Understanding Bacterial Resistance to Heavy Metals and Nanoparticles: Mechanisms, Implications, and Challenges.

Antimicrobial resistance is a global health problem as it contributes to high mortality rates in several infectious diseases. To address this issue, engineered nanoparticles/nano-formulations of antibiotics have emerged as a promising strategy. Nanoparticles are typically defined as materials with dimensions up to 100 nm and are made of different materials such as inorganic particles, lipids, polymers, etc.

Empowering self-care through patient education in heart failure patients: A multimodal approach comprising of P-PILs, videos, and personalized advice.

Background: Heart failure (HF) patients, in developing countries like India, have limited access to information regarding their health/disease state. To identify patient problems and patient expectations through focused group discussions (FGD) and develop a multimodal educational tool consisting of a pictogram-based patient information leaflet (P-PIL), HF video, and personalized counseling (PC) for HF patients.

Materials And Methods: Based on the results of the FGD with stakeholders, we developed, validated, and tested educational tools such as P-PIL and HF videos and personalized counseling for enhancing patient education.

Potentials of cytokinesis blocked micronucleus assay in radiation triage and biological dosimetry.

The measurement of micronucleus (MN) in the cytokinesis-block arrested binucleated cells has been extensively used as a biomarker in many radiation biology applications in specific biodosimetry. Following radiation casualties, medical management of exposed individuals begins with triage and biological dosimetry. The cytokinesis blocked micronucleus (CBMN) assay is the alternate for the gold standard dicentric chromosome assay in radiation dose assessment.

Unleashing the potential of natural protein based nanoparticles for the delivery of therapeutic nucleic Acid: A comprehensive review.

Nucleic acid-based therapeutics represent a revolutionary approach in treating genetic disorders, offering unprecedented potential for addressing pathologies at their molecular level. However, effective cellular delivery remains a critical challenge hindering their clinical implementation. While existing delivery systems, including viral vectors and lipid nanoparticles, have shown utility, they face limitations in immunogenicity, cargo capacity, and manufacturing complexity.

Correlation Between Self-reported or Supervised Physical Activity in Noncommunicable Diseases and Comorbidities During COVID-19 Pandemic: A Systematic Review.

Objective: The aim of the study is to systematically identify the protective and ameliorative effects of physical activity among people with noncommunicable diseases such as diabetes, cancer, chronic respiratory disease, chronic vascular disease, hypertension, and existing comorbidities during the coronavirus disease (COVID-19) pandemic.

Methods: The trial is registered in the PROSPERO registry and used the PICO (population, intervention, comparison, and outcomes) strategy to perform the search strategy. Assessors analyzed related studies in the MEDLINE, PROQUEST, PubMed, Cochrane Library, CINAHL, Embase, Google Scholar, Physiotherapy Evidence, and Science Direct databases between December 2022 and January 2023.

To Evaluate Structured Competency-Based Curriculum for Health Programs among Community Medicine Postgraduates: Mixed Method Approach.

Background: The postgraduate curriculum needs to be given a definite shape so as to make health programs more intensive and integrative. In the present scenario, most of the information is unclear and infrequent. A structured public health competency-based education is an important aspect to consider for integrative health care.

Unraveling Cochlear Dynamics: The Effect of Clicks, Tone Burst Frequencies, Polarity, and Stimulus Rates on Cochlear Microphonics in Individuals with Normal Hearing.

Background: Despite cochlear microphonic's potential clinical application, especially in ANSD diagnosis, the optimal parameters to record cochlear microphonics and the effect of various stimulus parameters are not well understood yet, which makes its recording a difficult procedure. The present study was undertaken to determine the effect of stimulus polarity, rate, stimulus type, and stimulus frequency on different aspects of cochlear microphonics, which could help to decide an optimal stimulus parameter that can be used to record CM.

Methods: The study involved 32 normal-hearing adults.

Assessment of the Bond Strength of Orthodontic Bracket on Ceramic Crown Surface Using Three Various Bonding Agents: A Comparative Study.

Aim: The current study's aim was to evaluate the orthodontic bracket's bond strength employing three different bonding agents on a ceramic crown surface.

Materials And Methods: Tooth preparation on 60 permanent maxillary premolar teeth extracted for orthodontic purposes was carried out. Supragingival finishing margins were made for all samples, and ceramic (PFM) crowns were fabricated.

Evaluation of Early Childhood Caries and Its Association with Risk Factors among School Children: A Cross-sectional Study.

Aim: The study aimed to assess early childhood caries and its correlation with risk variables among school children.

Materials And Methods: 242 children under the age of 5 years were clinically assessed and to ascertain early childhood caries, a validated structured questionnaire was utilized. Demographic data (four questions) and oral health-related activities questions (two questions) were included.

Comparative Evaluation of Microleakage below the Orthodontic Brackets after Bonding with Various Adhesive Agents: An Study.

Aim: The aim of the current study was to assess the microleakage below orthodontic brackets after bonding with three different adhesive materials.

Materials And Methods: In total, 75 healthy human premolars that had been extracted for orthodontic treatment were utilized in this investigation. The samples were divided into three groups of 25 samples randomly.

Sugar-coated Sleep: Raising Dental Red Flags in Smith-Magenis Syndrome.

Aim And Background: Smith-Magenis syndrome (SMS) is a rare condition characterized by abnormalities affecting chromosome 17 or RAI1, leading to physical, developmental, and behavioral challenges. SMS occurs in approximately 1 in 25,000 individuals, presenting complex clinical and dental issues.

