Use of Oral Rub and Rinse Technique for Oral Cancer Screening: Results from a Community-based Program in an LMIC.

Background: Oral cancer screening programs can aid in the early identification of potentially malignant oral lesions. The objective of the present study was to evaluate the effectiveness of the Oral Rub and Rinse (ORR) technique as an oral cancer screening tool and to test its potential in detecting genetic alterations in exfoliated cells obtained through ORR.

Methods: The screening programs were conducted in rural Dakshina Kannada and Udupi districts in Karnataka.

Evaluation of the Efficiency of Ultrasonography and Color Doppler in Diagnosis of Intraosseous Jaw Lesions: An Study.

Aim: The current investigation aimed to evaluate the accuracy of ultrasonography and color Doppler performed in the diagnosis of intraosseous jaw lesions.

Materials And Methods: A total of 30 patients with intraosseous jaw lesions between the ages of 12 and 60 were selected for the present study. For every jaw lesion, a preliminary diagnosis was done using preoperative conventional radiographs.

Association of Epstein-Barr Virus and its clinical relevance in Human Papillomavirus-negative oral squamous cell carcinoma: A cohort study from South India.

Objective: The study assessed the prevalence and clinical implications of Epstein Barr Virus (EBV)-positive but Human Papillomavirus (HPV)-negative oral squamous cell carcinoma (OSCC) in a tertiary care hospital setting. The overall goal was to elucidate the potential impact of EBV on OSCC disease progression and prognosis.

Design: A total of 134 surgically resected and histopathologically confirmed OSCC tumor biopsies were collected from a tertiary care hospital.

Assessment of the association between coronary artery blockage and periodontal health status in patients undergoing coronary angiography: a cross-sectional study.

Background: Growing evidence suggests a potential link between periodontal disease and the development of atherosclerosis, positioning periodontal disease as a possible risk factor for cardiovascular diseases (CVD). This study aimed to evaluate periodontal status in patients with coronary artery disease (CAD) by measuring the Periodontal Inflamed Surface Area (PISA) score in individuals undergoing coronary angiography.

Material And Methods: In this cross-sectional study, 300 patients scheduled for coronary angiography at K.

Development and evaluation of chitosan-coated virgin coconut oil-asiatic acid-loaded nanoemulgel for enhanced wound management.

Wound management remains a significant challenge due to complications such as delayed healing and microbial infections, particularly in the conditions like diabetes mellitus, vascular disorders, and immunosuppression. This study aimed to develop a chitosan-coated virgin coconut oil-asiatic acid-loaded nanoemulsion gel (CS-ASA-NEG) to enhance wound healing outcomes. A central composite design (CCD) was employed using Design Expert 11 software to optimize the nanoemulsion formulation, with ternary phase diagrams (TPD) evaluating stable regions for Tween 20: Span 80 (T20:S80) ratios.

Navigating Tumor Microenvironment Barriers with Nanotherapeutic Strategies for Targeting Metastasis.

Therapeutic strategy for efficiently targeting cancer cells needs an in-depth understanding of the cellular and molecular interplay in the tumor microenvironment (TME). TME comprises heterogeneous cells clustered together to translate tumor initiation, migration, and proliferation. The TME mainly comprises proliferating tumor cells, stromal cells, blood vessels, lymphatic vessels, cancer-associated fibroblasts (CAFs), extracellular matrix (ECM), and cancer stem cells (CSC).

Reducing heart failure events via individualized patient education program in patients with reduced ejection fraction.

Background: Disease management programs for heart failure (HF) often include various strategies such as medication management and lifestyle modifications, and are known to improve clinical outcomes.

Objectives: To evaluate the effectiveness of an individualized patient education program (IPEP) specifically designed for patients with reduced ejection fraction (HFrEF) on clinical outcomes.

Methods: In our prospective interventional study involving 164 patients, participants were divided into control (CG) and intervention (IG) groups.

A comparative study of polydopamine vs. glass ionomer cement for adhesion mechanisms on enamel and dentin using SEM and shear bond strength evaluation.

Polydopamine (PD), inspired by the wet adhesion mechanism of mussel foot proteins, has emerged as a promising adhesive material with wide-ranging applications. This study aimed to compare the adhesive properties of PD and Glass Ionomer Cement (GIC) on enamel and dentin substrates, evaluating PD's potential as an alternative adhesive in dental practice. A total of 120 human premolars were prepared, with 80 teeth allocated for Scanning Electron Microscopy (SEM) analysis and 40 teeth reserved for shear bond strength testing.

Effect of Vocal Loading in Female Bharatanatyam Dance Teachers After an Hour-Long Class.

Objectives: To compare certain acoustic, aerodynamic, and perceptual parameters before and after an hour-long class to analyze vocal loading characteristics in female Bharatanatyam dance teachers.

Study Design: Prospective study.

Method: The study included 52 female Bharatanatyam dance teachers aged 19 to 40years.

Metal-organic framework catalysed multicomponent reactions towards the synthesis of Pyrans.

Metal-Organic Frameworks (MOFs) gaining increasing interest in heterogeneous catalysis owing to their advantageous properties such as superior porosity, high surface area, ample catalytic sites. Their properties can be tailored by varying the metal ions or metal clusters (nodes) and organic linkers. Magnetically active nano core-shell MOF composites are also discovered for easy separation and reuse of catalyst.

Examining the impact of the exercise package on eye and neck strain (EPENS) among adolescents: A pre-experimental study at a selected preuniversity college in Mangalore.

Background: Electronic devices like laptops, desktops, and cell phones are now essential in modern life, especially for students, due to their convenience and time-saving benefits. However, concerns about social issues related to prolonged use, particularly among kids and teenagers, have arisen. This study aimed to evaluate the efficacy of an exercise package in mitigating symptoms of eye and neck strain among adolescents who are regular users of electronic devices.

