Complication of salmonella bacteremia in a case of treated fungal endophthalmitis.

This is to report a case of bacteremia caused by Salmonella typhi in a treated unilateral fungal endogenous endophthalmitis in an 18-year-old male from one of the South Asian countries. Microbiological and molecular investigations were carried out on the eviscerated material and routine blood culture was carried out. Direct examination of eviscerated material revealed the presence of fungal filaments.

Toxicogenomics of nanoparticulate delivery of etoposide: potential impact on nanotechnology in retinoblastoma therapy.

To develop a suitable formulation with high entrapment efficiency, etoposide-loaded poly(lactide--glycolide) nanoparticles (NPs) were formulated by single emulsion-solvent evaporation method by changing different formulation parameters such as drug loading, choice of organic solvent and percentage of emulsifier polyvinyl alcohol. The NPs showed higher entrapment efficiency, ~86% (with 15% (/) drug loading). The physicochemical parameters revealed smooth topology with size range (240-320 nm), a negative zeta potential (~19 mV) and in vitro sustained-release activity (~60% drug release in 40 days).