Consensus statement on prehabilitation and rehabilitation of osseointegration patients.

Rehabilitation protocols vary according to the osseointegration (OI) implant system and the institutions implanting bone-anchored limbs (BALs). While there are limited peer-reviewed OI publications quantifying details for optimizing surgical candidacy and rehabilitation protocols to ensure support across the BAL spectrum, the authors recommend a multidisciplinary team approach over the user's lifetime. Breakout sessions at the Global Collaborative Congress on OI (GCCO) were convened around key topics, including rehabilitation.

Basic science review of transcutaneous osseointegration: current status, research gaps and needs, and defining future directions.

Basic science research is vital for advancing the emerging field of bone-anchored limb replacement (BALR), or osseointegration (OI). This article discusses clinical challenges for BALR/OI, summarizes current basic science research regarding those challenges, identifies research gaps, and proposes future directions. OI research draws from related fields such as orthopaedic implants and dentistry.

Retrobulbar/intraconal tube placement in patients with glaucoma: Ahmed FP-7 and tube extender case series with 1 year follow-up.

Purpose: The Ahmed FP-7 valve is useful in the management of refractory glaucoma. However, this can often have ocular hypertensive phase and subconjunctival fibrosis that can lead to increased medication use and failure. We report how retrobulbar and intraconal plate placement with tube extension can avoid the ocular hypertensive phase, lower intraocular pressure, and reduce medication burden.

Adverse events and contributing factors in Chinese nursing homes: a multisite cross-sectional study.

Background: Adverse events in nursing homes, which are unintended incidents causing unnecessary harm to older residents. Previous studies in Chinese populations often focused on adverse events in hospitals, rather than residents in nursing homes. Additionally, they tended to focus on single incident rather than multiple types of adverse events.

Opportunities to encourage adoption of a biomarker-enabled care pathway for Alzheimer's in primary care.

Unlabelled: Identification of early-stage Alzheimer's disease (AD) remains a challenge due to limited specialist availability, diagnostic access, disease awareness, and cultural factors. Blood-based biomarkers (BBBM) could play a critical role in the identification and referral of patients suspected of AD to specialty care. A multidisciplinary AD Biomarker Task Force was convened to evaluate current biomarker use cases, define an optimal biomarker-enabled AD diagnostic care pathway, and understand factors impacting adoption.

Optical coherence tomography needle probe for real-time visualization of temperature-induced phase changes within subcutaneous fatty tissue.

: Selective cryolipolysis is a widely used aesthetic procedure that cools subcutaneous adipose tissue to temperatures as low as to induce fat cell destruction. However, real-time monitoring techniques are lacking, limiting the ability to optimize safety and efficacy. Traditional imaging methods either fail to provide adequate penetration depth or lack the resolution necessary for visualizing subcutaneous fatty tissue dynamics.

Computed tomographic angiographic study of common carotid artery anatomic relationships in the dog.

Objective: To further understand spatial relationships of common carotid arteries to adjacent structures through evaluation of computed tomographic angiograms in dogs.

Animals: 24 pet dogs.

Procedure: A database was searched for triplanar computed tomographic angiograms that included the heart base caudally and the 5th cervical vertebra cranially, without macroscopic abnormalities.

Association between behavioural risk factors for hypertension and concordance with the Dietary Approaches to Stop Hypertension dietary pattern among South Asians in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study.

South Asians are among the fastest-growing immigrant population group in the United States (U.S.) with a unique disease risk profile.

Ischaemic and bleeding risk after ST-elevation myocardial infarction in patients with active cancer: a nationwide study.

Aims: Treatment of patients with cancer presenting with ST-elevation myocardial infarction (STEMI) is complex given the increased risk of both thrombotic and major bleeding complications.

Methods And Results: A nationally linked cohort of STEMI patients between January 2005 and March 2019 was obtained from the UK Myocardial Infarction National Audit Project and the UK National Hospital Episode Statistics Admitted Patient Care registries. The primary outcomes were major bleeding and re-infarction at 1 year following admission with STEMI.

Symptom networks of common mental disorders in public versus private healthcare settings in India.

We present a series of network analyses aiming to uncover the symptom constellations of depression, anxiety and somatization among 2,796 adult primary health care attendees in Goa, India, a low- and middle-income country (LMIC). Depression and anxiety are the leading neuropsychiatric causes of disability. Yet, the diagnostic boundaries and the characteristics of their dynamically intertwined symptom constellations remain obscure, particularly in non-Western settings.

Proposed research classification criteria for Lyme disease in infection associated chronic illness studies.

Background: Research on patients with persistent symptoms despite prior treatment for Lyme disease can be challenging to interpret given the diversity of criteria selected to characterize Lyme disease and to define the syndrome of those with persistent symptoms. Because most research studies only include patients with well-documented prior Lyme disease, the generalizability of the study results is limited, excluding the larger group of patients often seen in community practice who do not meet these stringent enrollment criteria. Researchers at the Lyme and other Tick-borne Diseases Clinical Trials Network (LTD-CTN) recognized early on that a research classification system was needed to facilitate the design of studies that are more inclusive.

