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367 results match your criteria: "Newcastle University Newcastle[Affiliation]"
Eur Urol
January 2025
Department of Urology, Freeman Hospital Newcastle-upon-Tyne UK; Translational and Clinical Research Institute, Newcastle University Newcastle-upon-Tyne UK.
Background And Objective: Stress urinary incontinence (SUI), defined as any involuntary leakage of urine associated with physical activity, remains underdiagnosed and undertreated. This review aims to provide an updated overview of the prevalence, diagnosis, and treatment of SUI in women, drawing upon recent evidence-based literature and clinical guidelines.
Methods: A systematic search of the MEDLINE database was conducted to identify only the most up-to-date and relevant studies published up to February 26, 2024, including the reference ESTER systematic review.
Alzheimers Dement (N Y)
January 2025
Department of Health and Community Sciences, Medical School University of Exeter Exeter UK.
Abstract: Recent clinical trials on slowing dementia progression have led to renewed focus on finding safer, more effective treatments. One approach to identify plausible candidates is to assess whether existing medications for other conditions may affect dementia risk. We conducted a systematic review to identify studies adopting a data-driven approach to investigate the association between a wide range of prescribed medications and dementia risk.
View Article and Find Full Text PDFDigit Discov
January 2025
School of Natural and Environmental Sciences, Newcastle University Newcastle Upon Tyne NE1 7RU UK
FEgrow is an open-source software package for building congeneric series of compounds in protein binding pockets. For a given ligand core and receptor structure, it employs hybrid machine learning/molecular mechanics potential energy functions to optimise the bioactive conformers of supplied linkers and functional groups. Here, we introduce significant new functionality to automate, parallelise and accelerate the building and scoring of compound suggestions, such that it can be used for automated design.
View Article and Find Full Text PDFJ Vis
January 2025
Magic Leap Switzerland GmbH, Zürich, Switzerland.
When rendering the visual scene for near-eye head-mounted displays, accurate knowledge of the geometry of the displays, scene objects, and eyes is required for the correct generation of the binocular images. Despite possible design and calibration efforts, these quantities are subject to positional and measurement errors, resulting in some misalignment of the images projected to each eye. Previous research investigated the effects in virtual reality (VR) setups that triggered such symptoms as eye strain and nausea.
View Article and Find Full Text PDFRecent calls have been made for equity tools and frameworks to be integrated throughout the research and design life cycle -from conception to implementation-with an emphasis on reducing inequity in artificial intelligence (AI) and machine learning (ML) applications. Simply stating that equity should be integrated throughout, however, leaves much to be desired as industrial ecology (IE) researchers, practitioners, and decision-makers attempt to employ equitable practices. In this forum piece, we use a critical review approach to explain how socioecological inequities emerge in ML applications across their life cycle stages by leveraging the food system.
View Article and Find Full Text PDFRSC Adv
December 2024
Life Science Division, Sunresin New Materials Co. Ltd. 710076 Xi'an China
Diethylene glycol dimethacrylate (DEG)-crosslinked polystyrene (PS) resin offers a promising alternative to traditional divinyl benzene (DVB)-PS resin for solid-phase peptide synthesis (SPPS), particularly for challenging sequences with hydrophobic or bulky amino acids. DEG-PS resin's reduced hydrophobicity and enhanced flexibility improve synthesis efficiency, yielding peptides up to 28 residues with higher purities and yields compared to DVB-PS. In various syntheses, DEG-PS outperformed DVB-PS resin, with higher purities and yields for challenging peptides such as ABC analogue (73.
View Article and Find Full Text PDFReact Chem Eng
December 2024
Materials, Concepts, and Reaction Engineering (MatCoRE) Group, School of Engineering, Newcastle University Newcastle upon Tyne NE1 7RU UK
Metallic sealants are widely used with high-temperature membranes. Here we show that their use in supported molten-salt membranes results in order-of-magnitude differences in CO flux and introduces O co-permeation. The 'short-circuiting' effect they introduce has important implications for the design of future experiments, and the interpretation of past work.
View Article and Find Full Text PDFArrhythm Electrophysiol Rev
November 2024
Department of Pediatric Cardiology, Cleveland Clinic Children's Cleveland, OH, US.
In this review, we summarise the ongoing debate surrounding the anatomy of the atrioventricular conduction axis and its relevance to pacing. We highlight previous disagreements and emphasise the importance of understanding the anatomical location of the axis. We give credit and support to the initial descriptions by His and Tawara, in particular their attention to the relationship of the atrioventricular conduction axis with the membranous septum.
View Article and Find Full Text PDFEnviron Sci (Camb)
October 2024
School of Engineering, Newcastle University Newcastle upon Tyne NE1 7RU UK
This study develops quantifiable metrics to describe the resilience of Water Resource Recovery Facilities (WRRFs) under extreme stress events, including those posed by long-term challenges such as climate change and population growth. Resilience is the ability of the WRRFs to withstand adverse events while maintaining compliance or an operational level of service. Existing studies lack standardised resilience measurement methods.
View Article and Find Full Text PDFCell Stress
October 2024
University Medical Center Göttingen, Department of Otolaryngology-Head and Neck Surgery, InnerEarLab Göttingen Germany.
Stress granules (SGs) are highly dynamic micromolecular membraneless condensates that generate in cells subjected to stress. Formed from pools of untranslating messenger ribonucleoproteins (RNP), SGs dynamics constitute vital processes essential for cell survival. Here, we investigate whether established cytotoxic agents, such as the platinum-based chemotherapeutic agent cisplatin and the aminoglycoside antibiotic gentamicin, elicit SG formation in the House Ear Institute-Organ of Corti-1 (HEI-OC1) auditory cell line, H4 human neuroglioma cells and HEK-293T human embryonic kidney cells.
