28 results match your criteria: "New York (B.J.W.); and the University of South Carolina[Affiliation]"
Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.
Circ Cardiovasc Interv
December 2024
Cardiovascular Clinical Research Center, Department of Medicine, NYU Grossman School of Medicine, New York, NY (H.R.R., L.P., S.B., J.S.H.).
Background: The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of stress achieved, type of testing used, presence and extent of prior infarction, collateral blood flow, plaque characteristics, microvascular disease, coronary vasomotor tone, and genetic factors. Among chronic coronary disease participants with site-determined moderate or severe ischemia, we investigated associations between ischemia severity on stress testing and the extent of CAD on coronary computed tomography angiography.
Methods: Clinically indicated stress testing included nuclear imaging, echocardiography, cardiac magnetic resonance imaging, or nonimaging exercise tolerance test.
The impact of reference growth standards on small- and large-for-gestational age outcomes among pregnancies conceived by fresh and frozen embryo transfers.
F S Rep
June 2024
Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.
Objective: To describe differences in the frequency of small-for-gestational age (SGA) and large-for-gestational age (LGA) driven by different birth weight curves in assisted reproductive technology (ART)-conceived pregnancies.
Design: Retrospective cohort study.
Setting: Single academic medical center.
Ablating Myocardium Using Nanosecond Pulsed Electric Fields: Preclinical Assessment of Feasibility, Safety, and Durability.
Circ Arrhythm Electrophysiol
July 2024
Helmsley Electrophysiology Center (M.N., K.W., I.K., V.Y.R., J.S.K.), Icahn School of Medicine at Mount Sinai, New York.
Article Synopsis
- This study examines a new catheter-based technique using nanosecond pulsed electric fields for cardiac ablation in pigs, focusing on its effectiveness at targeting both cell membranes and intracellular organelles.
- The research involved 25 pigs, assessing the impact of different ablation durations (low-dose and high-dose) on various heart sites, with evaluations conducted over various survival periods.
- Results showed that all targeted veins were successfully isolated, lesion depth was significant, and while there were some transient effects on the phrenic nerve and esophagus, most animals healed well over time with minimal long-term damage.
Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy.
N Engl J Med
January 2024
From St. John's Research Institute (P.D., R.F.), St. John's Medical College (T.T., J.M.R., A.V.K.), and Bruhat Bengaluru Mahanagara Palike (N.B., R.S.) - all in Bangalore, India; the Africa Academy for Public Health (A.M., S.M.K., M.M.S.), Muhimbili University of Health and Allied Sciences (M.B., A.B.P.), Dar es Salaam Regional Medical Office of Health (N.O.S.), and Ifakara Health Institute (H.M.M.) - all in Dar es Salaam, Tanzania; the Harvard T.H. Chan School of Public Health (C.R.S., M.W., N.P., C.P.D., W.W.F.), Harvard Medical School (M.W., C.P.D.), and Boston Children's Hospital (C.P.D.) - all in Boston; Columbia University Medical Center, New York (B.J.W.); and the University of South Carolina, Columbia (N.P.).
Background: The World Health Organization recommends 1500 to 2000 mg of calcium daily as supplementation, divided into three doses, for pregnant persons in populations with low dietary calcium intake in order to reduce the risk of preeclampsia. The complexity of the dosing scheme, however, has led to implementation barriers.
Methods: We conducted two independent randomized trials of calcium supplementation, in India and Tanzania, to assess the noninferiority of a 500-mg daily dose to a 1500-mg daily dose of calcium supplementation.
Salary Negotiations: Gender Differences in Attitudes, Priorities, and Behaviors of Ophthalmologists.
Am J Ophthalmol
January 2024
Department of Ophthalmology (L.A.A.), Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.. Electronic address:
Purpose: To investigate attitudes, priorities, and behaviors of ophthalmologists in salary negotiations.
Design: Cross-sectional study.
Methods: A Qualtrics survey was disseminated to U.
Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer.
Cell
August 2023
Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. Electronic address:
Article Synopsis
- Researchers analyzed the proteogenomic profiles of 242 high-grade serous ovarian cancers (HGSOCs) to better understand those that are resistant to chemotherapy.
- A specific 64-protein signature was identified that accurately predicts which HGSOCs are likely to be resistant to platinum-based treatments, confirming findings in multiple patient groups.
- The study also found a link between the absence of Ch17 loss of heterozygosity and chemotherapy resistance, leading to the classification of HGSOCs into five clusters, each suggesting different resistance mechanisms and potential treatment targets.
Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity.
Neuron
April 2023
Department of Neuroscience & Physiology and Neuroscience Institute, NYU Langone Medical Center, 435 E 30th St, New York, NY 10016, USA; Department of Neurology, NYU Langone Medical Center, 435 E 30th St, New York, NY 10016, USA. Electronic address:
Cannabidiol (CBD), a non-euphoric component of cannabis, reduces seizures in multiple forms of pediatric epilepsies, but the mechanism(s) of anti-seizure action remain unclear. In one leading model, CBD acts at glutamatergic axon terminals, blocking the pro-excitatory actions of an endogenous membrane phospholipid, lysophosphatidylinositol (LPI), at the G-protein-coupled receptor GPR55. However, the impact of LPI-GPR55 signaling at inhibitory synapses and in epileptogenesis remains underexplored.
View Article and Find Full Text PDFElectrophysiology, Pathology, and Imaging of Pulsed Field Ablation of Scarred and Healthy Ventricles in Swine.
Circ Arrhythm Electrophysiol
January 2023
Helmsley Electrophysiology Center (I.K., V.Y.R., S.R.D., J.S.K.).
