The Impact of Physical Activity on the Disability-Related Stress of Individuals With Physical Disabilities: A Five-Year Longitudinal Study.

People with physical disabilities report a higher prevalence of psychological distress and chronic stress than those without disabilities. Participation in physical activity (PA) has been considered an effective coping strategy to deal with stressors and improve the mental health of people with disabilities. However, very little research has been conducted to explore the relationship between disability-related stress and PA participation by people with physical disabilities longitudinally on an international scale.

A spatially-heterogeneous impact of fencing on the African swine fever wavefront in the Korean wild boar population.

In October 2019, South Korea's first case of African swine fever (ASF) was reported in wild boar in the north of the country. Despite the implementation of a 2300 km-long fencing strategy, the ASF wavefront continued to invade southward. Our study aimed to investigate the ASF wavefront dynamics in different regions of South Korea, as well as to assess the effectiveness of the fencing measures on ASF dispersal and wavefront velocity.

Long-range atmospheric transport of organochlorine pesticides from China to South Korea: Evidence from Deokjeok Island.

The influence of transboundary air pollutants originating from the Asian continent on South Korea has been a major concern. Although organochlorine pesticides (OCPs) have been banned for several decades, they continue to be detected in the Korean environment. However, studies on the long-range atmospheric transport (LRAT) of OCPs in South Korea, particularly in background areas, remain limited.

Clinical and genetic characterization of a progressive RBL2-associated neurodevelopmental disorder.

Retinoblastoma (RB) proteins are highly conserved transcriptional regulators that play important roles during development by regulating cell-cycle gene expression. RBL2 dysfunction has been linked to a severe neurodevelopmental disorder. However, to date, clinical features have only been described in six individuals carrying five biallelic predicted loss of function (pLOF) variants.

Nonmass Lesions on Breast Ultrasound: Interreader Agreement and Associations With Malignancy.

Nonmass lesions (NMLs) on breast ultrasound lack clear definition and encompass a broad range of benign and malignant entities. Given anticipated inclusion of NMLs in the BI-RADS 6th edition, thorough understanding of these lesions will be critical for optimal management. To evaluate interreader agreement for classification of lesions on breast ultrasound as NMLs and to identify imaging features associated with malignancy in these lesions.

Attachment and removal of porcine rotavirus (PRV) and Tulane virus (TV) on fresh and artificial phylloplanes of Romaine lettuce and Carmel spinach as affected by ultrasonication in combination with oxidant- or surfactant-based sanitizer(s).

This work examined the attachment of porcine rotavirus (PRV) and Tulane virus (TV), a surrogate for human norovirus, to fresh and artificial phylloplanes of Romaine lettuce and Carmel spinach. The effect of produce type, sanitizer, and ultrasound treatment on removal of PRV and TV from produce and artificial surfaces was also investigated. Sanitization was performed with two oxidant-based sanitizers (chlorine and peroxyacetic acid) and one surfactant-based sanitizer (0.

Structure-based virtual screening of Trachyspermum ammi metabolites targeting acetylcholinesterase for Alzheimer's disease treatment.

In recent decades, Alzheimer's disease (AD) has garnered significant attention due to its rapid global prevalence. The cholinergic hypothesis posits that the degradation of acetylcholine by acetylcholinesterase (AChE) contributes to AD development. Despite existing anti-AChE drugs, their adverse side effects necessitate new agents.

Moral distress, professional value, and vocational choice among senior nursing students: A cross-sectional study.

During clinical placement, nursing students may experience unease and moral distress, which negatively impacts their professional values and vocational choices. However, no instrument exists to measure moral distress in nursing students. Thus, this study constructs measurement items for moral distress and explores the factors that influence the vocational choices of nursing students.

Machine-Learning-Enabled Thermochemistry Estimator.

Modeling adsorbates on single-crystal metals is critical in rational catalyst design and other research that requires detailed thermochemistry. First-principles simulations via density functional theory (DFT) are among the prevalent tools to acquire such information about surface species. While they are highly dependable, DFT calculations often require intensive computational resources and runtime.

Association of Lupus Low Disease Activity State And Remission With Reduced Organ Damage And Flare in Systemic lupus erythematosus Patients With High Disease Activity.

Objective: High disease activity status (HDAS) in patients with systemic lupus erythematosus (SLE) is associated with adverse long-term outcomes. We examined the frequency of lupus low disease activity state (LLDAS) and remission (REM) attainment in HDAS patients and whether their attainment was associated with improved patient outcomes.

Methods: Demographic, clinical and outcomes data, collected prospectively from a multinational cohort between 2013 and 2020, were analysed.

Evaluation of joint external evaluation to COVID-19 and other infectious diseases mortality outcomes in 96 countries.

Background: This study evaluated the effectiveness of Joint External Evaluation (JEE) scores with regard to coronavirus disease 2019 (COVID-19) and other infectious diseases performance in 96 countries. To propose a revised JEE tool, potential JEE indicators were also examined.

