393 results match your criteria: "Nishtar Medical University.[Affiliation]"

This case report highlights the clinical complexity of Bardet-Biedl syndrome, a rare autosomal recessive disorder, emphasizing reproductive anomalies to aid in diagnosis and management. It underscores the importance of thorough assessment and advocates for genetic testing to optimize care, despite current financial, and laboratory constraints.

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Climate change represents an unprecedented global public health crisis with extensive and profound implications. The Lancet Commission identified it as the foremost health challenge of the 21st century. In 2015, air pollution alone caused approximately 9 million premature deaths worldwide.

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Renal fibrosis is a hallmark of chronic kidney disease, characterized by the excessive accumulation of extracellular matrix proteins. Sulforaphane, a potent antioxidant found in cruciferous vegetables, has shown promise in targeting renal fibrosis. By inhibiting fibrotic pathways, such as TGF-β signaling, and promoting antioxidant defenses, sulforaphane may offer a novel therapeutic strategy for mitigating kidney damage and slowing disease progression.

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Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia, insulin resistance, and decreased insulin secretion. With its rising global prevalence, effective management strategies are critical to reducing morbidity and mortality. This systematic review compares the efficacy, safety, and long-term outcomes of four major pharmacological treatments for T2DM: sodium-glucose cotransporter-2 (SGLT2) inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors, metformin, and insulin.

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This systematic review provides a comprehensive comparison of beta-blockers and angiotensin-converting enzyme (ACE) inhibitors in the management of chronic heart failure (CHF), with a focus on their long-term efficacy and safety profiles. By synthesizing evidence from randomized controlled trials (RCTs) and clinical studies, the review highlights the significant benefits of both drug classes in reducing mortality and hospital readmissions, and improving patient outcomes. Beta-blockers, such as bisoprolol and carvedilol, demonstrated superior efficacy in reducing sudden cardiac death, particularly in patients with heart failure with reduced ejection fraction (HFrEF).

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Background Sepsis is a challenging condition, especially in patients with malignancy, that is associated with worse mortality and increased complications. This study aimed to analyze the prevalence of sepsis, its complications, healthcare outcomes, and associated organism-specific mortality in patients with colorectal carcinoma using the National Inpatient Sample database. Methodology We included patients aged >18 years with a primary diagnosis of colon cancer.

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Objectives Emotional intelligence (EI) refers to the ability to perceive, understand, and manage emotions effectively, a skill essential in the high-stress environment of healthcare. Research suggests that healthcare professionals with higher EI are better equipped to handle stress, maintain resilience, and make sound judgments under pressure, ultimately enhancing job performance. This paper examines EI's predictive role in managing job performance and resistance to stress among healthcare professionals, aiming to explore how elevated EI may strengthen their coping abilities and contribute to improved stress management, professional judgment, and resilience in challenging work settings.

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Chronic kidney disease (CKD) has shown a growing association with osteoporosis, comprising part of the broader CKD-mineral and bone disorder (CKD-MBD). CKD-MBD is marked by alterations in calcium, phosphorus, parathyroid hormone (PTH), and vitamin D metabolism, significantly elevating fracture risk. While traditional osteoporosis treatments such as bisphosphonates, denosumab, and teriparatide have been adapted for CKD patients, recent innovations have introduced agents aimed at enhancing bone mass and reducing fracture incidence.

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This systematic review assessed the comparative effectiveness of surgical drainage techniques and postoperative interventions in reducing complications across various surgical fields. We conducted a comprehensive search across multiple databases, including PubMed, MEDLINE, Embase, the Cochrane Library, and CINAHL, covering studies from January 2019 to September 2024. Ten randomized controlled trials met our inclusion criteria, focusing on human surgical patients and comparing outcomes such as seroma, hematoma, infection rates, and postoperative pain.

