1 results match your criteria: "Newcastle University Newcastle Upon Tyne UK Oisin.Kavanagh@newcastle.ac.uk.[Affiliation]"
Cystine crystal nucleation and decay in the context of cystinuria pathogenesis and treatment.
RSC Adv
October 2024
School of Pharmacy, Newcastle University Newcastle Upon Tyne UK
Article Synopsis
- - Cystinuria is a rare disease characterized by cystine crystal formation in urine, which can lead to kidney damage, and this study investigates the sources of these crystals to better understand the disease's development.
- - The research replicates the formation of cystine crystals in different urine types and examines how various substances, including cysteamine and sodium bicarbonate, affect the dissolution rate of these crystals.
- - Findings reveal that the dissolution of cystine crystals is more influenced by pH levels than previously thought, challenging existing theories and suggesting that cysteamine's effectiveness might be attributed to its pH-related properties and disulfide exchange capabilities.