Background: Pulsed field ablation (PFA) has recently been shown to penetrate ischemic scar, but details on its efficacy, risk of arrhythmias, and imaging insights are lacking. In a porcine model of myocardial scar, we studied the ability of ventricular PFA to penetrate scarred tissue, induce ventricular arrhythmias, and assess the influence of QRS gating during pulse delivery.
Methods: Of a total of 6 swine, 5 underwent coronary occlusion and 1 underwent radiofrequency ablation to create infarct scar and iatrogenic scar models, respectively.
Clean Cooking Fuels to Improve Health during Pregnancy.
N Engl J Med
November 2022
From the Department of Obstetrics and Gynecology, Columbia University Vagelos College of Physicians and Surgeons, and the Collaborative for Women's Environmental Health - both in New York (B.J.W.); and Kintampo Health Research Centre, Research and Development Ghana Health Service, Kintampo North Municipality, Ghana (K.P.A.).
Pulsed Field Ablation of the Porcine Ventricle Using a Focal Lattice-Tip Catheter.
Circ Arrhythm Electrophysiol
September 2022
Helmsley Electrophysiology Center (I.K., V.Y.R., S.R.D., J.S.K.), Icahn School of Medicine at Mount Sinai, New York, NY.
Background: Our understanding of catheter-based pulsed field ablation (PFA) of the ventricular myocardium is limited. We conducted a series of exploratory evaluations of ventricular PFA in swine ventricles.
Methods: A focal lattice-tip catheter was used to deliver proprietary biphasic monopolar PFA applications to swine ventricles under general anesthesia, with guidance from electroanatomical mapping, fluoroscopy, and intracardiac echocardiography.
Aspirin and Statin Therapy for Nonobstructive Coronary Artery Disease: Five-year Outcomes from the CONFIRM Registry.
Radiol Cardiothorac Imaging
April 2022
Department of Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6 (P.I., S.B.Z., P.B., S.S., J.A.L.); Department of Cardiology, Concord Hospital, Sydney, Australia (C.N.); Department of Imaging, Cedars Sinai Medical Center, Los Angeles, Calif (H.G., D.S.B.); Department of Cardiology, Friedrich-Alexander-University, Erlangen-Nuremberg, Germany (S.A.); Department of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Tex (M.H.A.); Department of Radiology, Centro Cardiologico Monzino, IRCCS Milan, Milan, Italy (D.A., G.P.); Department of Medicine, Los Angeles Biomedical Research Institute, Los Angeles, Calif (M.J.B.); Department of Radiology, Cardiovascular Imaging Center, SDN IRCCS, Naples, Italy (F.C.); Department of Cardiology, Tennessee Heart and Vascular Institute, Henderson, Tenn (T.Q.C.); Division of Cardiology, Severance Cardiovascular Hospital, Severance Biomedical Science Institute, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea (H.J.C.); Department of Cardiology, William Beaumont Hospital, Royal Oak, Mich (K.C., G.L.R.); Department of Medicine and Radiology, University of Ottawa, Ottawa, Canada (B.J.W.C.); Department of Radiology, Miami Cardiac and Vascular Institute, Miami, Fla (R.C.C.); Department of Cardiology, Capitol Cardiology Associates, Albany, NY (A.D.); Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (G.F.); Department of Radiology and Nuclear Medicine, German Heart Center Munich, Munich, Germany (M.H.); Department of Cardiology, Medizinische Klinik I der Ludwig-Maximilians-Universität München, Munich, Germany (J.H.); Department of Nuclear Medicine, University Hospital, University of Zurich, Zurich, Switzerland (P.A.K.); Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea (Y.J.K.); Department of Radiology, Area Vasta 1/ASUR Marche, Fano, Italy (E.M.); Unit of Cardiovascular Imaging, Hospital da Luz, Lisbon, Portugal (H.M., P.d.A.G.); Department of Cardiology, Lady Davis Carmel Medical Center, The Ruth and Bruce Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel (R.R.); Department of Medicine, University of Virginia Health System, Charlottesville, Va (T.C.V.); Department of Radiology, New York-Presbyterian Hospital, Weill Cornell Medicine, New York, NY (F.Y.L., L.J.S.); Department of Cardiology, Mount Sinai Hospital, New York, NY (J.N.); and Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.).
Article Synopsis
- This study analyzed 5-year data from the CONFIRM registry to assess the impact of baseline aspirin and statin use on mortality and major cardiovascular events in individuals without significant coronary artery blockage.
- Researchers included 6,386 participants, predominantly middle-aged men, focusing on those with nonobstructive coronary artery disease (CAD) and confirmed that this condition increased all-cause mortality risk compared to those with no CAD.
- Results showed that while baseline aspirin use did not significantly lower cardiovascular events or mortality, statin use was linked to a reduced rate of major adverse cardiovascular events on risk-adjusted analysis.
Consensus Guidelines for the Definition of Time-to-Event End Points in Image-guided Tumor Ablation: Results of the SIO and DATECAN Initiative.
