The benefit of inhibitory control training for insomnia with short sleep duration phenotype: a pilot randomized trial.

Background: Two phenotypes of insomnia disorder (ID) have been identified based on objective total sleep duration (TST): one with short sleep duration (ISSD) and another with normal sleep duration (INSD). Recent proposals suggested that insomnia with objective short-sleep duration (TST < 7 h) is associated with impaired inhibitory function, leading to a dysregulation of cortical inhibition, which may underlie its prevalence. This study investigated the status of impaired response inhibition in these two phenotypes and examined the potential different effect of response inhibition training on these two phenotypes.

Early Continuous Electroencephalography, Clinical Parameters, and Short-Term Functional Outcomes in Pediatric Traumatic Brain Injury: Single-Center, Retrospective Cohort, 2010-2020.

Objectives: Traumatic brain injury (TBI) is a leading cause of pediatric morbidity and mortality. This study first investigates clinical characteristics and continuous electroencephalography (cEEG) parameters associated with short-term functional outcomes in pediatric patients following TBI. Second, we use these data for a hypothesis-generating model about outcomes.

SLA-MLP: Enhancing Sleep Stage Analysis from EEG Signals Using Multilayer Perceptron Networks.

: Sleep stage analysis is considered to be the key factor for understanding and diagnosing various sleep disorders, as it provides insights into sleep quality and overall health. : Traditional methods of sleep stage classification, such as manual scoring and basic machine learning approaches, often suffer from limitations including subjective biases, limited scalability, and inadequate accuracy. Existing deep learning models have improved the accuracy of sleep stage classification but still face challenges such as overfitting, computational inefficiencies, and difficulties in handling imbalanced datasets.

Increased spindle-related brain activation in right middle temporal gyrus during N2 than N3 among healthy sleepers: Initial discovery and independent sample replication.

The association between spindle metrics and sleep architecture differs during N2 vs. N3 sleep, the underlying neural mechanism is not clearly illustrated. Here, we tested the discrepancy in spindle-related brain activation between N2 and N3 within healthy college students (dataset 1: n = 27, 59 % females, median age 23 years), using simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI).

Partial activation of SIK3 delays the onset of wakefulness and alleviates hypersomnia due to the lack of protein kinase A-phosphorylation site.

Study Objectives: Sleep/wakefulness is regulated by intracellular signaling pathways composed of protein kinases such as salt-inducible kinase 3 (Sik3). Sik3-deficiency in neurons decreases NREM sleep time and electroencephalogram (EEG) delta power during NREM sleep, while Sik3Slp mice lacking a protein kinase A (PKA)-phosphorylation site, S551, show hypersomnia phenotype. In this study, we examined how a phosphomimetic mutation of the 221st threonine residue (T221E), which provides a partial (weak) constitutive activity of the kinase, affects sleep/wakefulness and circadian behavior.

Infantile epileptic spasms syndrome: When spasms come out of the blue.

Background: This study evaluates the electroclinical features of infantile epileptic spasms syndrome (IESS) suddenly appearing in previously normal patients, aiming to describe clinical outcomes and independent predictors.

Method: We retrospectively selected a homogeneous group of patients with IESS from two Italian centers. All patients had normal development prior to IESS onset and a follow-up period lasting at least one year.

A Novel Variant of the CTSD Gene Associated with Juvenile-onset Neuronal Ceroid Lipofuscinosis Type 10: A Case Report and Literature Review.

Neuronal ceroid lipofuscinosis type 10 (NCL10) is a rare progressive neurodegenerative disease associated with homozygous or compound heterozygous mutations in the CTSD gene encoding cathepsin D protein. It is classified as congenital, infantile, or juvenile NCL10 according to the age at onset of symptoms. Six cases of juvenile onset NCL10 (JNCL10) have been reported thus far in the literature.

Resting-State EEG Microstates Dynamics Associated with Interindividual Vulnerability to Sleep Deprivation.

Purpose: Sleep deprivation can induce severe deficits in vigilant maintenance and alternation in large-scale networks. However, differences in the dynamic brain networks after sleep deprivation across individuals have rarely been investigated. In the present study, we used EEG microstate analysis to investigate the effects of sleep deprivation and how it differentially affects resting-state brain activity in different individuals.

Metrics for evaluation of automatic epileptogenic zone localization in intracranial electrophysiology.

Introduction: Precise localization of the epileptogenic zone is critical for successful epilepsy surgery. However, imbalanced datasets in terms of epileptic vs. normal electrode contacts and a lack of standardized evaluation guidelines hinder the consistent evaluation of automatic machine learning localization models.

Case report: The case report of ofatumumab, a fully human anti-CD20 monoclonal antibody, in the treatment of KLHL11 encephalitis.

Anti-kelchlike protein 11 (KLHL11) encephalitis was first reported in 2019. This disease is very rare. The prevalence is higher in men than in women.

Insomnia disorder is associated with 24-hour cortical hyperarousal.

Objective: Cortical hyperarousal has been proposed as a primary underlying mechanism for insomnia disorder. However, most evidence comes from nighttime sleep and whether patients with insomnia disorder have cortical hyperarousal through the 24-h sleep/wake cycle is not resolved.

