702 results match your criteria: "New York Presbyterian- Columbia University[Affiliation]"

Background: Intracranial multimodal monitoring (iMMM) is increasingly used in neurocritical care, but a lack of standardization hinders its evidence-based development. Here, we devised core outcome sets (COS) and reporting guidelines to harmonize iMMM practices and research.

Methods: An open, decentralized, three-round Delphi consensus study involved experts between December 2023 and June 2024.

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Adult cardiac transplantation utilizing donors after circulatory death.

Ann Cardiothorac Surg

November 2024

Division of Cardiothoracic and Vascular Surgery, Lutheran Hospital, Indiana University School of Medicine - Fort Wayne, Fort Wayne, IN, USA.

Donation after circulatory death (DCD) presents both opportunities and challenges in the realm of heart transplantation. Its emergence holds promise for narrowing the gap between patients in need of organs and the available donor pool. The rapid emergence of DCD use has allowed heart transplant volume to increase worldwide.

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Purpose: The present study explored the extent to which early prelinguistic communication skills predict expressive language in toddlers with autistic siblings (Sibs-autism), who are known to be at high likelihood for autism and language disorder, and a comparison group of toddlers with non-autistic older siblings (Sibs-NA).

Method: Participants were 51 toddlers (29 Sibs-autism, 22 Sibs-NA) aged 12-18 months at the first time point in the study (Time 1). Toddlers were seen again 9 months later (Time 2).

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Background: Faculty tenure at U.S. medical schools has become less commonplace over the last several decades.

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Neurohospitalist Core Competencies.

Neurohospitalist

November 2024

Department of Neurology and Neurosciences, Stanford University School of Medicine, Stanford, CA, USA.

The Neurohospitalist Core Competencies comprise a set of competency-based learning objectives that encapsulate the knowledge, skills, and attitudes of neurohospitalitists who specialize in the care of hospitalized patients with neurologic conditions. These competencies serve to characterize the rapidly expanding field of neurohospitalist medicine. The 27 chapters are divided into 3 sections entitled: neurological conditions, clinical interventions and interpretation of ancillary studies, and neurohospitalist role in the healthcare system.

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Incidental identification of neonatal babesiosis: a case report.

BMC Pediatr

November 2024

Division of Infectious Diseases, Department of Pediatrics, New York Presbyterian-Columbia University Irving Medical Center, 650 W 168TH St, New York, NY, 10032, USA.

Article Synopsis
  • - This text discusses a case of neonatal babesiosis, a rare condition caused by a parasite transmitted by ticks, which was discovered during a typical evaluation for suspected sepsis in a newborn.
  • - A full-term male neonate presenting with fever was found to have Babesia microti parasites in his blood, and maternal history showed prior signs of thrombocytopenia and anemia linked to the same parasite.
  • - The case emphasizes the need for healthcare providers to consider babesiosis as a possible diagnosis in feverish neonates, especially in areas where the disease is common, and to review maternal health records and blood tests thoroughly.
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Background: Surgical site infections (SSIs) are a major driver of morbidity after combined liver and colorectal surgery for metastatic colorectal cancer. Available literature is inadequate to characterize risk factors and benchmarks for quality improvement.

Methods: Consecutive cases of simultaneous liver and colorectal surgery for colorectal adenocarcinoma from November 2013 through September 2022 were reviewed for SSIs per National Surgical Quality Improvement Program (NSQIP) and National Healthcare Safety Network (NHSN) criteria.

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Article Synopsis
  • The study focuses on the impact of tricuspid regurgitation (TR) on heart remodeling, comparing outcomes in patients treated with the TriClip device versus those receiving standard medical therapy in a randomized controlled trial.
  • Researchers utilized advanced imaging techniques, including cardiac magnetic resonance and 4D-CT, to assess heart changes at baseline, 30 days, and one year follow-ups.
  • Results showed that the TriClip significantly reduced TR volume by 70% at 30 days, leading to notable reductions in right ventricular size and area, with these improvements maintained after one year, unlike the control group.
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Two-stage glenohumeral fusion for the paralytic shoulder.