Radiology
December 2021
From the Department of Radiology, Center of Image-guided Tumor Ablation, Amsterdam University Medical Centers, Location VUMC, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands (R.S.P., H.J.S., M.R.M.); Department of Radiology, Onze Lieve Vrouwe Gasthuis (OLVG) Hospital, Amsterdam, the Netherlands (R.S.P.); Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass (M.A., S.N.G.); Department of Radiology, King's College, St Thomas' Hospital, London, England (A.A.); Department of Radiology, National Cancer Center Hospital, Tokyo, Japan (Y.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (R.A., D.A.G.); Department of Radiology, Institut de Cancérologie Gustave Roussy, Villejuif, France (T.d.B.); Department of Radiology, Medical University Innsbruck, Innsbruck, Austria (R.B.); Clinical and Epidemiological Research Unit, Comprehensive Cancer Centre, Institut Bergonié, Bordeaux, France (C.B.); Department of Radiology, Kantonsspital Winterthur, Winterthur, Switzerland (C.A.B.); Department of Radiology, Biomedical Engineering, and Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wis (C.L.B., F.T.L.); Department of Radiology, University Hospital Southampton, Southampton, England (D.J.B.); 2nd Department of Radiology, University General Hospital "ATTIKON" Medical School, National and Kapodistrian University of Athens, Athens, Greece (E.B., D.F., A.K.); Department of Radiology, Mayo Clinic, Rochester, Minn (M.R.C.); Department of Radiology, Dipartimento di Scienze Medico-Chirurgiche, IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy (G.C.); Department of Radiology, Yale University School of Medicine, New Haven, Conn (J.C., H.S.K., D.C.M.); Department of Radiology, IRCCS Ospedale San Raffaele, Milan, Italy (F.d.C.); Department of Epidemiology and Data Science, Decision Modeling Center, Amsterdam University Medical Centers, Location VUMC, Amsterdam, the Netherlands (V.M.H.C., B.I.L.W.); Department of Radiology, University of Pisa, Pisa University Hospital, Pisa, Italy (L.C.); Department of Radiology, CHUV University of Lausanne, Lausanne, Switzerland (A.D.); and Department of Radiology, Brown Medical School, Cape Cod Hospital, Hyannis, Mass (D.E.D.); Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY (J.P.E., C.T.S., S.B.S.); Department of Radiology, University Hospital of Strasbourg, Strasbourg, France (A.G.); Department of Radiology, The London Clinic, London, England (A.R.G.); Society of Interventional Oncology, Washington, DC (T.G.); Department of Radiology, University Hospital of Dijon, Dijon, France (B.G.); Department of Radiology, University Hospitals Schlewsig-Holstein, Lübeck, Germany (T.H.); Department of Radiology, Agostino Gemelli University Policlinic, Catholic University of the Sacred Heart, Rome, Italy (R.I.); Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (T.W.K., M.W.L., H.R.); Department of Radiology, Universitätsklinikum Augsburg, Augsburg, Germany (T.K.); Department of Radiology, University of Washington Medical Center, Seattle, Wash (S.K.); Department of Radiology, David Geffen School of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, Calif (E.W.L., D.S.L.); Department of Radiology, Chinese PLA General Hospital, Beijing, China (P.L.); Department of Radiology, IEO Istituto Europeo di Oncologia, Gruppo Ospedaliero San Donato, Milan, Italy (G.M.); Department of Radiology, Ospedale Valduce, Como, Italy (M.F.M.); Department of Radiology, St George's University Hospitals, London, England (R.M.); Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (G. Nadolski, M.C.S.); Department of Radiology, Baptist Health of South Florida, Miami Cardiac and Vascular Institute, Miami, Fla (G. Narayanan); Department of Radiology, University of California, San Diego Health, San Diego, Calif (I.N.); Department of Radiology, Cooley Dickinson Hospital, Northampton, Mass (B.N.); Department of Radiology, European Institute of Oncology, IRCCS, Milan, Italy (F.O.); Department of Radiology, Academic Hospital Ruprecht-Karls-University Heidelberg, SLK Clinics GmbH, Heilbronn, Germany (P.L.P.); Department of Radiology, Tan Tock Seng Hospital, Singapore (U.P.); Department of Radiology, Klinikum der Universität München, Munich, Germany (J.R.); Department of Radiology, Medical College of Wisconsin, Milwaukee, Wis (W.R.); Department of Radiology, Northwestern University, Chicago, Ill (R.S.); Department of Radiology, Humanitas University, Ospedale Generale, Milan, Italy (L.A.S.); Department of Radiology, Stanford University, Stanford University Medical Center, Stanford, Calif (D.S., D.S.W.); Department of Radiology, John Radcliffe Hospital, Oxford, England (R.U.); Department of Radiology, University of Frankfurt, University Hospital Frankfurt Johann Wolfgang Goethe-University, Frankfurt, Germany (T.J.V.); and Department of Radiology and Imaging Science, National Institutes of Health, Bethesda, Md (B.J.W.); Department of Radiology, Image-guided Therapy and Interventional Oncology Unit, Hadassah Hebrew University Hospital, Jerusalem, Israel (S.N.G.); and Department of Radiology, Noordwest Ziekenhuisgroep, Alkmaar, the Netherlands (M.R.M.).
There is currently no consensus regarding preferred clinical outcome measures following image-guided tumor ablation or clear definitions of oncologic end points. This consensus document proposes standardized definitions for a broad range of oncologic outcome measures with recommendations on how to uniformly document, analyze, and report outcomes. The initiative was coordinated by the Society of Interventional Oncology in collaboration with the Definition for the Assessment of Time-to-Event End Points in Cancer Trials, or DATECAN, group.
View Article and Find Full Text PDFFederated learning for predicting clinical outcomes in patients with COVID-19.
Nat Med
October 2021
Center for Advanced Medical Computing and Analysis, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Federated learning (FL) is a method used for training artificial intelligence models with data from multiple sources while maintaining data anonymity, thus removing many barriers to data sharing. Here we used data from 20 institutes across the globe to train a FL model, called EXAM (electronic medical record (EMR) chest X-ray AI model), that predicts the future oxygen requirements of symptomatic patients with COVID-19 using inputs of vital signs, laboratory data and chest X-rays. EXAM achieved an average area under the curve (AUC) >0.
