361 results match your criteria: "New York Presbyterian Columbia University Medical Center[Affiliation]"

Background: Faculty tenure at U.S. medical schools has become less commonplace over the last several decades.

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Background: Surgical site infections (SSIs) are a major driver of morbidity after combined liver and colorectal surgery for metastatic colorectal cancer. Available literature is inadequate to characterize risk factors and benchmarks for quality improvement.

Methods: Consecutive cases of simultaneous liver and colorectal surgery for colorectal adenocarcinoma from November 2013 through September 2022 were reviewed for SSIs per National Surgical Quality Improvement Program (NSQIP) and National Healthcare Safety Network (NHSN) criteria.

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  • The study focuses on the impact of tricuspid regurgitation (TR) on heart remodeling, comparing outcomes in patients treated with the TriClip device versus those receiving standard medical therapy in a randomized controlled trial.
  • Researchers utilized advanced imaging techniques, including cardiac magnetic resonance and 4D-CT, to assess heart changes at baseline, 30 days, and one year follow-ups.
  • Results showed that the TriClip significantly reduced TR volume by 70% at 30 days, leading to notable reductions in right ventricular size and area, with these improvements maintained after one year, unlike the control group.
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Summary Of Background Data: Although pseudoangina is most commonly caused by cervical disc herniation, several cases have been described where thoracic herniation produced symptoms of pseudoangina. If thoracic herniation can produce angina-like pain, then it is important to consider whether pathology of the thoracolumbar spine, in general, can trigger false pain syndromes distinct from pseudoangina.

Objective: We seek to provide the most comprehensive study regarding the diagnosis and treatment of spinal conditions causing false pain syndromes.

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  • Bruton tyrosine kinase inhibitors (BTKi) have significantly improved treatment for B-cell malignancies, but many patients stop using them due to side effects, with cardiac issues being the most common reason for discontinuation.* -
  • The BRUIN study tested pirtobrutinib, a new non-covalent BTKi, on 127 patients who were intolerant to previous BTKi treatments, finding that many experienced fewer or no cardiac issues while showing a high overall response rate.* -
  • Results indicated pirtobrutinib had a median time on treatment of 15.3 months, with notable side effects like fatigue and neutropenia; overall, it proved to be a safe and effective alternative for
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Abdominal pain is one of the most common presenting complaints to the emergency department, and appendicitis and diverticulitis are common causes. Intra-abdominal infections have historically been managed with admission to the hospital, antibiotics, and surgical interventions, and best-practice pathways are an important part of quality programs. Advances in diagnostics and management, supported with outcome data, are impacting care pathways.

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  • BMS-986365 is a novel oral treatment for metastatic castration-resistant prostate cancer (mCRPC), targeting the androgen receptor (AR) through a unique dual mechanism that both degrades and antagonizes it.
  • In a Phase 1 clinical trial involving 95 patients, the drug was found to be well tolerated, with common but manageable side effects, and showed signs of effectiveness, particularly in patients who had not previously undergone chemotherapy.
  • The primary goals of the study included assessing safety and determining the highest dose that could be tolerated, while key outcomes such as a significant drop in prostate-specific antigen levels and improved progression-free survival were also evaluated.
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Background: Increasing representation in clinical trials is a priority for the National Cancer Institute and Children's Oncology Group (COG). Our survey of COG-affiliated institutions revealed that many sites have insufficient processes and resources to enroll children whose parents use languages other than English (LOE). We describe reported barriers and facilitators to enrolling children in clinical trials when parents use LOE and propose opportunities for improvement.

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  • Tumor Treating Fields (TTFields) therapy, approved for recurrent and newly diagnosed glioblastoma, disrupts cancer cell processes and has undergone a long-term safety analysis involving over 25,000 patients across multiple countries.* -
  • The study found that 73% of patients experienced all-cause adverse events, while 56% had TTFields-related events, with the most common issues being localized skin reactions and sensations like tingling and warmth.* -
  • Overall, TTFields therapy showed good tolerability and a consistent safety profile across different age groups, sexes, and diagnoses, indicating its potential for broad use in treating central nervous system malignancies.*
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  • The study looked at how different surgeons perform two types of surgeries for carotid artery problems: carotid endarterectomy (CEA) and transcarotid artery revascularization (TCAR).
  • It analyzed patient data from 2021 to 2023 to see how the number of surgeries a surgeon does impacts the risks of problems like strokes or injuries after the surgery.
  • Results showed that surgeons who primarily do TCAR or CEA have different rates of complications, suggesting that experience with one type affects outcomes for patients.
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The association between sex and outcomes after thoracic endovascular repair for acute type B aortic dissection.

J Vasc Surg

October 2024

Division of Vascular and Endovascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Electronic address:

Objective: Prior literature has found worse outcomes for female patients after endovascular repair of abdominal aortic aneurysm and mixed findings after thoracic endovascular aortic repair (TEVAR) for thoracic aortic aneurysm. However, the influence of sex on outcomes after TEVAR for acute type B aortic dissection (aTBAD) is not fully elucidated.

