5,085 results match your criteria: "New York University Grossman School of Medicine[Affiliation]"
Epilepsia
December 2024
Comprehensive Epilepsy Center, New York University Grossman School of Medicine, New York, New York, USA.
Objective: Randomized controlled trials (RCTs) are necessary to evaluate the efficacy of novel treatments for epilepsy. However, there have been concerning increases in the placebo responder rate over time. To understand these trends, we evaluated features associated with increased placebo responder rate.
View Article and Find Full Text PDFBMC Med Res Methodol
December 2024
Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, 180 Madison Avenue, New York, NY, USA.
Background: In cohort studies with time-to-event outcomes, covariates of interest often have values that change over time. The classical Cox regression model can handle time-dependent covariates but assumes linear effects on the log hazard function, which can be limiting in practice. Furthermore, when multiple correlated covariates are studied, it is of great interest to model their joint effects by allowing a flexible functional form and to delineate their relative contributions to survival risk.
View Article and Find Full Text PDFNeurocrit Care
December 2024
Department of Clinical Pharmacology, University of Tennessee Health Science Center College of Pharmacy, Knoxville, TN, USA.
Background: There is practice heterogeneity in the use, type, and duration of prophylactic antiseizure medications (ASM) in patients hospitalized with acute nontraumatic intracerebral hemorrhage (ICH).
Methods: We conducted a systematic review and meta-analysis assessing ASM primary prophylaxis in adults hospitalized with acute nontraumatic ICH. The following population, intervention, comparison, and outcome (PICO) questions were assessed: (1) Should ASM versus no ASM be used in patients with acute ICH with no history of clinical or electrographic seizures? (2) If an ASM is used, should levetiracetam (LEV) or phenytoin/fosphenytoin (PHT/fPHT) be preferentially used? and (3) If an ASM is used, should a long (> 7 days) versus short (≤ 7 days) duration of prophylaxis be used? The main outcomes assessed were early seizure (≤ 14 days), late seizures (> 14 days), adverse events, mortality, and functional and cognitive outcomes.
J Gen Intern Med
December 2024
Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Background: Structured faculty development programs focused on integrating health equity into medical education curricula remain limited.
Aim: To describe an interdisciplinary faculty development program grounded in adult learning theory and to assess its impact on participants' professional growth.
Setting And Participants: Twenty-one faculty members across six academic-affiliated health systems.
Diabetes Care
December 2024
The Welch Center for Prevention, Epidemiology and Clinical Research, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Objective: To characterize the prevalence of continuous glucose monitoring (CGM)-defined glucose abnormalities in a large, community-based population of very old adults (>75 years).
Research Design And Methods: A cross-sectional analysis of 1,150 older adults with and without diabetes who attended the Atherosclerosis Risk in Communities Study (2021-2022). Diabetes was based on a self-reported diagnosis of diabetes by a health care provider, use of diabetes medication, or a hemoglobin A1c (HbA1c) ≥6.
Nat Immunol
December 2024
Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.
The mechanisms underlying the efficacy of anti-programmed cell death protein 1 (PD-1) and anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4) therapy are incompletely understood. Here, by immune profiling responding PD-1CD8 T (T) cell populations from patients with advanced melanoma, we identified differential programming of T cells in response to combination therapy, from an exhausted toward a more cytotoxic effector program. This effect does not occur with anti-PD-1 monotherapy.
View Article and Find Full Text PDFAm J Prev Med
December 2024
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address:
Introduction: Varicose veins are common in older adults and are associated with adverse clinical outcomes such as deep venous thrombosis. Established risk factors for varicose veins include female sex, height, and obesity, but other risk factors are relatively uncharacterized.
Methods: This was a prospective cohort analysis of 6241 participants aged 66-70 years from the Atherosclerosis Risk in Communities (ARIC) Study.
Atherosclerosis
November 2024
Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:
Background And Aims: Myeloproliferative neoplasms (MPNs) are associated with arterial thrombosis, including acute coronary syndrome (ACS). Prior studies have suggested similar in-hospital mortality among patients with MPN compared to those without. However, post-ACS outcomes have not been thoroughly evaluated.