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Article Synopsis
  • - Rasmussen aneurysm is a serious condition that can develop in tuberculosis patients, involving an aneurysm of a pulmonary artery next to a tuberculous cavity.
  • - This condition can cause sudden or severe bleeding from the lungs, known as hemoptysis, which is a medical emergency.
  • - Quick diagnosis and treatment, typically through a procedure called endovascular embolization, are crucial to prevent life-threatening complications.
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Small cell lung cancer with concurrent pleural effusion and superior vena cava obstruction is a rare presentation with high risk of respiratory and circulatory compromise warranting prompt and multidisciplinary treatment.

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Pulmonary tuberculosis with the simultaneous development of the complications of empyema, multiloculated pyopneumothorax, subcutaneous emphysema and pneumomediastinum is rare. The development of these complications leads to remarkably increased incidence of morbidity and mortality in patients. So appropriate and timely management needs to be ensured for better outcomes.

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Introduction And Importance: Odontoid fractures of the second cervical vertebra (C2) are categorized into three types, with type III extending into the body of the axis. These fractures, often resulting from high-energy trauma, can cause significant instability and neurological issues. This case report discusses a 43-year-old male with a type III odontoid fracture and C1-C2 fracture dislocation, demonstrating the effectiveness of traditional neurosurgical techniques in managing such complex injuries.

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Bilateral improvement in age-related macular degeneration following unilateral Aflibercept injection.

BMC Ophthalmol

December 2024

Department of Ophthalmology, Jinnah Hospital, Allama Shabbir Ahmad Usmani Road, Lahore, Punjab, 54550, Pakistan.

Article Synopsis
  • * Only the right eye of the patient received treatment due to financial limitations, yet both eyes showed significant visual improvement within weeks, suggesting the potential benefits of this effect.
  • * The findings point to the need for further research on anti-VEGF therapies, personalized treatment plans, and highlight the urgency of accessible AMD treatments in developing countries, especially after recent treatment restrictions in Pakistan.
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Article Synopsis
  • Cancer is predicted to rise significantly, with 35 million new cases expected by 2050, mainly impacting low- and middle-income countries, particularly in the SAARC region.
  • There is a research investment and output gap in SAARC countries compared to high-income nations, leaving a lack of local studies and clinical trials in crucial areas like targeted therapy and immunotherapy.
  • Addressing the challenges of healthcare access, cultural and economic barriers, and limited funding in SAARC countries requires collaboration, improved research infrastructure, and local studies to develop practical and affordable cancer treatments.
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Article Synopsis
  • - The South Asian region faces a critical shortage of oncology professionals due to inadequate education and training programs, impacting the quality of cancer care.
  • - Challenges for oncology workers include lack of trained personnel, poor healthcare infrastructure, and limited educational resources.
  • - The paper suggests both short-term strategies to enhance training and long-term goals to create self-sufficient cancer care systems through regional collaboration and innovative education.
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Article Synopsis
  • Cancer care in SAARC countries faces major challenges like poor infrastructure, lack of skilled professionals, and economic issues, leading to delayed diagnoses and worse health outcomes.
  • There are significant disparities in healthcare systems across the region, with some countries providing free public services while others rely heavily on out-of-pocket payments, creating financial inequities for cancer patients.
  • To improve cancer care, coordinated efforts are needed, including better infrastructure, expanded health insurance, and national cancer control programs, along with regional collaboration to ensure equitable access and advance health goals.
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Article Synopsis
  • * In 2022, cancer accounted for about 9.3% of global cases and 12% of deaths in this region, with major cancers including lung, head and neck, gastrointestinal, cervical, and breast cancers.
  • * The text emphasizes the need for regional collaboration to create an effective cancer control plan, stressing the importance of strong political commitment to tackle the growing cancer crisis and align with Sustainable Development Goals for 2030.
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Background and aim The study aimed to address the need for reliable and non-invasive biomarkers (NIBM) for detecting fibrosis among patients with chronic liver disease (CLD). Material and methods This was a diagnostic validation study executed at the Department of Gastroenterology, Jinnah Hospital, Lahore. The study was carried out from July 2023 to June 2024, enrolling a total of 88 patients using non-probability consecutive sampling.

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