20,468 results match your criteria: "New York State Psychiatry Institute & Columbia University[Affiliation]"

Adverse Childhood Experiences and Insufficient Sleep.

Acad Pediatr

November 2024

Global Psychiatric Epidemiology Group (S Forthal, S Lin, and K Cheslack-Postava), Division of Child and Adolescent Psychiatry, Department of Psychiatry, Columbia University-New York State Psychiatric Institute, New York, NY. Electronic address:

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Introduction: Factors influencing attention-deficit/hyperactivity disorder (ADHD) treatment preferences have been studied among patients but not physicians in the United States (US) and Canada. This study assessed treatment preferences of physicians treating adult patients with ADHD in both countries.

Methods: An online discrete choice experiment (DCE) was conducted (October 4-20, 2023) among physicians from Dynata's US and Canadian panel who treated adult patients with ADHD.

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Gene-dose-dependent reduction of Fshr expression improves spatial memory deficits in Alzheimer's mice.

Mol Psychiatry

November 2024

Mount Sinai Center for Translational Medicine and Pharmacology, Department of Pharmacological Sciences, and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Article Synopsis
  • High levels of follicle-stimulating hormone (FSH) in post-menopausal women are linked to the development of Alzheimer's disease (AD), as shown by studies in mice.
  • Mice lacking FSH receptors displayed improved spatial memory, indicating that blocking FSH signaling can help prevent memory loss related to aging and AD-like pathology.
  • The findings suggest that targeting FSH could be a potential strategy for preventing memory deficits in post-menopausal women.
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Background: A prolonged first episode of psychosis (FEP) without adequate treatment is a predictor of poor clinical, functional, and health outcomes and significant economic burden. Team-based "coordinated specialty care" (CSC) for early psychosis (EP) has established effectiveness in promoting clinical and functional recovery. However, California's CSC program implementation has been unsystematic and could benefit from standardizing its processes and data collection infrastructure.

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Article Synopsis
  • Psychedelic-assisted therapy (PAT) with substances like psilocybin and MDMA shows potential for treating depression and PTSD, with possible approval as medicines within the next decade.
  • A study involving 879 U.S. healthcare professionals found most respondents had strong belief in the therapeutic benefits of these substances, but exhibited low knowledge about their risks and uses.
  • Factors such as prior psychedelic use, greater self-rated knowledge, younger age, and specific professional roles influenced openness to using these therapies, highlighting the need for more training and education on the topic.
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From Neighborhood to Household: Connections Between Neighborhood Vacant and Abandoned Property and Family Violence.

J Urban Health

November 2024

Department of Social, Behavioral, and Population Sciences, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, 1440 Canal St. Tulane, New Orleans, LA, 70112, USA.

Rates of family violence, including intimate partner violence (IPV) and child maltreatment, remain high in the USA and contribute to substantial health and economic costs. How neighborhood environment may influence family violence remains poorly understood. We examine the association between neighborhood vacant and abandoned properties and family violence, and the role collective efficacy may play in that relationship.

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Who transitions to bipolar disorder? A comparison of major depressive disorder, anxiety, and ADHD.

J Affect Disord

February 2025

Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address:

Article Synopsis
  • Diagnostic delays in Bipolar Disorder (BD) are common and the study aimed to understand conversion rates from other disorders like Major Depressive Disorder (MDD), anxiety, and ADHD using a large dataset from Johns Hopkins Medicine.
  • Of the 21,341 patients studied, 1,232 transitioned to BD, with one-year conversion rates of 4.2% for MDD, 3.4% for anxiety, and 4.0% for ADHD, highlighting certain risk factors like age, treatment setting, and medication.
  • The findings suggest that patients with MDD face the highest risk of developing BD, while anxiety disorders and ADHD are also significant precursors, especially in adults.
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Predictors of study dropout in cognitive-behavioural therapy with a trauma focus for post-traumatic stress disorder in adults: An individual participant data meta-analysis.

