The Interplay Between Stigma and Asian Cultural Values in People with Parkinson's Disease and Their Caregivers.

Parkinson's Disease (PD), the second most prevalent neurodegenerative disorder globally, often carries stigma for those affected; however, stigma's impact on PD caregivers is not well understood. This study investigates PD stigma and its interplay with cultural values, as well as explores the role of depressive symptomatology in shaping help-seeking attitudes among individuals with PD and the provision of support by PD caregivers. Using cross-sectional data collected from people living with PD and their caregivers, this study examines how adherence to Asian values influences the link between self-stigma and help-seeking tendencies in PD patients, as well as how affiliate stigma is linked to caregivers' willingness to help.

Visions by WIMIN: Imposter Phenomenon.

The imposter phenomenon (IP) is a destructive set of beliefs, traits, and experiences in which high-achieving individuals fail to internalize their accomplishments and falsely perceive themselves as frauds. IP is a function of underrepresentation and contributes to and perpetuates a cycle of low self-worth, perfectionism, and anxiety, all of which negatively affect job performance and reinforce the IP cycle. Mitigating the deleterious effects of IP requires first naming this phenomenon and recognizing the patterns of IP.

The Role of Regional Anesthesia in ICU Pain Management.

Purpose Of Review: The purpose of this review is to provide the most recent update and summary on the consideration, benefits and application of regional anesthesia in the ICU setting, as it pertains to the management of perioperative pain.

Recent Findings: Regional anesthesia and analgesia have become ubiquitous in the perioperative setting, with numerous indications and benefits. As integral part of the multimodal analgesia approach, various regional blocks have been increasingly utilized in critically ill patients.

Dialysis Headache: An Updated Literature Review.

Purpose Of Review: The objective of this review is to describe recent updates in the understanding of dialysis headache. These recent findings will be placed in a historical context that reviews the clinical features, classification, epidemiology, pathophysiology, and treatment of dialysis headache.

Recent Findings: There is something intrinsic to the dialysis procedure itself that leads to headaches in susceptible individuals.

Vitiligo and the microbiome of the gut and skin: a systematic review.

Vitiligo is a chronic autoimmune skin condition characterized by depigmentation due to the destruction of melanocytes. Recent research has identified potential links between vitiligo and alterations in both the gut and skin microbiomes. This systematic review aims to explore these microbiome changes and their potential role in the onset and progression of vitiligo.

Polariton spectra under the collective coupling regime. I. Efficient simulation of linear spectra and quantum dynamics.

We outline two general theoretical techniques to simulate polariton quantum dynamics and optical spectra under the collective coupling regimes described by a Holstein-Tavis-Cummings (HTC) model Hamiltonian. The first one takes advantage of sparsity of the HTC Hamiltonian, which allows one to reduce the cost of acting polariton Hamiltonian onto a state vector to the linear order of the number of states, instead of the quadratic order. The second one is applying the well-known Chebyshev series expansion approach for quantum dynamics propagation and to simulate the polariton dynamics in the HTC system; this approach allows us to use a much larger time step for propagation and only requires a few recursive operations of the polariton Hamiltonian acting on state vectors.

Illustrating the structures of bias from immortal time using directed acyclic graphs.

Background: Immortal time is a period of follow-up during which death or the study outcome cannot occur by design. Bias from immortal time has been increasingly recognized in epidemiological studies. However, the fundamental causes and structures of bias from immortal time have not been explained systematically.

Mental Health Care Utilization and Prescription Rates Among Children, Adolescents, and Young Adults in France.

Importance: Amid escalating mental health challenges among young individuals, intensified by the COVID-19 pandemic, analyzing postpandemic trends is critical.

Objective: To examine mental health care utilization and prescription rates for children, adolescents, and young adults before and after the COVID-19 pandemic.

Design, Setting, And Participants: This population-based time trend study used an interrupted time series analysis to examine mental health care and prescription patterns among the French population 25 years and younger.

Genome Assembly for an Endangered Lemur Using Portable Nanopore Sequencing in Rural Madagascar.

As one of the most threatened mammalian taxa, lemurs of Madagascar are facing unprecedented anthropogenic pressures. To address conservation imperatives such as this, researchers have increasingly relied on conservation genomics to identify populations of particular concern. However, many of these genomic approaches necessitate high-quality genomes.

Guidance and Considerations When Performing Data-Validity Checks.

This response to a Commentary by Delgado-Ron, Jeyabalan, Watt, and Salway (2024) on Cimpian, Timmer, and Kim's (2023) paper discusses and clarifies some key issues in applying the new data-validity sensitivity analysis proposed by Cimpian et al. (2023). The differences in the applications of the method by Delgado-Ron et al.

Impact of gamma radiation on marginal adaptation of nanohybrid composite and composition of dental hard tissues - Scanning electron microscopy and X-ray diffraction analysis: An pilot study.

Aims: This pilot study aimed to compare the marginal adaptation of composite resin at the tooth-restoration interface, before and after radiation.

Subjects And Methods: Fifteen extracted premolars were divided into 2 experimental groups (based on the timing of irradiation) and 1 control group of 5 teeth each. In Group I (control group), teeth were restored but not exposed to radiation at any stage, Group II: teeth were irradiated before cavity preparation and restoration, and Group III: after cavity preparation and restoration employing selective etch technique, teeth were exposed to radiation.

Severe Reversible Heart Failure Enhanced by Sorafenib Treatment for Hepatocellular Carcinoma.

The multitarget oral tyrosine kinase inhibitor sorafenib is an effective first-line treatment option in unresectable hepatocellular carcinoma. Through its mechanism of action, it has been associated with cardiotoxicity, mainly hypertension, which is usually low-grade and well-managed with behavioral changes and antihypertensor treatment adjustment, if needed. Acute, symptomatic heart failure is rarely described.

