68 results match your criteria: "Ningbo Medical Center Li Huili Hospital[Affiliation]"

Background: Nurses face significant risks of excessive daytime sleepiness (EDS), which adversely affects workplace safety and productivity. Yet, the extent of EDS in this workforce remains inadequately characterized.

Aim: The aims of this systematic review were to assess the pooled prevalence of EDS among nurses.

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This study investigates the potential molecular mechanisms by which O-GlcNAc modification of YTHDF2 regulates the cell cycle and participates in intervertebral disc degeneration (IDD). We employed transcriptome sequencing to identify genes involved in IDD and utilized bioinformatics analysis to predict key disease-related genes. In vitro mechanistic validation was performed using mouse nucleus pulposus (NP) cells.

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Article Synopsis
  • * Various indicators, like neutrophil/lymphocyte ratio (NLR) and controlling nutritional status score (CONUT), were identified as strong predictors of severe conditions and mortality in these patients.
  • * These findings suggest that assessing nutritional status in COVID-19 patients is crucial, as it can help healthcare providers identify those at higher risk for critical outcomes and guide nutritional interventions.
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A Janus hydrogel that enables wet tissue adhesion and resists abdominal adhesions.

Mater Today Bio

October 2024

Ningbo Medical Center Li Huili Hospital, Health Science Center, Ningbo University, Ningbo, 315000, PR China.

Hydrogels have indeed achieved significant advancements, yet their clinical translation has been hampered by their inherent limitations in wet adhesion properties. Furthermore, the design of adhesive hydrogels that can resist postoperative adhesions remains an intricate challenge. In this study, we introduce a Janus hydrogel (JGP) that offers a novel approach to address these challenges.

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As the aging process progresses, age-related intervertebral disc degeneration (IVDD) is becoming an emerging public health issue. Site-1 protease (S1P) has recently been found to be associated with abnormal spinal development in patients with mutations and has multiple biological functions. Here, we discovered a reduction of S1P in degenerated and aging intervertebral discs, primarily regulated by DNA methylation.

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Background: Patients treated with anti-CD20 monoclonal antibodies could have a higher risk of adverse outcomes of coronavirus disease 2019 (COVID-19). The novel anti-CD20 monoclonal antibody obinutuzumab has shown greater B-cell depletion and superior in vitro efficacy than rituximab. We aimed to assess whether obinutuzumab would result in worse COVID-19 outcomes than rituximab.

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Article Synopsis
  • - The study focused on the nutritional status and body composition of head and neck cancer patients receiving complete nutritional support during surgery, using assessments like NRS 2002 and PG-SGA to evaluate factors related to weight loss and skeletal muscle mass (SMM).
  • - Patients with a low skeletal muscle index showed lower overall weight and body composition, and key nutritional markers (albumin, prealbumin, PNI, LMR) dropped post-surgery but improved by two weeks after surgery, while inflammatory markers like NLR and PLR increased.
  • - The findings indicate that adipose tissue loss happens before muscle loss post-operatively, and prealbumin levels can be an important indicator to monitor recovery in these patients.
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A bioinspired switchable adhesive patch with adhesion and suction mechanisms for laparoscopic surgeries.

Mater Today Bio

August 2024

Ningbo Medical Center Li Huili Hospital, Health Science Center, Ningbo University, Ningbo, 315000, PR China.

Medical adhesives play an important role in clinical medicine because of their flexibility and convenient operation. However, they are still limited to laparoscopic surgeries, which have demonstrated urgent demand for liver retraction with minimal damage to the human body. Here, inspired by the suction cup structure of octopus, an adhesive patch with excellent mechanical properties, robust and switchable adhesiveness, and biocompatibility is proposed.

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Aim: To evaluate the effect of sodium picosulfate/magnesium citrate (SPMC) and 3 L split-dose polyethylene glycol (PEG) with or without dimethicone on bowel preparation before colonoscopy.

Methods: In this multicenter, prospective, randomized, controlled study conducted from April 2021 to December 2021, consecutive adult patients scheduled for colonoscopy were prospectively randomized into four groups: SPMC, SPMC plus dimethicone, 3 L PEG, and 3 L PEG plus dimethicone. Primary endpoint was colon cleansing based on Boston Bowel Preparation Scale (BBPS).

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Comparing Outcomes of Thrombectomy Versus Intravenous Thrombolysis Based on Middle Cerebral Artery M2 Occlusion Features.