J Shoulder Elbow Surg

November 2024

Department of Orthopaedic Surgery, Harvard Medical School, Massachusetts General Hospital, Boston Shoulder Institute, Boston, MA, USA.

Background: Shoulder fusion after nerve injury can improve overall arm function; however, high revision and low patient satisfaction rates have been described. The purpose of this study is to describe a 2-stage shoulder fusion, first pinning in a position of function and then converting to a shoulder fusion. Our hypothesis is that temporary pinning improves overall satisfaction after shoulder fusion in comparison to satisfaction reported in the literature.

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Background And Aims: Eosinophilic esophagitis (EoE) is associated with impaired health-related quality of life (HRQoL) and stigma perceptions. Therefore, we examined the real-world impact of EoE on the daily life and ability to function in adolescents (caregiver-reported) and adults with EoE in the United States of America in a noninterventional, cross-sectional, web-based survey.

Methods: HRQoL was assessed using the Short Form Health Survey (domains: vitality and social functioning) and the European Health Interview Survey (domain: sleep).

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Summary Of Background Data: Although pseudoangina is most commonly caused by cervical disc herniation, several cases have been described where thoracic herniation produced symptoms of pseudoangina. If thoracic herniation can produce angina-like pain, then it is important to consider whether pathology of the thoracolumbar spine, in general, can trigger false pain syndromes distinct from pseudoangina.

Objective: We seek to provide the most comprehensive study regarding the diagnosis and treatment of spinal conditions causing false pain syndromes.

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Background: Owing to the significant morbidity and mortality of open thoracoabdominal aortic aneurysm surgery, complex endovascular repairs have become increasingly common, but still carry substantial risk. These repairs require large-bore access, with resultant pelvic and lower extremity ischemia. We, therefore, hypothesized that operative timing would be associated with outcomes, because efficient surgery would limit the ischemic time as well as anesthesia time.

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Article Synopsis
  • * Critically ill patients often face dysphagia, a swallowing impairment that can lead to serious complications like aspiration pneumonia and even increased mortality if not properly managed.
  • * Regular assessments and interventions by trained specialists and ICU staff are essential to prevent and address dysphagia in these patients, highlighting the need for more research on effective management strategies.
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Comparison of open and endovascular repair of complex abdominal aortic aneurysms.

J Vasc Surg

October 2024

Division of Vascular and Endovascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Electronic address:

Objective: The aim of this study was to compare perioperative and 5-year outcomes following endovascular (FEVAR) and open repair (OAR) of complex abdominal aortic aneurysms (cAAAs) in males and females separately, given the known sex-related differences in perioperative outcomes.

Methods: We studied all elective cAAA repairs between 2014 and 2019 in the Vascular Implant Surveillance and Interventional Outcomes Network (VISION) registry. We stratified patients based on sex.

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Article Synopsis
  • The study examined the impact of polyvascular disease on outcomes after endovascular aneurysm repair (EVAR) using data from the Vascular Quality Initiative (VQI) from 2012-2022.
  • Researchers evaluated 21,160 patients, finding that those with disease in three arterial beds had higher rates of complications and major adverse cardiac events (MACEs) post-surgery compared to those with disease in fewer beds.
  • The findings concluded that polyvascular disease significantly worsens peri-operative outcomes, increasing the odds of MACEs and mortality after EVAR.
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Article Synopsis
  • Bruton tyrosine kinase inhibitors (BTKi) have significantly improved treatment for B-cell malignancies, but many patients stop using them due to side effects, with cardiac issues being the most common reason for discontinuation.* -
  • The BRUIN study tested pirtobrutinib, a new non-covalent BTKi, on 127 patients who were intolerant to previous BTKi treatments, finding that many experienced fewer or no cardiac issues while showing a high overall response rate.* -
  • Results indicated pirtobrutinib had a median time on treatment of 15.3 months, with notable side effects like fatigue and neutropenia; overall, it proved to be a safe and effective alternative for
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Curriculum Research: Disseminating Neuropalliative Care Education Through an Adaptable Curriculum: A Multisite Feasibility Trial.

