Sex-Based Differences in Endovascular Thrombectomy Outcomes for Large Ischemic Stroke: A SELECT2 Subanalysis.

Background: Several social and biological factors are shown to differentially affect stroke outcomes between men and women. We evaluated whether clinical outcomes and endovascular thrombectomy (EVT) treatment effects differed between the sexes in patients presenting with large ischemic stroke.

Methods: The SELECT2 trial (A Randomized Controlled Trial to Optimize Patient's Selection for Endovascular Treatment in Acute Ischemic Stroke) was a randomized controlled trial assessing the efficacy and safety of EVT in patients with large strokes across the United States, Canada, Europe, Australia, and New Zealand between October 2019 and September 2022.

Interpreting CNN models for musical instrument recognition using multi-spectrogram heatmap analysis: a preliminary study.

Introduction: Musical instrument recognition is a critical component of music information retrieval (MIR), aimed at identifying and classifying instruments from audio recordings. This task poses significant challenges due to the complexity and variability of musical signals.

Methods: In this study, we employed convolutional neural networks (CNNs) to analyze the contributions of various spectrogram representations-STFT, Log-Mel, MFCC, Chroma, Spectral Contrast, and Tonnetz-to the classification of ten different musical instruments.

Toward the Bayesian brain: a generative model of information transmission by vestibular sensory neurons.

The relative accessibility and simplicity of vestibular sensing and vestibular-driven control of head and eye movements has made the vestibular system an attractive subject to experimenters and theoreticians interested in developing realistic quantitative models of how brains gather and interpret sense data and use it to guide behavior. Head stabilization and eye counter-rotation driven by vestibular sensory input in response to rotational perturbations represent natural, ecologically important behaviors that can be reproduced in the laboratory and analyzed using relatively simple mathematical models. Models drawn from dynamical systems and control theory have previously been used to analyze the behavior of vestibular sensory neurons.

Streamlining Global Germplasm Exchange: Integrating Scientific Rigor and Common Sense to Exclude Phantom Agents from Regulation.

This collaborative work by over 180 researchers from 40+ countries addresses the challenges posed by "phantom agents"-putative pathogenic agents named in literature without supporting data on their existence. Those agents remain on regulatory lists, creating barriers in trade and plant certification. Historically identified based solely on symptoms, these agents lack isolates or sequence data, making reliable detection or risk assessment impossible.

No definite associations between opioid doses and severity of acute pancreatitis - Results from a multicentre international prospective study.

Background: Abdominal pain is the cardinal symptom of acute pancreatitis (AP), often requiring opioid therapy. This study aimed to investigate the dose-dependent relationship between opioid therapy and moderately severe or severe AP.

Methods: This was a post-hoc analysis of the prospective PAINAP database, which recruited patients with first-time AP from 118 centres across 27 countries between April-June 30, 2022.

Clinical practice patterns in the management of dry eye disease: A TFOS international survey 2023-4.

Aims: To understand current clinical management of dry eye disease (DED), based on its perceived severity and subtype by practitioners across the world.

Methods: The content of the anonymous survey was chosen to reflect the DED management strategies reported by the Tear Film and Ocular Surface Society (TFOS) 2 Dry Eye Workshop (DEWS II). Questions were designed to ascertain practitioner treatment choice, depending on the subtype and severity of DED.

Impact of Mild Hypercapnia on Renal Function After Out-of-Hospital Cardiac Arrest.

Background: Acute kidney injury (AKI) is a serious complication of out-of-hospital cardiac arrest (OHCA). Post-resuscitation cardiogenic shock (CS) is a key contributing factor. Targeting a higher arterial carbon dioxide tension may affect AKI after OHCA in patients with or without CS.

Practical considerations for the optimization of in situ mineralization of perfluorocarboxylic acids and polyfluoroalkyl substances using persulfate oxidation.

Military bases and airports are often contaminated by per- and polyfluoroalkyl substances (PFAS) due to the repeated use of aqueous film forming foams (AFFFs) from decades of training exercises, equipment testing, and extinguishing of fuel- and solvent-based fires. Pump-and-treat systems combined with sorption processes are common ex situ remediation strategies; however, they can be expensive and may require decades of operation, particularly at sites where long-term diffusion and desorption of contaminants are the primary release processes. Alternatively, in situ chemical oxidation is an effective remediation strategy in which oxidants (e.

Enhancing the texture and modulating digestive behavior of gluten-free quinoa sponge cakes via microwave-assisted alkaline amino acid treatment.

This study investigated the effects of microwave treatment combined with lysine and arginine on gluten-free quinoa sponge cakes. The results indicated that the addition of these amino acids during microwave treatment significantly increased the cakes' specific volume by 49 %. X-ray diffraction analysis revealed that cake crystallinity reached 56.

Comparison of Paired Immunofluorescent Antibody Serology and Real-Time Polymerase Chain Reaction Testing for the Detection of Acute Q Fever among Febrile Patients in Kilimanjaro, Tanzania, 2012-2014.

