272 results match your criteria: "Nihon University Itabashi Hospital[Affiliation]"

Aims: Direct oral anticoagulants (DOACs) are used to treat venous thromboembolism (VTE). However, their impact on thrombus regression and the clinical outcomes after 2-week post-therapy computed tomography (CT) monitoring remains unexplored. This study aimed to elucidate the characteristics of patients with VTE treated with individual DOACs, assess the incidence of clinical events, and evaluate their impact on pulmonary artery thrombus regression.

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: The 28-day mortality rate for septic shock is high, necessitating rapid and effective empiric antimicrobial therapy. In this study, we investigate whether the rate of catecholamine dose reduction in septic shock can indicate bacterial susceptibility to initial antimicrobial therapy or not. This retrospective observational study involved 108 adult patients with bacteraemia and septic shock admitted to the intensive care unit of Nihon University Itabashi Hospital between January 2017 and December 2023.

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Background: Motion correction (MC) is critical for accurate quantification of myocardial blood flow (MBF) and flow reserve (MFR) from F-flurpiridaz positron emission tomography (PET) myocardial perfusion imaging (MPI). However, manual correction is time consuming and introduces inter-observer variability. We aimed to validate an automatic MC algorithm for F-flurpiridaz PET-MPI in terms of diagnostic performance for predicting coronary artery disease (CAD).

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In prospective Japanese studies of pediatric renal tumors, 5-year event-free survival and overall survival (OS) for patients with nephroblastoma ranges from 75-90% and 89-97%, respectively. However, treatments strategies for recurrent nephroblastoma in Japanese patients remain unclear. This retrospective study aimed to inform the development of treatment strategies by analyzing the long-term results and side effects of salvage therapies for recurrent nephroblastoma in Japan.

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Impact of direct identification of bacteria in blood culture-positive specimens by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry on physician selection of antimicrobial therapy.

J Infect Chemother

October 2024

Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, 30-1 Oyaguchikamicho, Itabashi-ku, Tokyo, 173-8610, Japan; Department of Clinical Laboratory, Nihon University Itabashi Hospital, Itabashi-ku, Tokyo, 173-8610, Japan.

Background: Rapid identification of the causative organism in blood stream infections is essential for early initiation of appropriate antimicrobial therapy. Direct identification of bacteria in positive blood culture bottles using matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry is a promising application. A variety of direct identification methods have been reported; however, few studies have evaluated the impact of these methods on physician decision making regarding antimicrobial therapy.

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Objectives: This study was conducted to investigate factors involved in anaphylaxis related to diclofenac etalhyaluronate (DEH) [product name: Joyclu® (JCL)] (containing DEH and macrogol 400), which is used to treat patients with osteoarthritis.

Methods: Patients with osteoarthritis were divided into two groups that had (experienced patients) or had not experienced anaphylactic symptoms after JCL administration (non-experienced patients). Five tests performed to assess factors related to anaphylaxis consisted of a skin prick test (SPT) as the primary endpoint and the other tests including basophil activation test, allergen-specific IgE (sIgE) tests using enzyme-linked immunosorbent assay or immunochromatographic kits, and genetic study were secondary endpoints.

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Total knee arthroplasty (TKA) is a common surgical procedure to treat end-stage knee osteoarthritis. This study compared blood loss volume and other clinical outcomes between bicruciate-retaining (BCR) and bicruciate-stabilized (BCS) TKA. Ninety-seven participants who underwent unilateral TKA were enrolled.

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Article Synopsis
  • In Japan, a study was conducted on the safety and efficacy of ligelizumab, an anti-IgE monoclonal antibody, for treating chronic spontaneous urticaria (CSU) in patients who weren't responding well to H1-antihistamines.
  • The study, which included 66 adult participants, showed that while 80.3% experienced mild to moderate side effects, there were no severe adverse events or anaphylaxis, and only 6.1% stopped treatment due to side effects.
  • Significant improvements were noted: UAS7 scores improved quickly by Week 4 and continued to improve by Week 52, with 50% of patients achieving no symptoms, and a notable increase in quality of life
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Background: Salvage robot-assisted radical prostatectomy (sRARP) after PSA failure in patients who underwent initial radiotherapy or focal therapy has rarely been reported in Japan. We aimed to report the oncologic and functional outcomes of the first 10 cases of sRARP.

Methods: Ten patients underwent sRARP after failing to respond to initial radiotherapy or focal therapy.

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Background: Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are crucial for ending the pandemic of coronavirus disease 2019 (COVID-19). Currently, the cumulative effect of booster shots of mRNA vaccines on adverse events is not sufficiently characterized.

