1,612 results match your criteria: "Noguchi Memorial Institute for Medical Research[Affiliation]"
Yale J Biol Med
December 2024
National Influenza Centre, Noguchi Memorial Institute for Medical Research, Accra, Ghana.
The Coronavirus Disease 2019 (COVID-19) pandemic, driven by the novel coronavirus and its variants, has caused over 518 million infections and 6.25 million deaths globally, leading to a significant health crisis. Beyond its primary respiratory impact, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been implicated in various extra-pulmonary complications.
View Article and Find Full Text PDFParasit Vectors
December 2024
Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, P.O. Box LG 581, Accra, Ghana.
Background: Microsporidia MB disrupts Plasmodium development in Anopheles mosquitoes, making it a possible biocontrol tool for malaria. As a tool for vector/disease control, its ecological distribution and the factors that determine their occurrence must be defined. We investigated the frequency of Microsporidia MB in Anopheles mosquitoes across selected sites in northern and southern Ghana, as well as the physicochemical parameters of mosquito breeding water that are associated with the occurrence of the fungus, by fitting regression models.
View Article and Find Full Text PDFMicrobiol Spectr
December 2024
Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Unlabelled: In the Global Polio Laboratory Network (GPLN), poliovirus (PV) screening results from acute flaccid paralysis (AFP) surveillance is based on virus isolation (VI) through cell culture, entailing long turnaround times and the amplification of live poliovirus. An alternative Direct Detection strategy (DD-ITD) for screening viral nucleic acid from stools, bypassing the need for virus culture, has been developed and extensively validated by GPLN partners. A multi-laboratory demonstration project was conceived to field-test the DD-ITD method by GPLN laboratories from the WHO African, Western Pacific, and Eastern Mediterranean regions, where wild serotype 1 or vaccine-derived polioviruses still circulate.
View Article and Find Full Text PDFBioinform Biol Insights
December 2024
Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana.
Background: Human papillomavirus (HPV) causes disease through complex interactions between viral and host proteins, with the PI3K signaling pathway playing a key role. Proteins like AKT, IQGAP1, and MMP16 are involved in HPV-related cancer development. Traditional methods for studying protein-protein interactions (PPIs) are labor-intensive and time-consuming.
View Article and Find Full Text PDFSci Adv
December 2024
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA.
There is currently limited evidence regarding how the rotavirus vaccine dosing schedule might be adjusted to improve vaccine performance. We quantified the impact of the previously implemented 6/10-week Rotarix vaccine (RV1) in Ghana to the model-predicted impact for other vaccine dosing schedules across three hospitals and the entire country. Compared to no vaccination, the model-estimated median percentage reductions in rotavirus ranged from 28 to 85% and 12 to 71% among children <1 and <5 years old, respectively.
View Article and Find Full Text PDFPLoS Biol
December 2024
Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
To keep ahead of the evolution of resistance to insecticides in mosquitoes, national malaria control programmes must make use of a range of insecticides, both old and new, while monitoring resistance mechanisms. The outdoor-biting malaria vector Anopheles arabiensis is of increasing concern for malaria transmission because it is apparently less susceptible to many indoor control interventions, yet knowledge of its mechanisms of resistance remains limited. Furthermore, comparatively little is known in general about resistance to non-pyrethroid insecticides such as pirimiphos-methyl (PM), which are crucial for effective control in the context of globally high resistance to pyrethroids.
View Article and Find Full Text PDFJ Parasitol Res
November 2024
Plant Development Department, Centre for Plant Medicine Research, Mampong-Akuapem, Ghana.
BMC Infect Dis
December 2024
Tokyo Medical and Dental University, Tokyo, Japan.
Background: Viral hemorrhagic fevers (VHFs) belong to a group of viral infectious diseases that interfere with the blood's clotting mechanism. VHF has a wide host range, including bats, rodents, or arthropods such as mosquitoes and ticks. Most VHFs emerge suddenly as outbreaks, making it difficult to predict occurrence.
View Article and Find Full Text PDFBMC Infect Dis
December 2024
Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Lancet Respir Med
November 2024
Division of Infection and Immunity, Center for Clinical Microbiology, University College London, London NW3 2PF, UK; NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London UK. Electronic address:
Environ Health Insights
November 2024
Department of Medical Microbiology, University of Ghana Medical School, Korle Bu, Accra, Ghana.
Background: Antibiotic resistance (ABR) poses a critical global health challenge, necessitating its surveillance across both human and animal health sectors. This study evaluated ABR in bacteria harboured in reared inland fishes sold in Accra and the pond water from which they originated.
Method: The study was cross-sectional, involving fishes and water sampled from 80 ponds.
Trop Med Infect Dis
November 2024
Virology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.
