161 results match your criteria: "Ningbo Eye Hospital[Affiliation]"

The increasing prevalence of LED technology heightened blue light (BL) exposure, raising concerns about its long-term effects on ocular health. This study investigated the transcriptomic response of conjunctiva to BL exposure, highlighting potential biomarkers for conjunctival injury. We exposed human conjunctival epithelial cells and C57BL/6 mice to BL to establish in vitro and in vivo models and identified the responsive genes in mice's conjunctiva to BL exposure by RNA sequencing transcriptome analysis.

View Article and Find Full Text PDF

Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease.

Invest Ophthalmol Vis Sci

December 2024

State Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: The purpose of this study was to investigate the potential roles of endoplasmic reticulum (ER) stress in the development of dry eye disease (DED).

Methods: Single-cell RNA sequencing (scRNA-seq) data from the Gene Expression Omnibus (GEO) database, derived from corneal tissues of a dry eye mouse model, was processed using the Seurat R program. The results were validated using a scopolamine-induced dry eye mouse model and a hyperosmotic-induced cell model involving primary human corneal epithelial cells (HCECs) and immortalized human corneal epithelial (HCE-2) cells.

View Article and Find Full Text PDF

Background: Visual impairments (VI) are common in the older adults and may affect cognitive functions through mechanisms such as reduced sensory input and increased social isolation. Although current understanding of this association is incomplete, evidence suggests a potential link between poor vision and cognitive decline. This study aims to investigate the relationship between Subjective Visual Impairment (SVI), Objective Visual Impairment (OVI), and cognitive decline in the older adults, and assess whether these associations remain significant after controlling for multiple confounding factors.

View Article and Find Full Text PDF

Background: Systemic diseases, such as cardiovascular and cerebrovascular conditions, pose significant global health challenges due to their high mortality rates. Early identification and intervention in systemic diseases can substantially enhance their prognosis. However, diagnosing systemic diseases often necessitates complex, expensive, and invasive tests, posing challenges in their timely detection.

View Article and Find Full Text PDF

Background: This study aims to explore the effects of the iris-ciliary angle (ICA) on the accurate prediction of the vault after implantable collamer lens (ICL) using the manufacturer's online calculation and ordering system (OCOS).

Methods: The participants were categorized into three groups according to the size of ICA as follows: narrow ICA group (< 40°); normal ICA group (40°-60°); wide ICA group (> 60°). We compared the preoperative ocular characteristics and postoperative vault at 3 months among the three groups.

View Article and Find Full Text PDF

Effects of eyelid pressure on corneal tomography and biomechanics: Quantitative analysis using a novel blepharo-tensiometer.

Cont Lens Anterior Eye

December 2024

National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China; National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China. Electronic address:

Article Synopsis
  • The study aimed to validate a blepharo-tensiometer and examine the link between eyelid pressure (ELP) and corneal health metrics like tomography and biomechanics.
  • Researchers evaluated the repeatability and reproducibility of the tensiometer across different angles and operators while measuring various ocular parameters in 36 eyes from different subjects.
  • Results indicated the tensiometer had good precision, showing that increased ELP correlates with improved corneal biomechanical properties, which could have implications for understanding corneal disorders.
View Article and Find Full Text PDF

DeepMonitoring: a deep learning-based monitoring system for assessing the quality of cornea images captured by smartphones.

Front Cell Dev Biol

August 2024

Ningbo Key Laboratory of Medical Research on Blinding Eye Diseases, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, China.

Smartphone-based artificial intelligence (AI) diagnostic systems could assist high-risk patients to self-screen for corneal diseases (e.g., keratitis) instead of detecting them in traditional face-to-face medical practices, enabling the patients to proactively identify their own corneal diseases at an early stage.

View Article and Find Full Text PDF

Promoting smartphone-based keratitis screening using meta-learning: A multicenter study.

J Biomed Inform

September 2024

Ningbo Key Laboratory of Medical Research on Blinding Eye Diseases, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo 315040, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China. Electronic address:

Objective: Keratitis is the primary cause of corneal blindness worldwide. Prompt identification and referral of patients with keratitis are fundamental measures to improve patient prognosis. Although deep learning can assist ophthalmologists in automatically detecting keratitis through a slit lamp camera, remote and underserved areas often lack this professional equipment.