BMJ Ment Health

November 2024

Department of Clinical, Neuro- and Developmental Psychology, World Health Organization Collaborating Center for Research and Dissemination of Psychological Interventions, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Background: Available empirical evidence on participant-level factors associated with dropout from psychotherapies for post-traumatic stress disorder (PTSD) is both limited and inconclusive. More comprehensive understanding of the various factors that contribute to study dropout from cognitive-behavioural therapy with a trauma focus (CBT-TF) is crucial for enhancing treatment outcomes.

Objective: Using an individual participant data meta-analysis (IPD-MA) design, we examined participant-level predictors of study dropout from CBT-TF interventions for PTSD.

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Background: Data obtained from the National Hockey League (NHL) have shown that a risk prediction model, including both visible signs and mechanisms of injury, improves the identification of possible concussion. However, only about half of concussions diagnosed by club medical staff in the NHL exhibit visible signs. At present, the NHL concussion spotter protocol does not include central league spotters' subjective judgments of the severity of forces associated with a direct hit to the head (perceived force severity [PFS]) or whether players brace before a hit (bracing).

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Article Synopsis
  • - Development of Alzheimer's disease (AD) pathology occurs faster in individuals with Down's syndrome (DS) compared to others; this study focuses on comparing specific biomarkers in DS individuals and their siblings.
  • - Researchers found that plasma levels of glial fibrillary acidic protein (GFAP) and pTau-217 were elevated in individuals with DS, indicating increased astrogliosis and tau pathology, and GFAP played a mediating role in the relationship between amyloid and tau levels.
  • - The findings suggest that astrogliosis is crucial in the early stages of Alzheimer's in DS, and targeting neuroinflammation might be beneficial primarily for those with amyloid positivity.
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Background: Rates of cannabis use disorder (CUD) have increased disproportionately among Veterans Administration (VA) patients with psychiatric disorders compared to patients with no disorder. However, VA patient samples are not representative of all U.S.

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Human cognition supports complex behaviour across a range of situations, and traits (e.g. personality) influence how we react in these different contexts.

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Article Synopsis
  • Grip strength is a key health indicator, especially in individuals with alcohol use disorder (AUD), but factors influencing its decline in AUD have not been studied.
  • A research study analyzed data from 53 control participants and 110 individuals with AUD (including 53 with HIV) to identify factors that predict grip strength.
  • Key predictors for grip strength included brain structure measurements and health metrics, with unique factors identified for both controls and AUD participants, highlighting the importance of understanding different influences on grip strength in these groups.
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Aquaporin-4 Immunoglobulin G-seropositive Neuromyelitis Optica Spectrum Disorder MRI Characteristics: Data Analysis from the International Real-World PAMRINO Study Cohort.

