65 results match your criteria: "Ningbo Municipal Hospital of Traditional Chinese Medicine[Affiliation]"

Immunomodulatory insights of monoterpene glycosides in endometriosis: immune infiltration and target pathways analysis.

Hereditas

January 2025

Emergency Department, Ningbo Municipal Hospital of Traditional Chinese Medicine, Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, Zhejiang Province, China.

Endometriosis is a complex gynecological condition characterized by abnormal immune responses. This study aims to explore the immunomodulatory effects of monoterpene glycosides from Paeonia lactiflora on endometriosis. Using the ssGSEA algorithm, we assessed immune cell infiltration levels between normal and endometriosis groups.

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Transdermal delivery of natural products against atopic dermatitis.

Chin J Nat Med

December 2024

Department of Pharmacy, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo 315010, China. Electronic address:

Atopic dermatitis (AD) is a chronic inflammatory skin condition. Natural products have gained traction in AD treatment due to their accessibility, low toxicity, and favorable pharmacological properties. However, their application is primarily constrained by poor solubility, instability, and limited permeability.

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Objective: Obesity has become a significant public health concern, strongly linked to various diseases, particularly gynecologic and breast cancers. This bibliometric review aims to analyze global research trends on overweight women, particularly those with gynecologic and breast cancers, to identify research hotspots, key contributors, and emerging areas of study.

Methods: A comprehensive bibliometric analysis was conducted using the Web of Science Core Collection (WoSCC) database, covering the period from January 2013 to September 2024.

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Tetrastigma hemsleyanum (TH) has attracted much attention for its heat clearing and detoxification effects, but whether it can become an effective feed supplement in chickens remains unclear. Herein, a total of 120 male Jinhua yellow chickens (two-mth-old) were randomly divided into into four groups (CON, TH-L, TH-M, and TH-H) for a 56-day feeding trial to explore its effects on growth performance and underlying mechanism. Results revealed that dietary TH notably increased the average daily growth (ADG), and decreased the average daily feed intake (ADFI) and feed conversion ratio (FCR) in TH-H group during 29-56 days.

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Predictive value of Der p 2-specific IgE for subcutaneous immunotherapy in children with allergic rhinitis.

Sci Rep

October 2024

Department of Otorhinolaryngology, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, No. 819 Liyuan Roa, Haishu District, Ningbo, 315012, China.

Dermatophagoides pteronyssinus (Der p) subcutaneous immunotherapy (SCIT) has demonstrated efficacy in clinical trials of childhood allergic rhinitis (AR). Currently, there is a lack of some generally accepted biomarkers that may predict the clinical response to SCIT to eventually achieve personalized therapy. In this study, 28 children with AR received Der p SCIT for 26-30 months at baseline, and four efficacy endpoints, serum interleukin (IL)-5, periostin, Der p-specific IgE (sIgE), and Der p sIgG4, were measured by ELSIA.

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Analysis of riociguat and desmethyl riociguat by UPLC-MS/MS and its interaction with quercetin.

Front Pharmacol

September 2024

Department of Pharmacy, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, China.

Article Synopsis
  • Riociguat is a medication used for treating pulmonary hypertension and a new method was developed to accurately measure its levels and its metabolite in plasma.
  • The study also explored the interaction between riociguat and quercetin, a compound known for its anticancer properties that may help with pulmonary hypertension symptoms.
  • Results indicated that quercetin significantly hinders the metabolism of riociguat and its metabolite in rats, leading to higher levels of these substances in the bloodstream.
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Green Synthesis of Dracocephalum kotschyi-Coated Silver Nanoparticles: Antimicrobial, Antioxidant, and Anticancer Potentials.

Med Sci Monit

October 2024

Department of Pharmacy, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, Zhejiang, China.

BACKGROUND The environmentally friendly production of silver nanoparticles (AgNPs) has gained significant attention as a sustainable alternative to traditional chemical methods. This study focused on synthesizing AgNPs using extract of Dracocephalum kotschyi (D. kotschyi), a medicinal plant.

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Hair follicle-targeted delivery for hair recoloration using scalp-curvature-conforming microneedles based on sodium alginate and polyvinylpyrrolidone.