Methods: We identified patients who underwent TEVAR for aTBAD (<30 days) in the Vascular Quality Initiative from 2014 to 2022.

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The presence of adhesions and patent bypass grafts may create challenges for standard 14 mm outflow graft placement during left ventricular assist device implantation. We retrospectively describe our experience using a 10 mm Bioline Fusion graft (Getinge, Goteborg, Sweden) as the outflow graft in patients undergoing primary Heartmate 3 (Abbott, Abbott Park, IL) implantation. One hundred one patients underwent Heartmate 3 left ventricular assist device implantation, 80% via a thoracotomy approach, with the standard 14 mm outflow graft (78) or a 10 mm Bioline Fusion outflow graft (23).

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Objective: Postoperative outcomes following carotid revascularization are understudied in Asian patients. We aimed to assess whether disease severity and postoperative outcomes following carotid revascularization differ between Asian and White patients, and whether this varies with Asian procedure density.

Methods: We analyzed the Vascular Quality Initiative Carotid Endarterectomy and Carotid Artery Stenting datasets from 2003 to 2021.

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Ewing sarcoma (ES) is an uncommon mesenchymal neoplasm that typically develops as a bone mass, although up to 30% arise in extraskeletal sites. ES of the gastrointestinal (GI) and hepatobiliary tract is rare and may be misdiagnosed as other, more common neoplasms that occur in these sites. However, the correct classification of extraskeletal ES is important for timely clinical management and prognostication.

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  • A study evaluated the safety and performance of the Intrepid transapical transcatheter mitral valve replacement (TMVR) system over two years in patients with symptomatic, moderate to severe mitral regurgitation (MR) who are at high surgical risk.
  • 252 patients were analyzed, showing 13.1% all-cause mortality at 30 days, increasing to 36.2% by two years, along with significant heart failure rehospitalization rates.
  • Despite early challenges, more than half of the patients showed improvement in functional status and mild MR at two years, indicating potential benefits from the TMVR system.
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is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine, as interpreted by individual family physicians and medical educators in the USA and elsewhere around the world. In 'XII: Family medicine and the future of the healthcare system', authors address the following themes: 'Leadership in family medicine', 'Becoming an academic family physician', 'our call to act', 'The paradox of primary care and three simple rules', 'The quadruple aim-melding the patient and the health system', 'Fit-for-purpose medical workforce', 'Universal healthcare-coverage for all', 'The futures of family medicine' and 'The 100 essay.' May readers of these essays feel empowered to be part of family medicine's exciting future.

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  • Surgical mitral valve repairs may not hold up over time, leading to potential repeat surgeries; transcatheter mitral valve-in-ring (MViR) offers a new option for high-risk patients.
  • A study analyzed outcomes of MViR involving 820 patients, with most in poor heart function classes and significant mitral regurgitation; initial results showed a 30-day mortality rate of 8.3% and a 1-year rate of 22.4%.
  • At one year, MViR patients experienced improvements in heart function and reduced mitral regurgitation, but there were concerns about elevated pressure gradients and a 9.1% reintervention rate, affirming MViR as a viable
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Building the Future of Infectious Diseases: A Call to Action for Quality Improvement Research and Measurement.

J Infect Dis

November 2024

Division of Infectious Diseases and International Health, University of Virginia Health, Charlottesville, Virginia, USA.

Quality is central to value-based care, and measurement is essential for assessing performance and understanding improvement over time. Both value-based care and methods for quality measurement are evolving. Infectious diseases (ID) has been less engaged than other specialties in quality measure development, and ID providers must seize the opportunity to engage with quality measure development and research.

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The Milestones were initiated by the Accreditation Council for Graduate Medical Education (ACGME) to provide a framework for monitoring a trainee's progression throughout residency/fellowship. The Milestones describe stepwise skill progression through six core domains of clinical competency: Patient Care, Medical Knowledge, Interpersonal and Communication Skills, Practice-based Learning and Improvement, Professionalism, and Systems-based Practice. Since their introduction in 2013, several barriers to implementation have emerged.

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Background: Pancreatic cystic lesions (PCLs) are frequent on MRI and are thought to be associated with pancreatic adenocarcinoma (PDAC) necessitating long-term surveillance based on older studies suffering from selection bias.

Purpose: To establish the percentage of patients with PCLs on MRI with a present or future PDAC.

Study Type: Systematic review, meta-analysis.

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  • - The 'kickstand screw-rod' technique is introduced for correcting coronal malalignment in patients, using a new 'iliac kickstand screw' that interacts with a unique bone pathway in the ilium.
  • - A study of 50 pelvic CT scans aimed to define this osseous corridor, measuring structures to ensure safe placement of the screws with the help of 3D visualization software.
  • - Results indicate that the iliac kickstand screw can fit into a significant bone corridor with an average length of around 119.7 mm and a maximum potential diameter of 17.8 mm, along with identified starting points for insertion.
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