Vascular Tension Gone Wrong: Sigmoid Colon Herniation Leading to a Mesenteric Hematoma.

Mesenteric hematomas, a rare and clinically significant condition, are typically associated with abdominal trauma, vascular conditions, or surgical complications. Spontaneous mesenteric hematomas, an even rarer subtype, are often seen in patients who are on anticoagulation therapy or have inguinal hernias. In this case report, we discuss an 89-year-old male patient who initially presented with stable vital signs and abdominal pain but was later discovered to have a large, stable mesenteric hematoma on an abdominal computed tomography scan.

Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications.

The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-generation technology. Our keynote speaker shared the vision of using neuro artificial intelligence to predict depression using brain electrophysiology.

Fluorescent PyrAte-()-citalopram conjugates enable imaging of the serotonin transporter in living tissue.

Fluorescent labeling techniques have enabled the visualization of various biomolecules, cellular structures, and their associated physiological processes. At the same time, there remains a demand for developing novel fluorescent compounds possessing unique chemical properties for biological imaging. A recently developed class of fluorophores, termed , displays optimal brightness and large Stokes shifts that are ideal for fluorescence microscopy.

Using Metabolic Testing to Personalize Behavioral Obesity Treatment.

Background: There are large individual differences in weight loss and maintenance. Metabolic testing can provide phenotypical information that can be used to personalize treatment so that people remain in negative energy balance during weight loss and remain in energy balance during maintenance. Behavioral testing can assess the reinforcing value and change in the temporal window related to the personalized diet and exercise program to motivate people to maintain engagement in healthier eating and activity programs.

Engagement, user satisfaction, and the amplification of divisive content on social media.

Social media ranking algorithms typically optimize for users' revealed preferences, i.e. user engagement such as clicks, shares, and likes.

MechanoBioCAD: a generalized semi-automated computational tool for mechanobiological studies.

Soft micropillar arrays enable detailed studies of cellular mechanotransduction and biomechanics using traditional beam-bending models. However, they often rely on simplified assumptions, leading to significant errors in force estimation. We present MechanoBioCAD (MBC), a finite element method (FEM)-based tool designed specifically for micropillar research and error estimation.

New strategy for integration of anaerobic side-stream reactor with mainstream B-stage nitritation for short-cut nitrogen removal with granulation.

This study reported a successful mainstream B-stage nitritation reactor with sludge granulation that incorporated a side-stream anaerobic reactor to treat municipal wastewater A-stage effluent. With influent COD/N and COD/P ratios of 2.60 and 27.

A Clinical, Morphologic, and Molecular Comparison of Bonafide Spitz Melanomas and ASTs in the Pediatric Population.

Pediatric Spitz melanoma (SM) with bonafide metastatic disease is rare. In this study, we assembled the largest cohort to date of pediatric SM with a verified Spitz-associated genomic driver and clinical follow-up demonstrating bonafide metastasis. We compared the clinical, morphologic, and molecular features of these SMs to a control cohort of 57 pediatric atypical Spitz tumors (ASTs).

Active shooter preparedness for special education classrooms.

Active shooter planning for special education classrooms requires considerations commensurate to the needs of students with mobility, cognitive, auditory, visual, and communicative limitations. The federally established Run, Hide, Fight response methodology has no modified alternative for students who are not able to meet the criteria to run, hide, or fight. School districts that implement Run, Hide, Fight plans without any modified alternatives for special education students expose a compliance lapse of the American Disabilities Act, the Department of Education's Individuals with Disabilities Education Act, and the National Preparedness Goal.

The Emotional Impact of Clinical Ethics Work on Clinical Ethicists: A Qualitative Study.

Background: The experiences of clinical ethicists have recently begun to garner some attention, but very little is known about the emotional impact of clinical ethics work on clinical ethicists. The purpose of our study was to explore the experiences of clinical ethicists in the United States in order to better understand the impact that their professional responsibilities have on them as people, as well as to learn about the ways in which organizational structures and coping mechanisms help them navigate the emotional impact of their work.

Methods: This was a primary analysis of 34 semi-structured interviews with clinical ethicists across the United States.

An evaluation of important plant areas around the world.

Area-based approaches have long dominated biodiversity conservation and have been reinforced by the Kunming-Montreal Global Biodiversity Framework. The important plant area (IPA) approach is a leading framework for the spatial conservation prioritization of plants and fungi, but over 20 years since its launch, its application and conservation outcomes remained unevaluated. Through systematic mapping and semistructured interviews of key informants, we evaluated IPAs globally.

Large On-Off Enhancement of Au Nanocatalyst Contacts to ZnO Nanowires with Bulk and Surface Oxygen Modification.

Schottky diodes have been a fundamental component of electrical circuits for many decades, and intense research continues to this day on planar materials with increasingly exotic compounds. With the birth of nanotechnology, a paradigm shift occurred with Schottky contacts proving to be essential for enabling nanodevice inventions and increasing their performance by many orders of magnitude, particularly in the fields of piezotronics and piezoelectric energy harvesting. ZnO nanomaterials have proven to be the most popular materials in those devices as they possess high piezoelectric coefficients, high surface sensitivity, and low resistivity due to the high native n-type doping and low hole concentration.