Methods: We included 49 patients with insomnia disorder and 49 age-and sex-matched normal sleepers.

[Behavioral changes of transgenic mice carrying -A187V mutation with short sleep duration under different dietary conditions].

Objective: To observe the effects of restricted and high-fat diets on behavioral changes of wild-type () and transgenic mice carrying -A187V mutation () with short sleep durations.

Methods: and C57BL/6 mice were randomized into normal chow group (25 and 26 mice for behavioral monitoring), odor retention fasting group (17 and 19 mice for behavioral monitoring; 6 mice and 6 mice for EEG/EMG monitoring), absolute fasting group (6 and 4-5 mice for behavioral monitoring; 6 and 6 mice for EEG/EMG monitoring), and high-fat diet group (6 and 7 mice for behavioral monitoring; 6 and 6 mice for EEG/EMG monitoring). Electrodes for EEG and muscle activity monitoring were implanted on the skulls of the mice.

A randomized study on the effect of a wearable device using 0.75 Hz transcranial electrical stimulation on sleep onset insomnia.

Introduction: The normal transition to sleep is characterized by a reduction in higher frequency activity and an increase in lower frequency activity in frontal brain regions. In sleep onset insomnia these changes in activity are weaker and may prolong the transition to sleep.

Methods: Using a wearable device, we compared 30min of short duration repetitive transcranial electric stimulation (SDR-tES) at 0.

Effect of closed-loop vibration stimulation on sleep quality for poor sleepers.

Introduction: Recent studies have investigated the autonomic modulation method using closed-loop vibration stimulation (CLVS) as a novel strategy for enhancing sleep quality. This study aimed to explore the effects of CLVS on sleep quality, autonomic regulation, and brain activity in individuals with poor sleep quality.

Methods: Twenty-seven participants with poor sleep quality (Pittsburgh sleep quality index >5) underwent two experimental sessions using polysomnography and a questionnaire, one with CLVS (STIM) and the other without (SHAM).

Automatic sleep staging based on 24/7 EEG SubQ (UNEEG medical) data displays strong agreement with polysomnography in healthy adults.

Goal And Aims: Performance evaluation of automatic sleep staging on two-channel subcutaneous electroencephalography.

Focus Technology: UNEEG medical's 24/7 electroencephalography SubQ (the SubQ device) with deep learning model U-SleepSQ.

Reference Method/technology: Manually scored hypnograms from polysomnographic recordings.

Correlation between physical exercise levels, depressive symptoms, and sleep quality in college students: Evidence from electroencephalography.

Background: In recent years, depression has increasingly become a major global public health issue. Among its common physical symptoms, sleep disturbances are prevalent in individuals with depression and are considered a risk factor for the progression of the disorder. Poor sleep quality may be a significant contributor to depression among college students.

Lack variation of low slow-wave activity over time in the frontal region in NREM sleep may be associated with dyskinesia in Parkinson's disease.

Objective: Levodopa-induced dyskinesia (DYS) adversely affects the quality of life of Parkinson's disease (PD) patients. However, few studies have focused on the relationship between DYS and sleep and electroencephalography (EEG). Our study aimed to establish the objective physiological indicators assessed by polysomnography (PSG) that are associated with DYS in PD patients.

Density Spectral Array EEG for Sleep Staging in Pediatric Patients.

Purpose: Sleep is an essential physiologic process, which is frequently disrupted in children with illness and/or injury. Accurate identification and quantification of sleep may provide insights to improve long-term clinical outcomes. Traditionally, however, the identification of sleep stages has relied on the resource-intensive and time-consuming gold standard polysomnogram.

Education Research: Competency-Based EEG Education: An Online Routine EEG Examination for Adult and Child Neurology Residents.

Background And Objectives: We recently published expert consensus-based curricular objectives for routine EEG (rEEG) interpretation for adult and child neurology residents. In this study, we used this curriculum framework to develop and validate an online, competency-based, formative and summative rEEG examination for neurology residents.

Methods: We developed an online rEEG examination consisting of a brief survey and 30 multiple-choice questions covering EEG learning objectives for neurology residents in 4 domains: normal, abnormal, normal variants, and artifacts.

Effect of Earthing Mats on Sleep Quality in Rats.

Grounding, a therapeutic technique involving direct contact with the earth, has been proposed by various studies to potentially have beneficial effects on pressure, sleep quality, stress, inflammation, and mood. However, the scientific evidence supporting its sedative effects remains incomplete. This study examined the sedative effectiveness of an earthing mat on sleep quality and investigated the underlying neural mechanisms using electroencephalography (EEG) analysis in rodents, focusing on orexin and superoxide dismutase (SOD) levels in the brain.

Detection of sleep arousal from STFT-based instantaneous features of single channel EEG signal.

Sleep arousal, a frequent interruption in sleep with complete or partial wakefulness from sleep, may indicate a breathing disorder, neurological disorder, or sleep-related disorders. These phenomena necessitate the detection of sleep arousals. Uses of deep learning methods to detect features inhibits the scope to understand the specific distinctive nature of the signals and reduces the interpretability of the model.