2 results match your criteria: "No. 1 Hospital of Wuxi[Affiliation]"
Very early stage detection of acute myocardial infarction by harmonic ultrasonic integrated backscatter.
Ultrasound Med Biol
April 2008
The Cardiovascular Department of the No 1 Hospital of Wuxi of the Affiliated Hospital of Nanjing Medical University, Wuxi, Jiangsu, PR China.
To study the very early diagnosis of acute myocardial infarction (AMI) by harmonic imaging ultrasonic integrated backscatter (IBS). Thirty normal persons, 68 cases with AMI, of whom 28 cases were at the very early stage of acute myocardial infarction (in 2 h), and 40 cases with acute myocardial infarction (in 2 to 12 h) were examined by IBS and the cyclic variation of integrated backscatter (CVIB) with HP-5500 ultrasonic system in different segment (the segment of myocardial infarction and no myocardial infarction). In the segment of AMI of the very early stage (in 2 h) the IBS (dB) is much higher than that of the segment of no AMI (18.
View Article and Find Full Text PDFOverexpression of glucosylceramide synthase in associated with multidrug resistance of leukemia cells.
Leuk Res
March 2008
Central Laboratory, No. 1 Hospital of Wuxi, Wuxi, Jiangsu 214002, China.
Article Synopsis
- Ceramide plays a crucial role in regulating programmed cell death (apoptosis) in leukemia, and Glucosylceramide synthase (GCS) helps cancer cells evade this process by converting ceramide into glucosylceramide.
- A study examined the expression levels of GCS in both clinical leukemia samples and cell lines, finding a strong correlation between high GCS levels and multidrug resistance in leukemia cells.
- The use of a GCS inhibitor, PPMP, demonstrated that blocking GCS increases the sensitivity of resistant leukemia cells to chemotherapy drugs like adriamycin, highlighting the potential of targeting GCS to overcome drug resistance in leukemia treatment.