A study to evaluate the influence of non-axial forces on tooth - a split mouth cross-sectional study.

Purpose: Proper tooth alignment directs occlusal forces along the long axis, supporting optimal masticatory function and periodontal health. Deviations that lead to non-axial forces are common; however, teeth with such deviations often maintain optimal health. This study aims to assess various occlusal and periodontal parameters in teeth experiencing non-axial forces to better understand the underlying reasons and mechanisms that contribute to their maintained health status.

Enhanced Surgical Recovery Nursing Program: A Multidisciplinary Approach to Optimize Postoperative Patient Recovery.

Background: Enhanced recovery is currently considered to be the treatment of various elective major surgeries. Enhanced recovery after surgery (ERAS) includes applying various perioperative measures, strategies, and active participation of patients in the recovery process.

Materials And Methods: A quasi-experimental study was conducted in the surgical units of a hospital in Karnataka, India.

Bacteriophage induces modifications in outer membrane protein expression and antibiotic susceptibility in Acinetobacter baumannii.

Bacteriophages, the most abundant biological agents targeting bacteria, offer a promising alternative to antibiotics for combating multi-drug resistant pathogens like Acinetobacter baumannii. However, the rapid development of bacteriophage resistance poses a significant challenge. This study highlights the contribution of outer membrane proteins (OMPs) in the emergence of bacteriophage resistance in A.

In Vitro Cytotoxic Potential and Integrated Network Pharmacology, Molecular Docking and Molecular Dynamic Approaches to Decipher the Mechanism of Gymnostachyum febrifugum Benth., in the Treatment of Breast Cancer.

Gymnostachyum febrifugum, a less-known ethnomedicinal plant from the Western Ghats of India, is used to treat various diseases and serves as an antioxidant and antibacterial herb. The present study aims to profile the cytotoxic phytochemicals in G. febrifugum roots using GC-MS/MS, in vitro confirmation of cytotoxic potential against breast cancer and an in silico study to understand the mechanism of action.

Alkali-Activated Permeable Concretes with Agro-Industrial Wastes for a Sustainable Built Environment.

This research presents a proposal for alkali-activated permeable concrete composites with the use of industrial by-products, including ground granulated blast-furnace slag (GGBS) and waste-foundry sand, as well as agro-desecrate product, i.e., sugarcane bagasse ash (SBA).

Intentional Reimplantation Combining the Benefits of Leukocyte- and Platelet-rich Fibrin and Biodentine™ for the Treatment of a Large Periapical Cyst: A Case Report.

Background: This case report examines the efficacy of intentional reimplantation (IR) in endodontics and explores the increased interest driven by recent advancements in regenerative techniques.

Case Presentation: A 14-year-old male patient reported pain in the lower left back tooth (tooth #36). The radiographic assessment revealed a 4 mm × 4 mm periapical cyst.

Tech Bytes-Harnessing Artificial Intelligence for Pediatric Oral Health: A Scoping Review.

Aim And Background: The applications of artificial intelligence (AI) are escalating in all frontiers, specifically healthcare. It constitutes the umbrella term for a number of technologies that enable machines to independently solve problems they have not been programmed to address. With its aid, patient management, diagnostics, treatment planning, and interventions can be significantly improved.

Analysis of heat induced changes in dental tissue for forensic application: A scanning electron microscope study.

Introduction: In the forensic field, having accurate understanding of the macroscopic and microscopic alterations that occur in teeth when exposed to temperatures has remarkable significance. The preservation of delicate incinerated teeth is crucial in fire investigations that pertain to the temperature exposed, as well as the identification of victims. This preservation is necessary in order to conduct macroscopic and microscopic ultra-structural examinations, which provide valuable insights into the structural alterations that dental tissues undergo when exposed to low to high temperatures.

Root caries: Prevalence, risk indicators, and clinical characteristics - A cross-sectional study.

Objectives: The objectives of this study were to determine the prevalence of root caries (RC) in South Coastal population of India, to identify the risk indicators associated with it and to describe some clinical characteristics of RC lesions.

Materials And Methods: A cross-sectional study was conducted with a sample size of 1062 subjects to assess the prevalence of RC. Each subject underwent an oral examination, performed by a single-calibrated examiner.

Structural isomers of carene persuade apoptotic cell death by inhibiting cell cycle in breast cancer cells: An in silico and in vitro approach.

For the first time, our study provides a comprehensive examination of the anti-cancer effects of structural isomers of carene in breast cancer cells, specifically focusing on cell cycle inhibition and the induction of apoptosis. We utilized the hydro-distillation method to extract Piper nigrum seed essential oil (PNS-EO) and identified its bioactive components through gas chromatography-mass spectrometry (GC-MS) analysis. A total of 46 bioactive compounds were isolated via hydro-distillation, identified through GC-MS analysis, and validated by co-injection using GC analysis.

Correlation between radiological, macroscopic and microscopic depth of invasion in oral squamous cell carcinoma: A prospective study using contrast-enhanced computed tomography.

Background: Depth of invasion (DOI) significantly influences prognosis and treatment strategies in oral squamous cell carcinoma (OSCC). Accurate preoperative imaging, such as contrast-enhanced computed tomography (CECT), alongside postoperative histopathological evaluations, aids in determining DOI. This study evaluates the correlation between radiological DOI (rDOI), macroscopic DOI (PDOI), and microscopic DOI (pDOI) in OSCC.

In vitro and In silico investigation deciphering novel antifungal activity of endophyte Bacillus velezensis CBMB205 against Fusarium oxysporum.

Endophytes from medicinal plants are potential biocontrol agents against Fusarium oxysporum f. sp. cubense (Foc), which is the causative fungus of banana wilt disease.