[L-VDCC autoregulation abnormality contributes to calcium overload in myocardial ischemia-reperfusion injury].

Calcium overload is a vital mechanism of myocardial ischemia-reperfusion injury, which is a hot therapeutic target in cardiovascular research. It has been well recognized that the dysfunction of calcium relevant proteins, including L-type voltage- dependent calcium channel (L-VDCC), sarco/endoplasmic reticulum ATPase 2a (SERCA2a)/phospholamban (PLB), RyR2, Na/Ca exchanger, Na/H exchanger, etc. contributes to calcium overload in cardiomyocytes during ischemia-reperfusion injury, in which the diastolic calcium concentration is increased and the amplitude of calcium transients is decreased.

[Some bio-chemical indice change of rats striatum poisoned by rotenone].

Objective: To observe some of bio-chemical indice of rats striatum poisoned by rotenone.

Methods: Apply the method of back-implantation mini-effusion pump to observe influence of different concentration rotenone on the rat striatum. Utilize Fluoro-Jade B combined Fluorescent dying to observe the change conditions of the neural cells of the poisoned rat striatum.