Impact of the combination of sintilimab and chemotherapy on the tumor and paratumor PD-L1, IDO, TIM-3, FOXP3+ and CD8 expressions in patients with advanced esophageal squamous cell carcinoma.

Background: Anti-PD-1/PD-L1 therapeutics have been widely used in the clinic in various tumors, including advanced esophageal cancer, showing remarkable treatment efficacy. Factors determining the response to anti-PD-1/PD-L1 therapeutics are numerous, including the tumor microenvironment, such as CD8+ T cells and expression of PD-1/PD-L1. Our study aimed to explore the effect of chemoimmunotherapy on the expression of CD8+ T cells, TIM-3, and FOXP3+ in tumor, paratumor tissues, and the expression of PD-L1, IDO, in tumor, paratumor tissues, and lymph nodes, and analyze the correlation among these markers.

Primary intracranial papillary meningioma: Analysis of factors of prognosis and systematic review.

Objective: Papillary meningioma is rare and displays an aggressive clinical behavior with poor prognosis. Therefore, we performed an extensive literature review to evaluate the adverse factors and treatment strategy of survival.

Method: We performed Ovid, Medline, Embase, Pubmed, Web of Science and Cochrane database queries for articles published between 1938 and 2019 with the search term "WHO grade III meningioma" or "papillary meningioma" and "central nervous system", "cerebral", or "intracranial".

Correlation between MMP2 expression in lung cancer tissues and clinical parameters: a retrospective clinical analysis.

Background: Matrix metalloproteinase 2 (MMP2) has been found to be related to malignant tumors; the aim of this study was to investigate the correlation between MMP2 expression in lung cancer tissues and clinical parameters of lung cancer.

Methods: The expression of MMP2 in lung cancer tissues and in adjacent non-malignant tissues was tested by immunohistochemistry. The correlation between the expression of MMP2 and clinical parameters of lung cancer was analyzed by Kaplan-Meier curve and multiple regression analysis.

SNHG16 promotes cell proliferation and migration through sponging miR-132 in melanoma.

Melanoma, which originates from the transformation of normal melanocytes, is one of the three main types of skin cancer. We aimed to explore the functions of SNHG16 and miR-132 in melanoma. CCK-8, Transwell assays were used to measure the viability and migration, respectively.

Stathmin 1 promotes the progression of liver cancer through interacting with YAP1.

Objective: The present study aimed to explore whether Hippo/YAP signaling pathway was involved in STMN1 (stathmin 1)-mediated liver cancer progression.

Patients And Methods: STMN1 expression patterns were determined by Real Time-Polymerase Chain Reaction (PCR) assay (RT-PCR) and Western blotting. The relationship between STMN1 expression levels and the clinical features and the prognosis of patients with liver cancer were evaluated by χ2-test and student's t-test.

Knockdown of lncRNA HCP5 protects against cerebral ischemia/reperfusion injury by regulating miR-652-3p.

Previous studies have shown that lncRNAs play crucial roles in cerebral ischemia/reperfusion injury. In this study, the function and possible mechanism of lncRNA HCP5 in cerebral ischemia/reperfusion injury was investigated. An oxygen glucose deprivation (OGD) model in N2a cells was used to simulate cerebral ischemia/reperfusion injury in vitro.

Combined PLT and NE to predict the prognosis of patients with locally advanced cervical cancer.

Cervical cancer is one of the most common tumors in women. Neutrophils (NEs) and platelets (PLTs) are components of cells in circulating blood. NEs are one of the components of white blood cells (WBCs), accounting for the vast majority of WBCs, recognized as one of the indicators of inflammation.

Schizandrin A inhibits cellular phenotypes of breast cancer cells by repressing miR-155.

Aims: Schizandrin A (SchA) is a type of lignan with biological properties against oxidation, inflammation, and cancer. Here, we aimed to sustain the bioactive properties of SchA in proliferative and motional phenotypes of MDA-MB-231 cells and their molecular mechanism.

Methods: MDA-MB-231 cells were exposed to SchA.

Roflumilast, a phosphodiesterase-4 inhibitor, improves hyperoxia-induced lung injury via anti-inflammation.

Roflumilast is an inhibitor of phosphodiesterase-4 (PDE4) and can suppress the hydrolysis of cAMP in inflammatory cells, conferring anti-inflammatory effects. This study aimed to investigate the protective effects of roflumilast on hyperoxia-induced acute lung injury (HALI) in a rat model. Male Sprague-Dawley rats were randomly assigned into: control group; HALI group; 2.

Efficacy and Safety of Continuous Paravertebral Block after Minimally Invasive Radical Esophagectomy for Esophageal Cancer.

Objective: To compare the effects of continuous paravertebral block analgesia and patient-controlled intravenous analgesia after minimally invasive radical esophagectomy for esophageal cancer and their effects on postoperative recovery.

Methods: A retrospective analysis was performed among 233 patients who underwent minimally invasive esophageal cancer radical operation and met the requirements, including 87 patients (group C) who were successfully placed with a continuous paravertebral block device under direct vision and 146 patients (group P) who used a patient-controlled intravenous analgesia device. Visual analogue pain score (VAS) at rest and in motion for 1, 3, 6, 12, 24, 36, and 48 hours after awakening, incidence of adverse reactions of the two analgesic methods, occurrence of pulmonary complications after operation, use of emergency analgesics, and hospital stay after operation was recorded.

Bone marrow mesenchymal stem cells improve spinal function of spinal cord injury in rats via TGF-β/Smads signaling pathway.

Bone marrow mesenchymal stem cells (BMSCs) on the repair of spinal cord injury (SCI) in rats as well as the role of transforming growth factor-β (TGF-β)/Smads signaling pathway in the repair were investigated. Rat BMSCs and astrocyte-spinal cords (ASCs) were isolated and cultured , and the cell purity was detected by flow cytometry. ASCs were co-cultured with TGF-β1, BMSCs and BMSCs + TGF-β1, respectively, and grouped accordingly, and ASCs cultured conventionally were included into control group.

MiR-328 inhibits cell apoptosis and improves cardiac function in rats with myocardial ischemia-reperfusion injury through MEK-ERK signaling pathway.

Objective: To explore the influences of micro ribonucleic acid (miR)-328 on rats with myocardial ischemia-reperfusion (IR) injury through the methyl ethyl ketone (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway.

Materials And Methods: A total of 36 Sprague-Dawley rats were randomly assigned into the sham group (n=12), model group (n=12), and miR-328 group (n=12). The model of myocardial IR injury was established by ligating the left anterior descending coronary artery, without any intervention in the model group, while 200 μL of miR-328 antagomir was intravenously injected before modeling in the miR-328 group.