Stroke

June 2024

Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (H.Z., W.Z., T.Z., J.Y., M.L., S.Y.).

Background: Current evidence provides limited support for the superiority of endovascular thrombectomy (EVT) in patients with M2 segment middle cerebral artery occlusion. We aim to investigate whether imaging features of M2 segment occlusion impact the effectiveness of EVT.

Methods: We conducted a retrospective cohort study from January 2017 to January 2022, drawing data from the CASE II registry (Computer-Based Online Database of Acute Stroke Patients for Stroke Management Quality Evaluation), which specifically documented patients with acute ischemic stroke presenting with M2 segment occlusion undergoing reperfusion therapy.

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Macrophage-Derived GSDMD Plays an Essential Role in Atherosclerosis and Cross Talk Between Macrophages via the Mitochondria-STING-IRF3/NF-κB Axis.

Arterioscler Thromb Vasc Biol

June 2024

Department of Cardiology and The Key Laboratory of Cardiovascular Disease of Wenzhou, The First Affiliated Hospital, Wenzhou Medical University, Zhejiang, China (X.F., L.Z., R.S., Y.Z., Z.H., W.H., X.C., B.Y.).

Background: Macrophages play a crucial role in atherosclerotic plaque formation, and the death of macrophages is a vital factor in determining the fate of atherosclerosis. GSDMD (gasdermin D)-mediated pyroptosis is a programmed cell death, characterized by membrane pore formation and inflammatory factor release.

Methods: and mice, bone marrow transplantation, and AAV (adeno-associated virus serotype 9)-F4/80-shGSDMD (shRNA-GSDMD) were used to examine the effect of macrophage-derived GSDMD on atherosclerosis.

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Mrgprb2-mediated mast cell activation exacerbates Modic changes by regulating immune niches.

Exp Mol Med

May 2024

Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3, Qingchun Road East, Hangzhou, 310016, P. R. China.

Modic changes are radiographic features associated with microfracture, low-virulence organism infection and chronic inflammation with inflammatory cell infiltration in the vertebral endplate region. Mast cells, as innate immune cells similar to macrophages, are present in painful degenerated intervertebral discs. However, the involvement and mechanisms of mast cells in the development of Modic changes remain unclear.

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Background: Cuproptosis is a newly identified form of unprogrammed cell death. As a pivotal metabolic regulator, glutaminase (GLS) has recently been discovered to be linked to cuproptosis. Despite this discovery, the oncogenic functions and mechanisms of GLS in various cancers are still not fully understood.

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FATP2 regulates osteoclastogenesis by increasing lipid metabolism and ROS production.

J Bone Miner Res

July 2024

Department of Orthopaedic Surgery, Zhejiang University School of Medicine, Sir Run Run Shaw Hospital, Hangzhou, 310016, Zhejiang, China.

Lipid metabolism plays a crucial role in maintaining bone homeostasis, particularly in osteoclasts (OCs) formation. Here, we found that the expression level of FATP2, a transporter for long-chain and very-long-chain fatty acids, was significantly upregulated during OC differentiation and in the bone marrow of mice fed a high-fat diet (HFD). Notably, the use of FATP2 siRNA or a specific inhibitor (Lipofermata) resulted in significant inhibition of OC differentiation, while only slightly affecting osteoblasts.

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Article Synopsis
  • A multitask deep learning model was developed to predict microvascular invasion (MVI) and recurrence-free survival (RFS) in hepatocellular carcinoma (HCC) using preoperative MRI scans from 725 patients.
  • The model demonstrated high accuracy in predicting MVI, with AUC values ranging from 0.800 to 0.918 across training and external test sets, and improved radiologists' performance when utilized.
  • For RFS predictions, the model achieved moderate C-index values, indicating potential clinical utility, especially for patients at high risk of MVI and low survival scores, suggesting a need for further prospective studies.
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Biomimetic zwitterionic copolymerized chitosan as an articular lubricant.

Carbohydr Polym

April 2024

Cixi Biomedical Research Institute, Wenzhou Medical University, Zhejiang 315300, PR China; Zhejiang International Scientific and Technological Cooperative Base of Biomedical Materials and Technology, Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, PR China; Ningbo Cixi Institute of Biomedical Engineering, Ningbo 315300, PR China. Electronic address:

Restoration of the lubrication functions of articular cartilage is an effective treatment to alleviate the progression of osteoarthritis (OA). Herein, we fabricated chitosan-block-poly(sulfobetaine methacrylate) (CS-b-pSBMA) copolymer via a free radical polymerization of sulfobetaine methacrylate onto activated chitosan segment, structurally mimicking the lubricating biomolecules on cartilage. The successful copolymerization of CS-b-pSBMA was verified by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and H nuclear magnetic resonance.