View Article and Find Full Text PDFTherapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
N Engl J Med
August 2021
From the Peter Munk Cardiac Centre at University Health Network (P.R.L., M.E.F., V.D., J.P.G., L.C.G., G.H.), the University of Toronto (P.R.L., E.C.G., A.S.S., M.E.F., V.D., R.A.F., L.C.G., G.H., M.H.), University Health Network (E.C.G., M.H.), St. Michael's Hospital Unity Health (A.S.S., Z.B., J.C.M., M.S.), Ozmosis Research (L.B., L.P.G.D., V.W.), and Sunnybrook Health Sciences Centre (J.P.G.), Toronto, Ottawa Hospital Research Institute (M. Carrier, L.A.C., D.A.F., G.L.G., D.M.S.), Institut du Savoir Montfort (Marc Carrier, G.L.G.), and the University of Ottawa (L.A.C., D.A.F., D.M.S.), Ottawa, Université Laval (A.F.T.) and CHU de Québec-Université Laval Research Center (A.F.T.), Quebec, QC, the University of Manitoba (B.L.H., A. Kumar, R.Z., S.A.L., D.S., G.V.-G.), CancerCare Manitoba (B.L.H., R.Z.), and St. Boniface Hospital (N.M.), Winnipeg, MB, McGill University, Montreal (S.R.K., E.G.M.), McMaster University (P.L.G.) and the Thrombosis and Atherosclerosis Research Institute (P.L.G.), Hamilton, ON, Université de Sherbrooke, Sherbrooke, QC (F.L.), the University of British Columbia, Vancouver (S. Murthy, K.R.), and the University of Alberta, Edmonton (S.D.) - all in Canada; NYU Grossman School of Medicine (J.S.B., H.R.R., J.S.H., T.C., N.M.K., S.P.), the Icahn School of Medicine at Mount Sinai and Mount Sinai Heart (R.S.R.), NYU Langone Health, NYU Langone Hospital (T.C., J.M.H., E.Y.), and Bellevue Hospital (N.M.K.), New York, Montefiore Medical Center (M.N.G., H.H.B., S.C., J.T.C., R.N.) and Albert Einstein College of Medicine (M.N.G., H.H.B., B.T.G., A. Hope), Bronx, and NYU Langone Long Island, Mineola (R.D.H., A. Hindenburg) - all in New York; the University of Pittsburgh (M.D.N., B.J.M., D.T.H., M.M.B., D.C.A., A.J.K., C.M.L., K.L., S.K.M., C.W.S.), UPMC (M.D.N., B.J.M., D.C.A., K.L., S.K.M.), the Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, University of Pittsburgh (T.D.G.), and UPMC Children's Hospital of Pittsburgh (C. Horvat), Pittsburgh, and Emergency Medicine, Penn State Hershey Medical Center, Hershey (S.C.M.) - all in Pennsylvania; Instituto do Coracao, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (J.C.N., L.C.G., F.G.L.), Avanti Pesquisa Clínica (A.S.M.), Hospital de Julho (F.O.S.), and Hospital do Coracao (F.G.Z.), Sao Paulo, Hospital do Coração de Mato Grosso do Sul and the Federal University of Mato Grosso do Sul (M.P.), Hospital Universitário Maria Aparecida Pedrossia (D.G.S.J.), and Hospital Unimed Campo Grande (D.G.S.J.), Campo Grande, and INGOH, Clinical Research Center, Goiânia (M.O.S.) - all in Brazil; Instituto Mexicano del Seguro Social, Mexico City (J.E., Y.S.P.G.); the University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust (C.A.B.), Bristol, Imperial College London (A.C.G., F.A.-B., M.A.L.), Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), the London School of Hygiene and Tropical Medicine (B.-A.K.), University College London Hospital (R.H.), Kings Healthcare Partners (B.J.H.), the Intensive Care National Audit and Research Centre (P.R.M.), Guy's and St. Thomas' NHS Foundation Trust (M.S.-H.), and King's College London (M.S.-H.), London, Oxford University (A. Beane, S.J.S.) and NHS Blood and Transplant (L.J.E., S.J.S.), Oxford, and Queen's University Belfast and Royal Victoria Hospital, Belfast (D.F.M.) - all in the United Kingdom; Zuckerberg San Francisco General Hospital, University of California, San Francisco (L.Z.K., C. Hendrickson, M.M.K., A.E.K., M.A.M., B.N.-G.), Harbor-UCLA Medical Center, Torrance (R.J.L., S. Brouwer), Global Coalition for Adaptive Research (M. Buxton) and the University of California Los Angeles (G.L.), Los Angeles, the University of California San Diego School of Medicine, San Diego (T.W.C.), and Stanford University School of Medicine, Palo Alto (J.G.W.) - all in California; Larner College of Medicine at the University of Vermont, Burlington (M. Cushman); Australian and New Zealand Intensive Care Research Centre, Monash University (Z.M., A.M.H., C.J.M., S.A.W., A. Buzgau, C.G., S.P.M., A.D.N., J.C.P., A.C.C.), and Alfred Health (A.C.C., A.D.N.), Melbourne, VIC, St. John of God Subiaco Hospital (S.A.W., E. Litton) and Fiona Stanley Hospital (E. Litton), Perth, WA, and Flinders University, Bedford Park, SA (S. Bihari) - all in Australia; the University of Illinois (K.S.K., J.R.J., J.G.Q.), Cook County Health and Rush Medical College (S. Malhotra), and the University of Chicago (J.D.P.) - all in Chicago; SOCAR Research SA, Nyon (B.