Expanding perspectives and understanding relational potential: Are mutually beneficial human-animal relationships compatible with current animal agricultural practices?

Animal agriculture employs approximately one-eighth of world's human population and results in the slaughter of over 160 billion animals annually, representing perhaps the most extensive intertwining of human and animal lives on the planet. In principle, close, intersubjective relationships (involving shared attention and mental states) between humans and the animals in agriculture are possible, though these are infrequently studied and are unlikely to be achieved in farming, given systemic constraints (e.g.

Image Guidance is Associated with Improved Freedom From Recurrence After Superficial Radiation Therapy for Nonmelanoma Skin Cancer.

Purpose: This is the first study to quantify the 2-year freedom from recurrence for individuals with nonmelanoma skin cancer (NMSC) such as basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and squamous carcinoma in situ (SCCIS) treated with image guided superficial radiation therapy (IGSRT) versus SRT without image guidance.

Methods And Materials: This retrospective cohort study evaluates the 2-year freedom recurrence rate of NMSCs treated by IGSRT (March 2016 to January 2022) and compares it to existing data on NMSCs treated by SRT via 1 sample proportion tests. Individuals >18 years old with biopsy-proven SCC, SCCIS, and/or BCC treated with IGSRT were included in the study, and 1602 patients/2880 treated lesions were followed until January 14, 2022.

Cardiopulmonary Substructure Doses are Not Correlated With Cardiorespiratory Fitness Among Breast Cancer Survivors Treated With Contemporary Radiation Therapy.

Purpose: Breast cancer radiation therapy (RT) techniques have historically delivered mean heart doses (MHDs) in the range of 5 Gy, which have been found to predispose patients to cardiopulmonary toxicities. The purpose of this study was to apply artificial intelligence (AI) cardiac substructure auto-segmentation to evaluate the corresponding substructure doses, whether there are laterality- and technique-specific differences in these doses, and if the doses are significantly associated with cardiorespiratory fitness after state-of-the-art RT planning and delivery for breast cancer.

Methods And Materials: Cardiopulmonary substructures were AI auto-segmented.

Montreal cognitive assessment as a cognitive outcome measure in progressive supranuclear palsy.

Background: The Montreal Cognitive assessment (MoCA) is a well-validated global cognitive screening instrument. Its validity in progressive supranuclear palsy (PSP) has not been assessed.

Objectives: To evaluate the MoCA as an outcome measure in PSP clinical trials.

Botulinum toxin therapy in Parkinson disease-related lower limb dystonia. An 8 year retrospective review.

Background: Lower extremity dystonia (LED) is a frequent complication of Parkinson disease (PD). Treatment with botulinum neurotoxinA (BoNTA) over 8 years was retrospectively reviewed.Cases14 patients with LED received an average of 3.

Perception of Residency Program Diversity Is Associated With Vulnerability to Race and Gender Stereotype Threat Among Minority and Female Orthopaedic Trainees.

Introduction: Stereotype threat (ST) is a psychological phenomenon in which perceived fear of confirming negative stereotypes about one's identity group leads to impaired performance. Gender and racial ST has been described in various academic settings. However, it is prevalence in orthopaedic surgery, where women and minorities are underrepresented, has not been examined.

Patient perspectives on educational needs in scleroderma-interstitial lung disease.

Background: Systemic sclerosis is a chronic and rare connective tissue disease with multiorgan effects, including interstitial lung disease (ILD). Navigating systemic sclerosis-interstitial lung disease presents a challenge for patients due to the gaps in patient education, which can impact patient health and quality of life. This study utilized the nominal group technique to identify priority knowledge gaps among patients with systemic sclerosis-interstitial lung disease and inform future educational interventions and research.

Experientially-grounded and distributional semantic vectors uncover dissociable representations of conceptual categories.

Neuronal populations code similar concepts by similar activity patterns across the human brain's semantic networks. However, it is unclear to what extent such meaning-to-symbol mapping reflects distributional statistics, or experiential information grounded in sensorimotor and emotional knowledge. We asked whether integrating distributional and experiential data better distinguished conceptual categories than each method taken separately.

Safety of emergency endoscopic endonasal surgery in COVID-positive patients with hemorrhagic complications of pituitary region tumors: A case report and review of the literature.

Background: Pituitary apoplexy (PA) is a rare, life-threatening clinical syndrome that occurs in response to acute ischemic infarction or hemorrhage of a pituitary adenoma. We report two cases of sudden neurologic and visual decline in patients with pituitary region masses in coronavirus disease (COVID)-positive patients with a focus on potential pathophysiological mechanisms and a safe approach to treatment.

Case Description: Case one is a 58-year-old male presenting with sudden-onset headache and visual disturbance.

Denture use and a slower rate of cognitive decline among older adults with partial tooth loss in China: A 10-year prospective cohort study.

Objective: Denture use has been shown to improve nutritional intake and diet quality in people with tooth loss. Despite evidence linking tooth loss and dementia, few studies have examined the association between denture use and cognitive decline. We investigated the relationship between denture use and cognitive decline among Chinese older adults with tooth loss.

Combining a guided self-help and brief alcohol intervention to improve mental health and reduce substance use among refugee men in Uganda: a cluster-randomized feasibility trial.

Evidence on the effectiveness and implementation of mental health and psychosocial support (MHPSS) interventions for men in humanitarian settings is limited. Moreover, engagement and retention of men in such interventions has been challenging. Adaptations may therefore be required to improve the appropriateness and acceptability of these interventions for men.