View Article and Find Full Text PDFCurr Psychiatry Rep
December 2024
New York University Grossman School of Medicine, New York, USA.
Purpose Of Review: There is a mental health crisis affecting youth, and the utility of existing treatments is often limited by lack of effectiveness and tolerability. The aim of this review is to report on outcomes of clinical trials for psilocybin-assisted psychotherapy for adults with depression and MDMA-assisted psychotherapy for adults with post-traumatic stress disorder (PTSD) and discuss recommendations for exploring these treatments in adolescent populations.
Recent Findings: There have been encouraging data supporting the use of psilocybin-assisted psychotherapy for depression, including previously treatment-resistant symptoms.
Kidney Int Rep
December 2024
Division of Precision Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, USA.
Int J Dermatol
December 2024
The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, NY, USA.
Premature hair graying (PHG) is the early loss of natural hair color, influenced by genetic, biological, and environmental factors. This review discusses the significant psychological impacts of PHG and explores its underlying mechanisms, related health conditions, and available treatments. The review examines the roles of genetics, oxidative stress, and lifestyle factors such as smoking and diet in premature graying.
View Article and Find Full Text PDFAnn Med
December 2025
Department of Psychiatry, New York University Grossman School of Medicine, New York, New York, USA.
Background: Racial discrimination is associated with health disparities among Black Americans, a group that has experienced an increase in rates of fatal drug overdose. Prior research has found that racial discrimination in the medical setting may be a barrier to addiction treatment. Nevertheless, it is unknown how experiences of racial discrimination might impact engagement with emergency medical services for accidental drug overdose.
View Article and Find Full Text PDFPsychiatr Serv
December 2024
Department of Health Law, Policy, and Management, Boston University School of Public Health, Boston (Nguyen); Department of Health Services, Policy, and Practice (Nguyen) and Department of Epidemiology (Choy), Brown University School of Public Health, Providence, Rhode Island; Medicare Payment Advisory Commission, Washington, D.C. (Oh); Department of Population Health, Section for Health Equity, New York University Grossman School of Medicine, New York City (Ðoàn); Asian American Research Center on Health, San Francisco (Chu); Department of Health Policy and Management, Fielding School of Public Health (Banawa), Center for Health Policy Research (Banawa), and Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine (Oronce), University of California, Los Angeles, Los Angeles; Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles (Oronce); Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut (Choy); Department of Public Health, Wayne State University, Detroit (Zhou).
Asian American (AA) and Native Hawaiian and Pacific Islander (NHPI) people are often aggregated into a monolithic group, but when they are disaggregated into ethnic groups (e.g., Chinese), inequities can be identified.
View Article and Find Full Text PDFJ Surg Educ
December 2024
Department of Surgery, Veterans Affairs of New Jersey Healthcare System, East Orange, New Jersey. Electronic address:
Purpose: Surgical resident autonomy in procedures has been eroding over time, due to multiple factors that include duty hour restrictions, focus on operating time, complication rate, and trust among supervising physicians. This study examines whether urology residents at the Veterans Affairs hospitals (VA) have experienced decreased surgical autonomy and contributing factors.
Methods: The national VA Surgical Quality Improvement Program (VASQIP) was queried for the most common urologic procedures between 2004 to 2019 with resident involvement.
Sci Transl Med
December 2024
Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Sjögren's disease (SjD) is an autoimmune disorder characterized by progressive salivary and lacrimal gland dysfunction, inflammation, and destruction, as well as extraglandular manifestations. SjD is associated with autoreactive B and T cells, but its pathophysiology remains incompletely understood. Abnormalities in regulatory T (T) cells occur in several autoimmune diseases, but their role in SjD is ambiguous.
View Article and Find Full Text PDFLiver Transpl
December 2024
University of California, San Francisco, San Francisco, CA.
Pediatric liver transplant outcomes exhibit disparities, necessitating identification of modifiable risk factors to develop targeted interventions. We characterized associations between household material economic hardship (e.g.
View Article and Find Full Text PDFNatl Sci Rev
December 2024
Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.