-A.K.), and Inselspital, Bern University Hospital, University of Bern (T.T.), Bern - all in Switzerland; Berry Consultants, Austin (R.J.L., E. Lorenzi, S.M.B., L.R.B., M.A.D., M.F., A.M., C.T.S.), University of Texas Southwestern Medical Center, Dallas (A.P.), and Baylor Scott and White Health, Temple (R.J.W.) - all in Texas; Auckland City Hospital (C.J.M., S.P.M., R.L.P.) and the University of Auckland (R.L.P.), Auckland, and the Medical Research Institute of New Zealand, Wellington (C.J.M., A.M.T.) - all in New Zealand; Vanderbilt University Medical Center (A.W.A.) and TriStar Centennial Medical Center (A.L.G.) - both in Nashville; Fédération Hospitalo Universitaire, Raymond Poincaré Hospital, Université de Versailles Saint-Quentin-en-Yvelines, Garches (D. Annane), and Aix-Marseille University, Marseille (B.C.) - both in France; King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia (Y.M.A.); Nepal Mediciti Hospital, Lalitpur, and Nepal Intensive Care Research Foundation, Kathmandu (D. Aryal) - both in Nepal; Versiti Blood Research Institute, Milwaukee (L.B.K., L.J.E.), and the University of Wisconsin School of Medicine and Public Health, Madison (J.P.S.); National Intensive Care Surveillance-Mahidol Oxford Tropical Medicine Research Unit, Colombo, Sri Lanka (A. Beane); the University Medical Center Utrecht, Utrecht University, Utrecht (M. Bonten, R.E.G.S., W.B.-P.), and Radboud University Medical Center, Nijmegen (S. Middeldorp, F.L.V.) - both in the Netherlands; Jena University Hospital, Jena, Germany (F.B.); Cleveland Clinic (A.D.) and Case Western Reserve University, the Metro Health Medical Centre (V.K.) - both in Cleveland; Ochsner Medical Center, University of Queensland-Ochsner Clinical School, New Orleans (M.B.E.); Harvard Medical School (B.M.E., Y.K., N.S.R., A.B.S), Brigham and Women's Hospital (B.M.E., Y.K., S.M.H.), Boston University School of Medicine and Boston Medical Center (N.M.H.), and Massachusetts General Hospital (A.B.S., N.S.R.) - all in Boston; University of Alabama, Birmingham (S.G.); Hospital Ramón y Cajal (S.G.-M., J.L.L.-S.M., R.M.G.) and IdiPaz Research Institute, Universidad Autonoma (J.L.-S.), Madrid, and University Hospital of Salamanca-University of Salamanca-IBSAL, Salamanca (M.M.) - all in Spain; University of Antwerp, Wilrijk, Belgium (H.G.); Rutgers New Jersey Medical School, Newark (Y.Y.G.); University of Oxford, Bangkok, Thailand (R.H.); Ascension St. John Heart and Vascular Center, Tulsa (N.H.), and the University of Oklahoma College of Medicine, Oklahoma City (N.H.); the University of Cincinnati, Cincinnati (K.H.); University of Michigan, Ann Arbor (R.C.H., P.K.P.), Beaumont Health, Royal Oak, and the OUWB School of Medicine, Auburn Hills (G.B.N.) - all in Michigan; Mayo Clinic, Rochester (V.N.I.), and the Hennepin County Medical Center, Minneapolis (M.E.P.) - both in Minnesota; Apollo Speciality Hospital-OMR, Chennai, India (D.J.); Oregon Health and Science University, Portland (A. Khan, E.S.L.); the National Heart, Lung, and Blood Institute, Bethesda, MD (A.L.K.); University of Mississippi Medical Center, Jackson (M.E.K.); University College Dublin, Dublin (A.D.N.); University of Kansas School of Medicine, Kansas City (L.S.); Duke University Hospital, Durham, NC (L.W.); and Emory University, Atlanta (B.J.W.).
Background: Thrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.
Methods: In this open-label, adaptive, multiplatform, controlled trial, we randomly assigned patients who were hospitalized with Covid-19 and who were not critically ill (which was defined as an absence of critical care-level organ support at enrollment) to receive pragmatically defined regimens of either therapeutic-dose anticoagulation with heparin or usual-care pharmacologic thromboprophylaxis.
Integrating Eye Tracking and Speech Recognition Accurately Annotates MR Brain Images for Deep Learning: Proof of Principle.
Radiol Artif Intell
January 2021
Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065 (J.N.S., D.G., N.S., R.Y., S.E.W., A.H.); The National Institutes of Health Clinical Center, Bethesda, Md (H.C., B.J.W.); Department of Radiology, Columbia University Medical Center, New York, NY (S.J.); Department of Radiology, University of California-Irvine, Irvine, Calif (P.D.C.); Department of Radiology & Imaging Sciences, Emory University, Atlanta, Ga (E.K.); and Center for Research in Computer Vision, University of Central Florida, Orlando, Fla (U.B.).
Purpose: To generate and assess an algorithm combining eye tracking and speech recognition to extract brain lesion location labels automatically for deep learning (DL).
Materials And Methods: In this retrospective study, 700 two-dimensional brain tumor MRI scans from the Brain Tumor Segmentation database were clinically interpreted. For each image, a single radiologist dictated a standard phrase describing the lesion into a microphone, simulating clinical interpretation.
Electrocardiographic QT Intervals in Infants Exposed to Hydroxychloroquine Throughout Gestation.
Circ Arrhythm Electrophysiol
October 2020
New York University School of Medicine, New York, NY (R. Clancy, C.K.P., R. Cohen, M.M., B.J.W., A.S., P.M.I., J.P.B.).