Int J Biol Macromol

September 2024

Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Jinhua Institute of Zhejiang University, Jinhua 321000, China; Institute of Innovation and Entrepreneurship, Zhejiang University, Hangzhou 310018, China; Jiangsu Engineering Research Center for New-type External and Transdermal Preparations, Changzhou 213149, China. Electronic address:

Article Synopsis
  • Hair-related disorders are a significant concern for both scientists and the public, and microneedle technology shows potential for targeted drug delivery to hair follicles.
  • The study developed flexible microneedles made from sodium alginate and polyvinylpyrrolidone that adapt to the curvature of the scalp, enhancing drug delivery effectiveness.
  • Animal tests indicate that these flexible microneedles successfully deliver Psoralea corylifolia extract, potentially preventing hair graying associated with vitiligo.
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Safety and effectiveness of a drug-loaded haemostatic sponge in chronic rhinosinusitis: a randomized, controlled, double-blind study.

Sci Rep

September 2024

Department of Otorhinolaryngology, Ningbo Municipal Hospital of Traditional Chinese Medicine(TCM), Affiliated Hospital of Zhejiang Chinese Medical University, No. 819 Liyuan Roa, Haishu District, Ningbo, 315012, China.

Some cases of chronic rhinosinusitis (CRS) require surgical treatment and postoperative nasal packing, but bleeding and adhesion are common complications after nasal surgery. Biodegradable drug-loaded implants hold great therapeutic options for the treatment of CRS, but little data are available regarding the safety and efficacy of a novel drug-loaded haemostatic sponge (DLHS) in the sinus. The aim of this study was to investigate the safety and efficacy of DLHS in the sinus.

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Article Synopsis
  • - A study evaluated the real-world outcomes of fruquintinib in patients with metastatic colorectal cancer (mCRC), showing median progression-free survival (PFS) of 6.3 months and overall survival (OS) of 12.6 months from January 2020 to July 2022.
  • - Key independent predictors for overall survival included the presence of brain metastasis, a decrease in skeletal muscle index (SMI) of over 5%, and elevated carcinoembryonic antigen (CEA) levels, suggesting these factors could help predict patient outcomes.
  • - The treatment was generally safe, with hypertension, fatigue, and hand-foot syndrome being the most common side effects, and the study found that real
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Exosome-like nanoparticles derived from fruits, vegetables, and herbs: innovative strategies of therapeutic and drug delivery.

Theranostics

September 2024

State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Over the past ten years, significant advancements have been made in exploring plant-derived exosome-like nanoparticles (PELNs) for disease therapeutics and drug delivery. PELNs, as inherent nanoscale particles comprised of proteins, lipids, nucleic acids, and secondary metabolites, exhibit the capacity for cellular uptake by human cells. This intercellular interaction transcends biological boundaries, effectively influencing biological functions in animals.

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Severe pneumonia with empyema due to multiple anaerobic infections: case report and literature review.

Front Med (Lausanne)

August 2024

Department of Nephrology, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, China.

Article Synopsis
  • A 67-year-old man who was bedridden developed severe pneumonia and empyema from infections caused by bacteria that usually live in the mouth.
  • Diagnosing his condition was tough using regular tests, but advanced sequencing methods found the specific bacteria causing the infection.
  • After being treated with medication, the man's breathing problems got better, showing that the new testing method is really helpful in finding out what's wrong when regular tests don't work.
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Background: Smartphone distraction considerably affects the depression level of college students. These two variables are highly associated with social withdrawal and digital distress. However, the underlying mechanisms of how social withdrawal and digital stress were involved in the relationship between smartphone distraction and depression remain unclear.

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Background: The association between serological indexes and occurrence of complications in patients with autoimmune gastritis (AIG) remains unclear.

Methods: 91 patients with AIG were recruited and their clinical information were collected. The differences between serological indexes and complications of AIG were analyzed.

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Single-dose of integrated bilayer microneedles for enhanced hypertrophic scar therapy with rapid anti-inflammatory and sustained inhibition of myofibroblasts.

Biomaterials

January 2025

College of Pharmaceutical Sciences, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, China; State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China; Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, 315010, China; Jinhua Institute of Zhejiang University, Jinhua, 321000, China; Jiangsu Engineering Research Center for New-type External and Transdermal Preparations, Zhejiang University, Hangzhou, 310058, China. Electronic address:

Hypertrophic scar (HS) tends to raised above skin level with high inflammatory microenvironment and excessive proliferation of myofibroblasts. The HS therapy remains challenging due to dense scar tissue which makes it hard to penetrate, and the side effects resulting from intralesional corticosteroid injection which is the mainstay treatment in clinic. Herein, bilayer microneedle patches combined with dexamethasone and colchicine (DC-MNs) with differential dual-release pattern is designed.