View Article and Find Full Text PDF

Efficacy and Safety of Efdamrofusp Alfa versus Aflibercept in Participants with Neovascular Age-Related Macular Degeneration: A Randomized, Double-Masked, Active-Controlled, Noninferiority, Phase II Trial.

Ophthalmol Retina

August 2024

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Ophthalmic Diseases, Shanghai, China; Shanghai Key Laboratory of Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. Electronic address:

Article Synopsis
  • - The study aimed to compare the effectiveness and safety of efdamrofusp alfa with aflibercept in treating neovascular age-related macular degeneration (nAMD) through a randomized phase II trial involving 231 participants.
  • - Participants received either efdamrofusp alfa or aflibercept, with treatments administered monthly for the first three doses and then every eight weeks, measuring visual acuity changes over 52 weeks.
  • - Results showed that efdamrofusp alfa was as effective as aflibercept in improving vision, with similar rates of adverse effects, establishing its noninferiority in treatment outcomes.
View Article and Find Full Text PDF

CBX7 promotes choroidal neovascularization by activating the HIF-1α/VEGF pathway in choroidal vascular endothelial cells.

Exp Eye Res

October 2024

Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China; State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215006, China. Electronic address:

Vascular endothelial growth factor (VEGF) signaling is crucial for choroidal neovascularization (CNV), a major pathological feature of neovascular age-related macular degeneration (nAMD). Gene transcription of VEGF is mainly regulated by hypoxia-inducible factor 1-alpha (HIF-1α). The chromobox (CBX) family polycomb protein (Pc) subgroup includes CBX2, CBX4, CBX6, CBX7, and CBX8.

View Article and Find Full Text PDF

Automated early detection of acute retinal necrosis from ultra-widefield color fundus photography using deep learning.

Eye Vis (Lond)

August 2024

National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.

Article Synopsis
  • Acute retinal necrosis (ARN) is a serious eye condition caused by herpesvirus infections and can lead to significant vision loss if not diagnosed and treated quickly.
  • Researchers developed a deep learning model called DeepDrARN that uses ultra-widefield color fundus photography to effectively differentiate ARN from other forms of uveitis, utilizing a dataset of over 11,500 images.
  • DeepDrARN showed impressive performance, achieving high accuracy in identifying uveitis types and outperformed average ophthalmologists, suggesting it could be a valuable tool for timely diagnosis.
View Article and Find Full Text PDF

91 Circulating inflammatory proteins and the risk of age-related macular degeneration: A bidirectional Mendelian randomization study.

Int Immunopharmacol

September 2024

Department of Ophthalmology, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, China. Electronic address:

Previous observational studies have indicated a correlation between circulating inflammatory proteins and age-related macular degeneration (AMD), yet the causal nature of this relationship remains uncertain. This study aims to investigate the causal link between circulating inflammatory proteins and AMD utilizing a bidirectional two-sample Mendelian randomization approach. The findings indicated that elevated levels of four circulating inflammatory proteins, including C-C Motif Chemokine Ligand 11 (CCL11), Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1), TNF Superfamily Member 11 (TRANCE) and Vascular Endothelial Growth Factor A (VEGF-A) lead to the increased risk of AMD, while increased levels of two circulating inflammatory proteins, including Fibroblast Growth Factor 19 (FGF-19) and Interleukin 10 Receptor Subunit Alpha (IL-10RA), resulted in the decreased risk of AMD.

View Article and Find Full Text PDF

Malignant glaucoma treated by low-dose laser cycloplasty: a 1-year multicenter prospective non-comparative study.

Int J Ophthalmol

July 2024

National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China.

Aim: To report a one-year clinical outcomes of low-dose laser cycloplasty (LCP) among malignant glaucoma patients.

Methods: In this prospective, multicenter, non-comparative clinical study, participants with malignant glaucoma were recruited and underwent LCP at eight ophthalmic centers in China. Patients were followed up at 1wk, 1, 3, 6, and 12mo.

View Article and Find Full Text PDF

Deep learning for multi-type infectious keratitis diagnosis: A nationwide, cross-sectional, multicenter study.

NPJ Digit Med

July 2024

Ningbo Key Laboratory of Medical Research on Blinding Eye Diseases, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, 315000, China.