Background: Based on inhibition of viral replication and limited reports on clinical efficacy, hydroxychloroquine is being considered as prophylaxis and treatment of coronavirus disease-19 (COVID-19). Although hydroxychloroquine is generally considered safe during pregnancy based on studies in patients with systemic lupus erythematosus and other rheumatic conditions, there may still be reluctance to institute this antimalarial during pregnancy for the sole purpose of antiviral therapy.
Methods: To provide data regarding any potential fetal/neonatal cardiotoxicity, we leveraged a unique opportunity in which neonatal ECGs and hydroxychloroquine blood levels were available in a recently completed study evaluating the efficacy of hydroxychloroquine 400 mg daily to prevent the recurrence of congenital heart block associated with anti-SSA/Ro (anti-Sjögren's Syndrome A/Ro) antibodies.
Punctal Congestion Syndrome: A Reversible, Functional Punctal Stenosis Causing Epiphora in the Setting of Chronic Pretarsal Conjunctivitis.
Ophthalmic Plast Reconstr Surg
May 2021
Department of Ophthalmology, Columbia University Irving Medical Center, New York, New York.
Purpose: To describe a reversible syndrome of epiphora, functional punctal stenosis, and chronic pretarsal conjunctivitis associated with corticosteroid or corticosteroid-antibiotic eyedrop use.
Methods: This is an Institutional Review Board-approved retrospective review of patients diagnosed with epiphora, punctal stenosis, and chronic conjunctivitis by a single surgeon (B.J.
Immunotherapy and the Interventional Oncologist: Challenges and Opportunities-A Society of Interventional Oncology White Paper.
Radiology
July 2019
From the Interventional Radiology Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, H-118, New York, NY 10065 (J.P.E.); Department of Radiology and Imaging Sciences, University of Utah School of Medicine, Salt Lake City, Utah (G.C.F.); Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, the Netherlands (G.J.A., M.d.B.); Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass (M.A.); Division of Vascular and Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.); Department of Radiodiagnostic and Interventional Radiology, University of Lausanne, Lausanne, Switzerland (R.D.); Penn Image-Guided Interventions Laboratory and Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (S.J.H.); Department of Radiology, University of Colorado, Denver, Colo (D.T.J.); Department of Radiology, Ludwig-Maximilian University, Munich, Germany (J.R.); Division of Vascular and Interventional Radiology, Stanford University, Stanford, Calif (D.Y.S.); Division of Interventional Radiology, Mayo Clinic Florida, Jacksonville, Fla (B.B.T.); Center for Interventional Oncology, National Cancer Institute, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (B.J.W.); Department of Radiology, Mayo Clinic, Rochester Minn (D.W.); and Department of Radiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel (S.N.G.).
Interventional oncology is a subspecialty field of interventional radiology that addresses the diagnosis and treatment of cancer and cancer-related problems by using targeted minimally invasive procedures performed with image guidance. Immuno-oncology is an innovative area of cancer research and practice that seeks to help the patient's own immune system fight cancer. Both interventional oncology and immuno-oncology can potentially play a pivotal role in cancer management plans when used alongside medical, surgical, and radiation oncology in the care of cancer patients.
View Article and Find Full Text PDFComplications in Pediatric Regional Anesthesia: An Analysis of More than 100,000 Blocks from the Pediatric Regional Anesthesia Network.
Anesthesiology
October 2018
From the Departments of Anesthesiology (B.J.W.) Biostatistics and Medical Informatics (J.B.), University of Wisconsin School of Medicine and Public Health, American Family Children's Hospital, Madison, Wisconsin the Department of Anesthesiology, Emory University School of Medicine, Children's Healthcare of Atlanta at Egleston Children's Hospital, Atlanta, Georgia ( J.B.L.) the Department of Anesthesiology, University of Mississippi Medical Center, Jackson, Mississippi (M.S.) Axio Research LLC, Seattle, Washington (C.W.) the Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, Washington (A.T.B., S.H.F.) the Departments of Pediatrics and Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, Lucile Packard Children's Hospital, Palo Alto, California (E.J.K.) the Department of Anesthesiology, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts (N.F.S.) the Department of Pediatric Anesthesiology, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Chicago, Illinois (S.S.) the Departments of Anesthesiology and Pediatrics, Dartmouth Medical School, Children's Hospital at Dartmouth, Lebanon, New Hampshire (A.H.T.) the Departments of Anesthesiology and Pediatrics, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, Colorado (D.M.P.). Seattle Children's Hospital Seattle Children's Hospital Seattle Children's Hospital Seattle Children's Hospital Seattle Children's Hospital Seattle Children's Hospital Lurie Children's Hospital, Northwestern University Lurie Children's Hospital, Northwestern University Lurie Children's Hospital, Northwestern University Lucile Packard Children's Hospital at Stanford Children's Medical Center, Dallas Children's Medical Center, Dallas The Cleveland Clinic Boston Children's Hospital University of Texas, Houston University of Texas, Houston University of New Mexico University of New Mexico Texas Children's Hospital Texas Children's Hospital Texas Children's Hospital Texas Children's Hospital Doernbecher Children's Hospital, Oregon Health Sciences University Amplatz Children's Hospital/University of Minnesota Amplatz Children's Hospital/University of Minnesota Riley Hospital for Children at Indiana University Health Riley Hospital for Children at Indiana University Health Hospital for Special Surgery, New York Hospital for Special Surgery, New York Children's Healthcare of Atlanta at Egleston Children's Hospital, Emory University Children's Healthcare of Atlanta at Egleston Children's Hospital, Emory University Children's of Mississippi, University of Mississippi Joe DiMaggio Children's Hospital Columbia University University Hospital Rijeka, Croatia Nationwide Children's Hospital, Ohio State University Hospital Municipal Jesus, Rio De Janiero, Brazil Selçuk University, Konya, Turkey Monroe Carrell Children's Hospital, Vanderbilt University Wellstar Medical Group Children's National Medical Center Children's National Medical Center Massachusetts General Hospital for Children Massachusetts General Hospital for Children.
