Comparison of the long-term efficacy of tenofovir and entecavir in nucleos(t)ide analogue-naïve HBeAg-positive patients with chronic hepatitis B: A large, multicentre, randomized controlled trials.

Objective: We conducted this study to compare the efficacy and safety of entecavir and tenofovir in the treatment of treatment-naïve HBV e antigen (HBeAg)-positive patients with chronic hepatitis B (CHB) for 144 weeks.

Methods: A total of 320 treatment-naïve HBeAg-positive CHB patients who received randomly a single regimen of either entecavir capsule (ETV) (n = 160) or tenofovir disoproxil fumarate capsule (TDF) (n = 160) for 144 weeks were consecutively enrolled from 14 tertiary hospitals or university hospitals in China between January 2012 and December 2014.

Results: Two groups showed no difference in baseline characteristics.

SET7/9 promotes hepatocellular carcinoma progression through regulation of E2F1.

Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. Histone‑lysine N‑methyltransferase SET7/9 is a protein lysine monomethylase that methylates histone H3K4 as well as various non‑histone proteins. Deregulation of SET7/9 is frequently detected in human cancers.

[Clinical effect and safety of 144-week treatment with entecavir capsules in treatment-naïve HBeAg-positive patients with chronic hepatitis B].

To investigate the clinical effect and safety of entecavir capsules in the treatment of treatment-naïve HBeAg-positive patients with chronic hepatitis B (CHB). A total of 158 HBeAg-positive CHB patients were given oral entecavir capsules at a dose of 0.5 mg/time once a day for 144 weeks.

Increased serum pigment epithelium-derived factor in women with gestational diabetes is associated with type 2 diabetes.

Background. Pigment epithelium-derived factor (PEDF) is demonstrated to be elevated in diabetes patients. However, no reports have emerged in pregnant women with gestational diabetes mellitus (GDM).

Pulmonary solid tumor with coexisting pulmonary aspergillosis: case reports and literature review.

Background And Aims: The association of noncavitary untreated lung cancer with coexisting pulmonary Aspergillosis in immunocompetent patients is an extremely rare occurrence. The present paper aims to summarize the clinical data, and gives an overview of the current knowledge on the etiology, diagnosis and treatment of this condition.

Methods: We report four cases and review seven cases in the literature.

Association between FABP2 Ala54Thr polymorphisms and type 2 diabetes mellitus risk: a HuGE Review and Meta-Analysis.

Many studies have examined the association between the FABP2 (rs1799883) Ala54Thr gene polymorphism and type 2 diabetes mellitus risk (T2DM) in various populations, but their results have been inconsistent. To assess this relationship more precisely, A HuGE review and meta-analysis were performed. The PubMed and CNKI database was searched for case-control studies published up to April 2014.

[Study on inhibitory effect of aqueous extract of Taxus chinensis var. mairei on growth of A549 lung cancer xenografts in nude mice and its mechanism].

Objective: To study the effect of aqueous extract of Taxus chinensis var. mairei (AETC) on the growth of A549 lung cancer xenografts in nude mice and its mechanism.

Method: The A549 lung cancer xenograft model was established, and then randomly divided into the control group, and low, middle and high dose AETC experiment groups.

[Effects of three different treatments on atherosclerosis and adipose in rats].

Objective: To explore the effects of three different treatments, including probucol plus aspirin (PS), lovastatin plus aspirin (AS) and probucol, lovastatin plus aspirin (PAS) on atherosclerotic plaque and adipose.

Methods: A total of 31 SD rats with established atherosclerosis were randomly divided into control group (n = 7), high-fat group (n = 4), PS group (n = 8), AS group (n = 5) and PAS group (n = 7). The PS group rats were lavaged with probucol (104.

TNF-308 gene polymorphism and tuberculosis susceptibility: a meta-analysis involving 18 studies.

A number of studies have investigated the association between TNF-308 (rs1800629 G/A) polymorphisms and the susceptibility towards tuberculosis (TB) in different populations. However, many of these studies provided inconsistent results. In this study, a systematic review and meta-analysis of the published studies was performed to gain a clearer understanding of this association.

[The role of diabetes mellitus as a risk factor of acute myocardial infarction].

Objective: To determine the impact of elevated in-hospital glucose level on outcome of patients with acute myocardial infarction (AMI), and evaluate the role of diabetes mellitus as a risk factor of AMI.

Methods: The study included a retrospective analysis of AMI patients who were admitted to No. 81 Hospital of PLA from January 2000 to May 2010.

[Effect of rapid decompression on rat multifocal electroretinogram].

Objective: To observe the effect of rapid decompression on rat multifocal electroretinogram (mfERG) and to explore the characteristics of the retinal function impairment due to decompression sickness at early stage.

Methods: Twenty rats were randomly divided into 4 groups: normal control (NC) group, safe decompression (SD) group, 0 h and 6 h after rapid decompression (RD0 and RD6) groups. The treated rats in safe decompression group and each rapid decompression group were exposed in hyperbaric cabin and air pressure in the cabin rose up to 1.

[Continuous versus intermittent azithromycin administration for treatment of Mycoplasma pneumonia-induced pneumonia: effects and drug resistance in rats].

Objective: To evaluate the efficacy and drug resistance of azithromycin administered via continuous infusion versus intermittent administration in rats with Mycoplasma pneumonia-induced pneumonia.

Methods: Pneumonia was induced in rats by intranasal administration of mycoplasma suspension. The rats with established pneumonia were randomly divided into continuous and intermittent infusion groups with intraperitoneal azithromycin injection on a daily basis for 6 consecutive days, or for 3 consecutive days followed by a 3-day rest (which was repeated twice), respectively.

[Construction of a RU486 inducible recombinant adenoviral vector carrying murine interleukin-12 gene and experimental treatment of colonic carcinoma].

Objective: To construct a RU486 inducible recombinant adenovirus of murine IL-12 protein and study its effect and safety on colonic cancer.

Methods: The replication-defective recombinant adenovirus were produced after cotransfection of shutter vector pDC-RUmIL-12 and adenovirus DNA helper plasmid pBHGloxDeltaE1, 3Cre into HEK293 cells. The recombined adenovirus was purified by CsCl density gradient centrifugation and its titer was determined by end point dilution assay.