Radiology

November 2024

From the Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin & Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Lindenberger Weg 80, 13125 Berlin, Germany (C.C., H.Z., A.U.B., F.P.); NeuroCure Clinical Research Ctr (C.C., H.Z., A.U.B., J.W., F.P.), Dept of Psychiatry and Neurosciences, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany (C.C.); Medical Image Analysis Center, Basel, Switzerland (V.C.e.S., E.G., D.M.); Paulista School of Medicine, Dept of Neurology and Neurosurgery (D.B.B.), Dept of Diagnostic Imaging, Universidade Federal de São Paulo, São Paulo, Brazil (M.I.I.); Koc Univ, School of Medicine Neurology Dept and Istanbul Univ, Cerrahpasa School of Medicine, Neurology Dept, Istanbul, Turkey (A.A.); Dept of Neurology, Istanbul Univ, Cerrahpasa Faculty of Medicine, Istanbul, Turkey (U.T.); Div of Neurology, Dept of Medicine, Siriraj Hosp, Mahidol Univ, Bangkok, Thailand (S.S.); Bumrungrad International Hosp, Bangkok, Thailand (S.S.); Center for Advanced Neurologic Research, KS Hegde Medical Academy, Nitte Univ, Mangalore, India (L.P., A.D.); Dept of Neurology, Hosp de S. João, Al. Hernâni Monteiro, Porto, Portugal (M.J.S., R.F.); MS Center at Swedish Neuroscience Inst, Seattle, Wash (P.Q., C.T.); Dept of Neurology and Neuroimmunology Clinic, Rabin Medical Center, Petach Tikva, Israel (I.L.); Sackler Faculty of Medicine & Felsenstein Medical Research Center, Tel Aviv Univ, Tel Aviv, Israel (I.L., H.S.K.); Dept of Radiology, Rabin Medical Center, Beilinson Hosp, Israel, and Sackler Faculty of Medicine, Tel-Aviv Univ, Tel Aviv, Israel (V.K.); Dept of Neurology and Neuroimmunology, Rabin Medical Center, Beilinson Hosp, Israel, and Sackler Faculty of Medicine, Tel-Aviv Univ, Tel Aviv, Israel (M.A.H.); Neuro-Ophthalmology Div, Dept of Ophthalmology, Rabin Medical Center, Petah Tikva, Israel (H.S.K.); Div of Neurology, Univ of Toronto, St Michael's Hosp, Toronto, Canada (D.L.R., L.W.); Mellen Center, Cleveland Clinic, Cleveland, Ohio (D.O.), Dept of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio (K.N.); Multiple Sclerosis and Neuroimmunology Program, Univ Hosps of Cleveland, Case Western Reserve Univ School of Medicine, Cleveland, Ohio (H.A., M.O.S.); Michigan Inst for Neurologic Disorders, Farmington Hills, Mich (Y.M.D.); Inst of Clinical Neuroimmunology, LMU Hosp, Ludwig-Maximillians Universität München, Munich, Germany (J.H.); Dept of Neurology, Slagelse Hosps, Odense, Denmark (N.A.); Insts of Regional Health Research & Molecular Medicine, Univ of Southern Denmark, Odense, Denmark (N.A.); Dept of Radiology, Aleris Hosp, Copenhagen, Denmark (P.B.S.); NYU Multiple Sclerosis Comprehensive Care Center, Dept of Neurology, NYU School of Medicine, New York, NY (I.K.); Dept of Neurology, Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine Univ Düsseldorf, Düsseldorf, Germany (M.R.); School of Medicine and Dentistry, Gold Coast Campus, Griffith Univ, Queensland, Australia (S.B., S.A.); Dept of Neurology, Gold Coast Univ Hosp, Queensland, Australia (S.A.); Dept of Pediatrics, Univ of Utah, Salt Lake City, Utah (B.M., A.M.J., M.W., S.G., L.J.C.); Dept of Medicine, Divs of Molecular Medicine & Infectious Diseases, and Ludquist Inst for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, Calif (M.R.Y.); Dept of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif (M.R.Y.); Depts of Ophthalmology and Visual Sciences, Kellogg Eye Center, Univ of Michigan, Ann Arbor, Mich (T.J.S.); Div of Metabolism, Endocrine and Diabetes, Dept of Internal Medicine, Univ of Michigan Medical School, Ann Arbor, Mich (T.J.S.); Hoffmann-LaRoche, Basel, Switzerland (J.W.); Dept of Neurology, Charité-Universitätsmedizin Berlin, Germany (F.P.); Affiliated author members of the Guthy-Jackson Charitable Foundation (GJCF) International Clinical Consortium (ICC) for NMOSD are listed in Appendix S1.

Article Synopsis
  • Patients with neuromyelitis optica spectrum disorder (NMOSD) often have antibodies against aquaporin-4 (AQP4), making MRI monitoring critical for understanding the disease's progression.
  • A retrospective study involved MRI data from 525 AQP4-IgG-seropositive NMOSD patients across 11 countries, focusing on the types and locations of lesions in the central nervous system.
  • Results showed a high prevalence of hyperintense lesions in the brain and significant patterns of myelitis in the spinal cord, emphasizing the importance of MRI in tracking this condition.
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Objective: Narratives of mental illness and well-being are difficult to communicate in medical education. The arts convey these narratives and may strengthen medical student capabilities.