What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Complications in pediatric regional anesthesia are rare, so a large sample size is necessary to quantify risk. The Pediatric Regional Anesthesia Network contains data on more than 100,000 blocks administered at more than 20 children's hospitals. This study analyzed the risk of major complications associated with regional anesthesia in children.
View Article and Find Full Text PDFSpecies-specific susceptibility to cannabis-induced convulsions.
Br J Pharmacol
May 2019
Division of Pharmacology, School of Chemistry, Food and Nutritional Sciences, and Pharmacy, University of Reading, Reading, UK.
Background And Purpose: Numerous claims are made for cannabis' therapeutic utility upon human seizures, but concerns persist about risks. A potential confounder is the presence of both Δ -tetrahydrocannabinol (THC), variously reported to be pro- and anticonvulsant, and cannabidiol (CBD), widely confirmed as anticonvulsant. Therefore, we investigated effects of prolonged exposure to different THC/CBD cannabis extracts on seizure activity and associated measures of endocannabinoid (eCB) system signalling.
View Article and Find Full Text PDFPrognostic Significance of Nonobstructive Left Main Coronary Artery Disease in Women Versus Men: Long-Term Outcomes From the CONFIRM (Coronary CT Angiography Evaluation For Clinical Outcomes: An International Multicenter) Registry.
Circ Cardiovasc Imaging
August 2017
From the Department of Cardiology, Emory University School of Medicine, Atlanta, GA (J.X.X., P.E., T.V., A.G., P.K.M., W.K., L.J.S.); Department of Cardiology, University of British Columbia, Vancouver, Canada (J.L.); Department of Cardiology, Weill Cornell Medical College and the New York Presbyterian Hospital, NY (B.ó.H., J.K.M.); Department of Cardiology, Barbara Stresiand Women's Heart Center, Cedars-Sinai Medical Center, Los Angeles, CA (C.N.B.M., D.S.B., H.G.); Department of Cardiology, Harbor UCLA Medical Center, Los Angeles, CA (M.J.B.); Department of Cardiology, University of Erlangen, Germany (S.A.); Department of Cardiolog, Tennessee Heart and Vascular Institute, Hendersonville, TN (T.Q.C.); Department of Cardiology, Hospital da Luz, Lisbon, Portugal (H.M.); Department of Cardiology, The Ruth and Bruce Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel (R.R.); Department of Cardiology, Henry Ford Hospital, Detroit, MI (M.H.A.-M.); Department of Cardiology, University of Milan, Centro Cardiologico Monzino, IRCCS, Italy (D.A., G.P.); Department of Radiology/Centre de Recherche, Montreal Heart Institute/Universitè de Montreal, Quebec, Canada (F.C., E.M.); Department of Cardiology, William Beaumont Hospital, Royal Oaks, MI (K.C., G.R.); Department of Cardiology, Deutsches Herzzentrum Munchen, Munich, Germany (M.H.); Department of Cardiology, Medizinische Klinik I der Ludwig-Maximilians-Universität München, Munich, Germany (J.H.); Department of Cardiology, Medical University of Innsbruck, Austria (G.F.); Department of Cardiology, University Hospital, Zurich, Switzerland (P.A.K.); Department of Cardiology, Walter Reed Medical Center, Washington, DC (T.C.V); Department of Cardiology, University of Ottawa Heart Institute, Ontario, Canada (B.J.W.C.).
Background: Patients with obstructive (≥50% stenosis) left main (LM) coronary artery disease (CAD) are at high risk for adverse events; prior studies have also documented worse outcomes among women than men with severe multivessel/LM CAD. However, the prognostic significance of nonobstructive (1%-49% stenosis) LM CAD, including sex-specific differences, has not been previously examined.
Methods And Results: In the long-term CONFIRM (Coronary CT Angiography Evaluation For Clinical Outcomes: An International Multicenter) registry, patients underwent elective coronary computed tomographic angiography for suspected CAD and were followed for 5 years.
Relationship of Hypertension to Coronary Atherosclerosis and Cardiac Events in Patients With Coronary Computed Tomographic Angiography.
