Gestational Diabetes and Analysis of Maternal and Fetal Outcomes Among Pregnant Women: A Cross-Sectional Study.

Purpose Of The Study: To determine the occurrence of gestational diabetes mellitus and analyze the maternal and fetal outcomes among pregnant women.

Methods: A prospective cross-sectional study was conducted for a duration of 7 months in the Department of Gynecology and Obstetrics at tertiary care hospital where 518 pregnant women participants of age above 18 years who had come for labor and undergone DIPSI (diabetes in pregnancy study of India) test were included in the study after the ethical clearance and obtaining written informed consent, whereas pregnant women with pre-existing diabetes mellitus and on other medication that alter glucose metabolism were excluded from the study.

Results: The occurrence of GDM was found to be 15.

Association of Unsafe Sexual Behavior with Head and Neck Cancer: A Bibliometric Analysis.

Inappropriate sexual practice like oral sex has been linked with head and neck cancer (HNC). The recent data revealed that about 20% oropharyngeal caner among Indians are associated with oral sex. Thus, we aimed to comprehensively assess the trend of research in oral sex associated with HNC and to predict the research frontiers and potential hotspots in the near future.

Formulation and Characterization of RBCS Coated Carboplatin Loaded Nano-Liposomal Formulation for Managing Breast Cancer.

Cell membrane-coated Nano-Liposomes (CM-NLPs) offer a promising approach that combines the advantages of both host cells and synthetic nano-liposomes (NLPs). This technique involves coating liposomes with red blood cell (RBC) membranes to enhance their functionality. In this study, novel carboplatin-loaded NLPs (CP-NLPs) were formulated using phospholipids (Soya Phosphatidyl Choline) and cholesterol through the thin-film hydration method, and optimized using a 3 full factorial design.

Image-processing-based model for surface roughness evaluation in titanium based alloys using dual tree complex wavelet transform and radial basis function neural networks.

In this study, we examine the assessment of surface roughness on turned surfaces of Ti 6Al 4V using a computer vision system. We utilize the Dual-Tree Complex Wavelet Transform (DTCWT) to break down the images of the turned surface into sub-images oriented in directions. Three different methods of feature generation have been compared, i.

Computational-driven discovery of AI-2 quorum sensing inhibitor targeting the 5'- methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) to combat drug-resistant Helicobacter pylori.

MTAN is an attainable therapeutic target for H. pylori because it may minimize virulence production, limit resistance, and impair quorum sensing without affecting gut flora. Here, 457 compounds with anti-H.

Effects of Various Solutions on Color Stability and Surface Hardness of Nanohybrid Dental Composite Under Simulated Oral Conditions.

Aim: This study evaluated effects of various solutions on color stability and surface hardness of a nanohybrid dental composite in simulated oral environments.

Materials And Methods: Sixty-four composite disks were fabricated and randomly allocated into eight groups ( = 8 per group): Artificial saliva (AS), Biotene (B), passion fruit juice (PFJ), orange juice (OJ), Sprite (S), Coca-Cola (CO), apple cider vinegar (ACV), and cranberry juice (CJ). Specimens were immersed in respective solutions at 37°C for 28 days.

Exploring the Influence of Tropical Cyclones on Regional Air Quality Using Multimodal Deep Learning Techniques.

Tropical cyclones (TC) are dynamic atmospheric phenomena featuring extreme low-pressure systems and powerful winds, known for their devastating impacts on weather and the environment. The main purpose of this paper is to consider the subtle involvement of TCs in the air quality index (AQI), focusing on aspects related to the air quality before, during and after cyclones. This research employs multimodal methods, which include meteorological data and different satellite observations.

Synthesis, characterization, and evaluation of pyrimidinone-linked thiazoles: DFT analysis, molecular docking, corrosion inhibition, and bioactivity studies.

The paper describes the construction of a new series of pyrimidinone-linked thiazole derivatives through bromination of the initial Biginelli reaction product followed by the Hantzsch thiazole synthesis route. Various analytical techniques, including FT-IR, H NMR, C NMR, and LCMS analysis, were employed to confirm the formation of the products. The synthesized compounds were primarily evaluated for their antibacterial activity, with a specific focus on their IC values.

Locust bean gum-based silver nanocomposite hydrogel as a drug delivery system and an antibacterial agent.

Effective drug release is of utmost importance in the medical field for treating various diseases, particularly cancer. Nanocomposite hydrogels remain the best materials for enhancing the bioavailability and therapeutic levels of drugs as they enable sustained, targeted, or controlled drug release. In this work, a nanocomposite hydrogel containing locust bean gum (LBG), poly(4-acryloylmorpholine) (PAcM), and silver nanoparticles (SN) has been made using an eco-friendly microwave (MW)-assisted method and characterized by various advanced techniques.

Anti-quorum sensing activity of essential oils against multidrug-resistant Klebsiella pneumoniae: a novel approach to control bacterial virulence.

The increasing resistance of microbes to conventional drugs is a serious problem worldwide that has increased the need for alternative antimicrobial compounds. Naturally occurring essential oils (EOs) are considered an important component of traditional pharmacopeia because of their antimicrobial and antioxidant properties. This has attracted researchers to identify novel therapeutic anti-pathogenic agents that could act as non-toxic quorum sensing inhibitors, thus controlling infections without encouraging the development of bacterial resistance.