Although adeno-to-squamous transition (AST) has been observed in association with resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) in clinic, its causality, molecular mechanism and overcoming strategies remain largely unclear. We here demonstrate that squamous transition occurs concomitantly with TKI resistance in PC9-derived xenograft tumors. Perturbation of squamous transition via DNp63 overexpression or knockdown leads to significant changes in TKI responses, indicative of a direct causal link between squamous transition and TKI resistance.
View Article and Find Full Text PDFJAAD Case Rep
December 2024
Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York.
Dermatol Online J
October 2024
The Ronald O Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York.
All types of alopecia, including androgenetic alopecia, alopecia areata, and lichen planopilaris/frontal fibrosing alopecia, affect over half of men and women. Though a common dermatological experience, many patients with visible hair loss report significant psychological and social distress and, consequently seek treatment. Current existing therapeutic regimens have proven to be efficacious, though may result in various adverse effects and require lifelong use.
View Article and Find Full Text PDFNeurology
January 2025
Department of Neurology, Mayo Clinic, Jacksonville, FL.
Neurologic conditions are a leading cause of morbidity and mortality within the United States and worldwide. Brain health is a global concern, and the American Academy of Neurology's Brain Health Initiative promises to drive progress in this field over the next decades. Neurologists with detailed training and insight into brain function are uniquely positioned to apply emerging preventive health data to promote healthy brain development and maintain optimal brain function throughout the lifespan.
View Article and Find Full Text PDFJ Cataract Refract Surg
December 2024
ELZA Institute, Dietikon, Switzerland.
Purpose: To investigate the light transmission (LT) of UV-A and green light through infected corneas saturated with riboflavin or rose bengal in an ex vivo porcine model for infectious keratitis.
Setting: University of Zurich and EMPA.
Design: Laboratory study.
Epidemiology
December 2024
Center for Opioid Epidemiology and Policy, Division of Epidemiology, Department of Population Health, New York University Grossman School of Medicine, 180 Madison Ave, New York, NY 10016.
Background: Cannabis use and alcohol use are associated with self-harm injuries, but little research has assessed links between recreational cannabis outlet openings on rates of self-harm within communities or the interactions of cannabis outlets with the density of alcohol outlets. We estimated the associations of recreational cannabis outlets, alcohol outlets, and their interaction on rates of fatal and nonfatal self-harm injuries in California, 2017-2019.
Methods: Using California statewide data on recreational cannabis outlets, alcohol outlets, and hospital discharges and deaths due to self-harm injuries, we conducted Bayesian spatiotemporal analyses of quarterly ZIP code-level data over 3 years, accounting for confounders and spatial autocorrelation.
Laryngoscope Investig Otolaryngol
December 2024
Sean Parker Institute for the Voice, Department of Otolaryngology-Head and Neck Surgery Weill Cornell Medical College New York New York USA.
Objectives: To date, there has yet to be a rigorous exploration of voice and communication modification training (VCMT) among transgender and gender-nonconforming (TGNC) individuals using digital technology. We sought to evaluate and describe the iterative process of app development using a community-based approach.
Methods: An interprofessional team of voice health care professionals, application developers, designers, and TGNC community members was assembled to conceive the functionality, content, and design of a mobile app to support VCMT for TGNC people.
J Lipid Res
December 2024
Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle WA 98109; UW Medicine Diabetes Institute, University of Washington, Seattle WA 98109; Department of Laboratory Medicine and Pathology, University of Washington, Seattle WA 98109. Electronic address:
Long-chain acyl-CoA synthetase 1 (ACSL1) catalyzes the conversion of long-chain fatty acids to acyl-CoAs. ACSL1 is required for β-oxidation in tissues that rely on fatty acids as fuel, but no consensus exists on why ACSL1 is induced by inflammatory mediators in immune cells. We used a comprehensive and unbiased approach to investigate the role of ACSL1 induction by interferon type I (IFN-I) in myeloid cells in vitro and in a mouse model of IFN-I overproduction.
View Article and Find Full Text PDFCompr Psychiatry
December 2024
Department of Psychiatry, Faculty of Medicine, University of Southampton, UK and Hampshire and Isle of Wight Healthcare NHS Foundation Trust, Southampton, UK.