Acute Q fever diagnosis via paired serology is problematic because it requires follow-up for convalescent sample collection; as such, it cannot provide a diagnosis to inform a treatment decision at the time of acute presentation. Real-time polymerase chain reaction (PCR) may be a useful approach for the diagnosis of acute Q fever in endemic settings. Among febrile patients enrolled in a sentinel surveillance study for Q fever at two referral hospitals in Moshi, Tanzania, from 2012 to 2014, we analyzed those with paired sera for IgG to Coxiella burnetii (C.

Humanising processes after harm part 2: compounded harm experienced by patients and their families after safety incidents.

Background: Healthcare organisations risk harming patients and their families twofold. First, through the physical, emotional and/or financial harm caused by safety incidents themselves, and second, through the organisational response to incidents. The former is well-researched and targeted by interventions.

Exploring how researchers consider nutrition trial design and participant adherence: a theory-based analysis.

Introduction: Nutrition trials are important for informing dietary and clinical guidelines. Central to the success of these trials is participant adherence to dietary behaviors. However, trials commonly experience poor adherence.

Redefining Diabetes Care: Evaluating the Impact of a Carbohydrate-Reduction, Health Coach Approach Model in New Zealand.

This study explores a novel healthcare model employed in the primary care setting integrating a carbohydrate-reduction dietary approach and health coaching for managing prediabetes (PD) and Type 2 diabetes (T2D) in New Zealand. Using qualitative methods, we conducted focus groups with 46 patients and individual interviews with health coaches and general practitioners across two regions. Five major themes emerged from inductive thematic analysis: reduced carbohydrate lifestyles, health coaching, implementation, empowerment, and sustainability.

Assessment of the quality of life comparison between open and endovascular aortic arch surgery: a pilot study.

Background: Advancement in endovascular endografts have paved the way to the possibility of performing endovascular aortic arch repair in recent years. This has started to supersede the need for open aortic arch surgery. There remains a paucity of data looking into the quality of life comparison between open aortic arch surgery and endovascular aortic arch repair.

Nanopore sequencing as a novel method of characterising anorexia nervosa risk loci.

Background: Anorexia nervosa (AN) is a polygenic, severe metabopsychiatric disorder with poorly understood aetiology. Eight significant loci have been identified by genome-wide association studies (GWAS) and single nucleotide polymorphism (SNP)-based heritability was estimated to be ~ 11-17, yet causal variants remain elusive. It is therefore important to define the full spectrum of genetic variants in the wider regions surrounding these significantly associated loci.

Healthcare burden of public hospital gout admissions in New South Wales, Australia.

Background And Aims: In New Zealand, the Māori and Pacific Islander population has a higher rate of hospital admissions for gout; however, we lack data for these population groups who reside in Australia. This study examined the pattern of hospital gout admissions in New South Wales (NSW), the most populous state of Australia, with a particular focus on the Māori and Pacific Islander population.

Methods: This was a retrospective cohort study exploring the pattern of gout admissions in NSW public hospitals in the financial years 2017/2018 to 2019/2020.

The management of splanchnic vein thrombosis in acute pancreatitis: a global DELPHI consensus study.

Background: Splanchnic vein thrombosis (SpVT) occurs in 17%-23 % of acute pancreatitis cases. Serious sequelae include hepatic and bowel ischaemia. However, management with therapeutic anticoagulation remains controversial due to potential bleeding risk.

Emergency care experiences of patients known to palliative care services and their family: A qualitative interview study.

Background: With aging and comorbid populations and healthcare services under pressure, emergency department presentations related to palliative care needs are increasing. Little is known about patient and family experiences of care in this context. This study explores the emergency department care experiences of palliative patients and their family members.

The Effects of Neuroinflammation Induced by Typhoid Vaccine on Resting and Task-Based Electroencephalography.

Introduction: Considerable evidence suggests a pathophysiological role of neuroinflammation in psychiatric disorders. Lumbar puncture and positron emission tomography (PET) show increased levels of inflammation in psychiatric disorders. However, the invasive nature of these techniques, as well as their expense, make them undesirable for routine use in patients.

A systematic review of short- compared with standard-length Exeter stems in primary total hip arthroplasty.

Aims: The Exeter femoral stem has a cemented, polished taper-slip design, and an excellent track record. The current range includes short-length options for various offsets, but less is known about the performance of these stems. The aim of this study was to compare the survival of short-length stems with standard-length Exeter stems.

Anaesthetic and corticosteroid response immediately following epidural injection in patients with MRI confirmed lumbar disc herniation.

Objectives: To describe a rapid, community-based assessment, referral and management system for acute symptomatic LDH. To identify and describe specific local anaesthetic and corticosteroid patterns of pain intensity change during the first week post-epidural injection.

Setting: Private practice, specialist physiotherapy clinic, community-based radiology facility.

Investigation of solid-state fermentation of red seaweed (Pyropia spp.) with lactic acid Bacteria: Effects on protein profile and in vitro digestibility.

This study aimed to investigate the effects of solid-state fermentation (SSF) on the protein profile and digestibility of red seaweed (Pyropia spp.). The results indicated that compound lactic acid bacteria (LAB) performed better than a single strain in terms of growth and metabolism on the red seaweed substrate.