J Infect Dis
November 2024
Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Background: Acquired immunity to Plasmodium falciparum malaria is mainly mediated by immunoglobulin G (IgG) targeting erythrocyte membrane protein 1 (PfEMP1). These adhesins mediate infected erythrocyte (IE) sequestration, protecting IEs from splenic destruction. PfEMP1-specific IgG is therefore thought to protect mainly by inhibiting IE sequestration.
View Article and Find Full Text PDFLancet Infect Dis
November 2024
Department of Infection, Centre for Clinical Microbiology, Division of Infection and Immunity, University College London, London NW3 QG3, UK; NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, UK. Electronic address:
mSphere
December 2024
Research Group for Global Capacity Building, National Food Institute, WHO Collaborating Centre (WHO CC) for Antimicrobial Resistance in Foodborne Pathogens and Genomics, FAO Reference Laboratory (FAO RL) for Antimicrobial Resistance, European Union Reference Laboratory for Antimicrobial Resistance (EURL-AR), Technical University of Denmark, Kongens Lyngby, Denmark.
Health Res Policy Syst
November 2024
Institute for Global Health, University College London, London, United Kingdom.
Pan Afr Med J
November 2024
Université Joseph KI-ZERBO (UJKZ), Ouagadougou, Burkina Faso.
Introduction: the diversity of Plasmodium falciparum genotypes affects the dynamics of malaria transmission and is thought to be one of the factors hampering malaria control efforts. This study aimed to investigate the relationship between Plasmodium falciparum genetic diversity and chloroquine and sulfadoxine-pyrimethamine resistance markers in malaria endemic areas of Burkina Faso.
Methods: in a cross-sectional study, populations residing in Nouna health district were randomly recruited.
Digit Health
November 2024
Department of Population Health, NYU School of Medicine, New York, NY, USA.
Introduction: Sedentary lifestyle and consumption of an unhealthy diet are significantly associated with hypertension in Nigeria and Ghana. Increasing the uptake of physical activity and diet rich in fruits and vegetables has been a challenge in the region. This study aimed at assessing the effect of a mobile health intervention (mhealth) on physical activity, and fruits and vegetables intake in patients with hypertension in Nigeria and Ghana.
View Article and Find Full Text PDFAntimicrob Resist Infect Control
November 2024
National Institute for Communicable Diseases a division of NHLS and University of Witwatersrand, Johannesburg, South Africa.
Surveillance is essential in the fight against antimicrobial resistance (AMR), to monitor the extent of resistance, inform prevention, control measures, and evaluate intervention progress. Traditional surveillance methods based on phenotypic antimicrobial susceptibility data offer important but limited insights into resistance mechanisms, transmission networks, and spread patterns of resistant bacterial strains. Fortunately, genomic technologies are increasingly accessible and can overcome these limitations.
View Article and Find Full Text PDFPLoS One
November 2024
Department of Medical Microbiology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
Background: Vulnerable groups, such as pregnant women, are at increased risk of potentially life-threatening infections with extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) for both mother and newborn. However, data regarding ESBL-E carriage and associated risk factors in Ghanaian pregnant women remain scarce.
Objective: This study aimed to determine the prevalence of ESBL-E carriage and its associated risk factors among pregnant women attending the antenatal clinic at the Korle Bu Teaching Hospital.
Lancet Microbe
December 2024
MRC Centre for Genomics and Global Health, Big Data Institute, Oxford University, Oxford, UK.
Background: The population structure of the malaria parasite Plasmodium falciparum can reveal underlying adaptive evolutionary processes. Selective pressures to maintain complex genetic backgrounds can encourage inbreeding, producing distinct parasite clusters identifiable by population structure analyses.
Methods: We analysed population structure in 3783 P falciparum genomes from 21 countries across Africa, provided by the MalariaGEN Pf7 dataset.
Environ Microbiol Rep
December 2024
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.
Antimicrobial resistance (AMR) is under-monitored in Africa, with few reports characterizing resistant bacteria from the environment. This study examined physicochemical parameters, chemical contaminants and antibiotic-resistant bacteria in waste stabilization pond effluents, hospital wastewater and domestic wastewater from four sewerage sites in Kumasi. The bacteria isolates were sequenced.
View Article and Find Full Text PDFBiomed Res Int
November 2024
Department of Clinical Pathology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O. Box LG 581, Legon, Ghana.
Delile (VAD), also known as bitter leaf, is widely utilized in traditional medicine for the treatment of various ailments, including cancer. The presence of bioactive compounds in VAD is believed to be responsible for its characteristic bitterness. In Ghana, it is a common practice to mitigate the bitterness of VAD by combining it with (Christm.
View Article and Find Full Text PDFBMC Infect Dis
November 2024
West African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, Legon-Accra, Ghana.