Methods: This study evaluated the efficacy of a 2021 6-week seminar-style course for medical students focused on five mental states through the lens of visual arts, film, and literature to impact student capabilities.

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Associations between prenatal exposure to environmental phenols and child neurodevelopment at two years of age in a South African birth cohort.

Environ Res

January 2025

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA. Electronic address:

Objective: Evidence suggests that prenatal environmental phenol exposures negatively impact child neurodevelopment, however there is little research on the effects of mixtures of multiple phenol exposures. We analyzed associations between prenatal exposure to phenol mixtures and cognitive neurodevelopment at two years of age among 545 mother-child pairs from the South African Drakenstein Child Health Study.

Material And Methods: We measured maternal urine environmental phenol concentrations once during the second trimester of pregnancy.

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Introduction: Little is known about how pharmacists' attitudes and stigma toward naloxone and Medication for opioid use disorder (MOUD) influence effective linkage to treatment. We examine the psychometrics of a new Pharmacist Opioid Use Disorder Perceptions Questionnaire (P-OUDP-Q), a multidimensional measure to examine pharmacists' stigma and perceptions related to MOUD in the New York State (NYS) site of the HEALing Communities Study.

Methods: The study recruited a sample of 324 pharmacists from 16 counties in NYS between January and June 2022.

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A Site-Wise Reliability Analysis of the ABCD Diffusion Fractional Anisotropy and Cortical Thickness: Impact of Scanner Platforms.

Hum Brain Mapp

November 2024

Maryland Psychiatric Research Center, Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, Maryland, USA.

The Adolescent Brain and Cognitive Development (ABCD) project is the largest study of adolescent brain development. ABCD longitudinally tracks 11,868 participants aged 9-10 years from 21 sites using standardized protocols for multi-site MRI data collection and analysis. While the multi-site and multi-scanner study design enhances the robustness and generalizability of analysis results, it may also introduce nonbiological variances including scanner-related variations, subject motion, and deviations from protocols.

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Article Synopsis
  • Temporal lobe epilepsy (TLE) is difficult to diagnose due to its varied presentations and reliance on MRIs and EEGs, which may lead to underdiagnosis.
  • Symptoms can include unusual behaviors and psychiatric issues, and treatment with antiepileptic medications should be considered even if tests appear normal.
  • A case study is presented where a patient with behavioral issues and recurrent loss of consciousness, despite normal test results, significantly improved after starting divalproex sodium, demonstrating the need for awareness of TLE indicators.
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Excessive information sampling in psychiatric patients characterized by high trait anxiety has been inconsistently linked with alterations in inferential and valuation processes. Methodological limitations could account in part for these inconsistencies. To address this, computational models of inference and valuation were applied to data collected from a transdiagnostic sample of adults with and without an anxiety or compulsive disorder using a version of the beads task with enhanced experimental controls.

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Article Synopsis
  • - The study investigates attention problems in children born preterm (<30 weeks gestation) from ages 2 to 5, analyzing factors that influence these attention trajectories and their relationship to ADHD diagnoses.
  • - Using data from 608 infants in a large prospective study, researchers found that while most children displayed low initial attention problems, there were notable individual differences in symptom progression over time.
  • - The findings indicate that children with higher initial attention issues and faster increases in symptoms are at a greater risk for an ADHD diagnosis, highlighting the need for tailored interventions based on individual characteristics.
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An expanding repertoire of circuit mechanisms for visual prediction errors.

Trends Neurosci

December 2024

Center for Behavioral Neuroscience, Neuroscience Institute, Georgia State University, Atlanta, GA, USA; Emotional Brain Institute, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA; Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA. Electronic address:

Cortical responses to stimuli vary dependingon context and expectation. Adding insight into this process, Furutachi et al. recently demonstrated that higher-order thalamic input to visual cortex cooperates with interneurons to augment responses to unexpected stimuli, consistent with a body of literature implicating top-down modulation and local inhibition in predictive processing.

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