Article Synopsis
  • * The traditional diagnostic method, like corneal scraping cultures, is slow and often inaccurate, prompting the need for better solutions.
  • * This study introduces DeepIK, a deep learning system trained on over 23,000 slit-lamp images, which consistently outperforms existing algorithms in diagnosing various types of keratitis, aiding ophthalmologists in making faster and more accurate diagnoses.*
View Article and Find Full Text PDF

Objective: To observe the morphological characteristics of posterior scleral staphyloma (PSS) with or without macular retinoschisis (MRS) using optical coherence tomography (OCT). Additionally, the incidence and severity of other pathologic myopic maculopathy associated with posterior scleral staphyloma was also evaluated.

Methods: General information and OCT imaging data from 440 patients with posterior scleral staphyloma (PSS) and the PSS curvature > 20×10 μm were collected.

View Article and Find Full Text PDF

2-Ethylhexyl diphenyl phosphate (EHDPP) is a frequently utilized organophosphorus flame retardant (OPFR) and has been extensively detected in environmental media. Prolonged daily exposure to EHDPP has been linked to potential retinal damage, yet the adverse impacts on the retina are still generally underexplored. In this research, we explored oxidative stress, inflammation, and the activating mechanisms initiated by EHDPP in mouse retinal photoreceptor (661 W) cells following a 24 h exposure period.

View Article and Find Full Text PDF

With the advancement of retinal imaging, hyperreflective foci (HRF) on optical coherence tomography (OCT) images have gained significant attention as potential biological biomarkers for retinal neuroinflammation. However, these biomarkers, represented by HRF, present pose challenges in terms of localization, quantification, and require substantial time and resources. In recent years, the progress and utilization of artificial intelligence (AI) have provided powerful tools for the analysis of biological markers.

View Article and Find Full Text PDF

Background: The convergence of smartphone technology and artificial intelligence (AI) has revolutionized the landscape of ophthalmic care, offering unprecedented opportunities for diagnosis, monitoring, and management of ocular conditions. Nevertheless, there is a lack of systematic studies on discussing the integration of smartphone and AI in this field.

Main Text: This review includes 52 studies, and explores the integration of smartphones and AI in ophthalmology, delineating its collective impact on screening methodologies, disease detection, telemedicine initiatives, and patient management.

View Article and Find Full Text PDF

Aim: Conventional approaches to diagnosing common eye diseases using B-mode ultrasonography are labor-intensive and time-consuming, must requiring expert intervention for accuracy. This study aims to address these challenges by proposing an intelligence-assisted analysis five-classification model for diagnosing common eye diseases using B-mode ultrasound images.

Methods: This research utilizes 2064 B-mode ultrasound images of the eye to train a novel model integrating artificial intelligence technology.

View Article and Find Full Text PDF

Background: Cataracts, characterized by a decrease in vision due to the clouding of the lens, can progress to blindness in advanced stages. The rising incidence of cataract cases has led to a significant number of patients experiencing negative emotions associated with vision loss, thereby diminishing their quality of life. In clinical practice, it is imperative for healthcare professionals to consider the psychological well-being of cataract patients.

View Article and Find Full Text PDF

Multi-granularity learning of explicit geometric constraint and contrast for label-efficient medical image segmentation and differentiable clinical function assessment.

Med Image Anal

July 2024

Department of Eye and Vision Sciences, University of Liverpool, Liverpool, United Kingdom; Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom. Electronic address:

Automated segmentation is a challenging task in medical image analysis that usually requires a large amount of manually labeled data. However, most current supervised learning based algorithms suffer from insufficient manual annotations, posing a significant difficulty for accurate and robust segmentation. In addition, most current semi-supervised methods lack explicit representations of geometric structure and semantic information, restricting segmentation accuracy.

View Article and Find Full Text PDF

Background: To assess the age and timeline distribution of ocular axial length shortening among myopic children treated with photobiomodulation therapy in the real world situations.

Methods: Retrospective study of photobiomodulation therapy in Chinese children aged 4 to 13 years old where axial length measurements were recorded and assessed to determine effectiveness at two age groups (4 ∼ 8 years old group and 9 ∼ 13 years old group). Data was collected from myopic children who received photobiomodulation therapy for 6 ∼ 12 months.

View Article and Find Full Text PDF