed that virtual care (VC) is generally accepted by PLHIV, with high attendance and satisfaction rates, and it effectively supports virological outcomes, highlighting the need for diverse care models and proper training for successful implementation.
View Article and Find Full Text PDF
Article Synopsis
  • Anti-Hu antibodies are commonly linked to paraneoplastic syndromes (PNS), particularly associated with cancers like small cell lung cancer, breast cancer, and lymphoma.
  • A case study describes a 65-year-old woman with neurological symptoms and imaging revealing a mass, alongside positive anti-Hu antibody tests, but no definitive diagnosis of the primary tumor.
  • PNS is challenging to diagnose and manage; treating the underlying cancer and immune modulation are essential for improving patient outcomes, highlighting the need for early diagnosis and a multidisciplinary approach.
View Article and Find Full Text PDF
Article Synopsis
  • The study follows the PANORAMIC trial, investigating the long-term effectiveness of molnupiravir for COVID-19 on wellbeing, persistent symptoms, new infections, healthcare use, and time off work at 3 and 6 months post-randomization.
  • Participants included adults over 50 or younger with specific health issues, who were affected by COVID-19 for less than 5 days and were divided into either a molnupiravir treatment group or a standard care group.
  • The trial involved 25,783 participants and aimed to assess various secondary outcomes, including self-reported wellness, symptom severity, health-related quality of life, and overall healthcare usage after the initial
View Article and Find Full Text PDF
Article Synopsis
  • Clinicians evaluate patient factors such as polypharmacy and comorbidities when prescribing treatments for COVID-19, particularly focusing on direct-acting antivirals (DAAs).
  • The study analyzed data from over 788,000 hospitalized COVID-19 patients to identify potential drug-drug interactions (DDIs) that could affect the use of DAAs like nirmatrelvir/ritonavir, remdesivir, and molnupiravir.
  • Findings revealed that a significant portion of patients (52%) received medications either contraindicated or to be avoided with nirmatrelvir/ritonavir, especially in older patients and those with higher comorbidity scores.
View Article and Find Full Text PDF

Introduction: Single-station N2 (ssN2) versus multi-station N2 has been used as a selection criterion for treatment recommendations between surgical versus non-surgical multimodality treatment in stage III-N2 NSCLC. We hypothesized that clinical staging would be susceptible to upstaging on pathologic staging and, therefore, challenge this practice.

Methods: A retrospective study of prospectively collected routine clinical data for patients with stage III-N2 NSCLC that had completed computed tomography (CT), positron emission tomography (PET), and staging endobronchial ultrasound (EBUS) and had been confirmed clinical stage III-ssN2 at multidisciplinary team discussion and went on to complete surgical resection as the first treatment to provide pathologic staging.

View Article and Find Full Text PDF

Artificial intelligence (AI) uses sophisticated algorithms to "learn" from large volumes of data. This could be used to optimise recruitment of blood donors through predictive modelling of future blood supply, based on previous donation and transfusion demand. We sought to assess utilisation of predictive modelling and AI blood establishments (BE) and conducted predictive modelling to illustrate its use.

View Article and Find Full Text PDF

Preventing Pilonidal Sinus Recurrence With Laser Hair Epilation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Cureus

June 2024

General Surgery, Royal Albert Edward Infirmary, Wrightington, Wigan and Leigh (WLL) NHS Foundation Trust, Wigan, GBR.

Pilonidal sinus disease (PSD) is a common condition associated with significant morbidity and healthcare costs. High recurrence rates still pose a considerable challenge in managing PSD, with no universally accepted guideline in place to guide management. Laser hair epilation offers a way to reduce recurrence rates with reports within the current literature demonstrating positive outcomes compared to alternative approaches.

View Article and Find Full Text PDF

Background: Point-of-Care Ultrasound (POCUS) consists of a range of increasingly important imaging modalities across a variety of specialties. Despite a variety of accreditation pathways available in the UK, lung POCUS training remains difficult to deliver and accreditation rates remain suboptimal. We describe a multidisciplinary, multi-centre, and multi-pronged approach to lung POCUS education within a region.

View Article and Find Full Text PDF