1,659 results match your criteria: "Normal Sleep Sleep Physiology and Sleep Deprivation"
Sleep Sci
December 2024
Departamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Melanin-concentrating hormone (MCH) and hypocretins (Hcrt) 1 and 2 are neuropeptides synthesized in the lateral hypothalamic area by neurons that are critical in the regulation of sleep and wakefulness. Their receptors are located in the same cerebral regions, including the frontal cortex and hippocampus. The present study aimed to assess whether 96 hours of paradoxical sleep deprivation alters the functioning of the MCH and hypocretin systems.
View Article and Find Full Text PDFCNS Neurosci Ther
December 2024
The Postgraduate Training Base of Jinzhou Medical University and Department of Anesthesiology, The PLA Rocket Force Characteristic Medical Center, Beijing, China.
Aims: This study investigated the roles of lateral basal forebrain glial cell line-derived neurotrophic factor (GDNF) signaling and cholinergic neuron activity, apoptosis, and autophagy dysfunction in sleep deprivation-induced increased risk of chronic postsurgical pain (CPSP) in mice.
Methods: Sleep deprivation (6 h per day from -1 to 3 days postoperatively) was administered to mice receiving skin/muscle incision and retraction (SMIR) to determine whether perioperative sleep deprivation induces mechanical and thermal pain hypersensitivity, increases the risk of chronic pain, and causes changes of basal forebrain neurons activity (c-Fos immunostaining), apoptosis (cleaved Caspase-3 expression), autophagy (LC3 and p62 expression) and GDNF expression. Adeno-associated virus (AAV)-GDNF was microinjected into the basal forebrain to see whether increased GDNF expression could reverse sleep deprivation-induced changes in pain duration and cholinergic neuron apoptosis and autophagy.
J Clin Neurophysiol
November 2024
Faculty of Medicine and Pharmacy, INSERM, Clinical Investigation Center 1402, Research Team Is-Alive, University of Poitiers, Poitiers, France.
Purpose: Sleep deprivation (SD) reduces time to task failure during endurance exercises. The aim of our work was to study the effect of acute SD on the endurance of a skeletal hand muscle and to investigate cortical motor drive to muscle and perception of effort.
Methods: Origin of the early exhaustion after SD might be insufficient cortical motor drive to muscle or motor inhibition because of excessive perception of effort.
Sleep Med
January 2025
Guangzhou Institute of Technology, Xidian University, Xi'an, Shaan xi, 710126, China; Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaan xi, 710126, China. Electronic address:
Zhen Ci Yan Jiu
November 2024
Henan University of Chinese Medicine, Zhengzhou 450046, China.
Objectives: To observe the effect of electroacupuncture (EA) on the expression of synaptic function related proteins PSD95 and MeCP2 and synaptic ultrastructure in sleep deprived rats, so as to explore its mechanism underlying improvement of learning and memory ability caused by sleep deprivation.
Methods: SD rats were randomly divided into normal, model, EA and sham EA groups (=10). The sleep deprivation model was prepared by modified multi-platform water environment.
Eur J Neurosci
December 2024
Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Sickness sleep and rebound following sleep deprivation share humoral signals including the rise of cytokines, in particular interleukins. Nevertheless, they represent unique physiological states with unique brain firing patterns and involvement of specific circuitry. Here, we performed untargeted metabolomics of mouse cortex and hippocampus to uncover changes with sickness and rebound sleep as compared with normal daily sleep.
View Article and Find Full Text PDFCNS Neurosci Ther
November 2024
Department of Radiology, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
Study Objectives: Sleep deprivation (SD) is prevalent in our increasingly round-the-clock society. Optimal countermeasures such as ample recovery sleep are often unfeasible, and brief naps, while helpful, do not fully restore cognitive performance following SD. Thus, we propose that targeted interventions, such as repetitive transcranial magnetic stimulation (rTMS), may enhance cognitive performance recovery post-SD.
View Article and Find Full Text PDFHepatoma Res
October 2024
Hind Institute of Medical Sciences, Sitapur 261304, India.
JMIR Hum Factors
October 2024
School of Psychological Science, University of Bristol, Bristol, United Kingdom.
Background: Poor sleep is a common problem in adolescents aged 14 to 18 years. Difficulties with sleep have been found to have a bidirectional link to mental health problems.
Objective: This new research sought to involve young people in the co-creation of a new app, particularly those from underserved communities.
Neurosci Biobehav Rev
December 2024
Department of Psychology, Royal Holloway, University of London, Egham TW20 0EX, United Kingdom. Electronic address:
Modern life causes a quarter of adults and half of teenagers to sleep for less than is recommended (Kocevska et al., 2021). Given well-documented benefits of sleep on memory, we must understand the cognitive costs of short sleep.