Hypertension
August 2017
From the Los Angeles BioMedical Research Institute at Harbor UCLA Medical Center, Torrance, CA (R.N., M.J.B.); Departments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA (R.N., H.G., D.S.B.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, NewYork-Presbyterian Hospital and Weill Cornell Medicine (L.B., E.J., N.H., M.G., F.Y.L., J.K.M.); Department of Medicine, University of Erlangen, Germany (S.A.); King Saudbin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King AbdulAziz Cardiac Center, Ministry of National Guard, Health Affairs, Riyadh, Saudi Arabia (M.A.-M.); Department of Radiology, Montreal Heart Institute, Quebec, Canada (F.C., E.M.); Department of Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands (F.C., E.M.); Tennessee Heart and Vascular Institute, Hendersonville (T.Q.C.); Division of Cardiology, Severance Cardiovascular Hospital and Severance Biomedical Science Institute, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea (H.-J.C.); William Beaumont Hospital, Royal Oaks, MI (K.C., G.R.); Department of Medicine and Radiology, University of Ottawa, Ontario, Canada (B.J.W.C.); Capitol Cardiology Associates, Albany, New York (A.D.); Department of Radiology and Nuclear Medicine, German Heart Center Munich, Germany (M.H.); Medizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität München, Germany (J.H.); Baptist Cardiac and Vascular Institute, Miami, FL (R.C.); Department of Radiology, Medical University of Innsbruck, Austria (G.F.); Department of Medicine and Radiology, Seoul National University Hospital, South Korea (Y.-J.K.); Department of Medicine and Radiology, University of British Columbia, Vancouver, Canada (J.L.); Department of Nuclear Cardiology, Cardiovascular Center, University Hospital, Zurich, Switzerland (P.A.K.); Department of Cardiology, Emory University School of Medicine, Atlanta, GA (L.J.S.); Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD (T.C.V.); Duke Clinical Research Institute, Durham, NC (A.D.); UNICA, Cardiac CT and MRI Unit, Hospital da Luz, Lisbon, Portugal (H.M.); Department of Clinical Sciences and Community Health, University of Milan, Italy (G.P., D.A.); Centro Cardiologico Monzino, IRCCS, Italy (G.P., D.A.); Department of Cardiology at the Lady Davis Carmel Medical Center, The Ruth and Bruce Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel (R.R.); and Department of Cardiology, Leiden University Medical Center, HARTZ, The Netherlands (J.B.).
Hypertension is an atherosclerosis factor and is associated with cardiovascular risk. We investigated the relationship between hypertension and the presence, extent, and severity of coronary atherosclerosis in coronary computed tomographic angiography and cardiac events risk. Of 17 181 patients enrolled in the CONFIRM registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry) who underwent ≥64-detector row coronary computed tomographic angiography, we identified 14 803 patients without known coronary artery disease.
View Article and Find Full Text PDFEffect of Medicaid Coverage on ED Use - Further Evidence from Oregon's Experiment.
N Engl J Med
October 2016
From the Department of Economics (A.N.F.) and the Abdul Latif Jameel Poverty Action Lab (J-PAL) (A.N.F., K.B.), Massachusetts Institute of Technology (A.N.F.), and the National Bureau of Economic Research (A.N.F., S.L.T., K.B.), Cambridge, and the Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston (K.B.) - all in Massachusetts; Columbia University School of Social Work, New York (H.L.A.); and Providence Health and Services, Portland, OR (B.J.W.).
Prognostic and therapeutic implications of statin and aspirin therapy in individuals with nonobstructive coronary artery disease: results from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry) registry.
Arterioscler Thromb Vasc Biol
April 2015
From the Department of Medicine (Cardiology), University of Ottawa Heart Institute, Ottawa, Ontario, Canada (B.J.W.C., G.S., Y.Y., L.C., R.M.); Department of Medicine, University of Erlangen, Erlangen, Germany (S.A.); Department of Medicine, Henry Ford Hospital, Wayne State University, Detroit, MI (M.A.-M.); Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA (D.S.B., V.Y.C., T.L.); Department of Medicine, Harbor University of California, Los Angeles Medical Center (M.J.B.); Department of Radiology, Giovanni XXIII Hospital, Monastier di Treviso, Italy (F.C., E.M.); Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands (F.C., E.M.); Tennessee Heart and Vascular Institute, Hendersonville (T.Q.C.); Division of Cardiology, Severance Cardiovascular Hospital, Seoul, Korea (H.-J.C.); William Beaumont Hospital, Royal Oaks, MI (K.C.); Baptist Cardiac and Vascular Institute, Miami, FL (R.C.); Capitol Cardiology Associates, Albany, NY (A.D.); Department of Public Health (A.D.), Medicine and Radiology (F.L.), and Department of Radiology (J.K.M.), New York Presbyterian Hospital and the Weill Cornell Medical College; Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria (G.F.); Division of Cardiology, Technische Universität München, Munich, Germany (M.H., J.H.); Cardiovascular Medical Group, Los Angeles, CA (R.P.K.); Cardiac Imaging, University Hospital, Zurich, Switzerland (P.A.K.); Seoul National University Hospital, Seoul, South Korea (Y.-J.K.); Department of Medicine and Radiology, University of British Columbia, Vancouver, British Columbia, Canada (J.L.); Department of Cardiology, William Beaumont Hospital, Royal Oaks, MI (G.L.R.); Department of Medicine, Emory University School of Medicine, Atlanta, GA (L.J.S.); and Department of Medicine, Walter Reed Medical Center, Washington, DC (T.C.V.).
Objective: We sought to examine the risk of mortality associated with nonobstructive coronary artery disease (CAD) and to determine the impact of baseline statin and aspirin use on mortality.
Approach And Results: Coronary computed tomographic angiography permits direct visualization of nonobstructive CAD. To date, the prognostic implications of nonobstructive CAD and the potential benefit of directing therapy based on nonobstructive CAD have not been carefully examined.
Image-guided tumor ablation: standardization of terminology and reporting criteria--a 10-year update.
J Vasc Interv Radiol
November 2014
Department of Radiology, Image-Guided Therapy and Interventional Oncology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Image-guided tumor ablation has become a well-established hallmark of local cancer therapy. The breadth of options available in this growing field increases the need for standardization of terminology and reporting criteria to facilitate effective communication of ideas and appropriate comparison among treatments that use different technologies, such as chemical (eg, ethanol or acetic acid) ablation, thermal therapies (eg, radiofrequency, laser, microwave, focused ultrasound, and cryoablation) and newer ablative modalities such as irreversible electroporation. This updated consensus document provides a framework that will facilitate the clearest communication among investigators regarding ablative technologies.
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