Methods: A survey-based study on vaccine adverse events was conducted in a Japanese medical institute after the third dose of Pfizer BNT162b2.

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Article Synopsis
  • Major bleeding events in patients with atrial fibrillation (AF) using oral anticoagulants (OACs) were linked to worse long-term clinical outcomes, particularly major adverse cardiac and cerebrovascular events (MACCE).
  • Analysis of two large prospective registries found that 4.5% of AF patients experienced major bleeding, which significantly increased their risk of MACCE compared to those without bleeding.
  • Key factors predicting major bleeding included older age and the use of vitamin K antagonists and antiplatelet drugs; thus, minimizing bleeding risk could enhance clinical outcomes for these patients.
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Children with acute lymphocytic leukemia rarely develop secondary hematological neoplasms. A 5-year-old boy was diagnosed with standard-risk precursor B-cell acute lymphocytic leukemia. The patient exhibited aberrant chromosomal changes in the bone marrow at 6 months postchemotherapy: 46,XY,der(6) t(1;6)(q12;p22) dup(6)(p22p12)[15].

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Background: Despite the positive impact of implantable cardioverter defibrillators (ICDs) and wearable cardioverter defibrillators (WCDs) on prognosis, their implantation is often withheld especially in Japanese heart failure patients with reduced left ventricular ejection fraction (HFrEF) who have not experienced ventricular tachycardia (VT) or ventricular fibrillation (VF) for uncertain reasons. Recent advancements in heart failure (HF) medications have significantly improved the prognosis for HFrEF. Given this context, a critical reassessment of the treatment and prognosis of ICDs and WCDs is essential, as it has the potential to reshape awareness and treatment strategies for these patients.

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Article Synopsis
  • Ulcerative colitis (UC) and Crohn's disease (CD) are both types of inflammatory bowel diseases (IBDs) but require different treatment approaches due to their distinct causes.
  • A study was conducted to see if simple abdominal CT scans could help differentiate between UC and CD in first-time diagnosed patients by analyzing various health metrics, like fat areas and protein levels.
  • Results showed that visceral and subcutaneous fat measurements from CT scans effectively identified which disease a patient had, suggesting that these imaging techniques could aid in better IBD diagnosis.
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Background: Melanoma is rare as a secondary malignant neoplasm among childhood cancer survivors.

Case: We report a case of a 12-year-old boy who developed malignant melanoma with systemic metastases 17 months after completing treatment for hepatoblastoma. The diagnosis was made unexpectedly based on a bone marrow examination.

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Background: Dysfunctional breathing (DB) is a clinical condition characterized by irregular breathing patterns presenting a sensation of dyspnea and a feeling of chest tightness. DB is a known comorbidity of asthma that is difficult to control, leading to poor quality of life, so early diagnosis and therapeutic intervention are essential to improve the clinical condition of asthma. The Nijmegen Questionnaire (NQ), developed to screen for DB and translated into various languages, is used worldwide.

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Association between physical symptoms and psychosocial difficulties of cancer patients has been reported widely. Nevertheless, the effects of pain and other symptom control on anxiety in such patients have not been investigated well. We investigated the association of improvement of pain and other symptoms with patient anxiety, and assessed factors associated with improvement of such symptoms.

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Purpose: There have been numerous studies of the anterior cruciate ligament (ACL) anatomy, but few have focused on the long axis angle of the femoral ACL footprint. This study investigated the angle between the long axis of the femoral ACL footprint and the bony morphology of the knee.

Methods: This study is a cadaveric descriptive study.

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A novel scoring system to predict short-term mortality after living donor liver transplantation for acute liver failure.

Am J Transplant

October 2024

Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address:

Article Synopsis
  • Liver transplantation can save lives for people with serious liver problems, but it's important to know who might not survive after the surgery.
  • Researchers studied patients who received liver transplants from living donors between 2010 and 2020 to find out what factors make short-term survival harder.
  • They discovered 4 main risks that can cause death within a year: needing extra support like machines, having more severe liver disease, and having a low weight ratio between the donor and the recipient, which led to a new score system to help doctors evaluate patient risks.
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Article Synopsis
  • - Rotablation was done on a hard, calcified area in a patient’s blood vessel.
  • - This procedure allowed doctors to use different tools effectively further down the vessel.
  • - The main goal was to remove a trapped tool called the RotaWire that was stuck during the procedure.
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Dextromethorphan (DXM) is used to treat colds and coughs; however, it can cause central nervous system symptoms, such as severe serotonin syndrome (SS). To our knowledge, there is no specific treatment for severe DXM poisoning, and there are no reports on the clinical use of intravenous lipid emulsion (ILE) for its treatment. Herein, we report a case of severe DXM poisoning with SS that was successfully treated with ILE.

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