Methods: JEE data from 2016-2019 were linked with outcomes such as COVID-19 fatality rates and infections, as well as mortality rates for other infectious diseases.

Causing Powdery Mildew on in Korea.

Achillea millefolium L. (Asteraceae), commonly known as yarrow or common yarrow, is native to temperate regions of the Northern Hemisphere in Asia, Europe, and North America (https://www.missouribotanicalgarden.

Enhanced propionate degradation and CO electromethanogenesis in an up-flow dual-chamber electrocatalytic anaerobic bioreactor (UF-DC-EAB): Leveraging DIET-mediated syntrophy for microbial stability.

Anaerobic digestion faces numerous challenges, including high CO content in biogas and volatile fatty acids (such as propionate) accumulation in digestate. To address these issues, an up-flow dual-chamber electrocatalytic anaerobic bioreactor (UF-DC-EAB) was developed to enhance propionate degradation through microbial symbiosis while improving biogas quality via CO electromethanogenesis. Under the extreme conditions with propionate as the primary carbon source at 6-h HRT, the UF-DC-EAB achieved a propionate removal efficiency of 72.

Imlunestrant with or without Abemaciclib in Advanced Breast Cancer.

Background: Imlunestrant is a next-generation, brain-penetrant, oral selective estrogen-receptor (ER) degrader that delivers continuous ER inhibition, even in cancers with mutations in the gene encoding ERα ().

Methods: In a phase 3, open-label trial, we enrolled patients with ER-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer that recurred or progressed during or after aromatase inhibitor therapy, administered alone or with a cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor. Patients were assigned in a 1:1:1 ratio to receive imlunestrant, standard endocrine monotherapy, or imlunestrant-abemaciclib.

Identification of novel antioxidant and anti-inflammatory peptides from bovine hemoglobin by computer simulation of enzymolysis, molecular docking and molecular dynamics.

Unlabelled: Due to the structural diversity and complex mechanisms of action of bioactive peptides, screening for specific functional peptides is often challenging. To efficiently screen bioactive peptides with antioxidant and anti-inflammatory effects from bovine hemoglobin, we employed bioinformatics methods to perform virtual enzymatic hydrolysis using online tools and predicted the bioactivity, toxicity, and sensitization scores of the resulting peptides. Molecular docking and molecular dynamics simulations with Keap1 and TLR4 were subsequently conducted to screen for antioxidant and anti-inflammatory peptides.

Biosimilar SB17 versus reference ustekinumab in moderate to severe plaque psoriasis after switching: phase 3 study results up to week 52.

Introduction: SB17 is a biosimilar to reference ustekinumab (UST). We compared the efficacy, safety, and immunogenicity of SB17 to UST up to Week 52, including switching from UST to SB17.

Methods: Subjects were randomized to receive 45 mg of SB17 or UST subcutaneously up to Week 40.

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration.

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.

Co/CoO hetero-nanoparticles incorporated into lignin-derived carbon nanofibers as a self-supported bifunctional oxygen electrocatalyst for rechargeable Zn-air batteries.

The large-scale application of rechargeable Zn-air batteries (ZABs) necessitates the development of high-efficiency and cost-effective bifunctional electrocatalysts for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). Herein, the density functional theory calculations were performed to reveal the charge redistribution induced by the Co/CoO heterojunction integrating with N-doped carbon, which could optimize the d-band center, thereby accelerating O transformed into OOH* in the ORR and the conversion of O* into OOH* in OER. Guided by theoretical calculations, Co/CoO hetero-nanoparticles-decorated lignin-derived N-doped porous carbon nanofibers (Co-LCFs-800) were synthesized to use as an advanced self-supported bifunctional oxygen electrocatalyst.

Diagnosis of infections using artificial intelligence techniques versus standard microscopy in a reference laboratory.

Diagnosing malaria using standard techniques is time-consuming. With limited staffing in many laboratories, this may lead to delays in reporting. Innovative technologies are changing the diagnostic landscape and may help alleviate staffing shortages.

Prevalence and Outcomes of Chronic Kidney Disease-Associated Pruritus: International Results from Peritoneal Dialysis Outcomes and Practice Patterns Study.

Key Points: CKD-associated pruritus is highly prevalent among peritoneal dialysis patients. Pruritus is associated with reduced health-related quality of life, and the composite of mortality and transfer to hemodialysis for peritoneal dialysis patients. Efforts to better identify and manage pruritus in this population are needed.

Impact of the COVID-19 outbreak on the field of hematopoietic cell transplantation in the Asia-Pacific region: APBMT Activity Survey 2020/2021.

COVID-19 became a global pandemic in 2020 and significantly affected the activity of hematopoietic cell transplants (HCT) worldwide. Despite these challenges, a total of 28,793 transplants, including 18,518 allogeneic and 10,275 autologous transplants, were performed in 719 facilities in 2020 in the Asia-Pacific (AP) region. This represented a 5.