Safety and efficacy evaluation of sublingual allergen-specific immunotherapy a retrospective, multicenter study.

In recent years, several controlled studies have proved the efficacy and safety of sublingual specific immunotherapy, as a possible alternative to the classic subcutaneous route of administration. This alternative option has been officially confirmed by the recent WHO position paper "Allergen Immunotherapy: Therapeutic Vaccines for Allergic Diseases'". Since sublingual immunotherapy has now been widely used for years, we carried out an open, multicentric, retrospective study to investigate the efficacy and safety of this form of treatment in a large number of patients.

Unusual renal cell carcinoma metastasis to the gallbladder.

Herein we report a case of a renal cell carcinoma with synchronous metastases to the lung and gallbladder. This appears to be the first case of renal cell carcinoma with metastasis to the gallbladder detected prior to autopsy.