6 results match your criteria: "Noble hospital and Research Centre[Affiliation]"
Changes in cerebrospinal fluid proteins across the spectrum of untreated and treated chronic HIV-1 infection.
PLoS Pathog
September 2024
Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Article Synopsis
- Researchers used the Olink Explore 1536 platform to analyze 1,463 unique proteins in cerebrospinal fluid (CSF) from 303 samples, including uninfected controls and various groups of individuals with HIV-1 infection.
- The study found significant correlations between CSF proteins and HIV-1 RNA levels, as well as nerve damage markers, highlighting distinct patterns of protein changes associated with different stages of HIV-1 progression.
- Antiretroviral therapy was shown to lessen protein imbalances in the CSF, although levels didn’t always return to those of uninfected controls; a comprehensive dataset is available online for further research on HIV-1's effects on the CNS.
Goals of Care for Patients with Severe Comorbid Illnesses Hospitalized for an Acute Deterioration.
Indian J Crit Care Med
January 2022
Department of Anaesthesiology and Critical Care, Noble Hospital and Research Centre, Pune, Maharashtra, India.
Bande B. Goals of Care for Patients with Severe Comorbid Illnesses Hospitalized for an Acute Deterioration. Indian J Crit Care Med 2022;26(4):414-415.
View Article and Find Full Text PDFEpidemiology, clinical presentation and management of COVID-19 associated mucormycosis: A single centre experience from Pune, Western India.
Mycoses
May 2022
Department of Medicine, Noble hospital and Research Centre, Pune, India.
Article Synopsis
- The study focuses on the increase in cases of COVID-19 associated mucormycosis (CAM) during the second wave of COVID-19 in India, mainly affecting patients with diabetes.
- Conducted at Noble Hospital in Pune between April 2020 and August 2021, the research involved 59 CAM patients, revealing high mortality rates linked to factors like uncontrolled diabetes and high COVID-19 CT severity scores.
- Treatment success was achieved through surgical debridement and antifungal therapy, with 74.6% of patients recovering, highlighting the urgent need for appropriate steroid use in COVID-19 treatment to prevent complications like CAM.
Use of Tofacitinib in the Management of COVID-19 Pneumonia.
Indian J Crit Care Med
October 2021
Department of Anaesthesiology and Critical Care, Noble Hospital and Research Centre, Pune, Maharashtra, India.
Bande BD. Use of Tofacitinib in the Management of COVID-19 Pneumonia. Indian J Crit Care Med 2021; 25(10):1089-1090.
View Article and Find Full Text PDFCombination therapy of Tocilizumab and steroid for management of COVID-19 associated cytokine release syndrome: A single center experience from Pune, Western India.
Medicine (Baltimore)
July 2021
Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Cytokine release syndrome (CRS) or cytokine storm is thought to be the cause of inflammatory lung damage, worsening pneumonia and death in patients with COVID-19. Steroids (Methylprednislone or Dexamethasone) and Tocilizumab (TCZ), an interleukin-6 receptor antagonist, are approved for treatment of CRS in India. The aim of this study was to evaluate the efficacy and safety of combination therapy of TCZ and steroid in COVID-19 associated CRS.
View Article and Find Full Text PDFNeurological issues during severe COVID-19 in a tertiary level hospital in Western India.
Neurosci Lett
April 2021
Department of Medicine, Noble Hospital and Research Centre, Pune, Maharashtra, India.
India has the second largest COVID-19 epidemic in the world as per current estimates. Central and peripheral nervous system involvement in COVID-19 (Neuro COVID-19) has been increasingly identified and reported. This letter is the first report of the spectrum of neurological disorders observed in patients with severe COVID-19 from a resource limited setting like India.
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