Effect of medicated toothpastes and Tooth Mousse on cariogenic microbes of the oral cavity: An study.

Background: Dental caries, commonly known as tooth decay is a widespread oral health problem mainly attributed to the activity of cariogenic bacteria, such as and species. Tooth Mousse, containing remineralizing agents, herbal and fluoride containing toothpaste with antimicrobial agents have been developed to target cariogenic bacteria. Herbal, fluoride toothpaste, and Tooth Mousse are commonly prescribed to prevent, reduce, and control dental caries.

Homology modelling, molecular docking studies and synthesis of aminopyrimidines as inhibitors for deoxynucleoside kinase analogues in cancer chemoprevention.

The development of alternative anticancer agents with minimal side effects has become more critical due to the rising recurrence of mammalian malignancies and the severe side effects of chemotherapeutic treatments. Kinases are an essential target for neostatic impact as they play an important role in the modulation of growth factor signalling. Our work aims to screen novel nine-series of thiazole-based aminopyrimidines and sulphaminopyrimidines against the enzymes mitochondrial thymidine kinase 2, deoxyguanosine kinase (2OCP), deoxycytidine kinase (2QRN) and thymidylate kinase (1E2Q) by molecular docking, synthesise and to study their in vitro inhibitory studies.

Efficacy of Sodium Fluoride and Fluoridated Calcium Phosphate in Mitigating Dental Erosion on Human Enamel: An In Vitro Analysis.

Introduction: With increasing prevalence of dental erosion, this study explores the protective role of traditional fluoride-based products and newer formulations on eroded enamel.

Aims: To assess the protective effectiveness of casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and sodium fluoride (NaF) on human enamel against erosion using surface microhardness (SMH) and Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) analyses.

Materials And Methods: Ten extracted human third molars were sectioned to obtain 40 enamel sections and randomly assigned into four groups (n = 10) and treated as follows: G1 (Sound Enamel), G2 (Erosive Challenge), G3 (CPP-ACPF + Erosive Challenge), and G4 (NaF + Erosive Challenge).

Detection of transcriptionally active high-risk human papillomavirus in patients with oesophageal carcinoma by real-time PCR.

Background: Oesophageal malignancies (OC) are the sixth most common cause of cancer-related mortality worldwide. Traditional risk factors for OC include smoking, alcohol consumption, and poorly controlled acid reflux; however, the trends in the last decade have pointed out the potential carcinogenic roles of infectious agents, especially Human Papillomavirus (HPV), in the development of OC. The prevalence of HPV infection in OC varies greatly worldwide, mainly due to the inconsistencies of the detection assays employed.

Dirofilariasis in the hiding in oral cavity of a patient from Karnataka, India.

"Human dirofilariasis, caused by filarial worms of the genus , is considered an emerging zoonotic filarial infection transmitted to humans by zoo-anthropophilic blood-sucking insects. The most common species causing human infections include and . In this case report, we present the case of a 60-year-old male patient who reported the presence of an intraoral swelling in the right maxillary vestibular region.

Analytical and Experimental study of Liquid chromatography-mass spectrometry (LC-MS) profiling of the dehydrated Allium sativum and Allium cepa extracts; a gateway to therapeutic drug development.

Purpose: Practice of medicinal plants for the treatment of various ailments is a history for several decades. Occurrence of active compounds in these plants makes it significant in the era of modern medicine. Garlic and onion a monocotyledonous bulbous flowering plant belonging to the genus Allium has an extensive tradition for being used as anti-inflammatory, anti-cancer, anti-hyperepidemic, anti-diabetic, anti-bacterial, neuroprotective agent against various disorders.

Approaches towards pragmatic language assessment in Indian pre-schoolers: A survey among speech-language pathologists.

Background: Pragmatic language assessment in children is performed in line with standard protocols, guidelines, and best practices. The absence of these aspects in the Indian context has resulted in the quest to explore the approaches used by speech-language pathologists (SLPs) to assess pragmatic language impairments. This survey explored the current practices of SLPs towards the assessment of pragmatic language among preschool children in India.

Validation of Low Cost Patient Specific Implant Design Using Finite Element Analysis (FEA) for Reconstruction of Segmental Mandibular Defects: A Case Report and Literature Review.

Introduction: Mandibular continuity defects can cause functional and cosmetic deformities affecting a patient's quality of life. Reconstruction of such defects can be intricate even for the most seasoned maxillofacial surgeons. Reconstruction plates were the standard of care in the past, followed by a secondary reconstruction using autogenous grafts.

Exploring the gut microbiome and head and neck cancer interplay.

The gut microbiome, a complex community of microorganisms residing in the gastrointestinal tract, plays a crucial role in maintaining human health and influencing disease outcomes. Recent advancements in sequencing technologies have revealed the intricate relationship between gut microbiota and various health conditions. This review explores the impact of gut microbiome dysbiosis on immune function, chronic inflammation, and cancer progression.

Assessment of the Effectiveness of Desensitizing Dentifrices on Management of Dental Hypersensitivity: An Study.

Aim: The current study aimed to assess the efficiency of two desensitizing dentifrices on the management of dental hypersensitivity.

Materials And Methods: For the purpose of this investigation, 60 extracted human sound premolar teeth that were removed for orthodontic purposes were collected. On the buccal cervical areas, an inverted-cone bur was used to create cavities that were 2 mm deep and 3 mm wide.