Neurol Educ

June 2024

From the Division of Geriatric Medicine and Palliative Care (E.H.), Department of Medicine, NYU Langone Health, New York; Department of Neurology (B.L.T., C.J.C.), University of Washington, Seattle; Department of Neurology & Neurological Sciences (H.L.K.), Stanford University School of Medicine, Palo Alto, CA; Department of Neurology (S.G., K.T.K., T.G.), New York Presbyterian-Columbia University Irving Medical Center, NY; Division of Palliative Care (K.T.B.), Departments of Neurology and Medicine, Massachusetts General Hospital, Boston; and Cambia Palliative Care Center of Excellence (C.J.C.), University of Washington, Seattle.

Introduction And Problem Statement: Neurologic disease is a leading cause of disability and death worldwide. As the global population ages, the burden of these diseases is expected to increase. Despite this increased clinical need, neurology trainees are seldom taught skills and concepts in palliative care.

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Abdominal pain is one of the most common presenting complaints to the emergency department, and appendicitis and diverticulitis are common causes. Intra-abdominal infections have historically been managed with admission to the hospital, antibiotics, and surgical interventions, and best-practice pathways are an important part of quality programs. Advances in diagnostics and management, supported with outcome data, are impacting care pathways.

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Retroperitoneal vs transperitoneal approach for nonruptured open conversion after endovascular aneurysm repair.

J Vasc Surg

January 2025

Department of Surgery, Division of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Electronic address:

Objective: Several studies comparing the transperitoneal (TP) and retroperitoneal (RP) approach for abdominal aortic aneurysm (AAA) repair suggest that the RP approach may result in lower rates of perioperative mortality and morbidity. However, data comparing these approaches for open conversion are lacking. This study aims to evaluate the association between the type of approach and outcomes following open conversion after endovascular aneurysm repair (EVAR).

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Article Synopsis
  • BMS-986365 is a novel oral treatment for metastatic castration-resistant prostate cancer (mCRPC), targeting the androgen receptor (AR) through a unique dual mechanism that both degrades and antagonizes it.
  • In a Phase 1 clinical trial involving 95 patients, the drug was found to be well tolerated, with common but manageable side effects, and showed signs of effectiveness, particularly in patients who had not previously undergone chemotherapy.
  • The primary goals of the study included assessing safety and determining the highest dose that could be tolerated, while key outcomes such as a significant drop in prostate-specific antigen levels and improved progression-free survival were also evaluated.
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Background: Increasing representation in clinical trials is a priority for the National Cancer Institute and Children's Oncology Group (COG). Our survey of COG-affiliated institutions revealed that many sites have insufficient processes and resources to enroll children whose parents use languages other than English (LOE). We describe reported barriers and facilitators to enrolling children in clinical trials when parents use LOE and propose opportunities for improvement.

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Article Synopsis
  • The TRILUMINATE Pivotal trial investigated the impact of tricuspid regurgitation (TR) on end-organ function and the effectiveness of transcatheter edge-to-edge repair (TEER) compared to medical therapy alone in patients with severe TR.
  • The study included 572 patients who were split into TEER and control groups, examining how changes in end-organ function correlate with hospitalizations for heart failure (HF) and mortality over 12 months.
  • Results showed that while TEER did not significantly differ from medical therapy alone in overall end-organ function improvements, successful TEER did lead to enhanced function in specific patient subgroups, indicating potential benefits in targeted treatment.
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Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes of cutaneous T-cell lymphoma (CTCL). While MF generally follows an indolent course, a subset of patients will experience progressive and/or treatment-refractory disease; Sézary syndrome is an aggressive lymphoma associated with high morbidity and mortality. Although allogeneic hematopoietic cell transplant (allo-HCT) is the only currently available potentially curative treatment modality for MF/SS there is no published guidance on referral criteria, transplant timing orallo-HCT approach.

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