Neutrophil lipoxygenase activation and leukosequestration in postischemic myocutaneous flaps: role of LTB4.

Reperfusion of ischemic tissues leads to eicosanoid- and polymorphonuclear leukocyte (PMN)-dependent injury. The present experiments were undertaken to examine the effect of myocutaneous flap ischemia-reperfusion on neutrophil 5-lipoxygenase activity and to define the role of leukotriene B4 (LTB4) in postischemic PMN infiltration into such composite tissue grafts. Anesthetized Yorkshire pigs underwent 6 h of rectus abdominis myocutaneous flap ischemia or sham ischemia, and LTB4 generation was measured in calcium ionophore-stimulated neutrophils isolated from the circulation.

Acute hypoxemic respiratory failure in children following bone marrow transplantation: an outcome and pathologic study.

Objectives: To describe the pulmonary pathology and clinical outcome in children with acute hypoxemic respiratory failure after bone marrow transplantation.

Design: Review of medical records and pathologic material of patients diagnosed with acute hypoxemic respiratory failure after bone marrow transplantation.

Setting: Pediatric intensive care unit (ICU) of a teaching hospital.

OBSERVATIONS ON THE PATHOLOGICAL CHANGES FOLLOWING EXPERIMENTAL HYPERTENSION PRODUCED BY CONSTRICTION OF THE RENAL ARTERY.

The clinical histories and pathological findings of six animals dying within a few days following bilateral constriction of the renal arteries have been presented. No explanation for the rise in blood pressure was found. The clinical histories and pathological findings of twelve animals with a sustained hypertension have been considered together with the detailed account of one of these in which a marked degree of arterial disease was found.

STUDIES ON IMMUNITY IN A TYPE OF HUMAN ALLERGY (HAY FEVER): SEROLOGIC RESPONSE OF NON-SENSITIVE INDIVIDUALS TO POLLEN INJECTIONS.

Large injections of ragweed pollen extract into normal non-sensitive volunteers did not produce a sensitization to ragweed. Group 1 volunteers in whose skin many reactions were induced by injections of ragweed extract mixed with ragweed sensitive serum failed to show any serological changes. The theory that the immune substance found in the serum of treated ragweed sensitive cases was due to the reaction or to some substance created by it and not to the ragweed per se was not upheld.

THE RELATION OF BLOOD CHOLESTEROL AND THE SIZE OF PROSTATIC AND VESICULAR TRANSPLANTS IN THE ANTERIOR CHAMBER OF THE EYE.

In male rabbits, injections of the female sex hormone result in marked increase in the size of ocular transplants of the prostate and seminal vesicles and a correlated elevation of the blood cholesterol. Other hormones, which cause an increase in the size of the transplants, do not show this correlation. The ingestion of cholesterol with conspicuous increase of the blood cholesterol, has no effect on the size of the transplants.

THE PHYSIOLOGICAL RESPONSE OF PROSTATIC AND VESICULAR TRANSPLANTS IN THE ANTERIOR CHAMBER OF THE EYE.

1. With a photographic method for the determination of the size of prostatic and vesicular transplants in the anterior chamber of the eye, it has been possible to follow continuously the response to an injection of a hormone. 2.

VARIATION IN THE SIZE OF TRANSPLANTS OF THE PROSTATE AND SEMINAL VESICLE IN THE ANTERIOR CHAMBER OF THE EYE.

1. A method is described with which the two-dimensional size of a transplant in the anterior chamber of the eye may be measured daily with a high degree of accuracy. 2.

THE EFFECT OF AVITAMINOSIS-A ON THE PROSTATE.

1. Vitamin A deficiency alone in the white rat is associated with atrophy of the testis and accessory sexual glands. This would appear to be indicative of some disturbance in the hypophyseal-gonadalprostatic hormonal relationships.

SEROLOGICAL EVIDENCE OF IMMUNITY WITH COEXISTING SENSITIZATION IN A TYPE OF HUMAN ALLERGY (HAY FEVER).

Using ragweed hay fever as the representative of a certain type of allergy we have made studies to determine if possible the mechanism of the protection afforded by specific injections thus far established only by clinical observation. 1. Blood transfusions and serum injections from clinically immune, treated patients stopped the clinical reaction in untreated patients, thus indicating a transferable immunity.