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Background: Although cervical intervertebral disc (IVD) degeneration is closely associated with neck pain, its cause remains unclear. In this study, an animal model of cervical disc degeneration and discogenic neck pain induced by a low concentration of Propionibacterium acnes (P. acnes-L) is investigated to explore the possible mechanisms of cervical discogenic pain.

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Recent research advances on polysaccharide-, peptide-, and protein-based hemostatic materials: A review.

Int J Biol Macromol

March 2024

Ningbo Medical Center Li Huili Hospital, Health Science Center, Ningbo University, Ningbo 315000, PR China. Electronic address:

Hemorrhage is a potentially life-threatening emergency that can occur at any time or place. Whether traumatic, congenital, surgical, disease-related, or drug-induced, bleeding can lead to severe complications or death. Therefore, the development of efficient hemostatic materials is critical.

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Smart hydrogels responsive to external stimuli are promising for various applications such as soft robotics and smart devices. High mechanical strength and fast response rate are particularly important for the construction of hydrogel actuators. Herein, tough hydrogels with rapid response rates are synthesized using vinyl-functionalized poly(N-isopropylacrylamide) (PNIPAM) microgels as macro-crosslinkers and N-isopropylacrylamide as monomers.

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The beneficial effects of probiotics have been studied in inflammatory bowel disease, nonalcoholic steatohepatitis, and alcoholic liver disease (ALD). Probiotic supplements are safer and more effective; however, their potential mechanisms are unclear. An objective of the current study was to examine the effects of extracellular products of on acute alcoholic liver injury.

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Hepatocellular carcinoma (HCC) is a prevalent malignancy and there is a lack of effective biomarkers for HCC diagnosis. Living organisms are complex, and different omics molecules interact with each other to implement various biological functions. Genomics and metabolomics, which are the top and bottom of systems biology, play an important role in HCC clinical management.

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Clinical characteristics and outcomes of COVID-19 infection in Chinese patients with hematologic malignancies in the Omicron era.

Hematology

December 2023

Department of Hematology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

Article Synopsis
  • - Patients with hematologic cancers are more vulnerable to severe COVID-19, especially when they are older, have multiple health issues, or are receiving cancer treatment.
  • - Analysis showed that severe cases had low lymphocyte and albumin levels but high levels of D-dimer and other inflammatory markers.
  • - About 18.7% of these patients experienced long-lasting symptoms, and the inactivated vaccine did not seem to improve disease severity, highlighting the potential lack of effective immunity in these individuals.
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Objective: Today, the emergence of with the gene cassette in patients has presented a significant clinical challenge.

Methods: To present the detailed genetic features of the gene cassette of strain F4_plasmid pA, the whole bacterial genome was sequenced by Illumina and nanopore platforms, and mobile genetic elements related to antibiotic resistance genes were analyzed with a series of bioinformatics methods.

Results: strain F4 was determined to be a class A+C beta-lactamase, and was resistant to routinely used antibiotics, especially tigecycline, because of the gene localized on the F4_chromosome and on F4_plasmid A.

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Article Synopsis
  • Tongue cancer affects essential functions like chewing and swallowing, leading to challenges in eating, especially for patients undergoing treatments like radiotherapy and chemotherapy.
  • A comprehensive nutritional assessment was conducted for a patient experiencing dysphagia and feeding reflux, resulting in personalized nutritional programs and the use of thickening agents to facilitate oral feeding.
  • Ultimately, the patient successfully transitioned to eating five meals a day, with significant weight and albumin improvements, highlighting the importance of multidisciplinary teamwork in nutritional management for better quality of life.
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  • Angiogenesis and energy metabolism through exosomes from adipose mesenchymal stem cells (AMSC-exos) show potential as therapies for vascular diseases.
  • This study focused on the therapeutic effects of AMSC-exos on human umbilical vein endothelial cells (HUVECs) affected by oxygen and glucose deprivation (OGD), involving a specific pathway (SIX1/HBO1) that enhances cell function.
  • Results showed that AMSC-exos help HUVECs survive and improve their ability to form new blood vessels by enhancing glycolysis and reducing cell injury, suggesting a promising approach for treating ischemic diseases.
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