View Article and Find Full Text PDFProg Cardiovasc Dis
December 2024
Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center and Case Western Reserve School of Medicine, Cleveland, OH, United States of America. Electronic address:
The growing burden of coronary artery disease (CAD) has led to a deeper exploration of the pathophysiologic mechanisms underlying the disease process with the hope of finding novel treatments to reduce CAD morbidity and mortality. Sleep is a normal physiologic phenomenon essential for maintaining homeostasis. Disruption in sleep physiology has been linked to the activation of pro-inflammatory cytokines that may predispose to a greater risk of CAD.
View Article and Find Full Text PDFSci Transl Med
October 2024
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
J Tradit Chin Med
October 2024
Rehabilitation Medicine Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Brain Behav Immun
January 2025
School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99163, USA; Department of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA. Electronic address:
Interleukin-1β (IL1), a pleiotropic cytokine, is involved in sleep regulation, tumor ontogeny, and immune responses. IL1 receptor adaptor proteins, including the IL1 receptor accessory protein (AcP), and its neuron-specific isoform, AcPb, are required for IL1 signaling. The AcPb isoform is resultant from alternate splicing of the AcP transcript.
View Article and Find Full Text PDFPhysiol Meas
September 2024
Laboratory of Sleep/Wake Neurobiology, Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Moscow, Russia.
. Sleepiness assessment tools were mostly developed for detection of an elevated sleepiness level in the condition of sleep deprivation and several medical conditions. However, sleepiness occurs in various other conditions including the transition from wakefulness to sleep during an everyday attempt to get sleep.
View Article and Find Full Text PDFNeuroimage
October 2024
Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing 400715, China; Key Laboratory of Cognition and Personality (Ministry of Education), Chongqing 400715, China. Electronic address:
Sleep deprivation has been demonstrated to exert widespread and intricate impacts on the brain network. The human brain network is a modular network composed of interconnected nodes. This network consists of provincial hubs and connector hubs, with provincial hubs having diverse connectivities within their own modules, while connector hubs distribute their connectivities across different modules.
View Article and Find Full Text PDFbioRxiv
August 2024
Department of Translational Medicine and Physiology, Sleep and Performance Research Center. Elson S. Floyd College of Medicine. Washington State University, Spokane, WA, USA.
Sleep is an essential, tightly regulated biological function. Sleep is also a homeostatic process, with the need to sleep increasing as a function of being awake. Acute sleep deprivation (SD) increases sleep need, and subsequent recovery sleep (RS) discharges it.
View Article and Find Full Text PDFAm J Physiol Heart Circ Physiol
October 2024
Human Cardiovascular Physiology Laboratory, Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
Exaggerated blood pressure (BP) responses during exercise are independently associated with future development of hypertension. Partial sleep deprivation (PSD) can increase 24-h ambulatory BP, but the effects on exercise BP are unclear. We hypothesized that acute PSD would augment the BP response to constant load cycling exercise and a 20-min time trial.
View Article and Find Full Text PDFSci Rep
August 2024
School of Social and Behavioral Sciences, Department of Psychology, Nanjing University, Nanjing, 210023, China.
Under total sleep deprivation, both inhibitory and motor control are impaired. However, how circadian rhythm sleep loss caused by irregular sleep pattern affects motor inhibition and execution in continuous actions remains unknown. This study utilized a pointing task to investigate the question over 30 days.
View Article and Find Full Text PDFCurr Biol
August 2024
Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK; Simons Initiative for the Developing Brain (SIDB), Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK. Electronic address:
J Cereb Blood Flow Metab
December 2024
VISN 20 Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Healthcare System, Seattle, WA, USA.
We discuss two potential non-invasive MRI methods to study phenomena related to subarachnoid cerebrospinal fluid (CSF) motion and perivascular fluid transport, and their association with sleep and aging. We apply diffusion-based intravoxel incoherent motion (IVIM) imaging to evaluate pseudodiffusion coefficient, , or CSF movement across large spaces like the subarachnoid space (SAS). We also performed perfusion-based multi-echo, Hadamard encoded arterial spin labeling (ASL) to evaluate whole brain cortical cerebral blood flow (CBF) and trans-endothelial exchange () of water from the vasculature into the perivascular space and parenchyma.
View Article and Find Full Text PDFPLoS One
July 2024
Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, China.
Background: Cryptochrome-2 (CRY2) is a core rhythm gene that plays a crucial role in DNA damage repair. The present study investigated the potential role of CRY2 in mediating sleep deprivation-induced cognitive decline in 5xFAD mice.
Methods: To assess the effects of SD on different brain regions of the mouse brain, we used 18F FDG PET-CT.
Theranostics
July 2024
College of Life Sciences, Qingdao Agricultural University, Qingdao 266109, China.
Currently, there are occasional reports of health problems caused by sleep deprivation (SD). However, to date, there remains a lack of in-depth research regarding the effects of SD on the growth and development of oocytes in females. The present work aimed to investigate whether SD influences ovarian folliculogenesis in adolescent female mice.
View Article and Find Full Text PDFFront Neurosci
June 2024
Medical Support Technology Research Department, Systems Engineering Institute, Tianjin, China.