View Article and Find Full Text PDFInjury
December 2024
The Kennedy Institute of Rheumatology. Nuffield Department of Orthopaedic, Rheumatology and Musculoskeletal Sciences, University of Oxford. Oxford, United Kingdom.
Background: Ortho-plastic evidence-based clinical guidelines for open fractures have demonstrated to standardise care and improve outcomes for patients admitted following lower extremity trauma. Despite its benefits, very few countries have introduced such guidance. The aim of this study was to explore the attitudes, barriers and limitations to the development and implementation of guidelines for lower limb open fractures METHODS: Twelve renowned orthopaedic and plastic surgeons, based in countries with no guidelines at present, underwent semi-structured interviews.
View Article and Find Full Text PDFObjectives: To understand how psychosocial factors associated with physical activity differ based on disease severity in people with dementia, and how these factors are associated with physical activity participation.
Methods: Eighty-seven people with dementia, alongside their family carer were asked to complete a series of questions related to physical activity participation, including barriers, motivators, and facilitators. Regression models were developed to understand how psychosocial factors were associated with physical activity participation in the cohort.
Background: Older adults with non-ST-segment-elevation acute coronary syndrome are less likely to undergo an invasive strategy compared with younger patients. Randomized controlled trials traditionally exclude older adults because of their high burden of geriatric conditions.
Methods And Results: We searched for randomized controlled trials comparing invasive versus medical management or a selective invasive (conservative) strategy for older patients (age≥75 years) with non-ST-segment-elevation acute coronary syndrome.
J Med Ethics
October 2024
Politics, Newcastle University-Newcastle Campus, Newcastle upon Tyne, UK
The idea of a 'tobacco-free generation' promises to make smoking a thing of the past by making cigarettes unavailable to birth cohorts in the future. If implemented, such a generational ban would lead to a society in which some individuals are allowed the freedom to smoke while others are not. This paper examines the ethical significance of this fact through the lens of 'relational egalitarianism', an approach to social justice that emphasises equal and respectful social relationships.
View Article and Find Full Text PDFZookeys
October 2024
Museum of Zoology, Senckenberg Natural History Collections Dresden, A.B. Meyer Building, 01109 Dresden, Germany Museum of Zoology Dresden Germany.
The genus Wagler, 1828 comprises 20 species of semiaquatic snakes. It is mostly distributed in the cis-Andean region of South America, with only two trans-Andean species (, ). is endemic to Colombia and occurs through most of the trans-Andean region.
View Article and Find Full Text PDFObjectives: Ureterorenoscopy is seeing a bloom of technological advances, one of which is incorporating suction. The objective of this study is to systematically review existing literature regarding suction use in rigid and flexible ureterorenoscopy and perform meta-analysis of studies comparing suction versus no suction ureteroscopy or mini percutaneous nephrolithotomy (PCNL).
Methods: A literature search was performed (November 2023) in MEDLINE, Embase and Cochrane CENTRAL.
Background: Restricted and repetitive patterns of behaviour (RRBs) serve an adaptive role in development. Elevated levels of RRBs beyond the early years, however, are associated with poorer outcome in language, cognition, and wellbeing, and are seen across a range of neurodevelopmental conditions. This study aimed to characterize the association of distinct RRB subtypes at two and six years of age, with internalising and externalising difficulties in a community sample of children.
View Article and Find Full Text PDFLianas (woody vines and climbing monocots) are increasing in abundance in many tropical forests with uncertain consequences for forest functioning and recovery following disturbances. At a global scale, these increases are likely driven by disturbances and climate change. Yet, our understanding of the environmental variables that drive liana prevalence at regional scales is incomplete and geographically biased towards Latin America.
View Article and Find Full Text PDFRSC Adv
October 2024
School of Pharmacy, Newcastle University Newcastle Upon Tyne UK
J Am Heart Assoc
October 2024
National Cancer Control Institute, National Cancer Center Goyang Gyeonggi-do Republic of Korea.
Chem Sci
September 2024
School of Natural and Environmental Sciences, Newcastle University Newcastle Upon Tyne NE1 7RU UK
J Mater Chem A Mater
October 2024
Storage of Electrochemical Energy, Department of Radiation Science and Technology, Faculty of Applied Sciences, Delft University of Technology Mekelweg 15 2629JB Delft The Netherlands
Understanding diffusion mechanisms in solid electrolytes is crucial for advancing solid-state battery technologies. This study investigates the role of structural disorder in Li PS Br argyrodites using molecular dynamics, focusing on the correlation between key structural descriptors and Li-ion conductivity. Commonly suggested parameters, such as configurational entropy, bromide site occupancy, and bromine content, correlate with Li-ion diffusivity but do not consistently explain conductivity trends.
View Article and Find Full Text PDFEcol Evol
September 2024
Faculty of Science and Engineering, School of Life Sciences University of Wolverhampton Wolverhampton UK.
Studies in evolution, ecology and conservation are increasingly based on genetic and genomic data. With increased focus on molecular approaches, ethical concerns about destructive or more invasive techniques need to be considered, with a push for minimally invasive sampling to be optimised. Buccal swabs have been increasingly used to collect DNA in a number of taxa, including amphibians.
View Article and Find Full Text PDFArrhythm Electrophysiol Rev
August 2024
Johns Hopkins Hospital Baltimore, MD US.
Background: Atrioventricular (AV) conduction ablation has been achieved by targeting the area of penetration of the conduction axis as defined by recording a His bundle potential. Ablation of the His bundle may reduce the possibility of a robust junctional escape rhythm. It was hypothesised that specific AV nodal ablation is feasible and safe.
View Article and Find Full Text PDF