Case Description: This case report focuses on the dental care of a 3-year-old child diagnosed with SMS, emphasizing a comprehensive treatment plan.

A TOPSIS based multi-objective optimal deployment of solar PV and BESS units in power distribution system electric vehicles load demand.

The growing concerns regarding the depletion of fossil fuels, CO emissions, and the effects of climate change prompt the usage of plug-in electric vehicles (PHEVs) all over the world in a big way. The increased electrical demand brought on by the charging of electric vehicles puts a burden on the distribution network parameters like energy loss, voltage profile and thermal limits. Recently, renewable energy-based distribution generation (RDGs) units are firmly integrated with the transmission and distribution system networks to lower the carbon footprint generated due to conventional thermal power plants.

Evaluate the Role of Phosphodiesterase, Myeloperoxidase and Iron in Oral Cancer.

Objective: The present study aimed to estimate the levels of phosphodiesterase (PDE), myeloperoxidase (MPO) and iron levels in patients with oral cancer.

Method: 50 patients reporting to the Department of Oral Medicine and Radiology A.B.

Pharyngeal airway dimensions and hyoid bone position in children with class II malocclusion and sleep problems: A cross sectional study.

Objective: To evaluate the pharyngeal airway width and hyoid bone position in children with class II malocclusion and a positive history of sleep problems.

Methods: 60 children aged 8-12 years with skeletal class II malocclusion were segregated into two groups according to the existence of sleep problems: 30 participants with sleep disorders constituted the study group, while 30 participants without sleep disorders formed the control group. Pharyngeal airway space and hyoid bone position were evaluated via a clinical and radiographic examination.

Serum Biomarker for Cardiovascular Disease Risk Assessment in Patients With Diabetic Nephropathy.

Background & Objective: The objective of this study was to compare serum sirtuin 1 level in diabetic nephropathy patients with or without coronary artery disease. Methods: In this cross-sectional study, 108 diabetic nephropathy patients were included, among which 54 were diagnosed with coronary artery disease based on coronary angioplasty, lipid profile, drug details, and case history, while 54 were without coronary artery disease. Patients above 18 years with nephropathy, as per spot microalbuminuria test, were included.

Evaluation of Posterior Superior Alveolar Canal in Individuals With Cleft Lip and Palate Using Cone Beam Computed Tomography.

Objective: To evaluate the posterior superior alveolar canal (PSAC) in individuals with cleft lip and palate (CLP) by comparing them with individuals with no cleft lip and palate (NC) using cone beam computed tomography (CBCT).

Setting: This is a cross-sectional, analytical study with a prospective sample.

Patients, Participants: CBCT scans of 29 individuals with no cleft and palate (Group I) and 29 individuals with cleft lip and palate (Group II) were used.

Effectiveness of Exercise-Based Interventions on Fatigue among Head and Neck Cancer Patients on Radiotherapy: Systematic Review with Meta-Analysis.

Objectives: Fatigue is a significant challenge among head and neck cancer patients undergoing radiotherapy, impacting their well-being and daily functioning. Exercise-based interventions hold promise in alleviating this fatigue burden. This systematic review aims to evaluate the effectiveness of exercise-based interventions on fatigue among patients with head and neck cancer receiving radiotherapy.

Longitudinal Evaluation of Developmental Protein Malnutrition Resembling Marasmic-Kwashiorkor Condition in Wistar Rats.

Objectives: Protein malnutrition (PMN) is a significant public health concern that can aggravate pathological states. The impact of early malnutrition on metabolism needs extensive evaluation. Current models employ short-term diet restriction and are neither ethically correct nor clinically relevant.

Gestational Diabetes and Analysis of Maternal and Fetal Outcomes Among Pregnant Women: A Cross-Sectional Study.

Purpose Of The Study: To determine the occurrence of gestational diabetes mellitus and analyze the maternal and fetal outcomes among pregnant women.

Methods: A prospective cross-sectional study was conducted for a duration of 7 months in the Department of Gynecology and Obstetrics at tertiary care hospital where 518 pregnant women participants of age above 18 years who had come for labor and undergone DIPSI (diabetes in pregnancy study of India) test were included in the study after the ethical clearance and obtaining written informed consent, whereas pregnant women with pre-existing diabetes mellitus and on other medication that alter glucose metabolism were excluded from the study.

Results: The occurrence of GDM was found to be 15.

Association of Unsafe Sexual Behavior with Head and Neck Cancer: A Bibliometric Analysis.

Inappropriate sexual practice like oral sex has been linked with head and neck cancer (HNC). The recent data revealed that about 20% oropharyngeal caner among Indians are associated with oral sex. Thus, we aimed to comprehensively assess the trend of research in oral sex associated with HNC and to predict the research frontiers and potential hotspots in the near future.

Formulation and Characterization of RBCS Coated Carboplatin Loaded Nano-Liposomal Formulation for Managing Breast Cancer.

Cell membrane-coated Nano-Liposomes (CM-NLPs) offer a promising approach that combines the advantages of both host cells and synthetic nano-liposomes (NLPs). This technique involves coating liposomes with red blood cell (RBC) membranes to enhance their functionality. In this study, novel carboplatin-loaded NLPs (CP-NLPs) were formulated using phospholipids (Soya Phosphatidyl Choline) and cholesterol through the thin-film hydration method, and optimized using a 3 full factorial design.