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Global, regional, and national burden of cancers attributable to occupational risks from 1990 to 2019.

J Occup Health

January 2024

Department of Oncology, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, Zhejiang, China.

Background: Based on data from the Global Burden of Disease study, the burden of cancer attributable to occupational risks between 1990 and 2019 was explored.

Methods: The estimated burden in different regions was compared in terms of the age-standardized death rates (ASDRs), age-standardized disability-adjusted life years (DALYs) rates, and corresponding estimated annual percentage changes (EAPCs). The comparative risk assessment framework was used to estimate the risk of death and DALYs attributable to occupational risk factors.

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Background: Proton pump inhibitors (PPIs) are commonly prescribed for treating upper gastrointestinal hemorrhage, eradicating Helicobacter pylori, and stress ulcer prophylaxis, among other digestive system diseases. Recent case reports provided limited evidence of a correlation between PPIs and drug reactions with eosinophilia and systemic symptoms (DRESS). However, there is currently no established association between PPIs and DRESS.

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Background: Resistance to cisplatin (DDP) in patients with ovarian cancer (OC) poses a great challenge to improving the quality of life of patients. Past reports have revealed that naringin can induce apoptosis of OC cells and delay the occurrence of drug resistance in OC cells. However, the molecular role by which naringin inhibits DDP resistance in OC has not been definitively proven by researchers.

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Objective: This study endeavors to translate and psycho-metrically validate the metacognitive awareness inventory scale (MAS) for nursing students in China.

Method: A total of 592 nursing students were enlisted from four universities situated in the eastern, southern, western, and northern regions of China. Content validity and reliability were evaluated using the content validity index and item-total correlation coefficient, and Cronbach's alpha coefficients, respectively.

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Diagnostic value of retinol-binding protein 4 in diabetic nephropathy: a systematic review and meta-analysis.

Front Endocrinol (Lausanne)

May 2024

Department of Clinical Laboratory, Ningbo Municipal Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Ningbo, China.

Objective: Diabetic nephropathy (DN) is a major microvascular complication of diabetes and the leading cause of end-stage renal disease. Early detection and prevention of DN are important. Retinol-binding protein 4 (RBP4) has been considered as a single diagnostic marker for the detection of renal impairment.

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Chinese herbal medicine (CHM) is integral to a traditional Chinese medicine (TCM) system. Accurately identifying Chinese herbal medicine is crucial for quality control and prescription compounding verification. However, with many Chinese herbal medicines and some with similar appearances but different therapeutic effects, achieving precise identification is a challenging task.

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Knowledge, attitudes and practices towards community-acquired pneumonia and COVID-19 among general population: a cross-sectional study.

Antimicrob Resist Infect Control

January 2024

Department of Radiology, Ningbo Municipal Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Ningbo, 315010, China.

Background: This study aimed to assess the knowledge, attitudes, and practices (KAP) of the general population to community-acquired pneumonia (CAP) and COVID-19.

Methods: A cross-sectional study was conducted between September 2022 and February 2023, involving the general population from Ningbo Municipal Hospital of Traditional Chinese Medicine with a self-developed questionnaire.

Results: A total of 637 valid questionnaires were collected, with the majority of participants being female (62.

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Sodium butyrate alleviates right ventricular hypertrophy in pulmonary arterial hypertension by inhibiting H19 and affecting the activation of let-7g-5p/IGF1 receptor/ERK.

Eur J Pharmacol

February 2024

College of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, China; Department of Pharmacy, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China; Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang, 453003, China; Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang, 453003, China. Electronic address:

Pulmonary arterial hypertension (PAH) is a complex and fatal cardio-pulmonary vascular disease. Decompensated right ventricular hypertrophy (RVH) caused by cardiomyocyte hypertrophy often leads to fatal heart failure, the leading cause of mortality among patients. Sodium butyrate (SB), a compound known to reduce cardiac hypertrophy, was examined for its potential effect and the underlying mechanism of SB on PAH-RVH.

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Postmenopausal osteoporosis (PMOP) has become one of most frequent bone diseases worldwide with aging population. Lycii Fructus, a common plant fruit with the property of drug homologous food, has long since been used to treat PMOP. The aim of this study is to explore pharmacological mechanisms of Lycii Fructus against PMOP through using network pharmacology approach.

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